Clinical trials · North Carolina
Infections clinical trials in North Carolina
We’re tracking 69 recruiting infections studies with a site in North Carolina — including Phase 1, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT05721781Recruiting
Reducing infection risk after gum and tooth issues
This study looks at ways to lower the risk of infective endocarditis, a serious heart infection that can happen after certain bacteria enter the bloodstream from the mouth. You may be asked to pause routine dental cleanings for a period while they track dental health and infection risk.
Charlotte, North CarolinaAges 18 years+ - NCT05624450RecruitingPhase 3
Test drug tozorakimab for hospitalized viral lung infection needing oxygen
This Phase 3 study tests tozorakimab to see if it helps people hospitalized with a viral lung infection that is causing low oxygen levels. You might qualify if you still need supplemental oxygen when the study starts.
Chapel Hill, North CarolinaAges 18 years+ - NCT05471973Recruiting
Study for suspected heart device infection care improvement
This study is testing an approach to improve how clinicians care for people with suspected infections around an implanted heart device (like a pacemaker or defibrillator). It may help ensure the infection is recognized and treated appropriately, especially when device removal (extraction) might be needed.
Greensboro, North CarolinaAges 18 years+ - NCT05361941Recruiting
Antibiotic graft to help bone regrow in infected knee surgery areas
This trial tests an antibiotic “graft” placed into or near infected bone cavities around a knee replacement (TKA) to help new bone grow. You may be considered if you have an infected knee implant area and can safely take part in follow-up visits and treatment.
Charlotte, North CarolinaAges 22 years+ - NCT04665037RecruitingPhase 2
Posaconazole study for infants under 2 with serious fungal infection
This trial tests whether posaconazole, given through a vein or by mouth, can treat invasive fungal infections in children under 2 years old. It may help improve outcomes for infants with hard-to-treat fungal disease.
Durham, North CarolinaAges 1 day–2 years - NCT04484025Enrolling by invitationPhase 2
Study of an oral drug for hospitalized COVID-19 patients
This trial tests an oral drug called SPI-1005 for people hospitalized with moderate COVID-19. The drug may help reduce inflammation and protect the lungs, and the study will compare it to a placebo (a pill with no active medicine) to see if it helps people recover.
Durham, North CarolinaAges 18 years+ - NCT03808922RecruitingPhase 3
DAS181 treatment for COVID-19 lung infection in immune-compromised adults
This Phase 3 trial tests DAS181 to treat lower lung (chest) viral infections in people with weakened immune systems, including a COVID-19 subgroup. It may help by targeting certain viruses in the lungs, but joining depends on your oxygen needs, recent diagnosis, and other safety factors.
Durham, North CarolinaAges Any age - NCT06627764Recruiting
Family support program for Latino families with teens
This study tests a family-based program to help Latino families with teenagers aged 12-17. The program addresses overlapping health and social challenges to improve family well-being.
Durham, North CarolinaAges 12–100 - NCT07610395RecruitingPhase 2
Testing an oral drug for cold virus in COPD patients
This trial tests an oral medication (VPV) to see if it can safely treat rhinovirus (a common cold virus) in people with COPD. The goal is to help you recover faster and prevent serious COPD flare-ups.
Kings Mountain, North CarolinaAges 40–85 - NCT07645287RecruitingPhase 2
New HIV Combination Therapy for People on Biktarvy
This study tests a new HIV medication (GS-3242) combined with lenacapavir against your current Biktarvy regimen. Both are all-oral treatments for people whose HIV is well-controlled.
Huntersville, North CarolinaAges 18 years+ - NCT07556107RecruitingPhase 4
Safety study of two antibiotics for serious hospital infections
This study watches how safely two common antibiotics (vancomycin and a combination called piperacillin/tazobactam) work together in hospitalized patients with serious infections. Researchers want to make sure the combination doesn't harm kidney function.
Winston-Salem, North CarolinaAges 18 years+ - NCT06679140RecruitingPhase 3
Study of Ibuzatrelvir for COVID-19 in high-risk patients
This trial tests if a new medicine called ibuzatrelvir can help people with COVID-19 who have certain health risks avoid severe illness. It is for patients who cannot or choose not to take another COVID-19 pill called Paxlovid.
Monroe, North CarolinaAges 12 years+ - NCT07755618Enrolling by invitationPhase 1
Doxycycline levels and adherence study
This study looks at how the antibiotic doxycycline stays in your body and how well people stick to taking it. It may help find better ways to prevent infections.
Chapel Hill, North CarolinaAges 18–65 - NCT07758140Recruiting
At-home cervical cancer screening study
This study tests if women can collect their own samples at home to screen for cervical cancer, which could make screening easier and more comfortable. You would provide a sample and compare it to a standard doctor-collected sample.
Raleigh, North CarolinaAges 25–65 - NCT07719491RecruitingPhase 1
Study of GS-0415 in People with HIV
This study tests a new drug, GS-0415, for people with HIV. The study will see if this drug can help control the virus. Participants will continue taking their regular HIV medication.
Durham, North CarolinaAges 18–65 - NCT07650916RecruitingPhase 3
A study of two ultra-long-acting HIV shots
This trial tests a new ultra-long-acting injectable combination of cabotegravir and rilpivirine for people with HIV who already have the virus under control. It aims to see if these shots can keep the virus suppressed with fewer doses.
Greensboro, North CarolinaAges 12 years+ - NCT07596888RecruitingPhase 1
Early safety study of experimental HIV treatment IAP-086-1
This is an early-stage trial testing a new experimental drug (IAP-086-1) in people with HIV who have their virus well-controlled on current medications. Researchers want to understand how safe the drug is and how the body handles it.
Durham, North CarolinaAges 18–70 - NCT07393594Enrolling by invitation
Tracer study for kidney transplant monitoring
This study looks at a new blood test to help monitor the health of your transplanted kidney and check for early signs of rejection. The test will be done as part of your usual care after a kidney transplant.
Greenville, North CarolinaAges 18 years+ - NCT07281430Recruiting
HPV self-test for cervical cancer screening
This study tests if a self-collected sample for HPV testing works as well as standard colposcopy to prevent cervical cancer. If you've recently had an abnormal cervical cancer screening and need a colposcopy, this trial may be an option for you.
Chapel Hill, North CarolinaAges 25 years+ - NCT07266831RecruitingPhase 2/Phase 3
New HIV treatment for people not yet on medication
This study tests a new combination medicine for people with HIV who have never taken treatment. It aims to see if it is safe and helps reduce the amount of virus in the blood.
Charlotte, North CarolinaAges 18 years+ - NCT00404989Recruiting
Pregnancy drug safety registry for people with HIV treatment
This trial is a pregnancy registry that collects information about birth outcomes when certain HIV medicines are taken during pregnancy. It helps detect any major birth defects so future pregnancies can be safer.
Wilmington, North CarolinaAges 12–60 - NCT07214571RecruitingPhase 2
Study of S-337395 for RSV in high-risk adults
This trial tests an experimental drug called S-337395 for adults with RSV who are not in the hospital but are at high risk for severe illness. It aims to see if the drug can help prevent symptoms from getting worse.
Winston-Salem, North CarolinaAges 18 years+ - NCT07202546RecruitingPhase 2
New oral HIV drug trial for people new to treatment
This trial tests a new oral HIV medication (VH4524184) in people who have never taken HIV treatment before. It looks at how well the drug controls the virus and how safe it is.
Charlotte, North CarolinaAges 18 years+ - NCT07069400Recruiting
Observational study of adults with acute infection
This study observes adults hospitalized with a new or recent infection (symptoms started within 30 days). The goal is to learn more about how infections affect people in the hospital, without testing any new drugs or treatments.
Durham, North CarolinaAges 18 years+
Where these studies are running in North Carolina
Institutions with a site for the recruiting infections studies listed above.
- Wake Forest University Health Sciences · 4 studies
- Duke Early Phase Clinical Research Unit · 2 studies
- Duke University Medical Center · 2 studies
- GSK Investigational Site · 2 studies
- Atrium Health
- Atrium Health Infectious Disease
- Atrium Health's Carolinas Medical Center
- CRC Kings Mountain
What taking part in a infections study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Infections trials in other states
Common questions
- Are there infections clinical trials in North Carolina?
- Yes. We're currently tracking 69 recruiting infections studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a infections study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a infections trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New infections studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.