Clinical trials
Knee Osteoarthritis clinical trials
Below are recruiting knee osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 408 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06611618Recruiting
Predicting fall risk in knee osteoarthritis using muscle tests
This study looks at how loss of muscle strength and control in people with knee osteoarthritis can predict falls. It uses tests and MRI to understand your risk, with the goal of helping prevent future falls.
BolognaAges 65–80 - NCT06617871Recruiting
Comparing two ways to align a new knee replacement
This study compares two different techniques (mechanical alignment vs. kinematic alignment) used during knee replacement surgery with a special knee system. It aims to see which technique leads to better results for patients.
Chicago, IllinoisAges 21–79 - NCT07464080Recruiting
Brain imaging study for knee replacement patients
This study uses advanced brain scans to understand how pain and recovery change after knee replacement surgery. It may help researchers develop better ways to manage pain after surgery.
Ottawa, OntarioAges 18 years+ - NCT07121556Recruiting
Fat tissue vs fat tissue plus gel for knee osteoarthritis
This trial compares two injections for knee arthritis: one uses your own fat tissue, the other adds a lubricating gel. Researchers want to see if the combination helps pain and function more than fat tissue alone.
BolognaAges 18–75 - NCT07347821Recruiting
Study of osteoarthritis in hip and knee replacement patients
This study looks at why osteoarthritis happens in the hip and knee by studying tissue samples taken during joint replacement surgery. If you are already scheduled for a first-time hip or knee replacement and have osteoarthritis, you may be able to join.
Ostrów Mazowiecka, Masovian VoivodeshipAges 18 years+ - NCT04821154Recruiting
Testing outcomes after revision knee replacement with a Persona system
This study looks at how well a specific revision knee replacement system (the Persona system) works after earlier knee problems or surgeries. You may be eligible if you need a revision knee and can follow follow-up care instructions; the trial also checks for certain infection, bone, and health-safety factors.
Fayetteville, ArkansasAges 18 years+ - NCT07532785Recruiting
Water and Land Exercise Before Knee Replacement Surgery
This trial tests whether a 6-week program combining weekly water-based exercise and three times weekly land-based training can help reduce knee pain and improve strength before total knee replacement surgery. The program aims to help you recover better after your operation.
London, EnglandAges 18 years+ - NCT07703293Recruiting
Testing nerve branches for chronic knee pain relief
This study tests a procedure targeting specific nerve branches in the thigh to treat long-lasting knee pain from osteoarthritis. It may help people who haven't found relief from standard treatments like pain relievers or physical therapy.
AnkaraAges 45–80 - NCT06083480RecruitingPhase 4
Reducing stress to prevent long-term pain after knee replacement
This trial tests if lowering oxidative stress (damage from natural body processes) during knee replacement surgery can prevent chronic pain afterward. It may help people with osteoarthritis who have moderate to severe pain before surgery.
Nashville, TennesseeAges 50 years+ - NCT06122727Recruiting
Custom vs standard knee replacement for better fit
This trial compares custom-made knee replacements (built to fit your unique knee shape) with standard, off-the-shelf knee replacements. It aims to see if a custom implant leads to better function and satisfaction after surgery.
BolognaAges 40–70 - NCT07080814Recruiting
Balance exercises after knee replacement
This study tests whether special balance exercises on a platform can help people who have recently had a knee replacement walk better and feel steadier.
Ankara, YenimahalleAges 18 years+ - NCT07556003Recruiting
Physical Therapy After Knee Replacement Surgery
This study tests whether a physical therapy program helps improve walking ability and foot pressure patterns in women who have had knee replacement surgery or have knee problems. The goal is to see if structured rehabilitation helps you walk better and more comfortably.
SakakahAges 40–70 - NCT06485843RecruitingPhase 2
Testing a new injection for moderate to severe knee osteoarthritis
This study tests the safety of an experimental injection called OA-SYS for people with moderate to severe knee osteoarthritis. It may help if you have not had recent injections or certain other health problems.
Las Vegas, NevadaAges 35–75 - NCT06603662RecruitingPhase 4
Steroids for sudden osteoarthritis pain in the emergency room
This trial tests if a short course of oral steroids (glucocorticoids) can relieve sudden osteoarthritis pain in the knee, hip, or shoulder for people who come to the emergency department and are well enough to go home.
York, PennsylvaniaAges 18 years+ - NCT07396233Recruiting
Knee Osteoarthritis Therapy: Diagonal Movement Patterns
This trial tests a type of physical therapy called proprioceptive neuromuscular facilitation for people with knee osteoarthritis. It may help reduce pain and improve how well your knee works.
Karachi, SindhAges 40–60 - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Birmingham, AlabamaAges 45–80 - NCT07308873Recruiting
Gait and knee osteoarthritis pain study
This study looks at how walking patterns relate to knee pain from osteoarthritis. It aims to understand individual differences to improve future treatments.
Pittsburgh, PennsylvaniaAges 45–80 - NCT07424352Recruiting
Rotational exercise for knee osteoarthritis
This study tests a special rotational exercise device to see if it can improve knee function and reduce pain in people with knee osteoarthritis. It involves supervised sessions at the university and may help you move better without surgery.
Aurora, ColoradoAges 40–70 - NCT07666347Recruiting
Botox and Hyaluronic Acid Injections for Knee Osteoarthritis
This study tests if injecting Botox and hyaluronic acid into the knee joint can reduce pain and improve function in people with advanced knee osteoarthritis. It compares this combination to a standard treatment.
Tanta, El-GharbiaAges 50 years+ - NCT07093229Enrolling by invitation
Gait analysis for knee arthritis in seniors
This trial studies how walking patterns change in people over 65 with long-term knee osteoarthritis. It aims to understand gait to improve treatment and rehabilitation plans.
CraiovaAges 65–80 - NCT07065591RecruitingEarly Phase 1
Metformin, Exercise, and Diet for Knee Osteoarthritis
This trial tests whether a common diabetes drug (metformin) combined with exercise and a healthy diet can help people with knee osteoarthritis who are overweight.
Hong Kong, Sandy BayAges 40–80 - NCT07484594Recruiting
Trunk stabilization plus knee rehab for knee-spine syndrome
This trial tests whether adding trunk stabilization exercises to standard knee osteoarthritis rehab can improve outcomes for people with both knee pain and low back pain. It may help if you have moderate knee arthritis and have had back pain for at least 3 months.
Islamabad, ALAges 40–60 - NCT04275362Recruiting
Walking analysis after a specific knee replacement design
This study looks at how people walk after receiving a particular total knee replacement design. It compares movement patterns (gait analysis) to help understand how well the knee works in real life.
Phoenix, ArizonaAges 50 years+ - NCT07231471Recruiting
Platelet-rich plasma for muscle and joint pain
This study tests whether an injection of your own platelet-rich plasma (PRP) can help heal muscle, tendon, or joint problems that haven't gotten better with other treatments like physical therapy or medications.
Salt Lake City, UtahAges 18 years+
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Common questions
- Are there clinical trials for knee osteoarthritis?
- Yes. Clin2 currently lists 408 recruiting knee osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.