Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 205 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06798766Recruiting
Understanding darker skin tones and vein disease care
This study looks at how people with darker skin tones experience chronic venous insufficiency (a condition that affects blood flow in the legs) and aims to improve how it's diagnosed and treated. It involves two parts: one is sharing your experience through an interview, and the other includes a skin check and photos at the hospital.
London, LondonAges 18 years+ - NCT05240014Recruiting
Powered leg braces to help people move more easily
This study tests modular powered leg braces (orthoses) to improve voluntary movement and walking ability in adult participants. It may help you learn whether the braces are safe and useful for your kind of mobility and daily movement.
Ann Arbor, MichiganAges 18–85 - NCT06777134Recruiting
Pelvic floor issues and leg strength in MS patients
This study looks at how pelvic floor problems relate to leg strength and function in people with multiple sclerosis. It may help understand how to better treat these issues.
Istanbul, IstanbulAges 18–65 - NCT06780943Recruiting
Study on how people with leg amputations adapt their walking
This study looks at how people with a leg amputation change the way they walk to make up for lost function. It may help improve rehabilitation and prosthetic care.
NîmesAges 18–80 - NCT06731608Recruiting
Fracture prevention study for older adults in rehab
This study tests a system to help prevent another broken bone after a hip, leg, or pelvis fracture. It is for people 65+ who are in a skilled nursing facility for rehab and plan to return home or to assisted living.
Baltimore, MarylandAges 65 years+ - NCT06729021Recruiting
Predicting leg blood clots after heart or lung surgery
This study tests whether a simple score (Modified Caprini) and a blood test (D-dimer) can help predict and prevent blood clots in the legs after heart or lung surgery. If you are having cardiothoracic surgery and will be in the hospital for a few days, you may be able to join.
BaghdadAges 18 years+ - NCT06725602Enrolling by invitation
Prehospital tourniquet study for arms and legs
This trial tests different tourniquet models used in emergencies to stop blood flow in arms and legs. It may help find the best way to control bleeding before reaching a hospital.
Ribeirão Preto, São PauloAges 18–60 - NCT06696040Enrolling by invitation
Kinesiotherapy machine for leg stiffness and walking in neurological patients
This trial tests if a passive kinesiotherapy machine can improve leg stiffness (spasticity) and walking ability in people with neurological conditions like stroke or cerebral palsy. It may help those who have trouble moving their legs due to tight muscles.
Caxias do Sul, Rio Grande do SulAges 9 years+ - NCT06690658Recruiting
Home arm exercises with a robotic trainer
This trial tests whether a robotic trainer can help people do upper body exercises on their own. It may be a good fit if you can sit without back support and follow simple instructions.
Raanana, IsraelAges 18 years+ - NCT06011018Recruiting
Mirror Therapy with Electrical Stimulation or Sound Beats after Stroke
This study tests if combining mirror therapy with either gentle electrical stimulation or special sound beats can help improve leg movement and brain activity after a stroke. It is designed for people who had their first stroke at least 6 months ago and have some movement in their leg.
Kaohsiung CityAges 20–80 - NCT06525532Recruiting
Tracking reabsorbable implant for flatfoot in kids
This study tracks how well a special reabsorbable implant works over time in children and teens who had subtalar surgery for flatfoot. You'll have an MRI to see how the implant has changed and if it helped your foot.
BolognaAges 8–15 - NCT06517251Recruiting
Arm-hand boost therapy for stroke recovery
This trial tests a special arm and hand therapy program for people who are still in the hospital after a stroke. If you have trouble using your arm or hand, this treatment may help you recover better.
Edegem, AntwerpenAges 18 years+ - NCT06492733Recruiting
FastWire device for unblocking leg arteries (FREEFLOW trial)
This trial tests a new wire system to reopen completely blocked leg arteries without surgery. It is for people with severe leg pain or tissue damage caused by blocked arteries, and aims to restore blood flow and improve walking ability.
Wilmington, DelawareAges 18–85 - NCT06471855Recruiting
Rehabilitation support for leg amputation due to diabetes
This study is for people with diabetes or blood vessel disease who are at risk for losing a leg, have already had a lower leg amputation, or use a prosthetic leg. It focuses on a rehabilitation program that helps with both physical and emotional adjustment.
Pavia, PVAges Up to 80 years - NCT06462625Recruiting
Knee realignment surgery for arthritis with bowed legs
This study tests how well a realignment surgery (osteotomy) works for people with mild knee arthritis and a bent knee that's at least 3 degrees off center. The surgery may also fix other knee problems like a torn meniscus or ligament at the same time.
BolognaAges 18–70 - NCT06472518RecruitingPhase 4
Clot-busting treatment plus blood thinners for severe leg clots
This trial tests whether combining a clot-busting procedure (pharmaco-mechanical thrombolysis) with standard blood thinners works better than blood thinners alone for people with severe, recently formed deep vein clots in the upper leg.
NantesAges 18 years+ - NCT06452186Recruiting
Study of a new leg prosthetic controller for improved balance
This study tests a new prosthetic leg controller that helps people with below-knee amputations walk more steadily and with better balance. You may be eligible if you have used a prosthetic leg for at least a year and are comfortable walking in the community.
Raleigh, North CarolinaAges 18–99 - NCT05112705Recruiting
Finding deep vein clots early in ICU patients
This study focuses on diagnosing deep-vein thrombosis (DVT, blood clots in the leg) early in people who are very ill in the ICU. It aims to test an approach to better detect clots sooner, which could help prevent complications.
Riyadh, Riyadh RegionAges 18 years+ - NCT06370273RecruitingPhase 3
Blood thinners for leg casts after injury
This study tests whether taking a blood thinner (anticoagulant) pill can prevent dangerous blood clots in people who have a hard cast or brace on their leg after an injury. It compares two different blood thinners to see which works better.
Carshalton, SurreyAges 16 years+ - NCT06296082RecruitingPhase 2/Phase 3
Dry Needling vs Botox for Post-Stroke Leg Stiffness
This study compares two treatments for leg stiffness after a stroke: dry needling (tiny needles placed in trigger points) and Botox injections. It may help you if you've had a first stroke within the past year and have mild to moderate tightness in the calf muscles that limits ankle movement.
Antwerp, FlandersAges 18–75 - NCT06275282Recruiting
Nerve surgery for better leg prosthetic control
This trial tests a new nerve surgery technique to help people with above-knee leg amputations have better control of their prosthetic leg. The goal is to improve how well the prosthesis responds to your movements.
Ann Arbor, MichiganAges 18–75 - NCT06127316Recruiting
Heel lift height and foot pressure with custom braces
This study tests if changing the height of a heel lift in a custom foot brace can improve how weight is distributed on your foot after a serious ankle or hindfoot injury. If you have pain when walking, this could help find better ways to reduce that pain.
Iowa City, IowaAges 18–65 - NCT05543785Recruiting
Ketorolac pain block for lower-limb surgery with a tourniquet
This trial looks at whether a ketorolac pain medicine given directly to the leg during surgery can reduce pain after lower-limb orthopedic operations. It may help people who are having one leg operated on with spinal anesthesia and a tourniquet, but it has several safety limits.
Al MansurahAges 19–60 - NCT04800276Recruiting
Exercise program for leg artery disease
This trial tests a supervised exercise program for people with leg pain when walking caused by narrowed leg arteries. The goal is to see if exercise can improve walking ability and quality of life.
Le MansAges 18 years+
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 205 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.