Clinical trials · North Carolina
Infections clinical trials in North Carolina
We’re tracking 69 recruiting infections studies with a site in North Carolina — including Phase 1, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT07095361RecruitingPhase 4
Daily enzyme therapy for infected pleural fluid
This trial tests a once-daily enzyme treatment given through a chest tube to clear infected fluid from around the lungs. It may help people with complicated pneumonia or empyema who still have fluid buildup after initial drainage.
Chapel Hill, North CarolinaAges 18 years+ - NCT05699174RecruitingPhase 3
Compare two antibiotic routes for infected broken bones after surgery
This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.
Charlotte, North CarolinaAges 18 years+ - NCT07214311RecruitingPhase 2/Phase 3
Preventing repeat knee infection after joint-saving surgery
This trial tests a new medicine called PLG0206 to help prevent a knee infection from coming back after a procedure to clean the joint while keeping the artificial knee in place. If you qualify, you'll receive the study medicine or a placebo along with standard antibiotics.
Leland, North CarolinaAges 18–85 - NCT06841913RecruitingPhase 4
Woodsmoke, flu, and your nasal immune response
This study tests how breathing woodsmoke affects your nose's ability to fight off the flu virus. You will be exposed to woodsmoke and then given a live flu vaccine to see how your immune system responds.
Chapel Hill, North CarolinaAges 18–49 - NCT06155747Recruiting
NTM outbreak study for people with positive lung samples
This study looks at how NTM bacteria spread among people. If you have had a positive NTM test from your lungs, you may be able to help by sharing a sample for research.
Chapel Hill, North CarolinaAges 1 month–99 years - NCT05645107RecruitingPhase 3
XEMBIFY plus usual care to prevent infections
This Phase 3 study tests whether XEMBIFY (an immune protein therapy) plus standard medical treatment can better prevent serious or repeated infections. It is for people with certain cancers of blood/immune systems who are already having trouble with infections.
Greenville, North CarolinaAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Durham, North CarolinaAges birth–20 years - NCT07222670RecruitingPhase 2
Nasal spray to prevent respiratory infections in healthy adults
This trial tests a nasal spray, INNA-051, that may help your nose and airways fight off viruses that cause respiratory infections like colds and flu. It is for healthy adults aged 18-45 who are around many people and may be exposed to germs.
Raleigh, North CarolinaAges 18–45 - NCT07513285RecruitingPhase 2
Ibezapolstat pill for recurrent C. difficile infection
This trial tests a new oral antibiotic called ibezapolstat to treat recurrent C. difficile infection (CDI)—a serious diarrheal illness caused by bacteria in your gut. The study focuses on patients who have had multiple CDI episodes and may benefit from a different treatment approach.
Winston-Salem, North CarolinaAges 18–90 - NCT06462235RecruitingPhase 2
Testing a new antibiotic for hospitalized babies with infection
This study tests a new antibiotic called aztreonam-avibactam (ATM-AVI) for treating serious bacterial infections in hospitalized babies under 9 months old. The goal is to see if it's safe and works well.
Durham, North CarolinaAges Up to 9 months - NCT07781501Recruiting
Study of long-term effects of covid-19
This study looks at the long-term effects of COVID-19, sometimes called Long COVID. By studying saliva and health info, researchers hope to understand why some people have lasting symptoms.
Chapel Hill, North CarolinaAges 18–75 - NCT03827694Recruiting
Testing a noninvasive scan for serious lung mold infections in kids
This study uses noninvasive breathing/relates imaging (MRI or CT) to help diagnose mold infections in the lungs in children and young adults. It may help doctors find these infections sooner, especially in people with weakened immune systems.
Durham, North CarolinaAges 4 months–21 years - NCT07387367RecruitingPhase 3
Comparing two drugs for adenovirus after stem cell transplant
This trial tests a new drug, brincidofovir (BCV), against an existing drug, cidofovir (CDV), for treating adenovirus infection in people who recently had a stem cell transplant. The goal is to see which works better with fewer side effects.
Durham, North CarolinaAges 2 months+ - NCT07285213RecruitingPhase 2
Preventing C. diff return with an antibody
This study tests a new antibody (AZD5148) to prevent C. diff infection from coming back. If you have a current C. diff infection and are being treated with antibiotics, you may be able to join.
Salisbury, North CarolinaAges 18 years+ - NCT06925321RecruitingPhase 3
Testing Fosmanogepix for Serious Mold Infections
This trial tests a new drug, Fosmanogepix, for treating serious mold infections that are hard to treat with current medicines. It may be an option for people with limited treatment choices.
Durham, North CarolinaAges 18 years+ - NCT06859424RecruitingPhase 2
Testing a new GVHD prevention method after donor stem cell transplant
This trial tests a new way to prevent graft-versus-host disease (a common side effect of stem cell transplant) using a drug called cyclophosphamide after transplant. It is for adults with certain blood cancers who need a transplant from a partially matched unrelated donor.
Chapel Hill, North CarolinaAges 18–66 - NCT06856174RecruitingPhase 4
Menopause Hormone Therapy for Women with HIV
This trial tests whether hormone therapy can help manage hot flashes and night sweats in women living with HIV who are going through menopause. It's designed to see if this treatment is safe and effective for this group.
Chapel Hill, North CarolinaAges 40–60 - NCT06822426RecruitingPhase 3
Catheter lock solution to prevent bloodstream infections in patients on IV nutrition
This study tests a catheter lock solution called DefenCath (taurolidine and heparin) against a standard heparin lock to see if it reduces central line bloodstream infections in people receiving IV nutrition (total parenteral nutrition) for more than 3 months.
Durham, North CarolinaAges 12 years+ - NCT06801223RecruitingPhase 1
Testing sulbactam-durlobactam for children with ABC infection
This trial tests a new combination of antibiotics (sulbactam-durlobactam) for children with a serious infection caused by Acinetobacter bacteria. The goal is to see if this treatment is safe and works well for kids.
Greenville, North CarolinaAges 1 day–18 years - NCT06738407RecruitingPhase 4
Doxycycline to prevent STIs in high-risk people
This study tests whether taking a daily antibiotic (doxycycline) can prevent sexually transmitted infections in people at high risk. If you've had an STI recently and sometimes have sex without condoms, you might be able to join.
Chapel Hill, North CarolinaAges 13–29 - NCT06649890Recruiting
Testing a new irrigation solution in breast reconstruction after mastectomy
This study tests a new surgical irrigation solution (Xperience) used during breast reconstruction after double mastectomy. It aims to see if it can reduce complications and improve outcomes for people receiving implants or tissue expanders.
Chapel Hill, North CarolinaAges 18 years+ - NCT06472765Enrolling by invitation
Study of the Vaginal Ecosystem in Healthy Women
This study looks at the natural balance of bacteria and other factors in the vagina of healthy women. It aims to learn more about what a healthy vaginal ecosystem looks like.
Winston-Salem, North CarolinaAges 18–89 - NCT06428448RecruitingPhase 2
Antibiotic nail for ankle infection treatment
This study tests a special antibiotic-coated nail placed inside the ankle bone to treat infections. It may help people with ankle infections avoid more serious complications.
Durham, North CarolinaAges 21 years+ - NCT06262282Enrolling by invitation
Phage therapy for stubborn NTM infection in cystic fibrosis
This trial tests whether a special virus therapy (phage) can help clear stubborn NTM lung infections in people with cystic fibrosis who have been on antibiotics for over a year without success. Participants will continue their antibiotics while receiving the phages.
Chapel Hill, North CarolinaAges 6 years+
Where these studies are running in North Carolina
Institutions with a site for the recruiting infections studies listed above.
- Duke University Medical Center · 5 studies
- University of North Carolina at Chapel Hill · 4 studies
- University of North Carolina · 2 studies
- 3201 Chapel Hill CRS
- 3203 Greensboro CRS
- Accellacare
- Accellacare of Piedmont HealthCare
- Atrium Health, Carolinas Medical Center
What taking part in a infections study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Infections trials in other states
Common questions
- Are there infections clinical trials in North Carolina?
- Yes. We're currently tracking 69 recruiting infections studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a infections study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a infections trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New infections studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.