Clinical trials · North Carolina
Infections clinical trials in North Carolina
We’re tracking 69 recruiting infections studies with a site in North Carolina — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT06738407RecruitingPhase 4
Doxycycline to prevent STIs in high-risk people
This study tests whether taking a daily antibiotic (doxycycline) can prevent sexually transmitted infections in people at high risk. If you've had an STI recently and sometimes have sex without condoms, you might be able to join.
Chapel Hill, North CarolinaAges 13–29 - NCT06815536Recruiting
Testing a new test for ciprofloxacin-resistant gonorrhea
This study is testing a new way to quickly check if gonorrhea bacteria are resistant to the antibiotic ciprofloxacin. If you have a positive gonorrhea test, your leftover sample may be used to see if this new test can help guide better treatment.
Durham, North CarolinaAges Any age - NCT06856174RecruitingPhase 4
Menopause Hormone Therapy for Women with HIV
This trial tests whether hormone therapy can help manage hot flashes and night sweats in women living with HIV who are going through menopause. It's designed to see if this treatment is safe and effective for this group.
Greensboro, North CarolinaAges 40–60 - NCT06859424RecruitingPhase 2
Testing a new GVHD prevention method after donor stem cell transplant
This trial tests a new way to prevent graft-versus-host disease (a common side effect of stem cell transplant) using a drug called cyclophosphamide after transplant. It is for adults with certain blood cancers who need a transplant from a partially matched unrelated donor.
Chapel Hill, North CarolinaAges 18–66 - NCT06472765Enrolling by invitation
Study of the Vaginal Ecosystem in Healthy Women
This study looks at the natural balance of bacteria and other factors in the vagina of healthy women. It aims to learn more about what a healthy vaginal ecosystem looks like.
Winston-Salem, North CarolinaAges 18–89 - NCT06262282Enrolling by invitation
Phage therapy for stubborn NTM infection in cystic fibrosis
This trial tests whether a special virus therapy (phage) can help clear stubborn NTM lung infections in people with cystic fibrosis who have been on antibiotics for over a year without success. Participants will continue their antibiotics while receiving the phages.
Chapel Hill, North CarolinaAges 6 years+ - NCT07610395RecruitingPhase 2
Testing an oral drug for cold virus in COPD patients
This trial tests an oral medication (VPV) to see if it can safely treat rhinovirus (a common cold virus) in people with COPD. The goal is to help you recover faster and prevent serious COPD flare-ups.
Kings Mountain, North CarolinaAges 40–85 - NCT07758140Recruiting
At-home cervical cancer screening study
This study tests if women can collect their own samples at home to screen for cervical cancer, which could make screening easier and more comfortable. You would provide a sample and compare it to a standard doctor-collected sample.
Raleigh, North CarolinaAges 25–65 - NCT07214571RecruitingPhase 2
Study of S-337395 for RSV in high-risk adults
This trial tests an experimental drug called S-337395 for adults with RSV who are not in the hospital but are at high risk for severe illness. It aims to see if the drug can help prevent symptoms from getting worse.
Winston-Salem, North CarolinaAges 18 years+ - NCT07013474RecruitingPhase 3
Study of ibuzatrelvir for immunocompromised adults with COVID-19
This trial tests an investigational medicine called ibuzatrelvir for adults with COVID-19 who have a weakened immune system. The study aims to see if it helps them recover and avoid severe illness.
Durham, North CarolinaAges 18 years+ - NCT07645287RecruitingPhase 2
New HIV Combination Therapy for People on Biktarvy
This study tests a new HIV medication (GS-3242) combined with lenacapavir against your current Biktarvy regimen. Both are all-oral treatments for people whose HIV is well-controlled.
Huntersville, North CarolinaAges 18 years+ - NCT04678154RecruitingPhase 3
Antibiotic trial for severe open fractures of the leg or foot
This trial tests a new way of giving antibiotics to people with severe open fractures in the leg, ankle, or foot. The goal is to see if it helps prevent infections after surgery.
Chapel Hill, North CarolinaAges 18–64 - NCT03713528Enrolling by invitationPhase 4
Antibiotic placed in bone to help save an infected knee implant
This trial tests whether putting antibiotics directly inside the bone during surgery can improve outcomes for an infected knee prosthesis when the implant is being kept. It may help more people avoid needing full implant removal and replacement.
Charlotte, North CarolinaAges 18 years+ - NCT07596888RecruitingPhase 1
Early safety study of experimental HIV treatment IAP-086-1
This is an early-stage trial testing a new experimental drug (IAP-086-1) in people with HIV who have their virus well-controlled on current medications. Researchers want to understand how safe the drug is and how the body handles it.
Chapel Hill, North CarolinaAges 18–70 - NCT06660342Recruiting
Safety of vonoprazan in pregnant women study
This study looks at the safety of vonoprazan (a medicine for acid reflux) when taken during pregnancy. It follows pregnant women who took the drug and those who didn't, to see how it affects mothers and their babies.
Wilmington, North CarolinaAges 15–50 - NCT06071767RecruitingPhase 1/Phase 2
Immune therapy trial for early-treated HIV
This study tests whether a combination of three immune therapies can help control HIV without daily medication. You may qualify if you started HIV treatment very early and have had a suppressed viral load for at least a year.
Chapel Hill, North CarolinaAges 18 years+ - NCT06010433Recruiting
CERAMENT G treatment tracking study
This study tracks how well the CERAMENT G device works for people getting it as part of their treatment. It helps doctors gather real-world safety and effectiveness information.
Charlotte, North CarolinaAges 18 years+ - NCT05773001RecruitingPhase 1
Study of an immune treatment for ozone-related lung inflammation
This early-phase study tests how an immune-targeting treatment affects inflammation in the lungs after ozone exposure. It may help researchers understand—and eventually reduce—lung inflammation triggered by air pollution.
Durham, North CarolinaAges 18–55 - NCT07650916RecruitingPhase 3
A study of two ultra-long-acting HIV shots
This trial tests a new ultra-long-acting injectable combination of cabotegravir and rilpivirine for people with HIV who already have the virus under control. It aims to see if these shots can keep the virus suppressed with fewer doses.
Greensboro, North CarolinaAges 12 years+ - NCT06679140RecruitingPhase 3
Study of Ibuzatrelvir for COVID-19 in high-risk patients
This trial tests if a new medicine called ibuzatrelvir can help people with COVID-19 who have certain health risks avoid severe illness. It is for patients who cannot or choose not to take another COVID-19 pill called Paxlovid.
Monroe, North CarolinaAges 12 years+ - NCT07202546RecruitingPhase 2
New oral HIV drug trial for people new to treatment
This trial tests a new oral HIV medication (VH4524184) in people who have never taken HIV treatment before. It looks at how well the drug controls the virus and how safe it is.
Charlotte, North CarolinaAges 18 years+ - NCT07069400Recruiting
Observational study of adults with acute infection
This study observes adults hospitalized with a new or recent infection (symptoms started within 30 days). The goal is to learn more about how infections affect people in the hospital, without testing any new drugs or treatments.
Durham, North CarolinaAges 18 years+ - NCT05243966Recruiting
Registry for soft tissue repair using a special matrix
This study is a registry that collects information from people who had soft tissue repair using a specific matrix and/or morcell material. It may help researchers understand how this approach performs in real-world care and patient outcomes over time.
Greensboro, North CarolinaAges 18 years+ - NCT03325855Recruiting
Fecal transplant registry for patients and donors
This study is a national “registry” that collects information from people who get fecal microbiota transplant (a stool-based treatment) and from people who donate stool. It helps researchers understand who receives these treatments and how they do over time.
Chapel Hill, North CarolinaAges Any age
Where these studies are running in North Carolina
Institutions with a site for the recruiting infections studies listed above.
- University of North Carolina at Chapel Hill · 7 studies
- Duke University Medical Center · 3 studies
- GSK Investigational Site · 2 studies
- OrthoCarolina Research Institute · 2 studies
- Atrium Health Mercy
- Atrium Health Wake Forest Baptist Medical Center (Wake Forest Baptist)
- Camel City Women's Wellness
- Carolinas Medical Center/Levine Cancer Institute
What taking part in a infections study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Infections trials in other states
Common questions
- Are there infections clinical trials in North Carolina?
- Yes. We're currently tracking 69 recruiting infections studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a infections study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a infections trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New infections studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.