Clinical trials
High Grade Glioma (III or IV) clinical trials
Below are recruiting high grade glioma (iii or iv) clinical trials, each written for real people, not researchers. We’re tracking 1,259 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07086560Recruiting
Comparing diltiazem and adenosine for SVT in the ER
This study compares how patients feel about two common medicines (adenosine and diltiazem) used to treat a fast heart rhythm called SVT in the emergency department. If you were treated for SVT in the ER, you may be able to share your experience through a survey.
Iowa City, IowaAges 18–100 - NCT07077616RecruitingEarly Phase 1
Personalized vaccine for recurrent glioma
This trial tests a personalized vaccine created by AI to target your specific brain tumor. It is for people with a glioma that came back after standard treatments like surgery, radiation, or chemotherapy, and whose tumor has enough genetic mutations to make the vaccine.
ThessalonikiAges 18 years+ - NCT07083583Recruiting
IV iron for bleeding in inherited bleeding disorders
This trial tests if IV iron can reduce bleeding symptoms in people with inherited bleeding disorders who also have low iron stores. If you have a condition like von Willebrand disease or a platelet disorder and your iron is low, this treatment might improve your bleeding and quality of life.
Pittsburgh, PennsylvaniaAges 15 years+ - NCT06640491RecruitingPhase 1/Phase 2
Antibiotics via bone injection for knee replacement
This study tests giving antibiotics (cefazolin and vancomycin) through a small needle into the shin bone during knee replacement surgery. The goal is to see if this way of giving antibiotics works well to prevent infection.
Houston, TexasAges 18 years+ - NCT07071961RecruitingPhase 2
Treatment for colorectal cancer with signs of remaining disease after therapy
This trial tests a combination of two drugs, regorafenib and lorigerlimab, for people with colorectal cancer that has a positive blood test for cancer DNA after they have finished standard treatments. The goal is to see if this treatment can delay or prevent the cancer from coming back.
Houston, TexasAges 18 years+ - NCT07054346RecruitingPhase 1
Radioactive drugs before prostate surgery for high-risk prostate cancer
This trial compares two radioactive drugs (177Lu-PSMA-617 and 225Ac-PSMA-617) given before prostate removal surgery in men with high-risk prostate cancer that has not spread far. The goal is to see which drug is better at shrinking the tumor and reducing the chance of cancer coming back.
San Francisco, CaliforniaAges 18 years+ - NCT07025226RecruitingEarly Phase 1
Combination drugs and vaccine for glioma with remaining tumor
This trial tests a combination of several drugs and a vaccine to see if they can help treat glioma that has not gone away with previous treatment. It is for people whose tumors have certain gene changes and who still have some tumor remaining after standard therapy.
Rochester, MinnesotaAges 18 years+ - NCT07009405Recruiting
Wireless skin sensor for IV site monitoring during infusions
This study tests a small, wireless device that sticks to the skin near an IV to monitor the site during and after an infusion treatment. It may help detect problems early and is designed for people receiving infusions lasting at least 30 minutes.
Skokie, IllinoisAges 12 years+ - NCT06997913Enrolling by invitation
Immunotherapy and chemoradiation after bile duct cancer surgery
This trial tests whether combining immunotherapy with chemotherapy and radiation after surgery can help prevent bile duct cancer from coming back in people who have a high risk of recurrence.
XiAn, ShanxiAges 18–70 - NCT06818331RecruitingPhase 2
Electroacupuncture study for recurring brain cancer
This trial tests if a special type of electroacupuncture can help chemotherapy (paclitaxel) reach the brain more effectively in patients whose high-grade glioma has come back after surgery. The goal is to see if this combination can slow tumor growth.
China, Hangzhou City, Zhejiang ProvinceAges 18–70 - NCT05928039RecruitingPhase 4
Choosing the best first biologic for Crohn’s in the ileum
This Phase 4 trial tests which type of biologic medicine works best as the first treatment for people with moderate-to-severe Crohn’s that mainly affects the ileum. It may help you and your care team choose a more effective first option, based on which strategy leads to better control of symptoms and intestinal inflammation.
Calgary, AlbertaAges 18 years+ - NCT06954116RecruitingPhase 2
Iparomlimab and Tuvonralimab before surgery for liver cancer
This trial tests two drugs given before surgery to people with liver cancer that has a high chance of coming back. The goal is to see if the drugs can shrink the tumor and lower the risk of recurrence.
Wuhan, HubeiAges 18–75 - NCT06954831RecruitingPhase 2
Short-course radiation for early-stage breast cancer
This trial tests a shorter, more intense radiation schedule for people with stage I-III breast cancer after lumpectomy. It aims to find if giving a higher daily dose over fewer sessions is safe and effective.
Arcadia, CaliforniaAges 40 years+ - NCT06409702RecruitingPhase 4
Treating high-risk multiple myeloma with MRD testing
This trial tests a treatment plan for people with newly diagnosed high-risk multiple myeloma. It uses a special test called minimal residual disease (MRD) detection to see how well the treatment is working and guide next steps.
Suzhou, JiangsuAges 18 years+ - NCT06910761RecruitingPhase 2
Radiation for cancer spread to brain lining
This trial tests whether a precise type of radiation to the brain and spine (craniospinal irradiation) can help control cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease) in people with breast cancer or non-small cell lung cancer. The goal is to improve symptoms and slow disease progression.
Duarte, CaliforniaAges 18 years+ - NCT06861478RecruitingPhase 2
PPIs for bleeding varices in liver disease
This trial tests whether proton pump inhibitors (PPIs) can help people with cirrhosis who are hospitalized for variceal bleeding. It looks at whether PPIs reduce complications during the hospital stay.
Monterrey, Nuevo LeónAges 18 years+ - NCT06794541RecruitingPhase 2
Testing eravacycline for kids with serious belly infections
This trial tests an antibiotic called eravacycline for children (ages 8–17) with serious belly infections. The medicine is given through an IV in the hospital to see if it is safe and tolerable.
Los Angeles, CaliforniaAges 8–17 - NCT06678269RecruitingPhase 1
Abemaciclib and radiation for metastatic breast cancer
This trial tests whether a targeted therapy (abemaciclib) combined with focused radiation (SBRT) to a bone tumor can help people with advanced breast cancer. It is for patients whose cancer is hormone receptor positive and HER2 negative, and who will continue abemaciclib after radiation.
Basking Ridge, New JerseyAges 18 years+ - NCT06639191RecruitingEarly Phase 1
Study of a new drug for cancers expressing CD44v6
This trial tests a new radioactive drug called [177Lu]Lu-AKIR001 for patients with certain advanced cancers (like thyroid, head and neck, lung, vulvar, or cervical cancer) that have a specific protein called CD44v6 on their surface. The goal is to see if this treatment can help when standard options have stopped working.
Stockholm, Stockholm CountyAges 18 years+ - NCT06636162RecruitingEarly Phase 1
Testing DSP-0390 before surgery for gliomas
This trial tests a drug called DSP-0390 in people with gliomas (a type of brain tumor). You take the drug for a short time before your scheduled surgery to see how it affects the tumor. It might help doctors find new ways to treat these tumors.
St Louis, MissouriAges 18 years+ - NCT06623110RecruitingPhase 2
RP2 vaccine to prevent mouth cancer in high-risk pre-cancer
This trial tests an injected virus therapy (RP2) to stop pre-cancerous mouth lesions from turning into cancer. It is for people with high-risk oral pre-cancer or a history of early-stage head and neck cancer with certain worrisome features.
Boston, MassachusettsAges 18 years+ - NCT06574789RecruitingPhase 2
Personalized ganciclovir dosing for CMV in children with weak immune systems
This study tests whether a personalized dose of the antiviral drug ganciclovir can better treat CMV infection in children with weakened immune systems. It aims to make the treatment more effective and safer for each child.
Sydney, New South WalesAges 1 month–18 years - NCT06546631Recruiting
Blood side effects of a chemotherapy for brain tumors
This study looks at why some people getting the chemotherapy drug temozolomide (TMZ) for high-grade brain tumors have serious blood side effects. If you are getting TMZ now or have had severe blood problems from it, your participation could help doctors predict and manage these risks better.
CorkAges 18 years+ - NCT06518057RecruitingPhase 2
Sparing memory during brain radiation for leptomeningeal metastases
This trial tests a special type of radiation that avoids the memory center of the brain (the hippocampus) while treating cancer that has spread to the lining of the brain and spinal cord. It may help reduce side effects on thinking and memory for people with breast or lung cancer.
San Francisco, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for high grade glioma (iii or iv)?
- Yes. Clin2 currently lists 1,259 recruiting high grade glioma (iii or iv) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high grade glioma (iii or iv) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high grade glioma (iii or iv) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.