Clinical trials
Intraoperative Pain clinical trials
Below are recruiting intraoperative pain clinical trials, each written for real people, not researchers. We’re tracking 25 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07315308Recruiting
Nerve block before heart surgery and painkiller use
This study tests whether a numbing injection in the chest before heart surgery can reduce the amount of pain medicine needed during the operation. It may help you manage pain better and recover more comfortably.
Gaziantep, SahinbeyAges 18–65 - NCT07002541Recruiting
Nerve block comparison for breast surgery pain
This study tests two different nerve-block methods (PECS-II and ESP) to see which better reduces painkiller use during breast surgery. A special monitor guides how much pain medicine you need. The goal is to help you recover with less opioid side effects.
IstanbulAges 18–80 - NCT07250399Recruiting
Pain after root canal treatment with different tools
This trial compares two different ways of cleaning a tooth's root canal to see which causes less pain during and after treatment. It is for people with severe tooth pain in an upper premolar.
CairoAges 20–50 - NCT07340970Recruiting
Sensory feelings during planned c-section
This study explores what sensations women feel during a planned cesarean delivery with spinal anesthesia. It may help understand how women experience touch, pressure, or other feelings during the procedure.
Vancouver, British ColumbiaAges 19 years+ - NCT07472959RecruitingPhase 4
Morphine for pain after heart bypass surgery
This study tests whether giving morphine during coronary artery bypass surgery can help control pain after the operation. It is for people having planned heart bypass surgery who are moderately sick and not already on strong pain medicines.
Istanbul, Outside of the USAges 18–80 - NCT06933498Recruiting
Nerve block for less pain meds in back surgery
This trial tests whether a nerve block (called an erector spinae plane block) given before surgery can reduce the amount of pain medicine and anesthesia needed during lumbar disc surgery. It may help people have less pain and fewer side effects.
AnkaraAges 18–75 - NCT06951802RecruitingPhase 4
Low-dose ketamine for pain during endometriosis surgery
This study tests whether giving a low dose of ketamine during endometriosis surgery can help reduce pain. If you qualify, you'll receive ketamine or a placebo during your procedure, and the team will check your pain levels afterward.
BernAges 18 years+ - NCT07064434Recruiting
Nerve block for safer blood pressure control during hip replacement
This trial tests a type of nerve block (sacral canal block) to help manage blood pressure during hip replacement surgery. It aims to see if it can safely lower blood pressure on purpose, which may reduce bleeding and improve recovery.
Yinchuan, NingxiaAges 45 years+ - NCT06182111Recruiting
Morphine during gallbladder removal
This study gives morphine during gallbladder removal surgery to see how it affects pain afterward. It may help you have less pain and recover more comfortably.
EsbjergAges 21 years+ - NCT07354750Recruiting
Parasternal block for pain in pediatric heart surgery
This trial tests whether a nerve block given before a heart surgery incision reduces the need for pain medicine during the operation in children aged 6 months to 7 years having their first heart surgery through the breastbone.
AnkaraAges 6 months–7 years - NCT07439679Recruiting
Anxiety Before Double Jaw Surgery and Your Recovery
This trial studies how anxiety before double jaw surgery affects your body during surgery and your recovery (pain, swelling, and ability to open your mouth). Researchers will use a simple anxiety questionnaire to see if feeling anxious changes your surgical experience.
IstanbulAges 18 years+ - NCT07429916RecruitingEarly Phase 1
Ketamine for shoulder pain after weight loss surgery
This trial tests if a single dose of ketamine, given during surgery, can reduce common shoulder pain after laparoscopic gastric sleeve surgery. If you are having this weight-loss procedure and meet the weight and health criteria, this study may help improve your recovery.
IrbidAges 18–60 - NCT06710405RecruitingPhase 4
Lidocaine for pain relief after children's chest surgery
This trial tests whether giving lidocaine during surgery can reduce pain and speed up recovery in children under 7 having chest surgery with a camera. If it works, it could mean less pain and a faster return to normal after the operation.
SeoulAges 6 months–7 years - NCT07513974Recruiting
Pain sensitivity test to predict opioid needs in heart surgery
This study measures how sensitive you are to pain using a special device, then tracks how much pain medication you need during heart surgery. The goal is to see if pain sensitivity can predict opioid requirements and help doctors customize pain control for you.
Brussels, AnderlechtAges Any age - NCT05831345RecruitingPhase 3
Methadone during surgery to prevent post-surgery pain
This Phase 3 trial tests whether giving methadone during hip or knee replacement surgery can reduce pain after surgery. It may help some people use less rescue pain medicine afterward, but it also has safety checks for kidney, liver, heart, and opioid-related risks.
BrusselsAges 18–80 - NCT05150795RecruitingEarly Phase 1
Testing pregabalin before surgery versus fentanyl during surgery
This trial compares two medicines used around the time of surgery—pregabalin given by mouth before surgery versus fentanyl given during surgery—to see which better controls pain after the operation. You might join if you’re a generally healthy surgical patient and aren’t using certain related medicines.
CairoAges 21–45 - NCT06507293Recruiting
Pain relief methods comparison for lung surgery
This trial tests two numbing injections to see which reduces pain medicine use during lung surgery. A special pain monitor guides the treatment. It may help you need fewer opioids during your procedure.
KocaeliAges 18–65 - NCT06753500RecruitingPhase 4
Numbing medicine during gallbladder surgery
This trial tests whether giving a special numbing medicine during gallbladder surgery helps reduce pain. It is for adults having laparoscopic (minimally invasive) gallbladder removal.
Barranquilla, AtlantivoAges 18 years+ - NCT07104825Recruiting
Nerve block for pain after weight loss surgery
This trial tests if a nerve block can help control pain after gastric bypass or sleeve gastrectomy. The goal is to reduce the need for strong pain medicines and improve recovery.
Evanston, IllinoisAges 18–90 - NCT06970431Recruiting
Anxiety and pain relief during C-section
This trial tests a way to reduce anxiety and pain before and during a C-section. It may help pregnant women feel calmer and more comfortable.
Wuhan, HubeiAges 18–40 - NCT07035314Recruiting
Comparing medicines for pain after tonsil removal in children
This study compares two ways to manage pain after tonsil removal in children: a medication given by mouth or injection versus a medication applied directly to the surgical site. The goal is to find which approach works better for pain control.
CairoAges 4–10 - NCT06804434Recruiting
Pain monitor during stomach or liver cancer surgery
This trial tests a device that monitors your pain level during surgery using a special index called the Nociception Level Index. It may help doctors manage your pain better without using too much medicine.
Cluj-Napoca, ClujAges 18 years+ - NCT06865378Enrolling by invitation
Breathing gas and nausea after hysterectomy study
This study looks at whether levels of carbon dioxide in your breath and blood flow measurements during surgery can help predict nausea, vomiting, or pain after a hysterectomy. It may help doctors better manage your recovery.
IstanbulAges 20–65 - NCT05196503RecruitingPhase 3
PRF gel in spine surgery to reduce nerve pain after herniation
This Phase 3 study tests whether applying a healing material called platelet-rich fibrin (PRF) around the nerve during disc herniation surgery can reduce leftover nerve pain afterward. If you qualify, your team will compare pain intensity between standard care and PRF during the operation.
Strasbourg, Bas-RhinAges 18 years+
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Common questions
- Are there clinical trials for intraoperative pain?
- Yes. Clin2 currently lists 25 recruiting intraoperative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a intraoperative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a intraoperative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.