Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 836 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06887829Recruiting
Radiation Therapy for Knee Osteoarthritis
This study tests a low-dose radiation treatment for knee osteoarthritis pain. If you have moderate arthritis pain and are a Mayo Clinic patient in Rochester, you may be able to join.
Rochester, MinnesotaAges 50–100 - NCT07151417RecruitingPhase 2/Phase 3
Steroid injection during total knee replacement
This study tests whether adding a corticosteroid (a type of anti-inflammatory medicine) to the standard pain injection during total knee replacement can improve pain relief. It is for adults getting their first knee replacement at certain military hospitals.
Bethesda, MarylandAges 18 years+ - NCT07065591RecruitingEarly Phase 1
Metformin, Exercise, and Diet for Knee Osteoarthritis
This trial tests whether a common diabetes drug (metformin) combined with exercise and a healthy diet can help people with knee osteoarthritis who are overweight.
Hong Kong, Sandy BayAges 40–80 - NCT07767812Recruiting
Motivational interviewing for knee osteoarthritis pain
This study tests whether talking with a counselor (motivational interviewing) helps people with knee osteoarthritis feel more confident in managing their pain and become more physically active. It may help you feel better and move more easily.
Afyonkarahisar, TürkiyeAges 40 years+ - NCT07767097Recruiting
Low-dose radiation after revision knee replacement for stiffness
This study tests whether a single low dose of radiation after revision knee replacement surgery can help reduce stiffness and improve knee movement in people who had a stiff knee after their first replacement. The radiation is given along with usual care after surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT07767409Recruiting
Home exercise app versus clinic physiotherapy for knee arthritis
This study compares doing exercises and self-care through a smartphone app to attending physiotherapy at a hospital clinic for people with knee osteoarthritis. It aims to see if the app is as helpful for reducing pain and improving function.
SingaporeAges 45–95 - NCT07767383RecruitingPhase 4
Improving sleep quality after knee surgery with added sedation and nerve blocks
This trial tests whether adding a calming medicine called dexmedetomidine to a nerve block around the knee can help you sleep better after arthroscopic knee surgery. It aims to find if this combination reduces sleep problems during recovery.
Nantong, JiangsuAges 18–85 - NCT06618820Enrolling by invitationPhase 3
Extended tranexamic acid after knee replacement
This trial tests whether taking tranexamic acid (a medicine that helps blood clot) for several days after knee replacement surgery reduces bleeding and improves recovery. It may help patients who have a standard knee replacement and are not on blood thinners.
Germantown, TennesseeAges 18 years+ - NCT06423716RecruitingPhase 4
Duloxetine to reduce opioid use after knee replacement
This study tests whether taking the pain medication duloxetine before and after knee replacement surgery can reduce the need for opioid painkillers. It may help patients manage pain with fewer side effects from strong narcotics.
Toronto, OntarioAges 50 years+ - NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT07756918Recruiting
Shockwave therapy versus dry needling for jumper's knee
This study compares two non-surgical treatments for jumper's knee (pain at the front of the knee from overuse): extracorporeal shockwave therapy (using sound waves to stimulate healing) and dry needling (using thin needles to release tension). The goal is to see which one works better for reducing pain. If you're eligible, you might get one of these treatments, and your progress will be followed to see how well it works.
Lahore, Punjab ProvinceAges 18–35 - NCT07664371Recruiting
Cold therapy versus heat therapy for knee arthritis pain
This study compares two minimally invasive treatments for knee pain caused by arthritis when other treatments haven't worked. One uses cold (cryoneurolysis) and the other uses heat (radiofrequency) to calm nerves and reduce pain.
TantaAges 18 years+ - NCT07754175Recruiting
Stem cell knee treatment for osteoarthritis patients
This study tests a stem cell injection for knee osteoarthritis in patients who previously received a placebo. It aims to see if the treatment is safe and effective over a longer period.
SeoulAges 19 years+ - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Birmingham, AlabamaAges 45–80 - NCT06578936Recruiting
Massage and warmth after knee replacement
This study tests whether gentle belly massage and a warm pack help people have a bowel movement more quickly after total knee replacement surgery done under spinal anesthesia. It looks at how these simple, drug-free treatments may help get your bowels working again after surgery.
AdanaAges 18 years+ - NCT04801654Recruiting
Knee replacement study using a specific metal implant coating
This study looks at outcomes after a primary knee replacement using the GMK Sphere TiNb implant. It may help researchers learn how well this specific implant works and how patients do over time.
Milan, MIAges 18 years+ - NCT04677907Recruiting
Testing a metal knee implant feature in osteoarthritis surgery
This trial studies a specific type of knee replacement and how well it works after surgery for people with knee osteoarthritis. It may help doctors understand which implant approach leads to better outcomes and recovery.
Glasgow, ScotlandAges 18 years+ - NCT07744789Recruiting
Knee ligament stiffness and osteoarthritis treatment
This study looks at how knee ligament stiffness changes in people with knee osteoarthritis and compares it to healthy volunteers. It may help find better ways to treat knee pain and stiffness.
Taipei, Taipei CityAges 20 years+ - NCT07199738Recruiting
Knee replacement study with a new implant option
This study tests a specific knee implant insert (LEGION Medial Stabilized) in people who need a total knee replacement due to arthritis or similar joint disease. It aims to see if the device is safe and works well over time.
Newton, MassachusettsAges 18–80 - NCT06833372Recruiting
Shock wave therapy for knee arthritis
This trial tests if shock wave treatment can reduce knee pain from osteoarthritis. It may help people with moderate knee arthritis who haven't had recent physical therapy or joint injections.
BariAges 45–80 - NCT06809231Recruiting
Long-term follow-up of CartiONE for knee cartilage repair
This study follows people who had CartiONE treatment for a knee cartilage lesion more than 6 months ago. Researchers want to see how well the treatment works and how safe it is over 1 to 13 years.
Ghent, Oost-VlaanderenAges 18 years+ - NCT06776562Recruiting
Corrective exercises for knee collapse in young women
This study tests whether specific corrective exercises can improve how your knees move when you squat or walk, focusing on women who have knee collapse (dynamic knee valgus) but no pain. If you qualify, you would attend supervised exercise sessions designed to strengthen and align your knees properly.
IstanbulAges 18–25 - NCT06768762Recruiting
Home activity program for knee replacement recovery
This study tests a home-based physical activity program for adults who have had a knee replacement at least a year ago. It aims to help you become more active with remote support and coaching.
Columbia, South CarolinaAges 18 years+ - NCT06748443Recruiting
Injury prevention in youth and adult amateur football players
This trial tests a program to prevent injuries in amateur football players aged 10 and older. It's for teams that practice at least twice a week during the season.
LinköpingAges 10 years+
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 836 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.