Clinical trials
Knee Osteoarthritis clinical trials
Below are recruiting knee osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 408 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03949400Recruiting
Exercise therapy and a soft knee brace for knee arthritis
This study tests whether an exercise program plus education, along with a soft brace, helps improve symptoms and function in adults with knee osteoarthritis. It may help people who have knee pain by combining movement training with daily support.
Aalborg, NothernAges 18 years+ - NCT06388811Recruiting
Turkish version of a knee pain questionnaire study
This study tests a Turkish questionnaire for early knee osteoarthritis. It may help doctors better identify and treat early knee pain.
IstanbulAges 18 years+ - NCT04732962Recruiting
Special shoes to help knee osteoarthritis symptoms without surgery
This study tests whether custom biomechanical footwear can reduce pain and improve function in people with knee osteoarthritis. It may help as a non-surgical option to ease symptoms while you’re considering or preparing for care.
Danville, PennsylvaniaAges 45–80 - NCT07089251RecruitingPhase 4
Epinephrine and tranexamic acid in knee replacement surgery
This study tests if using epinephrine and tranexamic acid together helps reduce bleeding and improve outcomes during knee replacement surgery. It may be a good fit if you are planning to have knee replacement and do not have certain medical conditions or allergies to these medicines.
Riyadh, Riyadh RegionAges 18–70 - NCT07058623Recruiting
Nurse-led telehealth vs in-person follow-up after knee replacement
This trial compares follow-up care with a nurse via video calls or phone versus in-person visits after your first total knee replacement. It aims to see if telehealth is as good as in-person for your recovery.
Hong KongAges 18 years+ - NCT07246109Enrolling by invitation
Knee Brace and Muscle Training for Osteoarthritis
This study tests whether wearing a knee brace and doing muscle training exercises can help people with knee osteoarthritis feel better and move more easily. It may be a good option if you have not had knee surgery and are not already in another treatment program.
TaichungAges 55 years+ - NCT06280352Recruiting
Robotic vs custom knee replacement trial
This study compares two modern ways of doing knee replacement: robot-assisted surgery versus a custom-made implant tailored to your knee shape. It aims to see which approach leads to better recovery and function for people with osteoarthritis.
Graz, StyriaAges 40–90 - NCT06264076Recruiting
Ligament balancing in knee replacement
This trial tests a new method of balancing the ligaments during total knee replacement. If you are generally healthy and need a first-time knee replacement due to arthritis, you may be eligible.
Bærums verk, AkershusAges 40 years+ - NCT07468734Recruiting
Shock wave vs. physical therapy for knee arthritis
This study compares two treatments for chronic knee osteoarthritis: shock wave therapy and traditional physical therapy. The goal is to see which one helps reduce pain and improve function better.
CairoAges 40 years+ - NCT04901273Recruiting
PRP shot vs placebo for knee osteoarthritis in adults 65+
This trial compares an injection made from your own platelets (PRP) to a placebo shot to see if it helps knee osteoarthritis symptoms and function. It is designed for people over 65 with arthritis affecting only one knee.
BolognaAges 65 years+ - NCT07245121Recruiting
Sugar water injections for chronic knee arthritis pain
This trial tests whether injecting a sugar-water solution around the nerves of the knee can reduce chronic pain from osteoarthritis. It is for people with long-term knee pain, stiffness, and cracking who have not had recent knee treatments or surgery.
Athens, AtticaAges 38 years+ - NCT07481630RecruitingPhase 3
Testing a new medicine for weight loss and knee pain
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
Phoenix, ArizonaAges 18 years+ - NCT07442812Recruiting
Dexamethasone: pill vs. IV for knee replacement recovery
This trial compares two ways of giving dexamethasone (a strong anti-inflammatory) for people having knee replacement surgery. One group gets a pill and the other gets an IV. The goal is to see which method works better for pain, swelling, and recovery.
Istanbul, IstanbulAges 50–80 - NCT04364334Recruiting
Knee care registry for people treated at UMC Utrecht
This study is a “registry,” meaning researchers collect information about your knee care over time. It may help improve understanding and care for people who receive knee treatment at UMC Utrecht.
UtrechtAges Any age - NCT07630337Recruiting
Cryotherapy to reduce pain medication after knee replacement
This study tests whether applying cold therapy (cryotherapy) after knee replacement surgery helps patients need fewer opioid pain medications than standard care alone. If cryotherapy works, it could help you manage pain more safely after surgery.
Buenos Aires, Buenos AiresAges 18 years+ - NCT05596591Recruiting
Shockwave treatment for knee arthritis pain with MRI-confirmed lesions
This trial tests whether focused shockwave therapy (a non-surgical treatment) can reduce knee arthritis pain. It specifically targets people whose MRI shows a small bone problem in one area of the knee.
Cedar Knolls, New JerseyAges 30–80 - NCT04238143Recruiting
Knee and other joint arthritis tissue therapy
This trial tests a regenerative therapy made from a patient’s own fat tissue (a “cellular” treatment) to reduce pain and improve function in arthritis-related problems. It may help people with inflammatory or degenerative arthritis changes, if they meet safety and tissue-donation requirements.
Valencia, CaliforniaAges 18–90 - NCT06567301Recruiting
Shockwave vs. special gel for knee osteoarthritis pain
This trial compares two treatments for knee osteoarthritis: a shockwave therapy and a gel containing chitosan nanoparticles (tiny particles) applied with ultrasound. It uses AI to detect changes in knee tissues. The goal is to find which treatment better reduces pain and improves function.
Giza, El DokkiAges 40–60 - NCT07300384Recruiting
Blood flow restriction training for knee pain relief before surgery
This study tests whether a special type of strength training (called blood flow restriction training) can reduce pain in people with severe knee arthritis who are waiting for knee replacement surgery. The training uses a cuff on the thigh to lightly restrict blood flow while doing exercises until failure.
Valencia, ValenciaAges 50–85 - NCT07509307RecruitingPhase 3
Study of a new medicine for weight loss and knee pain in osteoarthritis
This trial tests if a new medicine, NNC0487-0111, can help people with excess weight and knee osteoarthritis lose weight and reduce knee pain. It is for people who have had knee pain for at least three months and who can stop taking pain relievers for short periods before study visits.
Escondido, CaliforniaAges 18 years+ - NCT05761015RecruitingPhase 4
Test of an NSAID to help osteoarthritis pain when walking
This trial studies whether taking an anti-inflammatory pain medicine (an NSAID) can reduce hip or knee osteoarthritis pain during walking. It may help people who have had walking pain for at least 3 months and don’t already take NSAIDs.
Clermont-FerrandAges 50–70 - NCT06878417Recruiting
Cannabinoids for osteoarthritis knee or hip pain
This study tests if cannabinoid medications can reduce pain interference in daily life for people with hip or knee osteoarthritis. It may be a new option for moderate to severe pain.
Toronto, OntarioAges 40–80 - NCT05407610Recruiting
Compare two types of nerve pain treatments for knee pain
This study compares conventional versus cooled radiofrequency treatments for long-lasting knee pain. It aims to see which method reduces pain better and helps patients function more comfortably.
AntwerpAges 18 years+ - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Ann Arbor, MichiganAges 18–80
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Common questions
- Are there clinical trials for knee osteoarthritis?
- Yes. Clin2 currently lists 408 recruiting knee osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.