Clinical trials
Headache clinical trials
Below are recruiting headache clinical trials, each written for real people, not researchers. We’re tracking 165 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07269561Recruiting
Headache registry and long-term follow-up study
This trial is a registry study that tracks people with various headache disorders over time. It aims to learn more about how headaches affect patients and to improve future care.
Wuhan, HubeiAges 6–70 - NCT07307508Recruiting
Scalp block for headache after aneurysm bleeding
This trial tests if a scalp nerve block can better manage severe headaches after a brain aneurysm rupture. It is for patients who had an aneurysm treated with coiling in the intensive care unit.
DohaAges 18 years+ - NCT07325513Recruiting
Brain stimulation for Gulf War-related pain
This study tests whether a type of brain stimulation (repeated transcranial magnetic stimulation, or rTMS) can help reduce headaches and body pain in veterans with Gulf War Illness. If you are a Gulf War veteran with ongoing moderate-to-severe pain, this trial could help find a new way to manage your symptoms.
San Diego, CaliforniaAges 18–65 - NCT07347730Recruiting
Trigger point injections for chronic headache from the neck
This study tests whether injections into muscle trigger points can reduce chronic headache pain that starts in the neck. It may help people who have not found relief from standard pain medications.
Beijing, Beijing MunicipalityAges 18–65 - NCT07354464RecruitingPhase 3
Treating spinal headache: nose spray vs. blood patch
This trial compares two treatments for the severe headache that can occur after a spinal tap or epidural. One treatment is a numbing medicine sprayed into the nose (sphenopalatine block), the other is a blood patch (injecting your own blood into your back). The goal is to see which works better and faster.
Clermont-FerrandAges 18 years+ - NCT07360782Recruiting
Personalized nerve treatment for medication overuse headache
This trial tests a treatment called personalized pulsed radiofrequency, which uses gentle electrical pulses on a nerve at the back of your head to help reduce headaches caused by using too much pain medication. It is designed for people who have been diagnosed with Medication Overuse Headache and want a non-drug option.
AnkaraAges 18–65 - NCT07366060Recruiting
Neck nerve treatment for headache from the neck
This study tests a procedure called pulsed radiofrequency on a nerve in your neck to see if it helps headaches that start from the neck. If standard treatments haven't worked for you, this might be an option.
Ankara, AnkaraAges 18 years+ - NCT07677137Recruiting
Testing a nerve stimulator for hard-to-treat chronic cluster headache
This trial tests a device that uses mild electrical pulses to the nerves at the back of the head to prevent cluster headaches. It is designed for people whose headaches have not responded to multiple standard treatments.
Sint-NiklaasAges 22–70 - NCT07477236Recruiting
Sleep and headache management study
This study tests a natural supplement to help adults manage everyday headaches and improve sleep. You will take the supplement daily and fill out weekly surveys and a daily log.
New York, New YorkAges Any age - NCT07477483Recruiting
Manual therapy for tension headaches in menopausal women
This study tests if manual therapy (gentle hands-on techniques) can help reduce tension-type headaches in women going through menopause or premenopause. It involves tracking your headache symptoms and receiving treatment over several sessions.
Konya, KonyaAges 45–65 - NCT07479082Recruiting
Ear nerve stimulation for headache after aneurysm coiling
This trial tests whether a gentle electrical device placed on your ear (called transcutaneous auricular vagus nerve stimulation) can help prevent or reduce headaches that sometimes happen after a procedure to treat an unruptured brain aneurysm. If you're scheduled for stent-assisted coiling or flow diverter treatment, this study may offer a non-drug option to manage post-surgery pain.
Beijing, Beijing MunicipalityAges 18–80 - NCT07508410Recruiting
Mulligan vs Myofascial Release for Neck-Related Headaches
This study compares two hands-on therapy techniques—Mulligan mobilization and myofascial release—to see which works better for headaches that start from the neck. If you have neck pain on one side and headaches that get worse with movement, this trial may help you find relief.
KonyaAges 18–65 - NCT07515456Recruiting
Comparing Three Medications for Spinal Headaches
This study tests three different medications—theophylline, sumatriptan, and gabapentin—to see which works best for headaches that occur after a spinal procedure. You would receive one of these treatments and be monitored to see how well it relieves your pain.
Tanta, El-GharbiaAges 21–50 - NCT07526025Recruiting
Neck exercises for headaches caused by neck problems
This study tests two types of neck exercises to treat headaches that start in the neck and travel to the head. The exercises focus on strengthening neck muscles and retraining how your neck moves to reduce pain.
Islamabad, Punjab ProvinceAges 18–45 - NCT07553533Enrolling by invitation
Temporary Nerve Stimulation for Headache Relief
This trial studies a temporary nerve-stimulation device placed near the back of your head to treat chronic headaches. The device sends mild electrical pulses to help reduce headache pain over 60 days, and your doctor has already decided this treatment is right for you as part of your regular care.
New Haven, ConnecticutAges 18 years+ - NCT07373275Enrolling by invitation
Lifestyle Medicine for Teen Migraine
This study tests whether a lifestyle medicine program (like healthy habits and stress management) can help reduce migraine headaches in teenagers. It's for teens who get frequent migraines and are patients at certain MaineHealth clinics.
Scarborough, MaineAges 14–18 - NCT07310823Enrolling by invitation
Manual therapy for neck-related headaches
This study tests if manual therapy (hands-on treatment) can help people whose headaches start from neck problems. If you have headaches at least once a week and limited neck movement, this trial may be an option.
GizaAges 20–40 - NCT07295587Enrolling by invitation
Headache impact study for Libbs employees
This trial looks at how headaches affect employees at Libbs Pharmaceutical. It uses health data from the Dr. Cefaleia app to understand the burden of headaches at work.
São Paulo, São PauloAges Any age - NCT07168512Enrolling by invitation
Release technique and exercises for cervicogenic headache
This trial tests whether a gentle hands-on therapy called myofascial release, alone or with exercises, can improve the neck curve, sleep, and mood in people whose headaches come from a neck problem. If you have headaches that start from your neck, this might help you find relief.
Gaza, Gaza StripAges 20–55 - NCT06822673Enrolling by invitation
Mind-Body Therapy for Children with Headaches
This study tests a mind-body therapy (MBI) to see if it can reduce headaches and improve well-being in children. It focuses on children aged 8 to 12 who get headaches and are otherwise healthy.
RawalpindiAges 8–12 - NCT06805591Enrolling by invitation
Study on low spinal fluid pressure causes and treatment
This study looks at what causes low spinal fluid pressure (intracranial hypotension) and how to treat it. It may help people who have symptoms like severe headache when upright.
Glostrup Municipality, CopenhagenAges 18–80 - NCT06800859Enrolling by invitation
Predicting headache after spinal puncture
This study looks at patients having spinal anesthesia to find patterns that might predict a post-dural puncture headache. It aims to create a risk model that can help prevent or manage this complication.
Wuhan, HubeiAges 3–34 - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT06405646Enrolling by invitation
Cannabidiol and Cannabinol for Chronic Jaw Muscle Pain
This study tests whether certain compounds from the cannabis plant (CBD and CBN) can help relieve long-term pain in the jaw muscles. It is for adults with chronic orofacial pain who have not recently taken medications that affect the nerves or muscles.
WroclawAges 18–80
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Common questions
- Are there clinical trials for headache?
- Yes. Clin2 currently lists 165 recruiting headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.