Lumbar Surgery clinical trials

Personalized pain relief after back fusion surgery

This trial tests a personalized plan to manage pain after lumbar (lower back) fusion and decompression surgery. It may help reduce difficult pain while guiding safe use of opioids around the time of surgery.

Long-term results after surgery for lumbar spinal stenosis

This study looks at patients who had back surgery for lumbar spinal stenosis and a condition called spondylolisthesis between 2007 and 2015. They want to see how many people needed another operation years later.

Numbing injection for pain relief after back fusion surgery

This study tests whether a special numbing injection (called an erector spinae plane block) given near the spine during surgery can reduce pain after lumbar fusion. If you qualify, you might have less pain and need fewer painkillers after your operation.

Spine surgery study: genes, thinking, and pain

This study is for people getting planned spine surgery. It looks at how your genes and thinking skills might affect your pain and use of pain medicine after surgery.

Ear Stimulation After Back Surgery

This study tests whether a gentle electrical stimulation placed on the ear (tAuricular Neurostimulation) can help reduce pain and improve recovery after lumbar spine surgery. It is for people who are already scheduled for a lumbar fusion or laminectomy and want to see if this non-invasive approach can ease their post-surgery discomfort.

Light device to help place epidural needles

This trial tests a new device that uses light to help doctors place an epidural needle more accurately in your lower back. It may make the procedure safer and more comfortable.

Comparing two types of back pain blocks after lumbar spine surgery

This trial compares two ways of delivering a pain-blocking injection (erector spinae plane block) after a single-level lower back surgery. The goal is to see which approach provides better pain relief after surgery.

Rehabilitation With Empowered STrategies to Optimize REcovery

Spinal fusion vs. no surgery for chronic low back pain

This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.

Comparing two bone graft materials for lumbar fusion surgery

This trial compares two types of bone graft materials (Magnetos Putty and GlassBone Putty) used in lower back fusion surgery for adults with degenerative disc disease. The goal is to see which material works better for helping the bones fuse together, which may reduce pain and improve function.

Front vs back surgery for a slipped lower-back vertebra

This trial compares two surgical approaches—operating from the front/side versus from the back—for a specific type of lower-back slip called lumbar isthmic spondylolisthesis. You may be eligible if you need surgery at a single level and have not had prior spine surgery, and if your back condition matches their exact limits.

Precision treatment for lumbar nerve pain with targeted block

This trial tests if a targeted nerve root injection can improve outcomes for people with persistent leg pain from a compressed nerve in the lower back, with the goal of tailoring surgery more precisely.

Study of muscle changes in chronic low back pain surgery

This study looks at how muscle degeneration relates to nerve-related symptoms in people with chronic low back pain. You may be eligible if you’ve tried non-surgical care but still need surgery to relieve nerve pressure.

Surgery vs. non-surgery for leg pain from a slipped disc

This trial compares surgery to non-surgical treatments for people with leg pain caused by a lumbar disc herniation (slipped disc). It tests if surgery provides better relief after at least 6 weeks of symptoms.

Massage therapy after upper or lower back surgery

This study tests if massage therapy can help children recover after their first back surgery (thoracic or lumbar fusion). It's for kids who can talk and don't have certain health problems like chronic pain or bleeding disorders.

Oliceridine vs morphine for pain after lumbar surgery

This study compares a new pain medicine called oliceridine with morphine or sufentanil to see which works better after lumbar spine surgery. It aims to find a safer and more effective way to manage pain after your operation.

MRI study of VersaWrap nerve protector after back surgery

This trial uses MRI scans to see how well a nerve protector called VersaWrap works after one-level lumbar decompression surgery. It may help understand if the device helps nerves heal better.

Lumbar surgery effect on walking complexity in chronic low back pain

This study looks at how lumbar spine surgery (fusion or artificial disc “prosthesis” on one or two levels) affects how complex your walking looks and feels. It may help doctors better understand what to expect from surgery and how it changes movement in people with long-term low back pain.

Nerve block vs. no block for hip surgery pain

This trial compares a lumbar erector spinae plane block (L-ESPB), a type of nerve numbing injection, to not using any block for managing pain after hip surgery. The goal is to see which approach works better and is safer.

Non-surgical spacer for spinal stenosis causing leg pain

This trial tests a minimally invasive (“through the skin”) procedure that places a small spacer between back bones to relieve lumbar spinal stenosis symptoms like leg pain when walking. It may help people who still need surgery based on their symptoms and MRI findings but may be treated without open surgery.

Activity levels in seniors having spine surgery

This study is tracking how active people are before and after surgery for lumbar spinal stenosis (a common cause of back and leg pain in older adults). It aims to see if activity monitoring can help improve recovery.

Balance in patients with lumbar spinal stenosis

This study looks at balance problems in older adults with lumbar spinal stenosis, a condition that narrows the spinal canal and can cause pain or trouble walking. It may help doctors understand how surgery affects balance and daily life.

Steroid injections for back and pelvic pain

This study is testing how well and how safely steroid injections work for different types of back pain. If you join, you'll receive the injection as part of your care and fill out surveys about your pain and ability to do daily activities before and after.

Numbing nerve block during minimally invasive low back surgery

This trial tests whether an “ESP block” (a numbing injection near the spine) can help control pain during minimally invasive low back fusion surgery. If you’re having this surgery, the goal is to improve comfort and reduce pain medicine needs.