Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06937242Recruiting
Testing a smarter prosthetic knee for safer walking
This study tests whether a microprocessor-controlled knee can reduce falls in people who walk limited distances. If you use a regular mechanical knee and have a moderate activity level, this trial might help you walk more safely.
Austin, TexasAges 18 years+ - NCT06915363Recruiting
BioPoly implant for knee cartilage repair
This trial tests a BioPoly implant to repair a small damaged cartilage spot in your knee. If you have a specific type of cartilage injury that didn't get better with other treatments, this implant may help relieve pain and improve function.
Fort Wayne, IndianaAges 30–65 - NCT06880497Recruiting
Comparing knee sounds after two types of knee replacement
This study compares how much noise the knee makes (and how it feels to the patient) after two different kinds of total knee replacement surgery. It aims to help patients know what to expect after surgery.
AuxerreAges 18 years+ - NCT04095637Recruiting
Compare two types of partial knee replacement surgeries
This study compares two implant types used for a partial knee replacement (only the inside/medial part) for people with “wear-and-tear” arthritis in that compartment. It looks to see which option leads to better outcomes after surgery and follow-up.
LondonAges 40–80 - NCT06726629Recruiting
Italian Knee Questionnaire Study
This study is testing a new Italian version of a questionnaire that measures how your knee feels and works after knee replacement. The goal is to make sure the questionnaire is accurate for Italian-speaking patients.
BolognaAges 18–85 - NCT06194838Recruiting
Mechanical vs. powered knee for above-knee amputees
This study compares a non-powered (mechanical) knee to a powered (battery-assisted) knee for people with above-knee amputations who walk at a moderate level (K2). It will help find out which knee type works better for your daily activities and mobility.
Austin, TexasAges 18 years+ - NCT06389435Recruiting
Robotic versus conventional knee replacement surgery
This study compares two ways of performing total knee replacement surgery: one using a robotic assistant and the other using traditional techniques. The goal is to see if robotic-assisted surgery leads to better outcomes for patients.
HässleholmAges 18 years+ - NCT06264076Recruiting
Ligament balancing in knee replacement
This trial tests a new method of balancing the ligaments during total knee replacement. If you are generally healthy and need a first-time knee replacement due to arthritis, you may be eligible.
Bærums verk, AkershusAges 40 years+ - NCT06203756Enrolling by invitation
Robotic-Assisted Knee Replacement Outcomes Study
This study tests a robotic-assisted system for knee replacement surgery. It aims to see how well patients do with the robotic help.
Flagstaff, ArizonaAges Any age - NCT05980442Recruiting
Navigation vs robotic-arm assisted knee replacement
This study compares two different high-tech tools used during total knee replacement surgery: one that uses a navigation system (OrthoPilot) and one that uses a robotic arm (MAKO). The goal is to see if one method leads to better results. If you're having a total knee replacement, this trial could help your surgeon choose the best approach.
Ulm, Baden-WurttembergAges 18–90 - NCT04226339Recruiting
Test walking analysis after knee replacement, different alignment methods
This study compares two ways of aligning the knee during a total knee replacement and checks how people walk afterward using a walking test. It may help doctors choose the alignment method that best supports safer, smoother walking.
LyonAges 55–80 - NCT07840391Recruiting
Recovery after same-day knee replacement surgery
This study looks at how your physical activity, sleep, and knee function change after you go home the same day as your knee replacement surgery. It aims to help you recover better by understanding these factors.
TampereAges Up to 80 years - NCT07804446Recruiting
Knee injection: comparing two needle angles for knee arthritis pain
This study compares two ways of giving a knee steroid injection to see which works better for pain and function in people with medial knee arthritis. You will get the injection as part of your normal care.
Bolingbrook, IllinoisAges 40 years+ - NCT07777757Recruiting
Robotic knee surgery: does implant type affect alignment accuracy?
This study compares two types of knee implants used during robotic-assisted surgery to see which one gives more accurate alignment. It may help find the best implant for your new knee.
Hong Kong, Sandy BayAges 18 years+ - NCT07731737Recruiting
Biofeedback vs foam roller for knee osteoarthritis
This trial compares two non-surgical therapies—pressure biofeedback and foam rolling—to see which better reduces pain, improves muscle function, and boosts quality of life in people with early-stage knee osteoarthritis.
LahoreAges 45–65 - NCT07674901Recruiting
Knee sleeve vs. no sleeve for chronic knee pain in older adults
This study tests whether wearing a fabric knee sleeve every day for up to 5 years helps reduce knee pain in people aged 50–64. It compares sleeve use to not using a sleeve to see if it makes a difference over time.
Springfield, MassachusettsAges 50–64 - NCT04692714Recruiting
Cemented vs cement-free robotic knee replacement surgery
This trial compares two ways surgeons can attach a knee replacement using robotic-assisted surgery: with cement or without cement. It may help improve how well the new knee lasts and how patients recover after a first-time knee replacement.
LyonAges 50–80 - NCT06720779Recruiting
Virtual rehab platform for knee replacement patients
This trial tests a virtual rehab platform for people recovering from knee replacement surgery. It may help you do your rehab exercises more easily at the hospital.
Barakaldo, Basque CountryAges 18–85 - NCT07555067Enrolling by invitation
Robotic Knee Replacement Surgery Comparison
This trial compares two different robotic systems used during knee replacement surgery for knee arthritis (wear and tear). The study helps doctors understand which robotic system may provide better results.
Bydgoszcz, Kuyavian-Pomeranian VoivodeshipAges 18 years+ - NCT07544576Enrolling by invitationPhase 4
Knee Arthritis Injection: Two Injection Methods Compared
This study compares two ways of injecting a steroid medication into arthritic knees: using landmark guidance (traditional method) with a higher dose versus ultrasound guidance (imaging) with a lower dose. The goal is to see which approach works better to reduce knee pain and improve function.
Ventura, CaliforniaAges 50 years+ - NCT07524387Recruiting
Nerve blocks for better leg strength after knee replacement
This study compares two types of numbing injections (nerve blocks) used during knee replacement surgery to see which one helps your thigh muscle recover strength faster. Both are standard care options; the trial tests which works better for early movement after surgery.
Ichinomiya, Aichi-kenAges 20 years+ - NCT07511842Recruiting
Keeping Your Knee Still After Surgery to Reduce Pain
This study tests whether keeping your knee immobilized (held still) for 72 hours after knee replacement surgery helps reduce pain. Researchers will compare this approach to standard care to see if it makes recovery easier.
Sherbrooke, QuebecAges 18 years+ - NCT06592248Recruiting
New ceramic knee replacement for active adults under 70
This trial is testing a new type of knee replacement that uses a ceramic surface to help the knee feel more natural. It may be a good option if you are under 70, have stubborn knee pain from arthritis, and your knee is not too bent out of shape.
ParisAges 18–70 - NCT07465484Recruiting
Total knee replacement for bow-leg deformity
This study looks at how well total knee replacement works for people who have severe knee arthritis and a bow-leg (varus) deformity. It may help you if you have a lot of knee pain and are considering surgery.
MoscowAges 18 years+
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.