Clinical trials · California
Heart Diseases clinical trials in California
We’re tracking 61 recruiting heart diseases studies with a site in California — including Early Phase 1, Phase 1, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT04124120Recruiting
Single vs multiple bypass grafts for women heart surgery
This study compares outcomes of using one bypass graft versus multiple bypass grafts during coronary artery bypass surgery in women. It aims to see which approach leads to better recovery and heart outcomes for eligible patients.
Pomona, CaliforniaAges 18 years+ - NCT06164730RecruitingPhase 1
Study of VERVE-102 for high cholesterol or early heart disease
This trial tests a new medicine called VERVE-102 for people with a specific type of high cholesterol (HeFH) or early coronary artery disease. It aims to see if it can help lower cholesterol levels.
Pomona, CaliforniaAges 18–70 - NCT06080074RecruitingPhase 2
Emergency heart-lung machine study for children with severe heart failure
This study tests a specific heart-lung machine called Cardiohelp to help children with severe heart failure. It looks at how well the machine works and whether a blood thinner (either heparin or bivalirudin) is safer and more effective.
Palo Alto, CaliforniaAges birth–16 years - NCT07714252Enrolling by invitation
Virtual palliative care team for veterans with heart or lung disease
This study tests a virtual team of nurses and social workers who provide palliative care to veterans with heart failure, COPD, or interstitial lung disease. The goal is to improve quality of life by offering extra support at home.
Long Beach, CaliforniaAges 18 years+ - NCT03209583Recruiting
Test of fast-pacing therapy for congenital heart rhythm issues
This trial studies whether a device-based fast pacing therapy (called ATP) can better treat certain rapid heart rhythm problems in people born with a heart condition. It may help prevent or reduce episodes of atrial (upper-chamber) arrhythmias that occur despite having a pacing/defibrillator device.
Orange, CaliforniaAges Any age - NCT05386173Recruiting
Tests fetal aortic valve balloon surgery for severe narrowing
This trial studies whether doing a procedure before birth to open a baby’s aortic valve improves outcomes. It compares this approach in a specific group of pregnancies with severe heart flow problems seen on ultrasound.
San Francisco, CaliforniaAges 5 months–7 months - NCT05637814Recruiting
Screening for critical heart defects with extra blood flow checks
This trial tests if adding blood flow measurements to standard pulse oximeter screening better detects critical congenital heart disease in fetuses and newborns. It may help identify babies who need early heart care.
Davis, CaliforniaAges birth–3 weeks - NCT04843072Recruiting
Comparing two new valve options for a failing replacement aortic valve
This trial compares two types of replacement heart valves (balloon-expandable and self-expanding) for people whose prior surgical aortic valve is no longer working. It looks at which valve type offers better outcomes when placed through a catheter in the leg.
Los Angeles, CaliforniaAges 18 years+ - NCT03277365Recruiting
Share your 23andMe data with a digital genetics study
This study tests a digital platform that uses people’s existing genetic information to support genetic research. If you are an adult and willing to share your 23andMe results from an Apple phone, you can likely participate.
La Jolla, CaliforniaAges 18 years+ - NCT07466745Recruiting
New Pulmonary Valve Study for Kids Needing Replacement
This study tests a new type of replacement valve for children who need a new pulmonary valve (the valve between the heart and lungs). Researchers want to see if the valve works safely and well in real-world use.
Los Angeles, CaliforniaAges 1.5 years–16 years - NCT07288216RecruitingPhase 2
Switching to KPL-387 alone for well-controlled pericarditis
This study tests whether a new drug, KPL-387, can keep your pericarditis under control as your only treatment, after you have been stable on other medicines. It is for people whose pericarditis is well controlled now but who have had flares in the past.
Los Angeles, CaliforniaAges 18–80 - NCT07130994Recruiting
Testing a new less invasive mitral valve replacement (SATURN)
This trial tests a new, less invasive device called the SATURN system to replace a severely leaky mitral heart valve without open-heart surgery. It is for people who are too high-risk for traditional surgery and are willing to take blood thinners.
Sacramento, CaliforniaAges 18 years+ - NCT07023367Recruiting
Parent navigator program for Latino families of babies with heart disease
This study offers a parent navigator program to help Latino families whose baby had early heart surgery. The program aims to support both the child's recovery and the parents' well-being.
Los Angeles, CaliforniaAges birth+ - NCT06854458Recruiting
Stress heart MRI for better diagnosis of heart artery disease
This study uses a special stress heart MRI to measure blood flow and find blockages in the arteries that supply your heart. It is for people with chest pain or abnormal EKG results who have risk factors for heart disease, to help doctors diagnose and treat coronary artery disease more accurately.
San Francisco, CaliforniaAges 35–85 - NCT06596902Recruiting
Physical activity program for Latino families near the U.S.-Mexico border
This trial tests a program to help Latino families become more active and fit. It takes place at community centers near the border and includes both parents and children.
San Diego, CaliforniaAges 6 years+ - NCT06563895RecruitingPhase 3
Testing acoramidis to prevent ATTR amyloidosis in gene carriers
This trial tests a daily pill called acoramidis to see if it can prevent ATTR amyloidosis in people who carry a gene mutation but have no symptoms yet. It aims to stop the disease before it starts.
La Jolla, CaliforniaAges 18–75 - NCT06400004RecruitingPhase 3
Lumason infusion vs. bolus for better heart imaging
This trial compares two ways of giving Lumason (an ultrasound contrast agent) to improve images of the left ventricle in people whose initial heart ultrasound was unclear. It may help those with a 'suboptimal' view of the heart's pumping chamber.
West Hills, CaliforniaAges 18 years+ - NCT06326996RecruitingEarly Phase 1
Thiamine before bypass surgery
This study tests if giving thiamine (vitamin B1) before heart bypass surgery can help people with low thiamine levels. It is designed for patients who are having a specific type of bypass that does not use a heart-lung machine.
Los Angeles, CaliforniaAges 60–80 - NCT05918211RecruitingPhase 3
Udenafil test during exercise for teens with Fontan circulation
This trial tests whether udenafil helps teens and young people with Fontan circulation do better on exercise and breathing-related measures over time. You’d need to be on blood-thinning medicine, and be able to complete exercise testing safely.
San Francisco, CaliforniaAges 12–18 - NCT05867381Recruiting
Air purifier use to slow heart artery plaque in older adults
This trial tests whether using indoor air filtration at home can slow the progression of heart artery plaque-related problems in people with a past history of ischemic heart disease. It may help by improving indoor air quality, which the study links to inflammation in the body.
Los Angeles, CaliforniaAges 65–84 - NCT05427370Recruiting
Compare bypass or stent treatment in weak heart patients
This study compares two ways to restore blood flow to the heart—bypass surgery (CABG) or stent procedure (PCI)—in people with a weak pumping heart. It looks at which approach works best when the heart muscle is not pumping well and there are multiple blocked heart arteries.
Los Angeles, CaliforniaAges 18 years+ - NCT03149341Enrolling by invitation
MRI and computer-heart simulations for heart disease
This study uses MRI scans and computer simulations to learn more about how the heart and blood flow work in people with certain heart or lung conditions. It may help researchers better understand heart problems and improve future care.
Palo Alto, CaliforniaAges Any age - NCT07017907Recruiting
AI tool for detecting thyrotoxic states
This study tests an artificial intelligence tool designed to help detect overactive thyroid conditions (thyrotoxicosis). It may be an option for people with Graves' disease, whether newly diagnosed or currently in treatment.
San Francisco, CaliforniaAges 22 years+ - NCT03826264Recruiting
Research registry for people getting TAVR
This is a research registry that collects information about people who receive TAVR, a procedure to help open a narrowed heart valve. It may help doctors understand outcomes and improve care, but it is not designed as a drug or device trial by itself.
Stanford, CaliforniaAges 19 years+
Heart Diseases trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting heart diseases studies listed above.
- Cedars-Sinai Medical Center · 4 studies
- University of California, San Francisco · 3 studies
- Children's Hospital Los Angeles · 2 studies
- Stanford University · 2 studies
- Children's Hospital of Los Angeles
- Children's Hospital of Orange County (CHOC)
- Clinical Study Center
- Fetal Cardiovascular Program, University of California San Francisco
What taking part in a heart diseases study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Heart Diseases trials in other states
Common questions
- Are there heart diseases clinical trials in California?
- Yes. We're currently tracking 61 recruiting heart diseases studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart diseases study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart diseases trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart diseases studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.