Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 922 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06833827Recruiting
Clot removal vs clot-busting drugs for severe lung clots
This study compares two ways to treat a large blood clot in the lungs that is causing life-threatening symptoms. One method uses a device to remove the clot, the other uses medicine to dissolve it.
Leiden, South HollandAges 18 years+ - NCT06696794RecruitingPhase 3
Testing mitomycin before surgery for high-risk bladder cancer
This trial tests whether giving mitomycin directly into the bladder before surgery can help people with high-risk non-muscle-invasive bladder cancer. The goal is to see if this approach is safe and effective at preventing cancer from coming back.
Wuhan, HubeiAges 18–75 - NCT06631391RecruitingPhase 1
NK cell therapy for high-risk neuroblastoma in children
This trial tests a new natural killer (NK) cell therapy from donated umbilical cord blood for children with high-risk neuroblastoma that has come back or not responded to treatment. The goal is to see if this immune cell therapy is safe and can help fight the cancer.
Guangzhou, GuangdongAges 1 day–18 years - NCT06818682RecruitingPhase 2
Shortened hormone therapy with radiation for high-risk prostate cancer
This trial tests whether a shorter course of hormone therapy (2 years) plus a new hormone drug (6 months) with radiation is as effective as longer treatment for high-risk prostate cancer that hasn't spread.
Mumbai, MaharashtraAges 19–99 - NCT07376603Recruiting
Radiation therapy alone for early-stage nasopharyngeal cancer
This trial tests whether intense radiation therapy (IMRT) alone is effective for people with stage IB nasopharyngeal carcinoma (a type of head and neck cancer) that has not spread to lower lymph nodes or formed large, matted nodes. If you qualify, you would receive targeted radiation without chemotherapy.
Fuzhou, FujianAges 18–70 - NCT07372131Recruiting
Shorter antibiotics for high-risk fever with low white blood cells
This study looks at how long antibiotics should be given to cancer patients with fever and very low white blood cell counts after finding a certain type of bacteria (Gram-negative) in their blood. The goal is to find the best treatment duration to help patients recover without complications.
Rozzano, MilanAges 18 years+ - NCT07375563RecruitingPhase 3
Chemoimmunotherapy with NK cells for high-risk neuroblastoma
This trial tests a combination of chemotherapy, immunotherapy, and natural killer (NK) cell therapy for children with high-risk neuroblastoma or ganglioneuroblastoma that has not responded to initial treatment or has come back after treatment. The goal is to see if this approach can help destroy cancer cells more effectively.
MoscowAges 1.5 years–18 years - NCT07378930Recruiting
ULTRA-SAFE: More frequent monitoring after advanced polyps
This trial compares a new, more frequent surveillance schedule (yearly stool tests and colonoscopies every 2 years) to the standard schedule for people who have had advanced polyps removed. It aims to see if the extra testing helps prevent future colon cancer.
Taipei, TaipeiAges 40–75 - NCT07366112RecruitingPhase 2
CDK4/6 inhibitor plus hormone therapy before breast cancer surgery
This trial tests a combination of a CDK4/6 inhibitor (a type of targeted therapy) with hormone therapy given before surgery for early-stage breast cancer that is hormone receptor-positive and HER2-negative. It aims to see if this approach can shrink tumors and improve outcomes.
Beijing, Beijing MunicipalityAges 18–75 - NCT07370246Recruiting
Carotid stenting for high-risk carotid surgery patients
This trial tests whether placing a stent in the narrowed carotid artery is a good option for people who are at high risk for the standard surgery (carotid endarterectomy). If you have significant blockages in your neck arteries and certain health or anatomical factors that make surgery riskier, this study may be for you.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07363161Recruiting
Drug-coated balloon vs. stent for high-risk heart disease
This trial compares two treatments for people with complex coronary artery disease who have high-risk conditions or complicated blockages: a drug-coated balloon (DCB) versus a drug-eluting stent (DES). Both are ways to open up narrowed arteries and keep them open without surgery.
HomburgAges 18 years+ - NCT07356492Recruiting
Support program for transitioning service members at moderate suicide risk
This study tests a program to help service members who are at moderate risk for suicide as they transition from military to civilian life.
The Bronx, New YorkAges 18 years+ - NCT07359768Recruiting
Testing a noninvasive device for heart disease risk
This trial uses a noninvasive device to examine small blood vessels in people at high risk for heart disease. It may help doctors better understand who needs preventive care.
Stockholm, DanderydAges Any age - NCT07360119Recruiting
Pancreas removal with islet transplant for high-risk tumors
This trial removes the whole pancreas in people with certain pancreatic tumors and then transplants the patient's own insulin-making cells (islets) into the liver. The goal is to prevent or reduce diabetes after surgery.
Baltimore, MarylandAges 18 years+ - NCT07361679RecruitingPhase 4
Aspirin plus heparin vs aspirin alone for preeclampsia prevention
This trial tests whether adding a daily blood-thinning injection (heparin) to low-dose aspirin helps prevent preeclampsia better than aspirin alone for pregnant women at high risk.
Athens, AtticaAges 18 years+ - NCT06848582Recruiting
NK cell therapy for high-risk pediatric soft tissue sarcoma
This trial tests whether giving immune cells called NK cells from donated umbilical cord blood can help children and teens with high-risk or returning soft tissue sarcoma. The goal is to see if it is safe and effective when other treatments have been tried.
Guangzhou, GuangdongAges Up to 18 years - NCT05512481RecruitingPhase 2
Study combination treatment before surgery for high-risk acral melanoma
This Phase 2 trial tests three medicines given before surgery for people with high-risk acral melanoma (a skin cancer type). It aims to shrink or control the cancer earlier and see how well the treatment works and is tolerated.
Beijing, Beijing MunicipalityAges 18–75 - NCT06208462RecruitingPhase 2
Combination therapy before surgery for high-risk bile duct cancer
This trial tests a combination of chemotherapy directly into the liver artery, an immunotherapy drug, and a targeted therapy pill before surgery for a type of bile duct cancer that has a high chance of coming back. The goal is to see if this approach can improve outcomes for patients whose cancer is still removable but has certain high-risk features.
Nanjing, JiangsuAges 18–75 - NCT06565247RecruitingPhase 3
Comparing PET and MRI scans before prostate cancer surgery
This trial tests if a special PET scan (PSMA-PET) plus MRI is better than MRI alone at finding the full extent of high-risk prostate cancer before surgery. It aims to improve surgical planning by checking scan results against the removed prostate tissue.
MalmöAges 18 years+ - NCT07349069RecruitingPhase 3
HRS-8080 vs. standard hormone therapy for early breast cancer
This trial tests a new oral drug (HRS-8080) against standard hormone therapy for women with intermediate- or high-risk early breast cancer who have already completed 2 to 5 years of hormone treatment. It aims to see if the new drug can reduce the risk of cancer coming back.
Nanjing, JiangsuAges 18–75 - NCT07348042RecruitingPhase 1
Study of RGL-270 with or without Adebelimab for high-risk solid tumors
This trial tests a new treatment (RGL-270) alone or with another drug (Adebelimab) to prevent cancer from coming back after surgery. It is for people with solid tumors that have a high chance of returning.
ShanghaiAges 18–75 - NCT07346014Recruiting
Sleep therapy for college students at risk of suicide
This study tests if improving sleep can help college students who are already getting mental health treatment for suicidal thoughts. You will try light therapy or sleep schedule changes to see if it reduces suicide risk.
Pittsburgh, PennsylvaniaAges 18–25 - NCT07347990Recruiting
Iptacopan for high-risk TA-TMA after stem cell transplant
This trial tests a new oral medicine called iptacopan for people who have a serious blood vessel complication after a stem cell transplant (TA-TMA) that is not improving with usual treatments. The goal is to see if iptacopan can help stop the damage and improve recovery.
Hangzhou, ChinaAges 12 years+ - NCT07352111Recruiting
Heart risk in those with family history of heart attack
This study looks at people who have a family history of heart disease but no known heart problems or symptoms. It aims to understand if hidden plaque buildup in the arteries may be present.
MilanAges 40–70
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 922 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.