Clinical trials
High Grade Glioma (III or IV) clinical trials
Below are recruiting high grade glioma (iii or iv) clinical trials, each written for real people, not researchers. We’re tracking 1,293 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06678269RecruitingPhase 1
Abemaciclib and radiation for metastatic breast cancer
This trial tests whether a targeted therapy (abemaciclib) combined with focused radiation (SBRT) to a bone tumor can help people with advanced breast cancer. It is for patients whose cancer is hormone receptor positive and HER2 negative, and who will continue abemaciclib after radiation.
Basking Ridge, New JerseyAges 18 years+ - NCT07290036RecruitingPhase 1
Testing different ways to give bimekizumab for psoriatic arthritis or axial spondyloarthritis
This study looks at whether giving bimekizumab in different ways is safe and how it moves through the body over time. It is for adults with active psoriatic arthritis or axial spondyloarthritis who may benefit from bimekizumab treatment.
Peoria, ArizonaAges 18 years+ - NCT06762782RecruitingPhase 2
Lenvatinib after liver cancer surgery to prevent recurrence
This trial tests whether taking lenvatinib after liver cancer surgery can lower the chance of the cancer coming back. It is for people who have a high risk of recurrence and have recently had their liver tumor completely removed.
Nanjing, JiangsuAges 18–80 - NCT06767774RecruitingPhase 4
Comparing two cholesterol treatments for heart patients
This study compares two different ways of lowering cholesterol: a moderate statin (pitavastatin) plus another drug (ezetimibe) versus a stronger statin alone. The goal is to see which approach is safer regarding the risk of developing new diabetes.
SeoulAges 18 years+ - NCT06818331RecruitingPhase 2
Electroacupuncture study for recurring brain cancer
This trial tests if a special type of electroacupuncture can help chemotherapy (paclitaxel) reach the brain more effectively in patients whose high-grade glioma has come back after surgery. The goal is to see if this combination can slow tumor growth.
China, Hangzhou City, Zhejiang ProvinceAges 18–70 - NCT06896890RecruitingPhase 1/Phase 2
Inhaled cisplatin for stage IV lung cancer
This trial tests a new way to give the chemotherapy drug cisplatin—as a dry powder you inhale—for people with stage IV non-small cell lung cancer who have not yet started treatment. The goal is to see if this inhaled form is safe and effective when added to standard immunotherapy or chemotherapy.
BrusselsAges 18 years+ - NCT06910761RecruitingPhase 2
Radiation for cancer spread to brain lining
This trial tests whether a precise type of radiation to the brain and spine (craniospinal irradiation) can help control cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease) in people with breast cancer or non-small cell lung cancer. The goal is to improve symptoms and slow disease progression.
Duarte, CaliforniaAges 18 years+ - NCT06942910RecruitingPhase 2
New combination therapy for chronic kidney disease with high proteinuria
This study tests a combination of two drugs (zibotentan and dapagliflozin) compared to dapagliflozin alone in people with chronic kidney disease and high protein in their urine. The goal is to see if the combination works better at protecting your kidneys.
AramilAges 18 years+ - NCT06954831RecruitingPhase 2
Short-course radiation for early-stage breast cancer
This trial tests a shorter, more intense radiation schedule for people with stage I-III breast cancer after lumpectomy. It aims to find if giving a higher daily dose over fewer sessions is safe and effective.
Arcadia, CaliforniaAges 40 years+ - NCT07077616RecruitingEarly Phase 1
Personalized vaccine for recurrent glioma
This trial tests a personalized vaccine created by AI to target your specific brain tumor. It is for people with a glioma that came back after standard treatments like surgery, radiation, or chemotherapy, and whose tumor has enough genetic mutations to make the vaccine.
ThessalonikiAges 18 years+ - NCT07083583Recruiting
IV iron for bleeding in inherited bleeding disorders
This trial tests if IV iron can reduce bleeding symptoms in people with inherited bleeding disorders who also have low iron stores. If you have a condition like von Willebrand disease or a platelet disorder and your iron is low, this treatment might improve your bleeding and quality of life.
Pittsburgh, PennsylvaniaAges 15 years+ - NCT07086560Recruiting
Comparing diltiazem and adenosine for SVT in the ER
This study compares how patients feel about two common medicines (adenosine and diltiazem) used to treat a fast heart rhythm called SVT in the emergency department. If you were treated for SVT in the ER, you may be able to share your experience through a survey.
Iowa City, IowaAges 18–100 - NCT07087860RecruitingPhase 2
Plasma exchange plus targeted therapy for advanced bladder cancer
This trial tests a procedure called therapeutic plasma exchange (TPE) combined with the drugs enfortumab vedotin and pembrolizumab for people with advanced bladder cancer that has stopped responding to standard treatments. The goal is to see if TPE helps the drugs work better.
Rochester, MinnesotaAges 18 years+ - NCT07105852RecruitingPhase 2
A new drug combo for advanced bile duct cancer
This trial tests a combination of two drugs, sacituzumab tirumotecan and pucotenlimab, for people with advanced bile duct cancer (including gallbladder cancer) that cannot be removed by surgery or has spread. The goal is to see if this treatment is safe and works well, especially for those with a protein called TROP2 on their cancer cells.
Hangzhou, ZhejiangAges 18 years+ - NCT07175155Recruiting
Breathing device and oxygen for endoscopy in severe obesity
This study tests a special breathing device (a tube placed in the throat) combined with high-flow oxygen through the nose during sedation for endoscopy in people with severe obesity. It aims to see if this combination helps keep oxygen levels stable and makes the procedure safer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07182097Recruiting
Comparing two pain meds for gallbladder surgery recovery
This study compares two pain medications, fentanyl and remifentanil, used during laparoscopic gallbladder removal. The goal is to see which one helps you recover bowel function faster and control pain better after surgery.
Karatay, KonyaAges 18–65 - NCT07218913RecruitingPhase 1
Testing a drug to reduce ear damage from chemo in testicular cancer
This trial tests whether adding Pedmark (sodium thiosulfate) to cisplatin chemotherapy can protect hearing in men with stage II or III testicular germ cell tumors. It aims to reduce the risk of drug-related ear damage while still treating the cancer.
Duarte, CaliforniaAges 18 years+ - NCT07025226RecruitingEarly Phase 1
Combination drugs and vaccine for glioma with remaining tumor
This trial tests a combination of several drugs and a vaccine to see if they can help treat glioma that has not gone away with previous treatment. It is for people whose tumors have certain gene changes and who still have some tumor remaining after standard therapy.
Rochester, MinnesotaAges 18 years+ - NCT07264647RecruitingPhase 2
Chemo-immunotherapy before surgery for stage III lung cancer
This trial tests combining chemotherapy with immunotherapy before surgery for people with stage III non-small cell lung cancer that has a PD-L1 level of 1% or higher. The goal is to see if this approach can improve outcomes.
Rome, Roma (RM)Ages 18–99 - NCT07279402Recruiting
Real-world study of atezolizumab for advanced lung cancer
This trial looks at how well atezolizumab works for people with stage IV non-small cell lung cancer that has a high level of PD-L1 (a protein that helps cancer hide from the immune system). It's for people getting atezolizumab as their first treatment.
AdanaAges 18 years+ - NCT07288034RecruitingPhase 2
Immunotherapy biomarkers for advanced lung cancer
This study looks at blood and tissue biomarkers to predict how well immunotherapy (with or without chemotherapy) works for advanced non-small cell lung cancer. It also helps decide the best second treatment if the first one stops working.
Goodyear, ArizonaAges 18 years+ - NCT07301866RecruitingPhase 1/Phase 2
Testing an improved dose of UM171 for cord blood transplant
This trial tests a higher dose of UM171 to make cord blood transplants safer and more effective for people with certain blood cancers or bone marrow diseases. It aims to help patients who don't have a suitable donor.
Montreal, QuebecAges 18–67 - NCT07317544RecruitingPhase 1/Phase 2
Study of a new hair loss treatment in healthy adults
This trial tests a new medication called ABS-201 for hair loss. It will first see if the medicine is safe in healthy people, then test if it helps those with male or female pattern baldness.
Sydney, New South WalesAges 18–65 - NCT07350837RecruitingEarly Phase 1
CAR-T therapy for highly sensitized kidney transplant patients
This trial tests a new CAR-T therapy that targets immune cells to reduce harmful antibodies in highly sensitized kidney transplant candidates. The goal is to help your body accept a kidney from a donor that would otherwise be rejected.
Wuhan, HubeiAges 18–65
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Common questions
- Are there clinical trials for high grade glioma (iii or iv)?
- Yes. Clin2 currently lists 1,293 recruiting high grade glioma (iii or iv) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high grade glioma (iii or iv) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high grade glioma (iii or iv) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.