Clinical trials · Pennsylvania
Heart Diseases clinical trials in Pennsylvania
We’re tracking 34 recruiting heart diseases studies with a site in Pennsylvania — including Phase 1, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT07214376Recruiting
Nerve ablation for pulmonary hypertension from left heart disease
This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.
Mechanicsburg, PennsylvaniaAges 18–85 - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Philadelphia, PennsylvaniaAges 18–100 - NCT06260059RecruitingPhase 4
Jardiance for adults with congenital heart disease and reduced heart function
This study tests a medicine called Jardiance (an SGLT2 inhibitor) to see if it helps improve heart function in adults with congenital heart disease who have recently experienced a drop in their heart pumping ability. Participants will take the medication alongside standard heart failure treatments.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Hershey, PennsylvaniaAges 18 years+ - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05932615Enrolling by invitation
Testing a new transcatheter valve for aortic valve narrowing
This trial studies how safe and effective the NAVITOR valve is for treating narrowed aortic valves placed through a catheter (no open-heart surgery). It may be an option if you’re at intermediate-to-low surgical risk and meet heart ultrasound/CT measurements.
Mechanicsburg, PennsylvaniaAges 18 years+ - NCT06153459Recruiting
Delayed cord clamping for babies with heart disease
This study looks at how long to wait before clamping the umbilical cord in babies born with a heart condition. It helps doctors understand the best timing for these newborns.
Philadelphia, PennsylvaniaAges 9 months–10 months - NCT04141605Enrolling by invitation
Heart transplant candidates matched for better heart preservation
This study creates a worldwide registry and information database to help improve how donor hearts are preserved for transplant. If you are a heart transplant candidate, your details may be recorded to see what matching and preservation approaches work best.
State College, PennsylvaniaAges Any age - NCT05933083Recruiting
In-person vs telehealth heart rehab comparison study
This study compares whether heart rehabilitation done in person or by telehealth (video/phone) works as well for people with certain heart conditions. It may help you and others choose the safest and most effective way to receive cardiac rehab.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06590467Recruiting
Abbott heart device registry study
This registry is a large, ongoing study that collects information about Abbott heart devices used in routine care. It helps doctors learn how well these devices work and how patients are doing over time, without changing your treatment plan.
Philadelphia, PennsylvaniaAges Any age - NCT06542432Enrolling by invitation
Genetic risk test for heart disease prevention
This trial uses a polygenic risk score to see if knowing your genetic risk for coronary artery disease can help prevent a first heart attack. If you have an intermediate 10-year risk and no prior heart events, you may be eligible.
Philadelphia, PennsylvaniaAges 40–70 - NCT04604418Recruiting
Tracking outcomes during non-heart procedures in children with heart defects
This study looks at how children with congenital heart disease do during routine non-heart procedures, including medical or minor treatments that are not heart-related. It also measures how much health care they use afterward, which may help improve care planning for families.
Philadelphia, PennsylvaniaAges Up to 21 years - NCT05610787Enrolling by invitation
Testing a device that helps move an EXCOR pediatric heart pump
This trial studies an “active driving” system that controls the EXCOR pediatric heart pump. It’s meant for children who need a heart pump as a bridge to heart transplantation, to help the pump work more safely and effectively.
Philadelphia, PennsylvaniaAges Up to 21 years - NCT07525843Recruiting
Well-being education program for teens with heart disease
This study tests whether a special education program about managing emotions and stress helps teenagers with moderate-to-severe congenital heart disease (a heart condition from birth) feel better and cope with their condition. Participants attend sessions and complete surveys over time.
Philadelphia, PennsylvaniaAges 12–17 - NCT03217006Recruiting
Compare one vs multiple heart artery grafts for bypass
This study looks at whether using one artery graft or multiple artery grafts during heart bypass surgery works better for people with specific coronary artery disease. You may be randomized to one approach, and the trial team will follow outcomes after surgery.
Pittsburgh, PennsylvaniaAges 18–70 - NCT04073420Recruiting
Cardiac surgery registry to track Medtronic device outcomes
This registry collects real-world information from people who have had—or plan to have—an eligible Medtronic cardiac surgery device. It aims to better understand how these treatments do over time and help guide future care.
Pittsburgh, PennsylvaniaAges Any age - NCT05913908Recruiting
Valve procedure study for severe tricuspid leakage
This trial tests how well a new catheter-based valve system works for people with severe (or worse) tricuspid valve leaking who still have symptoms despite medicines. It aims to improve outcomes by treating the leaking valve without open-heart surgery, if your heart structure and overall health fit the study.
Harrisburg, PennsylvaniaAges 18 years+ - NCT04451044Enrolling by invitation
Guided heart stent planning using an inside pressure sensor
This study tests whether using a tiny pressure sensor in heart arteries during a procedure can better guide where to place a stent. It may help doctors choose the safest and most effective stent plan by more accurately measuring artery narrowing.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06688396Recruiting
Finding early signs of dilated cardiomyopathy with AI and mobile screening
This trial uses a smartphone app to screen first-degree relatives of people with dilated cardiomyopathy (DCM) for early signs of the condition. It aims to detect heart muscle weakness before symptoms start, so that treatment can begin sooner.
Lancaster, PennsylvaniaAges 18 years+ - NCT02852031Recruiting
Care program for newborns needing the Norwood procedure
This trial focuses on improving care for babies born with certain complex heart conditions where only one pumping chamber works. It is meant for babies (including unborn babies) who are planned to have the Norwood procedure, which is a common early surgery.
Harrisburg, PennsylvaniaAges Up to 1.3 years - NCT04124120Recruiting
Single vs multiple bypass grafts for women heart surgery
This study compares outcomes of using one bypass graft versus multiple bypass grafts during coronary artery bypass surgery in women. It aims to see which approach leads to better recovery and heart outcomes for eligible patients.
Wynnewood, PennsylvaniaAges 18 years+ - NCT06027788Recruiting
Embolic protection during heart valve surgery
This trial tests a device that may help protect your brain from small particles during heart valve surgery. It is for people 60 and older having certain types of valve replacement or repair.
Philadelphia, PennsylvaniaAges 60 years+ - NCT06164730RecruitingPhase 1
Study of VERVE-102 for high cholesterol or early heart disease
This trial tests a new medicine called VERVE-102 for people with a specific type of high cholesterol (HeFH) or early coronary artery disease. It aims to see if it can help lower cholesterol levels.
Philadelphia, PennsylvaniaAges 18–70 - NCT05918211RecruitingPhase 3
Udenafil test during exercise for teens with Fontan circulation
This trial tests whether udenafil helps teens and young people with Fontan circulation do better on exercise and breathing-related measures over time. You’d need to be on blood-thinning medicine, and be able to complete exercise testing safely.
Pittsburgh, PennsylvaniaAges 12–18
Heart Diseases trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting heart diseases studies listed above.
- Children's Hospital of Philadelphia · 6 studies
- University of Pennsylvania · 6 studies
- University of Pittsburgh Medical Center · 5 studies
- UPMC Children's Hospital of Pittsburgh · 4 studies
- Allegheny General Hospital · 3 studies
- Thomas Jefferson University Hospital · 3 studies
- UPMC Presbyterian Hospital · 3 studies
- Allegheny Health Network · 2 studies
What taking part in a heart diseases study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Heart Diseases trials in other states
Common questions
- Are there heart diseases clinical trials in Pennsylvania?
- Yes. We're currently tracking 34 recruiting heart diseases studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart diseases study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart diseases trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart diseases studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.