Clinical trials · North Carolina
Infections clinical trials in North Carolina
We’re tracking 69 recruiting infections studies with a site in North Carolina — including Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT07013474RecruitingPhase 3
Study of ibuzatrelvir for immunocompromised adults with COVID-19
This trial tests an investigational medicine called ibuzatrelvir for adults with COVID-19 who have a weakened immune system. The study aims to see if it helps them recover and avoid severe illness.
Durham, North CarolinaAges 18 years+ - NCT06866405RecruitingPhase 3
RSV vaccine boost in a new pregnancy
This study tests whether a second dose of the RSV vaccine during a new pregnancy protects you and your baby from RSV. If you received the RSVpreF or Abrysvo vaccine in a past pregnancy, you may be able to join.
Durham, North CarolinaAges birth+ - NCT05129345Recruiting
HIV care program for heart health goals in the Southeast US
This trial tests an approach to help people living with HIV reach heart- and metabolism-related health goals, such as blood pressure, cholesterol, and blood sugar. It involves clinics and community partners and may offer education, support, and care coordination to remove barriers to treatment.
Charlotte, North CarolinaAges 18 years+ - NCT06660342Recruiting
Safety of vonoprazan in pregnant women study
This study looks at the safety of vonoprazan (a medicine for acid reflux) when taken during pregnancy. It follows pregnant women who took the drug and those who didn't, to see how it affects mothers and their babies.
Wilmington, North CarolinaAges 15–50 - NCT06399302Recruiting
Improving outcomes for lung transplant patients
This study looks at ways to improve outcomes for people who are waiting for or have recently received a lung transplant. It aims to find better management strategies for both donors and recipients.
Durham, North CarolinaAges 18 years+ - NCT06010433Recruiting
CERAMENT G treatment tracking study
This study tracks how well the CERAMENT G device works for people getting it as part of their treatment. It helps doctors gather real-world safety and effectiveness information.
Charlotte, North CarolinaAges 18 years+ - NCT05620329Recruiting
Pleural fluid registry for drainage in adults
This registry collects information from adults who have fluid around the lungs (pleural effusion) and need clinically indicated drainage because of infection or cancer. It helps researchers better understand these conditions and improve future care.
Chapel Hill, North CarolinaAges 18 years+ - NCT06080698Recruiting
Oral antibiotics for bloodstream infection trial
This trial tests whether switching from IV to oral antibiotics is just as effective for treating Gram-negative bloodstream infections. If you qualify, you may receive either continued IV antibiotics or switch to pills, with follow-up on your recovery and quality of life.
Durham, North CarolinaAges 18 years+ - NCT06056297RecruitingPhase 3
Study of Mavorixafor for chronic neutropenia with infections
This trial tests if mavorixafor can help people with certain types of long-term low neutrophil counts (chronic neutropenia) who still get frequent or serious infections. It aims to reduce infection risk by boosting your body's infection-fighting cells.
Durham, North CarolinaAges 12 years+ - NCT05753683Recruiting
Online group talks to build social support for young women
This study tests whether online discussion groups can increase social support for young Black/African American women who have had recent substance use. It also specifically focuses on women who are HIV negative and not using PrEP, to support healthier choices and community connection.
Durham, North CarolinaAges 18–30 - NCT05773001RecruitingPhase 1
Study of an immune treatment for ozone-related lung inflammation
This early-phase study tests how an immune-targeting treatment affects inflammation in the lungs after ozone exposure. It may help researchers understand—and eventually reduce—lung inflammation triggered by air pollution.
Durham, North CarolinaAges 18–55 - NCT05206500RecruitingPhase 4
Test whether urine genetic testing changes care
This study looks at whether next-generation DNA testing from your urine can help doctors make better decisions about your treatment. You may be asked to return for follow-up visits so researchers can compare outcomes over time.
Winston-Salem, North CarolinaAges 18–80 - NCT05603728Recruiting
Follow-up study for Exactech shoulder implants after surgery
This study follows people who get (or already had) a shoulder replacement to see how the implant is doing over time. It may help improve future care by tracking long-term performance and safety.
Asheville, North CarolinaAges 21 years+ - NCT05488340RecruitingPhase 2
Study drug for hard-to-treat bladder infection in women
This Phase 2 trial tests LBP-EC01 to treat a bladder infection (UTI) caused by drug-resistant E. coli. It may help by targeting the specific bacteria that make UTIs harder to cure with common antibiotics.
Raleigh, North CarolinaAges 18–75 - NCT05421741RecruitingPhase 4
Antibiotic-coated nail to help prevent infection
This trial studies a special nail for certain broken shin bones to lower the chance of infection after surgery. If you qualify, the study team will help you receive the antibiotic-coated nail and will follow you closely for about a year.
Concord, North CarolinaAges 18 years+ - NCT05243966Recruiting
Registry for soft tissue repair using a special matrix
This study is a registry that collects information from people who had soft tissue repair using a specific matrix and/or morcell material. It may help researchers understand how this approach performs in real-world care and patient outcomes over time.
Greensboro, North CarolinaAges 18 years+ - NCT05075967Enrolling by invitation
Study attitudes and services among southern gay and bisexual men
This study gathers opinions and experiences from gay and bisexual men and from clinic staff in the American South. It helps researchers understand what affects HIV prevention and care, and how programs can better support people at higher risk.
Durham, North CarolinaAges 15 years+ - NCT05026749RecruitingPhase 3
Azithromycin for severe RSV breathing failure in young children
This trial tests whether azithromycin (an antibiotic) can improve outcomes for babies and young children in the ICU who have RSV causing serious breathing problems. It mainly looks at children who start strong breathing support soon after RSV symptoms begin.
Chapel Hill, North CarolinaAges 3 days–2 years - NCT04678154RecruitingPhase 3
Antibiotic trial for severe open fractures of the leg or foot
This trial tests a new way of giving antibiotics to people with severe open fractures in the leg, ankle, or foot. The goal is to see if it helps prevent infections after surgery.
Charlotte, North CarolinaAges 18–64 - NCT03325855Recruiting
Fecal transplant registry for patients and donors
This study is a national “registry” that collects information from people who get fecal microbiota transplant (a stool-based treatment) and from people who donate stool. It helps researchers understand who receives these treatments and how they do over time.
Chapel Hill, North CarolinaAges Any age - NCT03713528Enrolling by invitationPhase 4
Antibiotic placed in bone to help save an infected knee implant
This trial tests whether putting antibiotics directly inside the bone during surgery can improve outcomes for an infected knee prosthesis when the implant is being kept. It may help more people avoid needing full implant removal and replacement.
Charlotte, North CarolinaAges 18 years+
Where these studies are running in North Carolina
Institutions with a site for the recruiting infections studies listed above.
- Duke University Medical Center · 4 studies
- Atrium Health Carolinas Medical Center · 2 studies
- Duke University Hospital · 2 studies
- University of North Carolina at Chapel Hill · 2 studies
- Wake Forest University Health Sciences · 2 studies
- Atrium Health Cabarrus
- Atrium Mercy Hospital
- Duke Department of Orthopedic Surgery
What taking part in a infections study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Infections trials in other states
Common questions
- Are there infections clinical trials in North Carolina?
- Yes. We're currently tracking 69 recruiting infections studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a infections study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a infections trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New infections studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.