Clinical trials
Headache clinical trials
Below are recruiting headache clinical trials, each written for real people, not researchers. We’re tracking 164 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07075874Recruiting
Blood test ratio and headache after C-section spinal
This study looks at whether a simple blood test result (the ratio of two types of white blood cells) can help predict and understand a common headache after spinal anesthesia during C-section. If you qualify, your existing medical records will be reviewed—no extra visits or procedures needed.
Istanbul, Merkez MahallesiAges 18 years+ - NCT04609709Recruiting
Physical therapy plus electrical dry needling for tension headaches
This trial tests whether specific physical therapy treatments—exercise, manual soft-tissue work, mobilization, and electrical dry needling/TENS—can reduce tension-type headaches. It may help if your headaches happen often and fit the trial’s “frequent” or “chronic” pattern.
Fort Wayne, IndianaAges 18–65 - NCT07071506Recruiting
New tools to track migraine prevention
This study tests new ways to monitor how well preventive migraine treatments are working. It is for people with chronic migraine who may be starting or already using preventive medications.
Aarhus C, DenmarkAges 18–65 - NCT07054801RecruitingPhase 2
Testing lidocaine and steroids for headache after bleeding stroke
This study tests whether giving two medicines (lidocaine and methylprednisolone) directly into the artery during a routine brain vessel procedure can help relieve headaches caused by a bleeding stroke. It may help find a new treatment for this type of headache.
San Francisco, CaliforniaAges 18 years+ - NCT06062446Recruiting
A new way to do lumbar puncture to prevent headaches
This study tests a modified lumbar puncture (spinal tap) procedure to reduce the chance of getting a headache afterward. It's for people who need a spinal tap as part of their regular medical care.
Houston, TexasAges 18 years+ - NCT06745648Recruiting
Head massage in a head-down position for headache relief
This trial tests a simple, non-drug technique (carotid sinus massage while lying with your head lower than your body) to see if it can relieve headaches. If you have a migraine, tension headache, or mixed headache that started in the last day, you may be able to join.
Trenque Lauquen, Buenos AiresAges 16 years+ - NCT06822673Enrolling by invitation
Mind-Body Therapy for Children with Headaches
This study tests a mind-body therapy (MBI) to see if it can reduce headaches and improve well-being in children. It focuses on children aged 8 to 12 who get headaches and are otherwise healthy.
RawalpindiAges 8–12 - NCT06824025RecruitingEarly Phase 1
Comparing two drugs for headache after spinal anesthesia in C-section
This trial tests if a combination of neostigmine and atropine works better than lidocaine for treating severe headaches that can happen after spinal anesthesia during a planned C-section. It aims to find a more effective way to relieve this type of headache.
MinyaAges 18–35 - NCT06805591Enrolling by invitation
Study on low spinal fluid pressure causes and treatment
This study looks at what causes low spinal fluid pressure (intracranial hypotension) and how to treat it. It may help people who have symptoms like severe headache when upright.
Glostrup Municipality, CopenhagenAges 18–80 - NCT06802471Recruiting
Can electroacupuncture help medication overuse headache?
This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can help people who have headaches very often because they use pain relievers too much. If you join, you will receive either real or sham (placebo) electroacupuncture, and your headaches and quality of life will be tracked for several months.
Beijing, Beijing MunicipalityAges 18–80 - NCT06800859Enrolling by invitation
Predicting headache after spinal puncture
This study looks at patients having spinal anesthesia to find patterns that might predict a post-dural puncture headache. It aims to create a risk model that can help prevent or manage this complication.
Wuhan, HubeiAges 3–34 - NCT03231241Recruiting
Study of worsening headaches using scans and blood testing
This study looks at why headaches can become long-lasting (“chronified”) by combining answers from online questionnaires, brain imaging, and blood protein tests. Your participation may help researchers find biological clues that could improve how headache problems are understood and treated.
Stanford, CaliforniaAges 18 years+ - NCT06621329RecruitingPhase 2/Phase 3
Numbing shot for headache after brain bleed
This trial tests a numbing injection inside the nose to quickly relieve severe headaches caused by a brain bleed (subarachnoid hemorrhage). It may help reduce pain without strong medicines.
Sacramento, CaliforniaAges 18–100 - NCT06608277RecruitingPhase 2
Ketamine and nerve block for headache or PTSD after brain injury
This study tests if ketamine infusions or a stellate ganglion block (a numbing injection near the neck) can help people with long-term headaches or PTSD after a traumatic brain injury. It compares these treatments alone and together.
Chicago, IllinoisAges 18 years+ - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT06582810Recruiting
Lidocaine for headaches after brain bleed
This study tests whether a lidocaine infusion (given through an IV) can safely reduce severe headaches after a subarachnoid hemorrhage (a type of brain bleed). You may qualify if you had a spontaneous bleed and can communicate your pain level.
Wichita, KansasAges 18 years+ - NCT06405646Enrolling by invitation
Cannabidiol and Cannabinol for Chronic Jaw Muscle Pain
This study tests whether certain compounds from the cannabis plant (CBD and CBN) can help relieve long-term pain in the jaw muscles. It is for adults with chronic orofacial pain who have not recently taken medications that affect the nerves or muscles.
WroclawAges 18–80 - NCT06203873Recruiting
Comparing biodegradable vs. metal heart-hole closures for migraine
This trial compares two types of devices (biodegradable vs. metal) to close a small hole in the heart (PFO) in people who have migraine not controlled by usual treatments. It aims to see which device works better to reduce migraine attacks.
Beijing, Beijing MunicipalityAges 18–65 - NCT06112093RecruitingPhase 1
Magnetic brain stimulation for headaches after a concussion
This study tests whether a non-invasive magnetic pulse treatment (repetitive transcranial magnetic stimulation) can help people with long-lasting headaches following a mild concussion. If you are 18 to 55 years old and have had daily headaches for at least 3 months after your head injury, this study may help find a new way to relieve your pain.
Syracuse, New YorkAges 18–55 - NCT06077747Recruiting
Lumbar vein treatment for chronic headaches with nutcracker anatomy
This study tests a procedure called lumbar vein embolization to treat daily headaches that feel like pressure and get worse when lying down. It's for people who have a rare anatomy where a vein in the kidney is pinched (nutcracker physiology), and standard headache medicines haven't helped.
Jacksonville, FloridaAges 18 years+ - NCT06041997Recruiting
Limiting smartphone use for headache relief
This trial tests whether reducing smartphone use can help treat primary headaches (migraines or tension headaches) in adults. If you get headaches that aren't caused by another medical condition, this study might be a good fit.
New Delhi, National Capital Territory of DelhiAges 18 years+ - NCT06008795RecruitingPhase 2
Pain-block injection for headache after brain bleed
This study tests a pain-block injection (called a PPF-block) for severe headaches after a brain bleed (subarachnoid hemorrhage). It compares the injection to standard pain medicine to see if it reduces headache and the need for opioids.
Gainesville, FloridaAges 18–85 - NCT06015451Recruiting
Exercise for concussion symptoms and headache
This trial tests whether a carefully supervised exercise program can help people who still have headaches or other symptoms weeks after a mild head injury. If you get symptoms when you try to be active, this study may offer a structured way to help you recover.
TrondheimAges 18–65 - NCT05902026Enrolling by invitation
Questionnaire study for jaw-related headache and pain impact
This study tests a biopsychosocial questionnaire (a survey about thoughts, daily life, and pain) for people with jaw-related headaches from temporomandibular disorder (TMD). It may help researchers better understand what influences headache severity and how to support treatment planning.
Gaziantep, Hasan Kalyoncu UniversityAges 18–60
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Common questions
- Are there clinical trials for headache?
- Yes. Clin2 currently lists 164 recruiting headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.