Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 940 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06492460RecruitingPhase 3
Two courses of chemo-radiation after surgery for high-risk head and neck cancer
This trial tests whether giving two rounds of cisplatin chemo along with radiation after surgery can help people with high-risk head and neck squamous cell carcinoma. It is for patients who have already had surgery and whose cancer showed signs of being more aggressive.
Guangzhou, GuangdongAges 18–70 - NCT06498622RecruitingPhase 2
Liver cancer relapse prevention after surgery
This trial tests a combination of two drugs (Donafenib and Envafolimab) after surgery to lower the risk of liver cancer coming back in people who have high-risk features. It may help if you qualify based on your tumor(s) and overall health.
Fuyang, AnhuiAges 18–80 - NCT06509724RecruitingPhase 3
Comparing standard vs. shorter radiation after hysterectomy for cervical cancer
This trial tests two different radiation schedules for women with high-risk cervical cancer after surgery. The goal is to see if a shorter course of radiation works as well as or better than the standard longer course, while possibly being more convenient.
Seoul, Gangnam-guAges 20–75 - NCT06509945Recruiting
Donor stem cell transplant for high-risk T-cell lymphoma
This trial tests giving a donor stem cell transplant (called allo-PBSCT) as the first treatment after chemotherapy for people with high-risk peripheral T-cell lymphoma. It may help prevent the lymphoma from coming back.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT06523556RecruitingPhase 1/Phase 2
Axatilimab with or without azacitidine for advanced blood cancers
This trial tests a new drug, axatilimab, given alone or with another drug (azacitidine) for people with advanced forms of blood cancers like certain leukemias and myelofibrosis. It may help if your disease has not responded to earlier treatments or if you are starting treatment for the first time.
Columbus, OhioAges 18 years+ - NCT06525571RecruitingPhase 3
Blue light surgery for high-risk bladder cancer
This trial tests if using blue light during surgery helps remove all cancer in people with high-risk non-muscle invasive bladder cancer. It may lower the chance of the cancer coming back.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06532851Recruiting
Exercise therapy for knee cartilage health
This study tests whether specific exercises can improve your knee cartilage health and daily function. It is for people with a meniscus tear who are at risk for knee arthritis but don't have arthritis yet.
Ar RamthaAges 35–55 - NCT06533384RecruitingPhase 3
PARP inhibitor or chemo plus immunotherapy after surgery for high-risk TNBC
This trial tests whether adding a PARP inhibitor or capecitabine (chemo) to a PD-1 inhibitor (immunotherapy) after surgery helps prevent triple-negative breast cancer from coming back. It's for people with high-risk disease who have completed initial treatment.
Guangzhou, GuangdongAges 18–70 - NCT06535230Recruiting
Propofol sleep induction in high-risk surgery patients
This trial tests a way to give the anesthetic drug propofol during sleep induction for high-risk patients having major, planned surgery. It uses a computer-controlled pump to deliver the drug, aiming to keep your blood pressure more stable.
IstanbulAges 18–100 - NCT06536959RecruitingPhase 2
VA plus PD-1 inhibitor for relapsed AML and high-risk MDS
This trial tests a combination of two drugs—a chemotherapy-like agent called VA and a PD-1 inhibitor (which helps your immune system fight cancer)—for people with AML or high-risk MDS that has not responded to or returned after initial treatment. The goal is to see if this combination can work better than standard treatments alone.
Beijing, Beijing MunicipalityAges 18–70 - NCT06541067RecruitingPhase 2
Posaconazole to prevent fungal infections after stem cell transplant
This trial tests whether the antifungal drug posaconazole can prevent serious fungal infections in people who are at high risk after a stem cell transplant. If you qualify, you would take posaconazole during your recovery.
Nantes, FranceAges 18 years+ - NCT06542640Recruiting
Understanding brain changes in youth at risk for psychosis
This research study looks at how the brain changes in young people who are at high risk for developing psychosis. It aims to find better ways to predict and prevent psychosis by using brain imaging and thinking tests.
Shanghai, Shanghai MunicipalityAges 15–35 - NCT06543173Recruiting
Preventive heart ablation with defibrillator in high-risk patients
This study tests if doing a special heart procedure (catheter ablation) at the same time as implanting a defibrillator (ICD) can prevent dangerous heart rhythms better than the ICD alone. It is for people with a very weak heart pump due to blocked arteries who are getting a first-time ICD.
Copenhagen, Region HAges 18 years+ - NCT06551233RecruitingPhase 1
Testing a new drug for high-risk bladder cancer
This trial tests a new drug called 9MW2821 for people with high-risk bladder cancer that hasn't grown into the bladder muscle. It's for those who have already tried other treatments that didn't work or who can't have standard therapy.
Nanjing, JiangsuAges 18 years+ - NCT06558981RecruitingPhase 3
Radiation therapy after thyroid surgery for high-risk cancer
This trial is testing whether giving radiation therapy after thyroid surgery can help destroy any leftover cancer cells in people with high-risk differentiated thyroid cancer. It is for those who had surgery but some cancer was still left behind.
ShanghaiAges 14–80 - NCT06559696RecruitingPhase 3
Radiation to internal mammary lymph nodes for high-risk breast cancer after chemo
This trial tests whether giving radiation to the internal mammary lymph nodes (the lymph nodes behind your breastbone) can help women with high-risk breast cancer after they have had chemotherapy before surgery. It is for people whose cancer has spread to nearby lymph nodes despite chemotherapy.
Fuzhou, FujianAges 18–75 - NCT06565247RecruitingPhase 3
Comparing PET and MRI scans before prostate cancer surgery
This trial tests if a special PET scan (PSMA-PET) plus MRI is better than MRI alone at finding the full extent of high-risk prostate cancer before surgery. It aims to improve surgical planning by checking scan results against the removed prostate tissue.
MalmöAges 18 years+ - NCT06566482RecruitingPhase 4
Medicine for pain after surgery in sleep apnea patients
This trial tests a combination of two medicines (dexmedetomidine and esketamine) given in small doses to help with pain after surgery. It is for people who have sleep apnea or are at risk for it, and who are having chest or belly surgery with a scope.
Beijing, Beijing MunicipalityAges 18–80 - NCT06573008RecruitingPhase 3
Testing GP681 Tablets for Flu in High-Risk Patients
This study tests an oral tablet called GP681 for people with flu who are at higher risk of serious complications. It compares the new drug to a placebo to see if it helps reduce symptoms faster.
ChizhouAges 12 years+ - NCT06574698Recruiting
Adding Naxitamb to high-risk neuroblastoma treatment
This trial is for children with high-risk neuroblastoma, a type of nerve cell cancer. It tests adding a new medicine called Naxitamb to standard induction therapy to see if it works better. High-risk means the cancer is advanced or has certain aggressive features.
Guanzhou, GuangdongAges 1–21 - NCT06575257RecruitingPhase 2
Darolutamide and Hormone Therapy Before Prostate Surgery
This trial tests giving a new hormone-blocking drug (darolutamide) plus standard hormone therapy before surgery for men with high-risk prostate cancer that has not spread. The goal is to see if this approach improves outcomes.
Xi’an, ShanxiAges 18–75 - NCT06576154RecruitingPhase 3
Antibiotics to prevent infection after hernia repair in high-risk patients
This trial tests whether giving antibiotics before surgery can lower the chance of infection after groin hernia repair in people who are at higher risk due to age, diabetes, obesity, or other health conditions. If you're over 60 and have one of these risk factors, this study may help you avoid a wound infection.
AleppoAges 18 years+ - NCT06594445RecruitingPhase 1
GTB-3650 TriKE for high-risk MDS and relapsed AML
This trial tests a new immunotherapy called GTB-3650 TriKE for people with high-risk MDS or AML that has come back or not responded to treatment. It aims to boost your immune system to fight the cancer.
Minneapolis, MinnesotaAges 18 years+ - NCT06601127RecruitingPhase 2
Tiprogrel for recent minor stroke or high-risk TIA
This trial tests a new anti-platelet drug called Tiprogrel to prevent another stroke in people who recently had a minor stroke or a transient ischemic attack (TIA) with certain artery narrowing or plaques. It aims to see if this medicine is safe and works better than current treatments.
Shenyang, LiaoningAges 40 years+
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 940 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.