Clinical trials · North Carolina
Infections clinical trials in North Carolina
We’re tracking 69 recruiting infections studies with a site in North Carolina — including Phase 1, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT05699174RecruitingPhase 3
Compare two antibiotic routes for infected broken bones after surgery
This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.
Charlotte, North CarolinaAges 18 years+ - NCT07095361RecruitingPhase 4
Daily enzyme therapy for infected pleural fluid
This trial tests a once-daily enzyme treatment given through a chest tube to clear infected fluid from around the lungs. It may help people with complicated pneumonia or empyema who still have fluid buildup after initial drainage.
Chapel Hill, North CarolinaAges 18 years+ - NCT07214311RecruitingPhase 2/Phase 3
A trial of PLG0206 to prevent knee joint infection after surgery
This trial tests if a new drug called PLG0206 can stop a knee joint infection from coming back after a surgery called DAIR. DAIR cleans the infected area and keeps the artificial knee in place, and this study wants to see if adding PLG0206 helps prevent the infection from returning.
Leland, North CarolinaAges 18–80 - NCT05645107RecruitingPhase 3
XEMBIFY plus usual care to prevent infections
This Phase 3 study tests whether XEMBIFY (an immune protein therapy) plus standard medical treatment can better prevent serious or repeated infections. It is for people with certain cancers of blood/immune systems who are already having trouble with infections.
Greenville, North CarolinaAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Chapel Hill, North CarolinaAges birth–20 years - NCT06155747Recruiting
NTM outbreak study for people with positive lung samples
This study looks at how NTM bacteria spread among people. If you have had a positive NTM test from your lungs, you may be able to help by sharing a sample for research.
Chapel Hill, North CarolinaAges 1 month–99 years - NCT06841913RecruitingPhase 4
Woodsmoke, flu, and your nasal immune response
This study tests how breathing woodsmoke affects your nose's ability to fight off the flu virus. You will be exposed to woodsmoke and then given a live flu vaccine to see how your immune system responds.
Chapel Hill, North CarolinaAges 18–49 - NCT04665037RecruitingPhase 2
Posaconazole study for infants under 2 with serious fungal infection
This trial tests whether posaconazole, given through a vein or by mouth, can treat invasive fungal infections in children under 2 years old. It may help improve outcomes for infants with hard-to-treat fungal disease.
Durham, North CarolinaAges 1 day–2 years - NCT07387367RecruitingPhase 3
Comparing two drugs for adenovirus after stem cell transplant
This trial tests a new drug, brincidofovir (BCV), against an existing drug, cidofovir (CDV), for treating adenovirus infection in people who recently had a stem cell transplant. The goal is to see which works better with fewer side effects.
Durham, North CarolinaAges 2 months+ - NCT06822426RecruitingPhase 3
Preventing infections in central lines for people on IV nutrition
This trial tests a new catheter lock solution (DefenCath) to prevent infections in people who need long-term IV nutrition through a central line. It compares the study drug to a standard heparin lock, and you'll be randomly assigned to one group.
Durham, North CarolinaAges 18 years+ - NCT06428448RecruitingPhase 2
Antibiotic nail for ankle infection treatment
This study tests a special antibiotic-coated nail placed inside the ankle bone to treat infections. It may help people with ankle infections avoid more serious complications.
Durham, North CarolinaAges 21 years+ - NCT06801223RecruitingPhase 1
Testing sulbactam-durlobactam for children with ABC infection
This trial tests a new combination of antibiotics (sulbactam-durlobactam) for children with a serious infection caused by Acinetobacter bacteria. The goal is to see if this treatment is safe and works well for kids.
Greenville, North CarolinaAges 1 day–18 years - NCT05361941Recruiting
Antibiotic graft to help bone regrow in infected knee surgery areas
This trial tests an antibiotic “graft” placed into or near infected bone cavities around a knee replacement (TKA) to help new bone grow. You may be considered if you have an infected knee implant area and can safely take part in follow-up visits and treatment.
Charlotte, North CarolinaAges 22 years+ - NCT05719441RecruitingPhase 2
Antibodies plus early HIV treatment to try for HIV remission
This study tests whether giving special HIV-fighting antibodies along with starting standard HIV medicine soon after infection can help you reach “HIV remission.” It may reduce or delay the return of detectable virus, but you must be willing to follow close monitoring and specific study steps.
Greensboro, North CarolinaAges 18–70 - NCT07222670RecruitingPhase 2
Study of INNA-051 to prevent viral respiratory illness in healthy adults
This trial tests whether INNA-051 can help prevent respiratory infections caused by viruses in healthy adults aged 18 to 45. It may be an option if you are at higher risk of catching such infections due to your living or work situation.
Statesville, North CarolinaAges 18–45 - NCT05624450RecruitingPhase 3
Test drug tozorakimab for hospitalized viral lung infection needing oxygen
This Phase 3 study tests tozorakimab to see if it helps people hospitalized with a viral lung infection that is causing low oxygen levels. You might qualify if you still need supplemental oxygen when the study starts.
Chapel Hill, North CarolinaAges 18 years+ - NCT06925321RecruitingPhase 3
Testing Fosmanogepix for Serious Mold Infections
This trial tests a new drug, Fosmanogepix, for treating serious mold infections that are hard to treat with current medicines. It may be an option for people with limited treatment choices.
Chapel Hill, North CarolinaAges 18 years+ - NCT03808922RecruitingPhase 3
DAS181 treatment for COVID-19 lung infection in immune-compromised adults
This Phase 3 trial tests DAS181 to treat lower lung (chest) viral infections in people with weakened immune systems, including a COVID-19 subgroup. It may help by targeting certain viruses in the lungs, but joining depends on your oxygen needs, recent diagnosis, and other safety factors.
Durham, North CarolinaAges Any age - NCT03827694Recruiting
Testing a noninvasive scan for serious lung mold infections in kids
This study uses noninvasive breathing/relates imaging (MRI or CT) to help diagnose mold infections in the lungs in children and young adults. It may help doctors find these infections sooner, especially in people with weakened immune systems.
Durham, North CarolinaAges 4 months–21 years - NCT07285213RecruitingPhase 2
Preventing C. diff return with an antibody
This study tests a new antibody (AZD5148) to prevent C. diff infection from coming back. If you have a current C. diff infection and are being treated with antibiotics, you may be able to join.
Salisbury, North CarolinaAges 18 years+ - NCT05471973Recruiting
Study for suspected heart device infection care improvement
This study is testing an approach to improve how clinicians care for people with suspected infections around an implanted heart device (like a pacemaker or defibrillator). It may help ensure the infection is recognized and treated appropriately, especially when device removal (extraction) might be needed.
Greensboro, North CarolinaAges 18 years+ - NCT05721781Recruiting
Reducing infection risk after gum and tooth issues
This study looks at ways to lower the risk of infective endocarditis, a serious heart infection that can happen after certain bacteria enter the bloodstream from the mouth. You may be asked to pause routine dental cleanings for a period while they track dental health and infection risk.
Charlotte, North CarolinaAges 18 years+ - NCT06462235RecruitingPhase 2
Testing a new antibiotic for hospitalized babies with infection
This study tests a new antibiotic called aztreonam-avibactam (ATM-AVI) for treating serious bacterial infections in hospitalized babies under 9 months old. The goal is to see if it's safe and works well.
Durham, North CarolinaAges Up to 9 months - NCT06649890Recruiting
Testing a new irrigation solution in breast reconstruction after mastectomy
This study tests a new surgical irrigation solution (Xperience) used during breast reconstruction after double mastectomy. It aims to see if it can reduce complications and improve outcomes for people receiving implants or tissue expanders.
Chapel Hill, North CarolinaAges 18 years+
Where these studies are running in North Carolina
Institutions with a site for the recruiting infections studies listed above.
- Duke University Medical Center · 7 studies
- University of North Carolina at Chapel Hill · 6 studies
- Carolinas Medical Center/Levine Cancer Institute · 2 studies
- OrthoCarolina Research Institute · 2 studies
- Research Site · 2 studies
- Accellacare
- Atrium Health
- Atrium Health Wake Forest Baptist Medical Center (Wake Forest Baptist)
What taking part in a infections study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Infections trials in other states
Common questions
- Are there infections clinical trials in North Carolina?
- Yes. We're currently tracking 69 recruiting infections studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a infections study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a infections trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New infections studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.