Clinical trials
Intraoperative clinical trials
Below are recruiting intraoperative clinical trials, each written for real people, not researchers. We’re tracking 284 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06039085Recruiting
Electrical sensing for real-time cancer margin check during prostate surgery
This study tests a new device that uses tiny electrical sensors to help surgeons check if all the cancer has been removed during prostate cancer surgery. It could give real-time feedback so the surgeon can remove leftover cancer right away.
Lebanon, New HampshireAges 18 years+ - NCT05971719Recruiting
Testing an air “sniffer” using aerosol glycerine during lung surgery
This trial checks whether a new system can detect and pinpoint tiny air leaks during lung transplant surgery. It uses a glycerine mist during the operation, which may help surgeons find leaks and repair them sooner.
MontrealAges 18 years+ - NCT05966519Recruiting
Study testing flexible planning for knee replacement with ROSA
This study looks at how flexible pre-op planning can be when you get a total knee replacement using the ROSA system. It may help doctors fine-tune surgery planning while keeping outcomes safe and effective.
Fukuoka, FukuokaAges 20 years+ - NCT05901545RecruitingPhase 1
Test an iodine-labeled drug to map neck lymph nodes
This Phase 1 study tests a labelling of panitumumab with iodine (111In) to see how well it can identify lymph nodes in head and neck cancer before surgery. The goal is to improve lymph node staging (which can help guide treatment), with the main focus on safety and early performance.
Nashville, TennesseeAges 19 years+ - NCT05893888RecruitingPhase 2/Phase 3
Testing three investigational drugs for mouth and lung cancers
This trial tests whether PRV111, PRV211, and PRV131 are safe and work better than expected for certain mouth (lip/oral cavity) cancers and lung cancers. It may help by trying a new approach given directly to the tumor and then monitoring how well it shrinks and how safe it is.
Duarte, CaliforniaAges 18–100 - NCT04842162RecruitingPhase 2
Near-infrared dye imaging to help remove all mouth/throat cancer
This Phase 2 study tests a special camera and dye during surgery to help surgeons confirm they removed all cancer at the edge of the removed tissue. If it works, it may lower the chance of cancer being left behind after oral cavity or oropharynx squamous cell cancer surgery.
AnderlechtAges 18 years+ - NCT05565118RecruitingPhase 1
Brain activity study during surgery for high-grade glioma
This early-stage study measures electrical brain activity during brain tumor surgery to see if it can predict tumor return or progression. You may be offered the additional measurements while your surgeon removes a suspected or known high-grade glioma.
Cleveland, OhioAges 18 years+ - NCT05576974RecruitingPhase 2
Test a dye used during surgery to find head and neck cancer
This trial tests whether a single dose of an imaging dye (given during surgery) can help doctors find the unknown origin of head and neck cancer and check safety. It may help guide surgery and biopsies when the primary cancer location hasn’t been identified.
Dallas, TexasAges 18–99 - NCT05196503RecruitingPhase 3
PRF gel in spine surgery to reduce nerve pain after herniation
This Phase 3 study tests whether applying a healing material called platelet-rich fibrin (PRF) around the nerve during disc herniation surgery can reduce leftover nerve pain afterward. If you qualify, your team will compare pain intensity between standard care and PRF during the operation.
Strasbourg, Bas-RhinAges 18 years+ - NCT05023434Recruiting
Brain stimulation study for hand strength in brain tumor patients
This study uses brain stimulation during surgery to see how it affects hand strength and hand function. It may help doctors understand which brain areas are important for hand movement in people with certain brain tumors.
Milwaukee, WisconsinAges 18–75 - NCT04780009Recruiting
Imaging tool during brain tumor surgery
This trial tests a special camera system used during surgery to help doctors see brain tumor tissue using fluorescent light. It may help the surgeon remove more tumor while protecting healthy brain areas.
Lexington, KentuckyAges 18–90 - NCT04790890Enrolling by invitation
Scan the eye during surgery to measure normal eye tissue
This study uses an imaging scan called optical coherence tomography (a non-painful light scan) during surgery to map what “normal” eye tissue looks like. It may help improve how eye specialists assess eyes in the future.
Nashville, TennesseeAges 18 years+ - NCT04752137RecruitingPhase 2
ICG dye imaging during surgery to check tumor edges
This trial tests whether a special dye (ICG) seen during your surgery can help doctors better identify the edges of a tumor in bone or soft tissue. It may help ensure as much of the tumor is removed as safely as possible.
Boston, MassachusettsAges 18 years+ - NCT04723810RecruitingPhase 1/Phase 2
Test a glowing scan to help surgeons find tumor tissue
This early-stage study tests an intraoperative imaging approach called “TumorGlow” to help surgeons better identify tumor tissue during surgery. It may help improve the completeness of tumor removal and reduce the chance of recurrence in certain patients.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04754321RecruitingPhase 1
Test immunotherapy with salvage surgery and IORT for head and neck cancer
This Phase 1 trial tests a new plan that combines immunotherapy with surgery, plus a targeted radiation treatment called IORT. It is for people whose head and neck squamous cell cancer has come back or never fully went away and can be operated on. The goal is to shrink or control the cancer and see how safe the approach is.
Columbus, OhioAges 18 years+ - NCT04518761Recruiting
Predicting breathing relaxation using a nerve monitoring test
This trial is testing a prediction method during surgery to estimate how strongly a medicine is relaxing your breathing muscles, using a nerve monitoring signal. It may help anesthesiology teams adjust anesthesia more safely during general anesthesia for non-heart surgeries.
Jette, Brussels CapitalAges 18 years+ - NCT04454203RecruitingPhase 4
Local anesthetic catheter to reduce tourniquet-related blood pressure spikes
This Phase 4 trial tests whether a local anesthetic catheter placed near a nerve and artery can prevent high blood pressure caused by a tourniquet during total ankle replacement surgery. If it works, it may make recovery safer and more comfortable for some patients.
Durham, North CarolinaAges 18–75 - NCT04182997RecruitingPhase 4
Epidural steroid shot during discectomy for back nerve pain
This trial studies whether giving a steroid medicine into the epidural space during discectomy (back surgery for a herniated disc) helps reduce nerve pain and symptoms. It is mainly for people whose MRI and exam show a single-level lumbar disc herniation after non-surgical treatments didn’t help.
Columbia, MissouriAges 18 years+ - NCT03873259Recruiting
Testing a new way to check kidney stones during surgery
This trial tests a method called burst wave lithotripsy (BWL) to help doctors assess and treat kidney stones during a planned ureteroscopy procedure. It may help surgeons confirm how well the stone is being broken while you are on the operating table.
Carmel, IndianaAges 18 years+ - NCT03713528Enrolling by invitationPhase 4
Antibiotic placed in bone to help save an infected knee implant
This trial tests whether putting antibiotics directly inside the bone during surgery can improve outcomes for an infected knee prosthesis when the implant is being kept. It may help more people avoid needing full implant removal and replacement.
San Francisco, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for intraoperative?
- Yes. Clin2 currently lists 284 recruiting intraoperative studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a intraoperative trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a intraoperative trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.