Clinical trials
Localized Prostate Cancer clinical trials
Below are recruiting localized prostate cancer clinical trials, each written for real people, not researchers. We’re tracking 482 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07059884Recruiting
Exercise program to help people with cancer stay active
This trial tests a distance-based exercise program designed to help people on chemotherapy maintain their physical function and prevent disability. It is for patients with certain cancers who are working full-time and can participate in moderate physical activity.
Dublin, CaliforniaAges 18 years+ - NCT07255664RecruitingPhase 1/Phase 2
TIL therapy for advanced colorectal or prostate cancer
This trial tests a new type of immunotherapy that uses your own white blood cells (TILs) to fight advanced colorectal or prostate cancer. You will have surgery to remove a tumor, then your TIL cells are grown in a lab and given back to you along with other treatments to boost your immune system.
FrankfurtAges 18 years+ - NCT07260435RecruitingPhase 3
Shorter hormone treatment for low volume spread prostate cancer
This study tests whether a shorter course of a newer hormone pill (apalutamide or enzalutamide) works well for men whose prostate cancer has spread to just a few spots and who recently started standard hormone therapy. It may allow you to take medication for less time while still controlling the cancer.
AlkmaarAges 18 years+ - NCT07276438Recruiting
Image-guided radiation therapy for localized prostate cancer
This trial tests a precise radiation technique that adapts to your body's daily changes. It may offer better outcomes for men with prostate cancer that hasn't spread outside the pelvic area.
Los Angeles, CaliforniaAges 18 years+ - NCT07308990Recruiting
Comparing limited vs. full lymph node removal during prostate surgery
This trial compares two types of lymph node removal during prostate cancer surgery to see if removing fewer lymph nodes is just as effective. It is for men with prostate cancer that has not spread beyond the pelvis.
Lyasny, Minsk OblastAges 18 years+ - NCT07313241RecruitingPhase 2
Salvage radiation with hormone therapy for prostate cancer recurrence
This trial tests how well salvage radiation therapy works for prostate cancer that has come back after surgery. It looks at whether adding hormone therapy based on PSA response improves outcomes.
Dallas, TexasAges 18 years+ - NCT07325721RecruitingPhase 2
Shorter radiation with a focused boost for high-risk prostate cancer
This trial tests a shorter course of radiation therapy with an extra 'boost' to the most aggressive part of the tumor, combined with hormone therapy, for men with high-risk or locally advanced prostate cancer that has not spread outside the pelvis.
Charleston, South CarolinaAges 18 years+ - NCT07332000RecruitingPhase 2
Gene therapy and radiation for intermediate-risk prostate cancer
This trial tests a new gene therapy (aglatimagene besadenovec) given as an injection into the prostate before standard radiation therapy for men with intermediate-risk prostate cancer. The goal is to see if adding this treatment can improve outcomes.
Peoria, ArizonaAges 18 years+ - NCT07335796RecruitingPhase 2
Testing a new drug combination before prostate cancer surgery
This trial tests a new drug (BMS-986365) combined with another hormone therapy (degarelix) before radical prostatectomy for high-risk prostate cancer. The goal is to see if this combination helps lower cancer activity before surgery.
Basking Ridge, New JerseyAges 18 years+ - NCT07343349Recruiting
Adding a higher radiation dose to prostate tumors during standard radiotherapy
This trial tests whether giving an extra, focused dose of radiation to the visible tumor inside the prostate can improve results for men with intermediate or high-risk prostate cancer that has not spread. The total treatment is given in 12 or 20 sessions.
AarhusAges 18 years+ - NCT07344844Recruiting
Custom Stereo Radiography for Early Prostate Cancer
This study tests a precise type of radiation (stereotactic radiotherapy) for men with early-stage prostate cancer. It aims to see if using custom radiation beams improves outcomes while reducing side effects.
Saint-DenisAges 60 years+ - NCT07483658Recruiting
Salvage pelvic radiotherapy: 20 vs 25 sessions for recurring prostate cancer
This trial compares two schedules of pelvic radiotherapy for men whose prostate cancer has returned after surgery. Both schedules aim to control the cancer with fewer visits for one of them.
Gatineau, QuebecAges 18 years+ - NCT07351461Recruiting
Anxiety in men on active surveillance for early prostate cancer and their partners
This study looks at anxiety levels in men who have chosen active surveillance for early prostate cancer, as well as in their partners or significant others. It aims to understand how this approach affects emotional well-being.
LilleAges 18 years+ - NCT07363486RecruitingPhase 1/Phase 2
Study of 225Ac-LNC1011 for advanced prostate cancer
This trial tests a new radioactive drug called 225Ac-LNC1011 for men with a specific type of advanced prostate cancer that has spread and no longer responds to standard hormone therapy. The goal is to see if it can shrink tumors or slow the disease.
Fuzhou, FujianAges 18–90 - NCT01050504Recruiting
Donate blood and tissue to study recurrent or metastatic cancers
This study collects and studies blood and, when possible, small tissue samples from people with prostate or bladder/urothelial cancer that has come back or spread. The goal is to better understand these cancers and support future research that may lead to better care.
Seattle, WashingtonAges 18 years+ - NCT01834001Recruiting
MRI checks how prostate cancer responds to radiation
This study uses MRI scans to see how prostate cancer changes after radiation treatment, especially in the local (prostate-area) response. It may help doctors better judge treatment effectiveness and plan care more precisely.
Bethesda, MarylandAges 18–120 - NCT00949819Recruiting
Active surveillance study for localized prostate cancer
This trial studies a “watchful waiting” approach, where doctors closely monitor certain prostate cancers with regular checkups and repeat biopsies. It may help people avoid or delay treatment side effects while watching for signs the cancer needs treatment.
Los Angeles, CaliforniaAges 30–85 - NCT02102477Recruiting
Surgery or radiation for prostate cancer in the pelvis
This trial compares surgery versus radiation for men with locally advanced prostate cancer that has not spread to distant sites. It aims to see which treatment works better and is easier to manage for people like you.
AalborgAges 18–75 - NCT02526368RecruitingEarly Phase 1
Scan your prostate with special MRI using pyruvate to find high-grade cancer
This trial tests whether a specialized MRI scan using a pyruvate tracer can better detect high-grade (more aggressive) prostate cancer. It may help doctors find cancer more accurately and guide treatment decisions or targeted follow-up.
San Francisco, CaliforniaAges 18 years+ - NCT06178354Recruiting
Freezing or ultrasound for early prostate cancer
This trial is testing whether freezing (cryotherapy) or using high-frequency ultrasound (HIFU) to destroy only the cancer spots in the prostate is safe and effective for men with early-stage prostate cancer. It's a less invasive option that targets just the tumor, not the whole prostate.
Sacramento, CaliforniaAges 18 years+ - NCT06826924Recruiting
Fasting or ketones for prostate cancer
This trial tests whether a 7-day water-only fast or taking ketone supplements can help treat prostate cancer. You would have a biopsy before and after to see how the tumor responds.
Baltimore, MarylandAges 18 years+ - NCT02759744Enrolling by invitation
Laser treatment for certain prostate tumors guided by MRI images
This trial tests whether a precisely targeted laser procedure—guided by MRI images—can treat prostate cancer. It may help some men who have a certain type and location of tumor while aiming to avoid nearby sensitive structures.
Bethesda, MarylandAges 18–100 - NCT01961713Recruiting
Blood test study during prostate surgery for localized prostate cancer
This trial studies prostate cancer cells in the blood (“circulating tumor cells”) while you undergo planned prostate surgery. It may help doctors better understand prostate cancer and how it behaves early, which could guide future treatment decisions.
Boston, MassachusettsAges 18 years+ - NCT07407608Recruiting
Radiation therapy for unfavorable prostate cancer
This trial tests a type of focused radiation therapy for men with intermediate or high-risk prostate cancer that hasn't spread. It aims to improve outcomes by targeting the main tumor seen on MRI.
Monza, MBAges 18–90
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Common questions
- Are there clinical trials for localized prostate cancer?
- Yes. Clin2 currently lists 482 recruiting localized prostate cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a localized prostate cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a localized prostate cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.