Clinical trials
Low-grade Glioma clinical trials
Below are recruiting low-grade glioma clinical trials, each written for real people, not researchers. We’re tracking 36 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04485559RecruitingPhase 1
Trametinib and everolimus for recurrent gliomas
This trial tests two drugs, trametinib and everolimus, for children and young adults with recurrent or progressive gliomas (a type of brain tumor). The goal is to see if this drug combination is safe and effective in treating these tumors.
Birmingham, AlabamaAges 1–25 - NCT06666348RecruitingPhase 1/Phase 2
Mirdametinib plus vinblastine for untreated low-grade glioma
This trial tests a combination of two drugs (mirdametinib and vinblastine) for children and young adults with a type of slow-growing brain tumor called low-grade glioma that has certain genetic changes. It may be an option for people who have not received any previous treatment for their tumor.
Calgary, AlbertaAges 2–25 - NCT04775485RecruitingPhase 2
Targeted medicine for children with certain brain or solid tumors
This Phase 2 study tests tovorafenib, a targeted cancer medicine, in children and young adults whose tumors have specific BRAF or RAF changes. It is for cancers that have come back or grown despite previous treatment, with measurable signs on scans.
San Francisco, CaliforniaAges 6 months–25 years - NCT04316039RecruitingPhase 2/Phase 3
Radiation alone or with temozolomide for brain tumor after surgery
This trial compares standard radiation therapy versus radiation plus a chemotherapy medicine called temozolomide in people with a newly diagnosed low-grade (WHO grade II) brain glioma after surgery. It’s designed to see if adding temozolomide improves outcomes while managing side effects.
Chengdu, SichuanAges 18–70 - NCT04166409RecruitingPhase 3
Selumetinib versus chemo for low-grade brain tumor in children
This trial studies whether the targeted drug selumetinib works better than standard chemotherapy (carboplatin and vincristine) for children and young adults with a specific type of low-grade glioma (grade 1 or 2). It may help shrink tumors and slow growth while comparing side effects between the two treatment approaches.
Birmingham, AlabamaAges 2–21 - NCT02358187RecruitingPhase 2
Vaccine for children and teens with low-grade brain tumors
This trial tests a peptide vaccine plus a medication called poly-ICLC for people with certain low-grade gliomas that cannot be fully removed. The goal is to help the immune system recognize and attack the tumor.
Pittsburgh, PennsylvaniaAges 1–21 - NCT03761121Recruiting
Imaging study for low-grade glioma in children and adults
This study is testing how to take faster, better brain images in people diagnosed with low-grade glioma (a type of brain tumor). Better imaging may help doctors see the tumor more clearly while reducing time spent in the scanner.
Boston, MassachusettsAges birth+ - NCT07110246RecruitingPhase 2
Dabrafenib and trametinib for BRAF-mutated low-grade gliomas
This trial tests two targeted drugs (dabrafenib and trametinib) for children and young adults with a specific type of low-grade brain tumor that has a BRAF V600 mutation. The drugs work by blocking signals that help the tumor grow.
Birmingham, AlabamaAges 1–25 - NCT05964569RecruitingPhase 2
Personalized planning for proton radiation in low-grade brain tumors
This Phase 2 study tests a personalized, computer-guided way to plan proton beam radiation for adults with low-grade glioma. The goal is to see if the approach is feasible and can improve how treatment is planned.
HeidelbergAges 18 years+ - NCT07441707RecruitingPhase 1
Tovorafenib for Japanese children and young adults with brain tumors
This study tests an experimental medicine called tovorafenib for children and young adults (6 months to 25 years) with Japanese ancestry whose low-grade brain tumors have returned or grown after prior treatment. The medicine targets tumors with a specific BRAF genetic change.
KanagawaAges 6 months–25 years - NCT06381570RecruitingEarly Phase 1
Vinblastine and tovorafenib for recurring pediatric low-grade glioma
This trial is testing a combination of two drugs, vinblastine and tovorafenib, for children and young adults (up to age 25) whose low-grade glioma has come back or worsened after prior treatment. It is for people whose tumor has a specific change in a gene called BRAF or CRAF.
Toronto, OntarioAges birth–25 years - NCT05996653Recruiting
CEST in low-grade glioma brain tumor study
This study uses a special MRI scan called CEST to look at low-grade brain tumors. It may help doctors learn more about these tumors without needing as many invasive tests. You may join if you have a low-grade glioma and haven't needed treatment yet.
Toronto, OntarioAges 12 years+ - NCT03948490Recruiting
Cognitive rehab and follow-up for lower grade brain tumors
This study offers cognitive rehabilitation and long-term monitoring for adults with lower grade gliomas. It aims to help improve thinking and memory problems you may be experiencing.
San Francisco, CaliforniaAges 18 years+ - NCT04065776Recruiting
Proton therapy that avoids the hippocampus for slow brain tumors
This study tests a proton radiation plan designed to spare the hippocampus (a memory area) in children and teens with certain low-grade brain tumors. It may help deliver treatment to the tumor while reducing unwanted brain effects.
Rochester, MinnesotaAges 6–21 - NCT04865315Recruiting
Donate tumor samples to build organoid tissue from glioma
This study collects tumor tissue during brain surgery to create lab-grown “organoids” (mini models of the tumor). It aims to build a tissue bank that researchers can use to better study gliomas and develop treatments.
Maastricht, LimburgAges 18 years+ - NCT04923126RecruitingPhase 1/Phase 2
Mirdametinib for children with low-grade brain tumors
This Phase 1/2 study tests mirdametinib, a targeted medicine, in children and young adults with low-grade glioma (a slower-growing brain tumor). It aims to find the best dose and see how well the treatment works, especially for tumors with certain “MAPK pathway” changes.
Memphis, TennesseeAges 2–24 - NCT05555550RecruitingEarly Phase 1
PET-MRI scan to study low-grade brain tumors in children
This early-phase study tests how well a special PET-MRI scan (using a radioactive tracer) can find and measure low-grade brain tumors. It may help doctors better track these tumors while you start or continue treatment.
Philadelphia, PennsylvaniaAges 1–21 - NCT06159478RecruitingPhase 2
Testing binimetinib for BRAF fusion brain tumors and pancreatic cancer
This trial tests a targeted drug, binimetinib, for people with low-grade glioma (a type of brain tumor) or pancreatic cancer that has a specific genetic change called a BRAF fusion. The drug aims to block signals that help these tumors grow.
Kashiwa, ChibaAges 12 years+ - NCT06610851Recruiting
Monitoring low-grade brain tumors with a blood test
This study is looking at whether a simple blood test that checks for tiny molecules (called miRNAs) can help monitor people with slow-growing brain tumors. If you had surgery for a grade 2 or 3 glioma at Caen University Hospital and are still being followed there, this study might be for you.
CaenAges 18 years+ - NCT06684795RecruitingPhase 2
Testing FG001 in brain tumor patients before surgery
This trial tests a fluorescent dye called FG001 to see if it can help surgeons see brain tumors more clearly during surgery. It is for adults with a meningioma or a low-grade glioma who are scheduled to have their tumor removed.
Copenhagen, Capital RegionAges 18 years+ - NCT06712875RecruitingPhase 1/Phase 2
Brain cancer drug combo for kids with BRAF mutations
This trial tests a combination of targeted therapy (dabrafenib and trametinib) and immunotherapy (nivolumab) for children and young adults with certain BRAF gene changes in their glioma. It aims to see if this drug combination can shrink tumors or stop them from growing.
Washington D.C., District of ColumbiaAges 1–26 - NCT06930846Recruiting
Brain cancer cognitive training study
This study tests a home-based program called HOBSCOTCH-CA to help with memory and thinking problems after brain cancer treatment. The program uses phone and internet sessions to teach self-management skills.
Lebanon, New HampshireAges 18 years+ - NCT01649830RecruitingPhase 3
Temozolomide after radiation for low-grade brain tumor
This trial tests whether adding temozolomide chemotherapy after radiation helps control a type of low-grade brain tumor that was not fully removed. It may help reduce the chance the tumor comes back, compared with standard post-radiation care.
Guangzhou, GuangdongAges 18–60 - NCT07506239Recruiting
Laser therapy for low-grade brain tumors in young people
This trial tests a laser treatment called LITT for low-grade glioma (a type of brain tumor) that has come back or is growing despite prior treatment. It aims to see if the laser is safe and effective in young people aged 2 to 25.
San Francisco, CaliforniaAges 2–25
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Low-grade Glioma trials by city
Studies with a site in or near these metro areas.
Low-grade Glioma trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for low-grade glioma?
- Yes. Clin2 currently lists 36 recruiting low-grade glioma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a low-grade glioma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a low-grade glioma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.