Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06452186Recruiting
Study of a new leg prosthetic controller for improved balance
This study tests a new prosthetic leg controller that helps people with below-knee amputations walk more steadily and with better balance. You may be eligible if you have used a prosthetic leg for at least a year and are comfortable walking in the community.
Raleigh, North CarolinaAges 18–99 - NCT07397468RecruitingPhase 1/Phase 2
Study of JUV-161 for leg immobilization recovery
This trial tests a drug called JUV-161 to see if it can help protect muscle from loss when a leg is immobilized (in a cast or boot). It is for healthy adults who are willing to undergo a leg immobilization period and muscle biopsy.
AucklandAges 45–65 - NCT02748226Recruiting
Study of artery procedures for leg artery disease outcomes
This study looks at results of a minimally invasive procedure done inside blood vessels (endovascular therapy) for people with painful or worsening leg artery disease. It uses both past (retrospective) and future (prospective) patient information to better understand outcomes.
SeoulAges 20 years+ - NCT07466823Recruiting
Spasticity Patterns and Quality of Life in MS
This study looks at patterns of muscle stiffness (spasticity) in people with multiple sclerosis and how these patterns affect daily life and well-being. It aims to better understand the link between spasticity and quality of life.
IstanbulAges 18 years+ - NCT07472543Recruiting
Virtual reality exercises for leg lymphedema after cancer surgery
This trial tests whether virtual reality-based exercises can help reduce leg swelling caused by lymphedema after gynecological or other cancer surgery. It may be a good option if you have lymphedema in one leg and can commit to daily sessions for a month.
AnkaraAges 18–65 - NCT07673328Recruiting
Knee brace study for people with knee arthritis
This study tests a motorized knee brace for people with knee osteoarthritis. The brace helps support your knee as you walk, climb stairs, and go up and down ramps.
Ann Arbor, MichiganAges 18–85 - NCT06998134Recruiting
Exoskeleton walking training for children and young adults
This trial tests whether a robotic leg exoskeleton can help improve walking in children and young adults with certain conditions (like cerebral palsy, muscular dystrophy, spina bifida, or spinal cord injury) or those with no walking issues. The goal is to find out if the exoskeleton is safe and effective for everyday use, especially in younger people who might lose the ability to walk as they get older.
Bethesda, MarylandAges 5–25 - NCT07554443Recruiting
Wearable Device to Improve Balance and Walking in Older Adults
This study tests a wearable device called Walkasins that uses gentle vibrations on your foot to help improve balance and walking ability. It's designed for older adults with nerve damage in their feet who have difficulty with balance.
Jacksonville, FloridaAges 60 years+ - NCT07558317Recruiting
Resistance Exercise for Lower Leg Swelling
This study tests whether strength-training exercises can help reduce swelling in the lower leg caused by lymphedema. You'll wear compression garments as usual and add supervised resistance exercises to see if they improve your symptoms and quality of life.
HerlevAges 18 years+ - NCT07576491Recruiting
Toilet Position, Ankle Movement, and Leg Strength in Children
This study looks at how the position children use on the toilet (sitting versus squatting) relates to their ankle flexibility and leg strength. Researchers want to understand if toilet posture affects physical development in healthy children ages 6–12.
Lahore, Punjab ProvinceAges 6–12 - NCT07625020Recruiting
Nerve Hydrodissection for Diabetic Nerve Entrapment Pain
This trial tests a minimally invasive ultrasound-guided procedure that uses fluid injection to free trapped nerves in the lower legs of people with diabetes. The goal is to relieve pain, numbness, and weakness when standard medications haven't worked well enough.
Chongqing, Chongqing MunicipalityAges 18–85 - NCT07642778Recruiting
Measuring Leg Strength in Kidney Disease Patients on Dialysis
This study measures how strong your leg muscles are in patients with chronic kidney disease who receive dialysis treatment. Understanding normal strength patterns may help doctors better support kidney disease patients' physical health and quality of life.
MadridAges 18–85 - NCT07578753Enrolling by invitation
Robot-assisted walking therapy for burn and fracture recovery
This study tests whether a robotic device that helps you walk can improve movement and function after you've had a severe burn and broken bone in your leg. The robot guides your leg through walking motions while you're healing, and researchers want to see if it helps you regain strength and independence faster.
SeoulAges 18–70 - NCT07397390Enrolling by invitation
Study of a new scoring balloon for leg artery blockages with heavy calcium buildup
This study tests a new balloon device that scores the artery walls to treat leg artery blockages with heavy calcium deposits. It aims to see if the device helps prepare the vessel safely and effectively before placing a stent.
Dalian, LiaoningAges 18–85 - NCT07198698Enrolling by invitation
Sahid method for leg swelling after surgery, infection, or treatment
This study tests a technique called the Sahid method to reduce leg swelling (lymphedema) in women. It might help if you have had swelling in one leg for two years or less due to surgery, infection, cancer, or an injury.
SantiagoAges 30–65 - NCT07093229Enrolling by invitation
Gait analysis for knee arthritis in seniors
This trial studies how walking patterns change in people over 65 with long-term knee osteoarthritis. It aims to understand gait to improve treatment and rehabilitation plans.
CraiovaAges 65–80 - NCT06906536Enrolling by invitation
Intermittent low oxygen to improve leg function after spinal injury
This trial tests whether short, controlled sessions of low oxygen (like breathing thin air) can improve leg movement and blood markers in people with spinal cord injuries. It may help with walking or standing.
Boulder, ColoradoAges 18–75 - NCT06725602Enrolling by invitation
Prehospital tourniquet study for arms and legs
This trial tests different tourniquet models used in emergencies to stop blood flow in arms and legs. It may help find the best way to control bleeding before reaching a hospital.
Ribeirão Preto, São PauloAges 18–60 - NCT06696040Enrolling by invitation
Kinesiotherapy machine for leg stiffness and walking in neurological patients
This trial tests if a passive kinesiotherapy machine can improve leg stiffness (spasticity) and walking ability in people with neurological conditions like stroke or cerebral palsy. It may help those who have trouble moving their legs due to tight muscles.
Caxias do Sul, Rio Grande do SulAges 9 years+ - NCT05646316RecruitingPhase 3
Sentinel lymph node mapping to reduce leg swelling after surgery
This study tests whether a special way of finding lymph nodes during hysterectomy can lower the risk of long-term leg swelling or related dysfunction in people with stage I endometrial cancer. It compares standard lymph node assessment with sentinel lymph node mapping and looks at how this affects day-to-day leg functioning.
Washington D.C., District of ColumbiaAges 18 years+ - NCT03594344Recruiting
Extra hyperbaric oxygen after leg amputation wounds heal
This study tests whether giving extra treatments with hyperbaric (pressure) oxygen after a leg amputation can improve healing or recovery. It’s meant for people whose amputation happened due to long-lasting infection or poor blood flow and who can attend follow-up visits.
OsloAges 18–90 - NCT07387653Recruiting
Leg circulation monitoring during pelvic surgery
This trial tests a new way to check blood flow and oxygen levels in your legs during pelvic surgery when you're in the lithotomy (legs-up) position. It aims to catch any circulation problems early, which could help prevent leg injuries.
Houston, TexasAges Any age - NCT07084740Recruiting
Study of blood flow in skin flaps for reconstruction
This study looks at how blood flows through special skin flaps used in reconstructive surgery. It may help doctors better understand and predict how these flaps heal, especially for people who need repair after injuries or pressure sores.
MontpellierAges 18–70 - NCT07610850Recruiting
Brain-controlled stimulation to improve arm and leg movement after stroke
This trial tests a new brain-controlled device that sends electrical signals to your spinal cord to help restore arm and leg movement after a stroke. If you had a stroke at least 9 months ago and have weakness on one side of your body, this may help you regain function.
Lausanne, Canton of VaudAges 18–70
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 194 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.