Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 984 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07791407Recruiting
Heart imaging to guide defibrillator placement in heart failure
This study uses an MRI scan of the heart to better identify which people with heart failure need a defibrillator along with a special pacemaker (cardiac resynchronization therapy). The scan may help doctors decide if the device could improve your heart's pumping and reduce risks.
Madurai, Tamil NaduAges 18 years+ - NCT06793371RecruitingPhase 2
Study of CK-4021586 for heart failure with preserved ejection fraction
This trial tests an investigational drug called CK-4021586 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug is safe and well-tolerated. You may qualify if you are 40 to 85, have heart failure symptoms, and have a heart that pumps well but shows signs of strain.
Fairhope, AlabamaAges 40–85 - NCT03876223Recruiting
Testing imaging to study heart symptoms without blocked arteries
This trial studies people who have heart-related symptoms but do not have clear blocked heart arteries, using special heart imaging. It may help researchers better understand early forms of heart weakness (with preserved pumping function) and improve how these conditions are diagnosed.
Los Angeles, CaliforniaAges 18 years+ - NCT07601087RecruitingPhase 1
Safety Study of HRS-7156 in Healthy Adults
This is an early-stage safety study of an experimental drug called HRS-7156 in people with no serious health conditions. Researchers will monitor how your body tolerates the drug and how it moves through your system.
Shanghai, Shanghai MunicipalityAges 18–55 - NCT07324772Recruiting
Exercise program to improve symptoms in atrial fibrillation and heart failure
This study tests if starting a supervised exercise program can help older adults with both atrial fibrillation and a type of heart failure called HFpEF feel better and have a better quality of life. You'll be asked to join exercise sessions and have regular check-ins to see how you're doing.
Chicago, IllinoisAges 60–99 - NCT07643818Enrolling by invitationPhase 2
Intravenous iron for heart failure patients with low iron
This study tests whether giving intravenous iron improves symptoms, quality of life, and exercise ability in people with heart failure and low iron levels. Participants will receive iron infusions and be monitored over time to see if their condition improves.
Saint HelierAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Phoenix, ArizonaAges birth–20 years - NCT00271180Recruiting
Tracks long-term performance of Medtronic heart devices
This study follows how well certain Medtronic heart devices work over the long term. You may be included if you have a qualifying Medtronic implant and the research team can reliably get your implant and follow-up information.
Birmingham, AlabamaAges Any age - NCT06195059Recruiting
Heart ultrasound with contrast during exercise to study lungs
This study uses a special ultrasound (echocardiography) with a contrast dye to see how blood flows through your lungs during exercise. It aims to help doctors better understand why patients get short of breath during activity.
Rochester, MinnesotaAges 18 years+ - NCT07207811RecruitingPhase 3
Coramitug for heart failure caused by ATTR amyloidosis
This trial tests a new medicine called Coramitug for people with heart failure due to ATTR amyloidosis, a condition where abnormal proteins build up in the heart. The study aims to see if Coramitug can improve heart function and quality of life.
Phoenix, ArizonaAges 18 years+ - NCT07398950Enrolling by invitation
AI screening for a heart condition called ATTR-CM
This study uses artificial intelligence (AI) to look at your heart tests (ECG and echo) and find people who might have a specific heart muscle disease called ATTR-CM. The goal is to catch it earlier so treatment can start sooner.
New Haven, ConnecticutAges 18 years+ - NCT06651970RecruitingPhase 4
Acalabrutinib for chronic lymphocytic leukemia with heart problems
This trial tests a targeted therapy called acalabrutinib (a pill) against other standard treatments for chronic lymphocytic leukemia (CLL) in people who also have heart conditions. The goal is to see if acalabrutinib is a safer or more effective option for this group.
Charlotte, North CarolinaAges 18–130 - NCT06812533Recruiting
Testing a new approach for heart failure with weak pump
This study tests a new device or procedure to help people with heart failure and a weak heart pump. If you have a low ejection fraction and are on standard medications, you may be able to join.
Los Angeles, CaliforniaAges 18 years+ - NCT05685303Recruiting
Testing a treatment for heart failure symptoms with normal pumping ability
This study is looking at a new treatment for people with heart failure where the heart’s pumping strength is not reduced much (HFpEF or HFmrEF), but pressure inside the heart is high during exercise. It may help relieve symptoms in people who still feel unwell during normal activity despite stable standard treatment.
Phoenix, ArizonaAges 40 years+ - NCT03238690Recruiting
LVAD conditioning to help your heart recover
This study looks at an approach called “conditioning” using your LVAD (a heart pump) while you wait for a transplant. It aims to see whether your heart muscle may recover better during planned changes in support.
Salt Lake City, UtahAges 18 years+ - NCT07420907Recruiting
Tracking heart health over time
This study uses a wearable patch to monitor heart-related signs in people with heart conditions. It aims to learn more about how these conditions progress, which could help improve future care.
Chicago, IllinoisAges 18 years+ - NCT07760363Recruiting
Foot exercise device for leg swelling
This study tests if using a foot pedal device while lying down can help reduce leg swelling in the hospital. It aims to see if this simple exercise can improve comfort and outcomes for people with fluid buildup.
Tulsa, OklahomaAges 18 years+ - NCT05230732Recruiting
Test a nerve-stimulation approach for heart inflammation
This trial studies a nerve-stimulation treatment to affect inflammation and blood vessel function in people with systolic heart failure. If you qualify, it may help improve how your heart and blood vessels work.
Oklahoma City, OklahomaAges 18–85 - NCT05180773RecruitingPhase 4
Bromocriptine for new postpartum heart weakness
This trial studies whether bromocriptine improves health outcomes in people recently diagnosed with peripartum cardiomyopathy (a weakened heart during late pregnancy or soon after delivery). You may be asked about timing after childbirth, heart strength tests, and whether you plan to keep breastfeeding.
Birmingham, AlabamaAges 18 years+ - NCT07086131Recruiting
Inspiratory muscle training and cardiac rehab for heart failure
This study tests if adding inspiratory muscle training (exercises for breathing muscles) to standard cardiac rehab helps people with heart failure exercise better. It aims to improve how you feel and function.
Rochester, MinnesotaAges 18 years+ - NCT07750873RecruitingPhase 2
Study of an investigational medicine for heart failure with reduced pumping function
This trial tests an investigational medicine called CRD-4730 (taken as a pill) to see if it can improve heart function and symptoms in people with heart failure and a reduced pumping ability. It may help you feel better and slow the progression of your condition.
Pasadena, CaliforniaAges 18–85 - NCT07749183Recruiting
Light-based detection of atrial fibrillation in heart failure
This study tests a new device that uses light to detect irregular heartbeats (atrial fibrillation) in people with heart failure. If you join, you'll wear a small sensor that may help catch early signs of this condition.
BratislavaAges 18 years+ - NCT05879211Enrolling by invitation
Care learning lab for Duke Health patients
This trial is a “learning laboratory” that studies how best to provide goal-focused care. It may help improve care experiences for Duke Health patients, based on what the study learns.
Durham, North CarolinaAges 18 years+ - NCT05700617RecruitingEarly Phase 1
Testing cardiac pumping strength in cardiogenic shock
This early study looks at how well the heart is pumping in people with cardiogenic shock, using measurements taken during a right-heart catheter (a small pressure-monitoring test). It may help doctors better assess heart function and guide next-step treatments like LVAD, heart transplant, or valve surgery.
Chicago, IllinoisAges 18 years+
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Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 984 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.