Clinical trials
Low Risk clinical trials
Below are recruiting low risk clinical trials, each written for real people, not researchers. We’re tracking 172 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07025148RecruitingPhase 4
Comparing two blood thinners after stenting for high-risk patients
This trial tests switching from a standard blood thinner (clopidogrel) to a lower dose of a stronger one (prasugrel) in people who have had a stent placed and are at high risk for both bleeding and heart problems. The goal is to see if the switch better prevents clots while keeping bleeding risks low.
Jacksonville, FloridaAges 18 years+ - NCT06487052Recruiting
Catheter-based clot-dissolving drug for intermediate-high risk pulmonary embolism
This trial tests whether a standard procedure using a catheter to deliver clot-dissolving medicine directly into the lung artery works well for people with a serious but not immediately life-threatening blood clot in the lungs (pulmonary embolism). It aims to improve heart function and reduce long-term complications.
Saint PetersburgAges 18 years+ - NCT06026267Recruiting
Comparing two doses of albumin for cirrhosis patients with SBP
This trial tests whether a lower dose of albumin works as well as the standard dose for people with cirrhosis and a type of infection called spontaneous bacterial peritonitis (SBP). It aims to see if the low dose can protect kidney function while reducing side effects and costs.
New Delhi, National Capital Territory of DelhiAges 18–75 - NCT06797635RecruitingPhase 2
Study of Patritumab Deruxtecan and Pembrolizumab for High-Risk Early Breast Cancer
This trial tests a combination of targeted therapies (patritumab deruxtecan plus pembrolizumab) along with other anticancer drugs for people with a high-risk type of early-stage breast cancer that is either triple-negative or has very low hormone receptors and is HER2-negative. The goal is to see if this approach can help prevent the cancer from coming back.
Santa Monica, CaliforniaAges 18 years+ - NCT01804634RecruitingPhase 2
Reduced-intensity stem cell transplant for high-risk solid tumors
This trial tests a less intense type of bone marrow (stem cell) transplant from a partly matched family donor for people with high-risk solid tumors. It aims to lower treatment intensity while still using the donor’s immune system to help control the cancer.
Baltimore, MarylandAges 1–50 - NCT05579626Enrolling by invitationPhase 4
Low-dose statin plus ezetimibe vs high-dose statin for prediabetes
This trial compares two cholesterol-lowering approaches in people with prediabetes to see which one is less likely to lead to new-onset diabetes. It may help you choose a safer medication plan if you need strong cholesterol treatment to prevent future heart problems.
Bucheon-siAges 18–75 - NCT04774159RecruitingPhase 3
Low-dose colchicine to lower risk in leg artery disease
This trial tests whether low-dose colchicine can reduce “residual” risk—future heart and blood-vessel problems—in people with peripheral artery disease (PAD). It targets PAD symptoms and complications like poor blood flow in the legs, even after certain procedures.
New Haven, ConnecticutAges 18 years+ - NCT06195306RecruitingPhase 2
Low dose tamoxifen and omega-3 for breast cancer prevention
This study tests whether low-dose tamoxifen (a breast cancer prevention drug) or omega-3 supplements can lower breast cancer risk in postmenopausal women who are overweight and have a higher chance of getting the disease. The study lasts about 6 months and involves blood draws and a breast fluid test to see how the treatment affects breast cells.
Kansas City, KansasAges 45–74 - NCT07380646RecruitingPhase 2
Leucogen to prevent low white blood cells from ribociclib in early breast cancer
This trial tests if Leucogen can prevent neutropenia (low white blood cells) caused by ribociclib, a targeted therapy for hormone receptor-positive, HER2-negative early breast cancer. It may help you stay on treatment without delays or dose reductions.
Hangzhou, ZhejiangAges 18 years+ - NCT06724393Enrolling by invitation
Blood Flow Restriction Exercise for Older Adults
This study tests whether low-intensity exercise with blood flow restriction (using special cuffs on your arms or legs) can improve strength and daily function in older adults. You join online classes from home and go to the campus three times for check-ups.
Montreal, QuebecAges 60 years+ - NCT07279077RecruitingPhase 2
Low-dose radiation with chemo and immunotherapy for high-risk colon cancer
This trial tests a combination of low-dose radiation, chemotherapy, and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of high-risk colon cancer that has not spread. The goal is to see if this approach can shrink the tumor before surgery and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT04938804Recruiting
One-time lung cancer screening with a low-dose chest CT
This study tests whether a one-time, low-dose chest CT scan can help find lung cancer early in certain people. You may be invited because of your age and location, and because you have not had recent related testing or symptoms.
Guangzhou, GuangdongAges 40–74 - NCT05941520RecruitingPhase 2
Acolbifene vs low-dose tamoxifen to prevent breast cancer
This Phase 2 trial compares acolbifene and low-dose tamoxifen to see which better lowers breast cancer risk in premenopausal women at high risk. You would be followed with health visits, blood tests, and a breast tissue sampling procedure.
Duarte, CaliforniaAges 35 years+ - NCT07358715Recruiting
Liquid biopsy to improve lung cancer screening
This study tests whether a simple blood test (liquid biopsy) can help find lung cancer earlier in people at high risk. It also includes people already diagnosed with lung cancer to refine the test.
SingaporeAges 21–75 - NCT04240834RecruitingPhase 4
Low-dose ticagrelor vs aspirin after heart stent placement
This study compares ticagrelor taken at a lower dose versus regular aspirin to help prevent future heart attacks in people who recently had a stent placed after acute coronary syndrome. You may qualify if you’re considered “high risk” for new blockages or clots and can take dual anti-platelet therapy for 12 months.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06058702RecruitingPhase 1
Genetics of cannabis use disorder and response
This study looks at how genes affect cannabis use disorder and how people respond to cannabis. It may help explain why some people develop problems with cannabis while others do not.
West Haven, ConnecticutAges 21–60 - NCT05365035RecruitingPhase 2
Phase 2 trial for high-risk blood cancers with timed chemo
This study tests a mix of medicines (cladribine, low-dose cytarabine, and venetoclax) alternated with azacitidine and venetoclax to treat higher-risk CMML or MDS after prior treatment or when standard treatment may not work well. It may help by improving blood counts and controlling the disease.
Houston, TexasAges 18 years+ - NCT05577988RecruitingPhase 3
Genetic-guided weaker blood thinner vs stronger standard therapy
This study tests whether switching early to a weaker anti-platelet medicine based on your genetics can reduce bleeding problems in people at high risk for bleeding after a heart attack. It compares this approach to the usual strategy of staying on a stronger anti-platelet medicine.
Paris, IDFAges 18 years+ - NCT06632613RecruitingPhase 2
Trial of ENN0403 to prevent kidney injury after heart surgery
This study tests a new drug (ENN0403) given during heart surgery to see if it prevents acute kidney injury—a sudden drop in kidney function. The trial is for people who are already at higher risk due to their specific heart surgery and other health factors.
ShanghaiAges 18–85 - NCT01515527RecruitingPhase 2
Cladribine plus low-dose cytarabine and decitabine for AML or MDS
This Phase 2 study tests a combination chemotherapy plan (cladribine, low-dose cytarabine, and decitabine) for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). It aims to shrink the leukemia/MDS and improve outcomes, including for certain people who may not tolerate standard treatment.
Houston, TexasAges 60 years+ - NCT07583940Recruiting
Energy Intake and Blood Pressure in College Athletes
This study looks at whether not eating enough calories affects blood pressure in Division I college athletes. Researchers want to understand if improving nutrition can help prevent high blood pressure in young athletes.
Greensboro, North CarolinaAges 18–26 - NCT07439822Enrolling by invitationPhase 4
High-flow oxygen for patients at risk of low oxygen during endoscopy
This trial tests whether high-flow oxygen therapy can prevent low oxygen levels in patients at risk during a digestive endoscopy with deep sedation. It might help if you have obesity, stable lung or heart disease, or sleep apnea.
Valladolid, ValladolidAges 18 years+ - NCT07036731Recruiting
Urine test study for second bladder surgery
This trial compares the need for a second surgery for people with early-stage bladder cancer. It uses a simple urine test to see if the test can help decide whether a second operation is necessary, which could save some patients from an extra procedure.
Nanjing, JiangsuAges 18–80 - NCT06387017Recruiting
Can blood tests improve lung cancer screening in smokers with artery disease?
This study looks at whether certain blood tests can help find lung cancer early in people who have smoked for a long time and also have artery disease. The goal is to see if adding these tests to current screening methods can better identify those at highest risk.
MarseilleAges 45–80
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Common questions
- Are there clinical trials for low risk?
- Yes. Clin2 currently lists 172 recruiting low risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a low risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a low risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.