Lumbar Fusion Surgery clinical trials

Comparing two spine surgeries for a slipped backbone

This study compares two types of spine surgery for a common condition where a lower back bone slips forward. It aims to see which surgery works better to relieve pain and improve function.

Wound drain after lumbar fusion surgery

This trial tests whether placing a drain after lumbar fusion surgery affects recovery. It may help reduce complications and improve outcomes.

Testing brace use after low back fusion surgery

This pilot study looks at whether wearing a brace helps after single-level low back fusion surgery. You may be offered screening if you’re healing from a specific type of fusion and don’t have certain risk factors.

Lumbar fusion outcomes with arthritis in nearby spine segments

This study looks at how well lumbar fusion surgery works long-term when the joint just above or below (adjacent segment) already shows wear-and-tear. It may help predict who benefits most and guide treatment planning.

Personalized pain relief after back fusion surgery

This trial tests a personalized plan to manage pain after lumbar (lower back) fusion and decompression surgery. It may help reduce difficult pain while guiding safe use of opioids around the time of surgery.

Zolpidem during recovery after lower-back fusion surgery

This trial studies whether taking zolpidem around the time of recovery from lower-back (lumbar) fusion surgery affects outcomes. It may help doctors understand how sleep medicine can (or can’t) support recovery in certain people.

Numbing injection for pain relief after back fusion surgery

This study tests whether a special numbing injection (called an erector spinae plane block) given near the spine during surgery can reduce pain after lumbar fusion. If you qualify, you might have less pain and need fewer painkillers after your operation.

Spinal fusion vs. no surgery for chronic low back pain

This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.

Lidocaine for pain control after spine surgery

This trial tests whether giving lidocaine through an IV during surgery can help reduce pain after lumbar fusion surgery. It may lead to less need for other pain medicines and a smoother recovery.

Nerve blocks to reduce bleeding and pain after spine surgery

This study compares two types of nerve blocks (numbing injections) given during lumbar spine fusion surgery to see which better reduces bleeding and pain after the operation. If you're having spine surgery, this trial might help your recovery be smoother with less pain and bleeding.

Titanium versus PEEK for one-level back fusion

This trial compares two different implanted materials (titanium vs. PEEK) used in a one-level spinal fusion for people with lumbar stenosis and spondylolisthesis. It’s meant to see which device performs better after surgery for pain and leg symptoms when non-surgical treatments haven’t helped.

Ketorolac for pain after lower back fusion surgery

This trial tests if a non-steroidal anti-inflammatory drug (NSAID) called ketorolac can help reduce pain after lower back fusion surgery. It is for people who are having elective surgery to fuse one or two bones in their lower back.

Erector spinae pain-block during lumbar fusion surgery

This study tests whether a numbing pain-block in a specific back muscle area (called an “erector spinae plane block”) can improve comfort during lumbar spinal fusion surgery. You might be eligible if you need this type of back surgery and can safely receive the numbing medicine.

Testing a new spinal implant for lower back fusion

This trial tests a new spinal implant system (CORUS-LX) for fusing two lower back discs that are causing pain. It is meant for people with severe, long-lasting back or leg pain that hasn't improved with non-surgical treatments.

Numbing medicine during back surgery to reduce pain

This trial tests a regional anesthesia (numbing medicine given near nerves) during minimally invasive lumbar spine surgery. The goal is to see if it helps control pain around surgery and improves recovery comfort.

Safety and effectiveness study of spinal implants and bone materials

This study tracks how well spinal implants (Titania systems) and bone-filling materials (BONEGRAFT) work after surgery and whether patients experience any problems. Researchers will follow patients after cervical or lower spine surgery to confirm these devices are safe and effective in real-world use.

Front vs back surgery for a slipped lower-back vertebra

This trial compares two surgical approaches—operating from the front/side versus from the back—for a specific type of lower-back slip called lumbar isthmic spondylolisthesis. You may be eligible if you need surgery at a single level and have not had prior spine surgery, and if your back condition matches their exact limits.

Comparing two types of spine surgery for disc-related low back pain

This study compares two different surgery methods (Mini-TLIF and MIDLIF) for treating low back pain caused by worn-out discs in the lower back. The goal is to see which one offers better recovery, fewer complications, and lower costs.

Study of Correlation Between the Level of Intradiscal Periostin Expression and Pfirrmann Grading.

Comparing two bone graft materials for lumbar fusion surgery

This trial compares two types of bone graft materials (Magnetos Putty and GlassBone Putty) used in lower back fusion surgery for adults with degenerative disc disease. The goal is to see which material works better for helping the bones fuse together, which may reduce pain and improve function.

Spinal Fusion Recovery in Older Adults

This study is looking at how older adults recover after spinal fusion surgery, a type of back surgery that connects bones in the spine. The goal is to find factors that help people heal faster and feel better afterward.

Testing whether one-level fusion is needed after lumbar decompression

This trial compares outcomes after decompression surgery for one affected area in the lower back, with and without adding spinal fusion. It may help patients avoid unnecessary extra surgery—or ensure fusion is used when it’s needed.

Back surgery approach trial for mild slip and leg pain

This trial compares a newer, “cortical bone trajectory” method with more traditional open surgery and a minimally invasive approach for treating certain low-back slips. It looks at short-term outcomes to see which approach helps patients recover better and relieve leg symptoms.

Visual feedback exercises after lower back surgery

This trial tests if a special exercise program that uses visual feedback helps people recover better after surgery for a herniated disc in the lower back. It may improve your recovery and reduce pain.