Clinical trials · San Jose, CA
Heart failure clinical trials in San Jose
We’re tracking 30 recruiting heart failure studies with a site in or near San Jose — including Phase 1/Phase 2, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near San Jose
- NCT06065761Enrolling by invitation
Better risk assessment for heart failure in the ER
This trial looks at ways to better understand how serious heart failure is for people who come to the emergency room. It could help doctors decide on the best treatment more quickly.
San Jose, CaliforniaAges 18 years+ - NCT06736574RecruitingPhase 3
Study of omecamtiv mecarbil for chronic heart failure with very weak heart pump
This study tests an investigational medicine (omecamtiv mecarbil) for people with chronic heart failure and very low pumping strength. It looks at whether the drug can help prevent heart failure events or the need for stronger treatments.
Santa Clara, CaliforniaAges 18–85 - NCT07567001RecruitingPhase 3
Testing NNC0487-0111 for Heart Failure and Obesity
This study tests whether a new medication called NNC0487-0111 can help people with heart failure who also have obesity. Researchers will compare it to a placebo (inactive pill) to see if it improves heart function and overall health.
Fremont, CaliforniaAges 18 years+ - NCT06939751Recruiting
Testing microRNA levels to personalize heart transplant care
This trial is studying whether a blood test that measures small molecules called microRNAs can help doctors personalize the medicines used to prevent rejection after a heart transplant. If you qualify, you would help researchers learn how to better match immunosuppression to each patient's needs.
Palo Alto, CaliforniaAges 18–99 - NCT06080074RecruitingPhase 2
Emergency heart-lung machine study for children with severe heart failure
This study tests a specific heart-lung machine called Cardiohelp to help children with severe heart failure. It looks at how well the machine works and whether a blood thinner (either heparin or bivalirudin) is safer and more effective.
Palo Alto, CaliforniaAges birth–16 years - NCT07460219Enrolling by invitation
Pharmacist-led heart failure medication study for VA clinics
This trial tests if pharmacists in VA regions can help adjust heart failure medications. It may improve how patients are treated.
Palo Alto, CaliforniaAges 18 years+ - NCT06541509RecruitingPhase 1/Phase 2
Semaglutide for heart failure in overweight patients
This trial studies whether the drug semaglutide can help people with heart failure who are overweight. It aims to see if the drug improves heart function and symptoms.
Palo Alto, CaliforniaAges 20–80 - NCT07217366Enrolling by invitation
Speech-to-text tool for heart failure patients
This study tests a speech-to-text tool to help people with heart failure report their symptoms and health information more easily. It aims to see if using voice instead of typing can improve data collection.
Palo Alto, CaliforniaAges 18 years+ - NCT05996328Recruiting
Meal delivery study for older veterans with heart failure
This study tests if providing ready-to-eat meals to older veterans recently hospitalized with heart failure can help them recover and avoid going back to the hospital. It aims to make it easier to follow a heart-healthy diet at home.
Palo Alto, CaliforniaAges 60 years+ - NCT05610787Enrolling by invitation
Testing a device that helps move an EXCOR pediatric heart pump
This trial studies an “active driving” system that controls the EXCOR pediatric heart pump. It’s meant for children who need a heart pump as a bridge to heart transplantation, to help the pump work more safely and effectively.
Palo Alto, CaliforniaAges Up to 21 years - NCT05714085RecruitingPhase 2/Phase 3
Vericiguat study for children with heart failure
This trial tests whether vericiguat helps children with chronic heart failure caused by weaker left heart pumping. It also checks safety and how the medicine behaves in the body (dose and processing).
Palo Alto, CaliforniaAges 4 weeks–17 years - NCT01790152Recruiting
Dexrazoxane study to monitor heart damage in cancer survivors
This study tests dexrazoxane (DRZ) to see how it affects blood and heart-related “biomarkers,” or measurable signs of heart damage, after cancer treatment. It mainly targets survivors who may be at risk for cardiomyopathy (heart muscle weakness) or related heart failure.
Palo Alto, CaliforniaAges Any age - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Palo Alto, CaliforniaAges birth–20 years - NCT05001009Enrolling by invitation
Goals of care conversation support for certain serious illnesses
This study helps primary care clinicians and their patients have structured “goals of care” conversations (about what matters most and care preferences). It may help you get clearer, earlier planning—especially if you have a serious illness and higher risk of hospitalization or death.
Palo Alto, CaliforniaAges 18 years+ - NCT05441696Enrolling by invitation
Check a noninvasive heart failure blood-flow measurement in hospital
This study tests a device that measures blood flow and pressure in a noninvasive way (using sensors on the body) for people admitted with worsening heart failure. It may help doctors monitor heart failure and potentially lower the chance of coming back to the hospital.
Palo Alto, CaliforniaAges 18 years+ - NCT04141605Enrolling by invitation
Heart transplant candidates matched for better heart preservation
This study creates a worldwide registry and information database to help improve how donor hearts are preserved for transplant. If you are a heart transplant candidate, your details may be recorded to see what matching and preservation approaches work best.
Stanford, CaliforniaAges Any age - NCT05696652Recruiting
Exercise training study for people with heart failure
This study looks for blood and other markers that can explain how people with heart failure respond to exercise training. It may help researchers better tailor exercise or treatment plans for heart failure in the future.
Stanford, CaliforniaAges 18–89 - NCT06217302RecruitingPhase 3
Sotagliflozin for kidney protection in type 1 diabetes
This study tests whether sotagliflozin (a pill that helps control blood sugar and protects the kidneys) can slow down kidney function decline in people with type 1 diabetes and diabetic kidney disease. You may qualify if you have had type 1 diabetes for at least 8 years, have moderate kidney damage, and are on standard treatments.
Stanford, CaliforniaAges 18–75 - NCT06150950Recruiting
Exercise rehab for Fontan failure
This trial tests if a supervised exercise program (cardiac rehabilitation) can help people who have had a Fontan procedure and are now experiencing heart failure symptoms. It aims to improve your strength, stamina, and overall well-being.
Stanford, CaliforniaAges 18 years+ - NCT00271180Recruiting
Tracks long-term performance of Medtronic heart devices
This study follows how well certain Medtronic heart devices work over the long term. You may be included if you have a qualifying Medtronic implant and the research team can reliably get your implant and follow-up information.
Stanford, CaliforniaAges Any age - NCT06895070Recruiting
Heart transplant study using a special preservation machine
This trial tests a special machine that preserves donor hearts for longer periods before transplant. It may help people waiting for a heart transplant who need a heart from a donor that may be older or has some heart risks.
Stanford, CaliforniaAges 18 years+ - NCT07207811RecruitingPhase 3
Coramitug for heart failure caused by ATTR amyloidosis
This trial tests a new medicine called Coramitug for people with heart failure due to ATTR amyloidosis, a condition where abnormal proteins build up in the heart. The study aims to see if Coramitug can improve heart function and quality of life.
Stanford, CaliforniaAges 18 years+ - NCT05180773RecruitingPhase 4
Bromocriptine for new postpartum heart weakness
This trial studies whether bromocriptine improves health outcomes in people recently diagnosed with peripartum cardiomyopathy (a weakened heart during late pregnancy or soon after delivery). You may be asked about timing after childbirth, heart strength tests, and whether you plan to keep breastfeeding.
Stanford, CaliforniaAges 18 years+ - NCT06361524Enrolling by invitation
Gut bacteria study in chronic heart failure
This study looks at the bacteria in your gut (your 'gut microbiome') and how it relates to chronic heart failure. It may help doctors understand why some people with heart failure do better than others and could lead to better treatments in the future.
Stanford, CaliforniaAges 18–75
Hear when a new Heart failure trial opens near San Jose, CA
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Heart failure trials in other cities
Where these studies are running near San Jose
Institutions with a site for the recruiting heart failure studies listed above.
- Stanford University · 8 studies
- Lucile Packard Children's Hospital at Stanford · 5 studies
- Kaiser Permanente Medical Center - Santa Clara · 2 studies
- Stanford Cancer Institute · 2 studies
- VA Palo Alto Health Care System · 2 studies
- Greenstone Biosciences
- Kaiser Permanente Fremont
- Kaiser Permanente Redwood City Medical Center
What taking part in a heart failure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting heart failure studies in California.
Common questions
- Are there heart failure clinical trials near San Jose?
- Yes. We're currently tracking 30 recruiting heart failure studies with a site near San Jose, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart failure study near San Jose?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in San Jose to take part?
- Not necessarily. These studies have a site near San Jose, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart failure studies open near San Jose regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.