Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 984 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05838287RecruitingPhase 4
Pioglitazone for heart failure with preserved pumping in type 2 diabetes
This trial tests whether pioglitazone (a diabetes medicine) helps people who have type 2 diabetes and a specific type of heart failure where the heart pumps normally. It may improve heart failure symptoms and function in carefully selected patients.
San Antonio, TexasAges 30–70 - NCT07352891Recruiting
Digital remote management vs. usual care for heart failure
This trial tests whether using a remote monitoring platform to help manage medications improves outcomes in people with heart failure and reduced pumping function. It compares this approach to standard follow-up care.
BeijingAges 18 years+ - NCT06678841Recruiting
Pacing therapy for heart failure with preserved pumping ability
This study tests a new pacing approach for people with a specific type of heart failure (HFpEF) to see if it can improve symptoms and quality of life. It involves a pacemaker-like device that adjusts heart rate based on your needs.
Phoenix, ArizonaAges 40 years+ - NCT05491655Recruiting
Testing a new pacing approach in some heart failure patients
This study looks at whether a high-intensity “His bundle” heart pacing method can help people with heart failure who have a specific heart rhythm pattern on ECG. It likely aims to improve heart pumping and symptoms in people who are otherwise a good match for an ICD and meet other criteria.
Acquaviva delle Fonti, BariAges 18–90 - NCT07486791Recruiting
Baduanjin exercise for heart health after heart attack
This study tests whether a gentle exercise called 'Lying-Sitting-Standing' Baduanjin can improve heart and lung function and quality of life in people who have had a heart attack and also have heart failure.
Taiyuan, ShanxiAges Up to 85 years - NCT07224906Recruiting
Observing patients having a right heart catheterization
This study observes people who are already scheduled for a right heart catheterization, a procedure that checks the pressure in your heart. It helps doctors learn more about heart conditions without adding any extra treatments or procedures.
Boulder, ColoradoAges 18 years+ - NCT06898515RecruitingPhase 3
Fluid removal study for acute heart failure patients
This trial tests a device designed to safely remove extra fluid from patients hospitalized with worsening heart failure. It may help those who are not responding well to standard water pills (diuretics).
Irvine, CaliforniaAges 22 years+ - NCT06033950RecruitingPhase 3
A study of finerenone for heart failure patients who can't take standard MRA drugs
This study tests whether finerenone, a new type of drug, can help people with heart failure who cannot take standard steroid-based MRAs (a kind of heart medication) because of side effects or other reasons. It aims to see if it improves symptoms and is safe for you.
Fairhope, AlabamaAges 18 years+ - NCT07076329Recruiting
Using a special diet to prevent malnutrition in older heart patients
This trial tests whether a special type of food can help prevent malnutrition in older adults with heart failure or atrial fibrillation. It looks at how the bacteria in your gut and inflammation in your body affect your brain and overall health.
FlorenceAges 70 years+ - NCT06052072Enrolling by invitation
Heart failure trial testing nerve treatment for lung pressure
This trial tests a new treatment that uses a device to calm overactive nerves in the lung's blood vessels. It is for heart failure patients who also have high blood pressure in their lungs, to see if it can help them breathe easier and feel better.
Chicago, IllinoisAges 22–85 - NCT07265986Recruiting
Comparing robotic remote heart ultrasound to standard care for heart failure
This trial tests whether a robot that performs heart ultrasounds from a distance works as well as a standard in-person ultrasound for managing heart failure. It could help people on the island of Marie-Galante get specialist care without traveling.
Grand-BourgAges 18 years+ - NCT05919342Recruiting
Screening for early heart failure in primary care or at home
This trial tests whether simple screening using a blood test (natriuretic peptides) plus an ultrasound of the heart (echocardiogram) can find early heart failure sooner. Finding it earlier may help doctors start the right management to prevent it from getting worse.
Cleveland, OhioAges 40 years+ - NCT05564689Recruiting
Tests coronary blood flow in heart failure patients with CRT
This study measures how well blood flows in the heart (coronary flow) in people with heart failure with reduced pumping strength and a specific heart rhythm problem called left bundle branch block. It focuses on people who already have a cardiac resynchronization therapy (CRT) device and have stable treatment, to see how coronary flow relates to their heart condition.
AalborgAges 18 years+ - NCT06241651Recruiting
Comparing two types of pacemakers for heart failure patients
This trial tests if a new pacemaker method (CSP) works better than the standard method (BiVP) for people with heart failure who already have a right ventricular pacemaker and need an upgrade.
Nanjing, JiangsuAges 18–80 - NCT06593327Recruiting
Heart failure screening trial for diabetes patients
This trial helps primary care providers screen and prevent heart failure in people with Type 2 diabetes. It uses a simple blood test to find early signs of heart problems.
Dallas, TexasAges Any age - NCT07375433Recruiting
Heart failure and COPD study for patients aged 50 to 70
This trial looks at how heart failure with preserved pumping function affects people who also have COPD. It aims to understand the course of the disease and long-term outlook.
Kazan'Ages 50–70 - NCT06107907Recruiting
Oxygen flow and pressure in heart failure patients
This study tests a new way to measure pressure in your lungs while you receive high-flow oxygen therapy. It may help doctors better understand how to use this treatment in people with heart failure who need extra breathing support.
TaipeiAges 18 years+ - NCT06705023RecruitingPhase 2
Fat-derived cell therapy for heart failure
This study tests whether taking a small amount of your own belly fat (through liposuction), processing it, and injecting the cells back into your heart can improve heart function in people with chronic heart failure due to blocked arteries. The trial is for patients whose heart pumps weakly (ejection fraction of 40% or less) and who are already on standard medications.
AstanaAges 21–80 - NCT04504188Recruiting
Adjusting beta-blocker dose for women using a wearable defibrillator
This trial checks whether doctors can use a lower or adjusted dose of beta-blocker medicine in women who are wearing a wearable defibrillator (WCD). It aims to find an approach that’s safe and works while you’re using the device for about 3 months to protect your heart.
Cincinnati, OhioAges 18 years+ - NCT05834803Recruiting
Stenting narrowed kidney artery to help high-risk patients
This trial studies whether placing a small stent in a severely narrowed kidney artery can improve outcomes for people with high-risk, artery-hardening kidney blood-flow problems. It focuses on people whose high blood pressure or kidney function has been getting worse despite multiple medications.
Aarhus NAges 18 years+ - NCT06688396Recruiting
Finding early signs of dilated cardiomyopathy with AI and mobile screening
This trial uses a smartphone app to screen first-degree relatives of people with dilated cardiomyopathy (DCM) for early signs of the condition. It aims to detect heart muscle weakness before symptoms start, so that treatment can begin sooner.
Lancaster, PennsylvaniaAges 18 years+ - NCT06921603Recruiting
Ultrasound-guided diuretics for heart failure
This trial tests whether using a bedside ultrasound to guide diuretic treatment improves outcomes in people hospitalized for worsening heart failure. It may help find the right dose of IV diuretics faster.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05933083Recruiting
In-person vs telehealth heart rehab comparison study
This study compares whether heart rehabilitation done in person or by telehealth (video/phone) works as well for people with certain heart conditions. It may help you and others choose the safest and most effective way to receive cardiac rehab.
San Francisco, CaliforniaAges 18 years+ - NCT05081115Recruiting
Stress echo imaging for people with heart valve or muscle issues
This trial studies a stress echocardiogram (an ultrasound of the heart during stress) to better understand and improve future heart imaging. It may help by comparing how well the test works for different heart conditions.
BeneventoAges 18–75
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Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 984 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.