Clinical trials
High Grade Glioma (III or IV) clinical trials
Below are recruiting high grade glioma (iii or iv) clinical trials, each written for real people, not researchers. We’re tracking 1,259 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06500481RecruitingPhase 3
Proton vs standard radiation for cancer spread to brain/spine lining
This trial compares a newer type of radiation (proton therapy) to standard radiation for people whose breast or lung cancer has spread to the lining of the brain and spinal cord. It aims to see if proton therapy can better control the disease while causing fewer side effects.
Phoenix, ArizonaAges 18 years+ - NCT06507449Enrolling by invitation
Treating Heavily Calcified Heart Blockages to Improve Microcirculation
This study is testing a technique to treat heavily calcified (hard) blockages in heart arteries. The goal is to see if a special way of preparing the blockage before placing a stent helps improve blood flow to the tiny blood vessels in the heart muscle.
KatowiceAges 18 years+ - NCT06488482RecruitingPhase 3
Short immunotherapy after melanoma surgery
This trial tests whether giving a shorter course of immunotherapy after surgery can help prevent melanoma from coming back. It is for people with high-risk melanoma who have had the cancer fully removed.
HelsinkiAges 18 years+ - NCT06475807Recruiting
Dietary changes for people on immunotherapy for cancer
This study tests whether a change in diet can help people with early-stage melanoma or lung cancer who are receiving immunotherapy (a type of treatment that helps your immune system fight cancer). You will be asked to follow a diet, give blood and stool samples, and complete questionnaires to see how the diet affects your body and treatment.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06430801RecruitingPhase 3
Study of tulisokibart for moderate to severe Crohn's disease
This trial tests a new medicine called tulisokibart for people with moderate to severe Crohn's disease. The medicine may help reduce inflammation and improve symptoms. It is for those who have not had success with other treatments.
Dothan, AlabamaAges 16–80 - NCT04772456RecruitingPhase 1
MRI scan using a special sugar to study infiltrating brain tumors
This early study (Phase 1) tests a new kind of MRI that uses a special labeled sugar (pyruvate) to help learn how infiltrating gliomas behave in the brain. If you have a suspected or known infiltrating glioma and are having brain surgery or biopsy, this may help your doctors learn more about tumor metabolism and guide future care.
Baltimore, MarylandAges 18–80 - NCT05067998Recruiting
Natural medicine and vitamin IV study for overall health
This study looks at whether natural medicine, vitamin IV fluids, and supplements can help people maintain good health. There don’t appear to be specific eligibility limits listed, so many people may be able to join, but you’d still need screening by the study team.
Dover, DelawareAges 21–80 - NCT06309485RecruitingPhase 2
Study of WGI-0301 for advanced liver cancer
This trial tests a new drug, WGI-0301, for people with advanced hepatocellular carcinoma (HCC, a type of liver cancer) that has progressed after standard treatments. It aims to see if WGI-0301 can help control the cancer when other options have stopped working or caused side effects.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06283979RecruitingPhase 2
Antibiotic bone filler vs standard care for infected pressure ulcers
This trial tests a special antibiotic bone filler (STIMULAN VG) compared to standard care for people with a serious pressure ulcer that has infected the bone. You need to be able to have surgery to clean and close the wound.
Phoenix, ArizonaAges 18 years+ - NCT06277050RecruitingPhase 3
Toripalimab and capecitabine after chemo-radiation for high-risk nasopharyngeal cancer
This trial tests whether adding the immunotherapy drug toripalimab to the chemotherapy pill capecitabine after standard treatment helps prevent nasopharyngeal cancer from coming back. It is for people with high-risk features who have already had chemo and radiation.
Ganzhou, JiangxiAges 18–70 - NCT06290193RecruitingPhase 2
Blood thinning before surgery for ovarian cancer
This trial tests if removing some blood before surgery and replacing it with fluids can reduce the need for transfusions in people with advanced ovarian cancer. It may help you have less blood loss during your operation.
Basking Ridge, New JerseyAges 18 years+ - NCT06140524RecruitingPhase 2
Study of Linvoseltamab for high-risk MGUS or smoldering myeloma
This trial tests if linvoseltamab can remove abnormal plasma cells that might turn into multiple myeloma. It is for patients with high-risk MGUS (a precancerous condition) or non-high-risk smoldering myeloma who have not yet developed active myeloma.
Baltimore, MarylandAges 18 years+ - NCT06138743Enrolling by invitationPhase 1/Phase 2
Investigational treatment for adult-onset myotonic dystrophy type 1
This trial is testing a new drug called SRP-1003 for people with myotonic dystrophy type 1 (DM1) who developed symptoms after age 12. The goal is to see if it can reduce muscle problems like myotonia (difficulty relaxing muscles) and improve daily function.
Liverpool, New South WalesAges 18–65 - NCT06114108Recruiting
Adding local treatment to drug therapy for stage IV lung cancer
This trial compares continuing drug therapy alone versus adding local treatments (surgery or radiation) for people with stage IV lung cancer that has responded to initial treatment but still has a few remaining spots (oligometastatic). The goal is to see if targeting those spots with local therapy helps control the cancer longer.
AarauAges 18 years+ - NCT06096844RecruitingPhase 3
Chemotherapy plus immunotherapy vs. immunotherapy alone for older adults with lung cancer
This study compares getting both chemotherapy and immunotherapy versus immunotherapy alone for older adults with advanced lung cancer. The goal is to see which approach is more effective and tolerable for people aged 70 and older.
Fayetteville, ArkansasAges 70 years+ - NCT04526587Recruiting
Study of breast cancer markers after CDK4/6 inhibitor treatment
This study looks at lab markers and clinical features in people with certain types of breast cancer who are being treated with, or have already been treated with a CDK4/6 inhibitor like abemaciclib (ciclib-based therapy). It aims to understand patterns that may help doctors better characterize breast cancer after these treatments.
Buffalo, New YorkAges 18 years+ - NCT04538053RecruitingPhase 4
Simpler antibiotics for uncomplicated bone and joint infections in children
This trial looks at whether a simpler antibiotic plan can work for children with uncomplicated bone or joint infections that start in the community. It may help reduce the need for complicated treatment while still keeping the infection under control.
Kingswood, New South WalesAges 1–18 - NCT06047379RecruitingPhase 1/Phase 2
Testing NEO212 for brain tumors and metastases
This trial tests a new drug called NEO212 for people with certain brain tumors (like astrocytoma or glioblastoma) or cancer that has spread to the brain from other parts of the body. The goal is to see if it is safe and if it can help shrink or control the tumors.
Beverly Hills, CaliforniaAges 18 years+ - NCT05965518Recruiting
High-intensity exercise for brain and blood-vessel health in HIV
This trial tests whether high-intensity exercise can improve blood-vessel health and brain function in adults with HIV who are not very active and have thinking/memory problems. If you qualify, you’ll be asked to safely complete exercise and other study assessments.
Birmingham, AlabamaAges 50 years+ - NCT05934487Recruiting
Monitoring device trial for stable heart failure symptoms
This trial tests whether a wearable home monitoring system (myCordella™) can help people with moderate heart failure (NYHA class II or III) by tracking heart pressure and supporting follow-up care. It may help detect changes earlier so clinicians can adjust treatment sooner.
Phoenix, ArizonaAges 18 years+ - NCT05914649Recruiting
Testing long COVID and POTS brain fog symptoms
This study tests how different long-COVID and POTS-related symptoms—especially “brain fog”—show up and improve. It may help researchers better measure symptoms so future treatments can be targeted more effectively.
Calgary, AlbertaAges 18–60 - NCT05837767Recruiting
Radiation study for tumors that spread to soft tissue areas
This study looks at how a planned form of palliative radiation therapy treats certain solid cancers that have spread outside the brain to larger soft-tissue areas. It may help shrink tumors and relieve symptoms, but it also asks you to meet specific safety and treatment-timing rules.
Basking Ridge, New JerseyAges 18 years+ - NCT04192773RecruitingEarly Phase 1
Brain-scan study of IV lidocaine for tinnitus
This early study uses an MRI/brain scan to see how IV lidocaine affects brain activity in people with tinnitus, and also compares it with people without tinnitus or with different hearing patterns. It may help researchers understand whether lidocaine could change tinnitus signals in the brain.
Boston, MassachusettsAges 18 years+ - NCT05746325Recruiting
Tumor-pulse device for spinal cancer fluid spread
This trial tests whether Tumor Treating Fields (a non-surgical device that delivers treatment signals to cancer cells through the scalp/skin) can help people whose breast or lung cancer has spread into the fluid around the spine and brain. It focuses on people who have cancer cells found in spinal fluid and can safely use the device most of the day.
Jacksonville, FloridaAges 18 years+
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Common questions
- Are there clinical trials for high grade glioma (iii or iv)?
- Yes. Clin2 currently lists 1,259 recruiting high grade glioma (iii or iv) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high grade glioma (iii or iv) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high grade glioma (iii or iv) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.