Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 922 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07625553RecruitingPhase 2
Relaxin Agonist to Protect Kidneys During Heart Surgery
This study tests whether a drug called R2R01 can help protect your kidneys during major heart surgery. Heart surgery can sometimes damage the kidneys, and this trial is looking to see if this new medication reduces that risk.
MilanAges 18 years+ - NCT07620834Recruiting
AI-Guided Bone Density Screening for High-Risk Adults
This study tests whether artificial intelligence can help identify people at risk for weak bones (osteoporosis) using chest X-rays. If you qualify, you'll be randomly assigned to either standard screening or AI-enhanced screening to see which approach works better.
ChanghuaAges 40–80 - NCT07628283Recruiting
Telemedicine stroke prevention program for rural elderly adults
This study tests whether using telemedicine (remote health technology) combined with care at a local village clinic can better prevent strokes and manage stroke risk in older adults living in rural areas. Participants will receive ongoing health monitoring and support tailored to their stroke risk factors.
Suqian, JiangsuAges 65 years+ - NCT07622836Recruiting
Chemotherapy plus QL1706 for high-risk triple-negative breast cancer
This study tests whether adding a new immunotherapy drug called QL1706 to standard chemotherapy after surgery can help patients with aggressive triple-negative breast cancer that has spread to lymph nodes. The goal is to see if this combination prevents cancer from coming back.
Nanjing, JiangsuAges 18–75 - NCT06587789Recruiting
Ribociclib plus hormone therapy for high-risk breast cancer
This trial tests adding ribociclib (a targeted pill) to standard hormone therapy for people with early but high-risk HR-positive, HER2-negative breast cancer, after surgery.
Hangzhou, ZhejiangAges 18–80 - NCT06612944RecruitingPhase 2
Preventing relapse after stem cell transplant for high-risk MDS
This trial tests whether giving medication after a donor stem cell transplant can prevent the return of very high-risk myelodysplastic syndrome (MDS). It is for people who have a suitable donor and are healthy enough for the procedure.
ShanghaiAges 18–70 - NCT07616921Recruiting
Home Exercise Program for Heart Health During Leukemia Transplant
This study tests whether doing gentle exercise at home can help protect your heart during stem cell transplant treatment for acute myeloid leukemia (a type of blood cancer). You'll use a smartphone app to guide daily workouts designed to be safe and manageable during your treatment.
Seattle, WashingtonAges 18 years+ - NCT07613294RecruitingPhase 3
Testing lepodisiran to reduce heart plaque buildup
This study tests whether a new medicine called lepodisiran can shrink plaque in heart arteries for adults with high Lp(a) (a type of cholesterol linked to heart disease) who have had a heart event or are at serious risk. The trial uses CT scans to monitor changes in your arteries.
La Jolla, CaliforniaAges 45–80 - NCT06437353RecruitingPhase 2
Surufatinib combo for first-line and maintenance in high-risk ovarian cancer
This trial tests a combination of drugs (Surufatinib with carboplatin/paclitaxel) as first treatment for high-risk ovarian cancer, followed by a different combination (Surufatinib with olaparib) to keep the cancer from coming back. It aims to see if these targeted therapies work better than the standard approach.
Hefei, AnhuiAges 18–75 - NCT06706596Recruiting
TB screening for high-risk groups in Barcelona
This trial offers free tuberculosis (TB) testing for people who are at high risk for the disease. It aims to find TB early so it can be treated quickly.
BadalonaAges Any age - NCT06573008RecruitingPhase 3
Testing GP681 Tablets for Flu in High-Risk Patients
This study tests an oral tablet called GP681 for people with flu who are at higher risk of serious complications. It compares the new drug to a placebo to see if it helps reduce symptoms faster.
ChizhouAges 12 years+ - NCT07602894Recruiting
Pain Relief for Perineal Surgery in High-Risk Children
This trial tests pain-relief methods for children with serious health conditions who need surgery in the perineal area (around the genitals and anus). The goal is to find safe, effective ways to manage pain for kids whose bodies are at higher risk during surgery.
ZagazigAges 1–12 - NCT07594964RecruitingPhase 1
Safety Study of XH001 Injection for High-Risk Recurrent Solid Tumors
This early-stage trial tests a new injection called XH001 as an additional treatment after surgery for patients with high-risk cancers that have come back. The goal is to check if it's safe and whether it helps prevent the cancer from returning again.
BeijingAges 18–70 - NCT06358495Recruiting
Sleep improvement to prevent depression and anxiety in teens
This study tests if improving sleep can help prevent depression and anxiety in teens who are at higher risk because a parent has had depression or anxiety. It's for teens who have trouble sleeping but don't have a history of depression or anxiety themselves.
Calgary, AlbertaAges 12–18 - NCT07591428Recruiting
Reducing risky drinking to prevent cancer
This study tests a program to help people who drink alcohol regularly cut back on high-risk drinking. The goal is to reduce cancer risk by changing drinking habits.
Tulsa, OklahomaAges 18–120 - NCT07591649RecruitingPhase 1/Phase 2
NK cells for high-risk blood cancers before transplant
This study tests a new type of immune cell therapy (called AdaptNK cells) for patients with high-risk myeloid diseases (blood cancers affecting bone marrow cells) who are preparing for a stem cell transplant. The goal is to help control the cancer and prepare your body for the transplant.
Minneapolis, MinnesotaAges 18 years+ - NCT07594392Recruiting
Heart Health Study for Cancer Survivors
This study looks at how cancer treatments affect the heart and blood vessels in adults who survived childhood cancer. Researchers will use imaging tests to find early signs of heart problems so they can help prevent serious complications like heart attacks or strokes.
Memphis, TennesseeAges 18 years+ - NCT07580196Recruiting
Comparing lymph node removal approaches in aggressive prostate cancer
This trial compares two surgical approaches for removing lymph nodes during prostate cancer surgery in men with high-risk disease on one side of the prostate. The goal is to determine whether removing lymph nodes from both sides or just one side provides better outcomes.
Rozzano, MilanoAges 18 years+ - NCT07582172RecruitingPhase 2
Stem Cell Transplant for Hard-to-Treat Blood Cancers in Older Adults
This trial tests a new combination of radiation and chemotherapy to prepare your body for a stem cell transplant from a matched donor. It's designed for older patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that hasn't responded well to standard treatments.
Duarte, CaliforniaAges 18 years+ - NCT06722612Recruiting
Chemo plus targeted therapy for high-risk HER2+ early breast cancer
This trial tests whether combining chemotherapy with targeted therapy works better for women with high-risk, HER2 positive early breast cancer that hasn't spread to lymph nodes. If you've had surgery and your tumor fits certain high-risk features, you may be eligible to join.
Beijing, Beijing MunicipalityAges Any age - NCT07573111RecruitingPhase 1
QUAIL-100 for Children With Blood Cancers After Stem Cell Transplant
This study tests a new experimental treatment called QUAIL-100 in children and young adults who have had a stem cell transplant for a serious blood cancer. The treatment is designed to help the immune system fight remaining cancer cells.
Palo Alto, CaliforniaAges 1.5 years–39 years - NCT07575971RecruitingPhase 1/Phase 2
CAR-T Cell Therapy for High-Risk B-Cell Acute Lymphoblastic Leukemia
This trial tests a new type of immune cell therapy (CAR-T cells) designed to target leukemia cells after chemotherapy has put your disease into remission. The goal is to help prevent the leukemia from coming back, especially for patients at high risk of relapse.
Beijing, Beijing MunicipalityAges 18–85 - NCT03116412Recruiting
Imaging check-ups after melanoma surgery trial
This trial studies whether adding or adjusting imaging scans during follow-up after melanoma surgery can help detect recurrence earlier. It compares different follow-up imaging schedules for people at higher risk after surgery.
BoråsAges 18 years+ - NCT07562490RecruitingPhase 2
Blood Test to Guide Chemotherapy After Colorectal Cancer Surgery
This study tests whether a special blood test (looking for cancer DNA) can help doctors decide if you need chemotherapy after colorectal cancer surgery. The goal is to avoid unnecessary chemotherapy while making sure patients who need it get treated.
ShanghaiAges 18–80
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 922 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.