Clinical trials · Massachusetts
Infections clinical trials in Massachusetts
We’re tracking 63 recruiting infections studies with a site in Massachusetts — including Phase 1/Phase 2, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT06237452RecruitingPhase 3
VE303 to prevent repeat C. diff infections
This trial tests a new medicine called VE303, a live bacterial therapy, to prevent C. diff infections from coming back. It is for people who have had C. diff at least once in the last 6 months, or who are at high risk for a repeat infection due to age or other health problems.
Boston, MassachusettsAges 12 years+ - NCT07110636Recruiting
Blood test for infection in immunocompromised adults
This trial tests a blood test that looks for infection by analyzing tiny bits of DNA from microbes. It may help find infections faster in people with weakened immune systems, such as transplant recipients or those with blood cancers.
Boston, MassachusettsAges 18 years+ - NCT02271243Recruiting
Find the source of bloodstream infections from central line germs
This study uses special genetic testing of bacteria from blood to figure out where central-line bloodstream infections come from. Results may help doctors better identify the source and improve prevention and treatment.
Boston, MassachusettsAges Any age - NCT07214311RecruitingPhase 2/Phase 3
A trial of PLG0206 to prevent knee joint infection after surgery
This trial tests if a new drug called PLG0206 can stop a knee joint infection from coming back after a surgery called DAIR. DAIR cleans the infected area and keeps the artificial knee in place, and this study wants to see if adding PLG0206 helps prevent the infection from returning.
Boston, MassachusettsAges 18–80 - NCT06529159Recruiting
Treating H. pylori with argon plasma during endoscopy
This trial tests a new way to treat H. pylori infection using argon plasma (a kind of energy) during an upper endoscopy. It may help people who haven't yet taken antibiotics for H. pylori and are already having an endoscopy.
Boston, MassachusettsAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Boston, MassachusettsAges birth–20 years - NCT07513285RecruitingPhase 2
Ibezapolstat pill for recurrent C. difficile infection
This trial tests a new oral antibiotic called ibezapolstat to treat recurrent C. difficile infection (CDI)—a serious diarrheal illness caused by bacteria in your gut. The study focuses on patients who have had multiple CDI episodes and may benefit from a different treatment approach.
Newton, MassachusettsAges 18–90 - NCT07387367RecruitingPhase 3
Comparing two drugs for adenovirus after stem cell transplant
This trial tests a new drug, brincidofovir (BCV), against an existing drug, cidofovir (CDV), for treating adenovirus infection in people who recently had a stem cell transplant. The goal is to see which works better with fewer side effects.
Boston, MassachusettsAges 2 months+ - NCT05592626RecruitingPhase 1/Phase 2
T cell activator STAR0602 for advanced solid tumors
This study tests an experimental drug called STAR0602 that aims to boost your immune system's T cells to fight advanced solid tumors. It's for patients whose cancer has not responded to standard treatments or for whom such treatments are not suitable.
Boston, MassachusettsAges 18 years+ - NCT05550298Recruiting
Study of virus infections after pediatric transplants
This study looks at how respiratory viruses behave and how the body responds in children who are about to receive, or have recently received, a transplant. It may help doctors better diagnose and treat viral infections in transplant patients by studying blood samples and test results.
Boston, MassachusettsAges Up to 18 years - NCT05361941Recruiting
Antibiotic graft to help bone regrow in infected knee surgery areas
This trial tests an antibiotic “graft” placed into or near infected bone cavities around a knee replacement (TKA) to help new bone grow. You may be considered if you have an infected knee implant area and can safely take part in follow-up visits and treatment.
Boston, MassachusettsAges 22 years+ - NCT05719441RecruitingPhase 2
Antibodies plus early HIV treatment to try for HIV remission
This study tests whether giving special HIV-fighting antibodies along with starting standard HIV medicine soon after infection can help you reach “HIV remission.” It may reduce or delay the return of detectable virus, but you must be willing to follow close monitoring and specific study steps.
Boston, MassachusettsAges 18–70 - NCT05624450RecruitingPhase 3
Test drug tozorakimab for hospitalized viral lung infection needing oxygen
This Phase 3 study tests tozorakimab to see if it helps people hospitalized with a viral lung infection that is causing low oxygen levels. You might qualify if you still need supplemental oxygen when the study starts.
Springfield, MassachusettsAges 18 years+ - NCT07435649Recruiting
New test for finding germs in spinal fluid during brain infections
This study tests a new type of test called Delve Detect that looks for germs in spinal fluid from people suspected of having a brain or spinal cord infection. It helps doctors find the cause faster and more accurately.
Burlington, MassachusettsAges Any age - NCT03562741Recruiting
Tracking outcomes of fecal transplant for repeated C. difficile
This study looks at how fecal microbiota transplantation (a transplant of healthy gut bacteria) works for people who get C. difficile infection repeatedly. It also focuses on collecting follow-up information to better understand which patients benefit and how.
Worcester, MassachusettsAges 16 years+ - NCT03808922RecruitingPhase 3
DAS181 treatment for COVID-19 lung infection in immune-compromised adults
This Phase 3 trial tests DAS181 to treat lower lung (chest) viral infections in people with weakened immune systems, including a COVID-19 subgroup. It may help by targeting certain viruses in the lungs, but joining depends on your oxygen needs, recent diagnosis, and other safety factors.
Boston, MassachusettsAges Any age - NCT03827694Recruiting
Testing a noninvasive scan for serious lung mold infections in kids
This study uses noninvasive breathing/relates imaging (MRI or CT) to help diagnose mold infections in the lungs in children and young adults. It may help doctors find these infections sooner, especially in people with weakened immune systems.
Boston, MassachusettsAges 4 months–21 years - NCT07285213RecruitingPhase 2
Preventing C. diff return with an antibody
This study tests a new antibody (AZD5148) to prevent C. diff infection from coming back. If you have a current C. diff infection and are being treated with antibiotics, you may be able to join.
Boston, MassachusettsAges 18 years+ - NCT05626530RecruitingPhase 4
Letermovir to prevent CMV after transplant illness
This trial studies whether letermovir can help prevent CMV (a common virus after transplant) from coming back after you’ve already been treated. If you qualify, you may be offered letermovir as “secondary prevention” and followed for about 6 months.
Boston, MassachusettsAges 18–75 - NCT05721781Recruiting
Reducing infection risk after gum and tooth issues
This study looks at ways to lower the risk of infective endocarditis, a serious heart infection that can happen after certain bacteria enter the bloodstream from the mouth. You may be asked to pause routine dental cleanings for a period while they track dental health and infection risk.
Boston, MassachusettsAges 18 years+ - NCT06462235RecruitingPhase 2
Testing a new antibiotic for hospitalized babies with infection
This study tests a new antibiotic called aztreonam-avibactam (ATM-AVI) for treating serious bacterial infections in hospitalized babies under 9 months old. The goal is to see if it's safe and works well.
Boston, MassachusettsAges Up to 9 months - NCT06631287RecruitingPhase 3
Testing baricitinib for persistent long COVID symptoms
This trial tests whether the anti-inflammatory drug baricitinib can improve persistent long COVID symptoms like brain fog, fatigue, and shortness of breath. You may qualify if you had COVID-19 at least 6 months ago and still have bothersome symptoms that affect your daily life.
Boston, MassachusettsAges 18 years+ - NCT06713382RecruitingPhase 2
Saline rinse for trapped lung infections
This trial tests if adding a simple saltwater rinse to standard chest tube drainage helps clear stubborn lung infections. It might be an option if you have an infected fluid pocket in your chest that isn't draining well.
Boston, MassachusettsAges 18 years+ - NCT06856174RecruitingPhase 4
Menopause Hormone Therapy for Women with HIV
This trial tests whether hormone therapy can help manage hot flashes and night sweats in women living with HIV who are going through menopause. It's designed to see if this treatment is safe and effective for this group.
Boston, MassachusettsAges 40–60
Infections trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting infections studies listed above.
- Brigham and Women's Hospital · 8 studies
- Massachusetts General Hospital · 6 studies
- Boston Children's Hospital · 4 studies
- Tufts Medical Center · 4 studies
- Beth Israel Deaconess Medical Center · 2 studies
- Newton-Wellesley Hospital · 2 studies
- Research Site · 2 studies
- Clinical Trial Site
What taking part in a infections study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Infections trials in other states
Common questions
- Are there infections clinical trials in Massachusetts?
- Yes. We're currently tracking 63 recruiting infections studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a infections study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a infections trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New infections studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.