Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06090097Recruiting
Game therapy for knee osteoarthritis
This trial tests a game-based therapy that uses biofeedback to help strengthen your knee. It may help you move better and feel less pain.
Chapel Hill, North CarolinaAges 30–75 - NCT06082531Recruiting
Platelet-rich plasma injection for knee osteoarthritis
This study tests whether injecting platelet-rich plasma (PRP) from your own blood can help knee pain caused by osteoarthritis or injuries to the cartilage and meniscus. It may be an option if you are between 20 and 60 years old and have not had recent steroid shots or certain health problems.
Xi'an, ShannxiAges 20–60 - NCT06040957Recruiting
Bone marrow vs fat cells for knee osteoarthritis treatment
This trial compares using cells from your bone marrow or belly fat to treat knee osteoarthritis, aiming to reduce pain and improve function. It's for people who haven't gotten better with standard treatments like physical therapy or medications.
BolognaAges 40–75 - NCT06004882Recruiting
Nerve stimulation vs. steroid injection for chronic knee pain
This study compares two treatments for long-term knee pain: a nerve stimulation device placed near the knee versus a steroid shot into the joint. The goal is to see which works better for pain relief.
Houston, TexasAges 18 years+ - NCT05920382Recruiting
Radiofrequency treatment for long-term knee pain after knee surgery
This trial studies whether a radiofrequency procedure can reduce chronic knee pain after knee replacement surgery. It may help people who still have bothersome pain between 6 months and 5 years after their operation, as long as their pain pattern and medications are stable.
Barcelona, CataloniaAges 18 years+ - NCT05839535RecruitingPhase 2
Baduanjin plus brain stimulation for knee osteoarthritis pain
This Phase 2 study tests whether combining Baduanjin (a guided mind-body movement) with neuromodulation can improve knee osteoarthritis symptoms and function. It compares education-based stretching/control and uses MRI scanning as part of the research.
Charlestown, MassachusettsAges 45–75 - NCT05831696Recruiting
Compare walking effort with two types of prosthetic knees
This trial studies how much energy it takes to walk when using passive versus powered prosthetic knees. It may help people understand which knee type could make walking feel easier depending on their needs.
Loma Linda, CaliforniaAges 18–75 - NCT05823727Recruiting
Collagen supplement study before and after knee replacement
This study tests whether taking collagen peptides can improve how knee tissues heal and remodel after total knee arthroplasty (knee replacement). It also looks at functional recovery and wound healing, especially during the physical therapy period in Little Rock.
Little Rock, ArkansasAges 50–75 - NCT05805774Recruiting
Compare fixing versus replacing a fractured thigh bone
This study looks at the best surgical option for an acute (new) fracture of the lower thigh bone near a stable knee replacement. It compares surgery that “fixes” the bone versus surgery that “replaces” part of the bone to help you walk again safely.
Toronto, OntarioAges 65 years+ - NCT05800457Recruiting
Test synovectomy to reduce pain after knee replacement
This study looks at whether a procedure called synovectomy (removing inflamed joint lining) can reduce pain after a first knee replacement on one side. It focuses on people with clear signs of inflammation on ultrasound and checks follow-up outcomes after surgery.
London, OntarioAges 41–80 - NCT05736549RecruitingPhase 2
Tested stronger pain-blocking shot for knee replacement surgery
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
New Haven, ConnecticutAges 18 years+ - NCT05616884Enrolling by invitation
Cemented vs cementless partial knee replacement study
This study compares two ways of fixing a partial knee replacement: cemented or cementless. It may help doctors learn which method works better for patients with certain types of knee bone.
Alexandria, VirginiaAges 18–85 - NCT05543941Recruiting
Test advanced irrigation during knee, hip, or shoulder replacement
This trial studies a cleaning solution used during surgery to lower the risk of complications and improve outcomes after joint replacement. It may be an option if you’re having a planned knee, hip, or humerus (shoulder) replacement and meet the specific health and allergy requirements.
Vancouver, British ColumbiaAges 18 years+ - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT05487053Recruiting
Nerve block type test after knee replacement
This study compares two pain-control methods for the leg after a total knee replacement: a single injection versus a continuous nerve-block catheter. It aims to see which option helps people recover and do rehab better.
MoscowAges 18 years+ - NCT05495334Recruiting
Add knee osteoarthritis outcomes to a patient registry
This study tests a new way to collect how people with knee osteoarthritis feel and function after usual care (like injections, nerve-blocking procedures, or knee replacement). It may help improve future treatment decisions by using your regular follow-up reports in an app or online.
Phoenix, ArizonaAges Any age - NCT05437562Recruiting
Trial compares recovery after lower-leg amputation in Veterans
This trial looks at outcomes after a below-knee (lower-leg) amputation in Veterans. It focuses on people who have blood flow likely to heal and who plan to join rehabilitation to walk again with a prosthesis.
Decatur, GeorgiaAges Any age - NCT05288803Recruiting
Personalized rehab after knee replacement for veterans
This study tests a personalized rehabilitation program for veterans who have had a total knee replacement. It aims to improve recovery by tailoring therapy to each person's progress.
Aurora, ColoradoAges 40–90 - NCT05279092RecruitingPhase 2
Testing two pain-control injections for knee replacement surgery
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
New Haven, ConnecticutAges 18 years+ - NCT05073276Recruiting
Controlled weight-bearing after PCL or MCL knee ligament repair
This trial tests a specific, step-by-step approach to how much weight you put on your healing knee after surgery for certain ligament injuries (like PCL and/or MCL, and some combined cases). It may help you heal safely and recover function without putting too much strain on the repair.
Edina, MinnesotaAges 14–59 - NCT05097976RecruitingPhase 4
Medrol tablets to reduce pain after knee replacement
This trial tests whether a short course of Medrol (methylprednisolone) can improve recovery after outpatient total knee replacement done for osteoarthritis. You would be randomly assigned to receive Medrol or a comparison treatment.
Oak Brook, IllinoisAges 18 years+ - NCT05020028RecruitingPhase 2/Phase 3
CBD to reduce knee pain from osteoarthritis
This study tests cannabidiol (CBD) to help lower pain from knee osteoarthritis. It may be an option if you have ongoing knee pain and meet age, safety, and medication guidelines.
New York, New YorkAges 40–75 - NCT05039463Recruiting
Platelet-Rich Plasma and Hyaluronic Acid for Knee Arthritis
This trial tests whether combining two types of injections—platelet-rich plasma (a concentration of healing cells from your own blood) and hyaluronic acid (a natural lubricant)—can reduce knee osteoarthritis pain and improve function over one year. You're eligible if you've already received or are about to receive these injections at Amiens University Hospital.
AmiensAges 18 years+ - NCT04998188Recruiting
Hydrolyzed collagen for one knee with osteoarthritis
This trial tests whether a hydrolyzed collagen drink or supplement can reduce knee pain and symptoms compared with a placebo (inactive treatment) in people with osteoarthritis. It may help if you’ve tried standard non-surgical treatments and still have ongoing knee trouble.
BolognaAges 18–75
Hear when a new Knee trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.