Clinical trials
Lung Cancer (Locally Advanced or Metastatic) clinical trials
Below are recruiting lung cancer (locally advanced or metastatic) clinical trials, each written for real people, not researchers. We’re tracking 5,859 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05937958Recruiting
MR-guided linac boost for gynecologic cancers when brachytherapy isn’t possible
This study tests a targeted radiation “boost” delivered using an MRI-guided machine for certain gynecologic cancers when the usual treatment (brachytherapy) can’t be done. It may help improve control of the cancer while still aiming for cure.
OdenseAges 18 years+ - NCT05946213RecruitingPhase 3
Shorter radiation treatment for high-risk prostate cancer
This trial tests whether a shorter course of radiation works as well as the usual longer course for people with high-risk prostate cancer. The goal is to keep cancer control while possibly reducing treatment time and inconvenience.
Birmingham, AlabamaAges 18 years+ - NCT05972343Recruiting
Cooling treatment to shrink breast tumors without surgery
This trial tests a cooling-based procedure (called cryoablation) to destroy a breast cancer tumor in people who cannot or do not want surgery. It may help shrink the visible tumor without needing an operating room.
St Louis, MissouriAges 18 years+ - NCT05999396RecruitingPhase 1
Testing a new antibody for colorectal cancer
This trial tests a new drug called CC-3, which is a type of antibody designed to help your immune system attack colorectal cancer cells. It is for people whose cancer has spread and who have already tried several standard treatments.
Tübingen, Baden-WurttembergAges 18 years+ - NCT06001658RecruitingPhase 2
Chemo plus immunotherapy before and after surgery for bile duct cancer
This trial tests a combination of chemotherapy (gemcitabine and cisplatin) and an immunotherapy drug (pembrolizumab) given before and after surgery for people with bile duct or gallbladder cancer that can be removed. The goal is to see if this approach helps prevent the cancer from coming back.
Baltimore, MarylandAges 18 years+ - NCT06007924RecruitingPhase 2
Study of avutometinib and defactinib for thyroid cancer
This trial tests two oral drugs (avutometinib and defactinib) for people with certain types of advanced thyroid cancer that have specific genetic changes. The goal is to see if this combination can shrink tumors or slow their growth.
Basking Ridge, New JerseyAges 18 years+ - NCT06039631RecruitingPhase 2
Immuno-chemo before surgery and organ-sparing treatment for throat cancer
This trial tests whether adding immunotherapy before surgery, followed by either radiation or organ-preserving surgery, can improve outcomes for people with locally advanced laryngeal or hypopharyngeal cancer. It may help avoid complete removal of the voice box.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06040762Recruiting
Get moving before bladder cancer surgery
This study tests whether a home-based exercise program before surgery can help improve physical function in people with bladder or upper tract urothelial cancer. If you are planning to have surgery to remove your bladder or upper urinary tract, you may be able to join.
Seattle, WashingtonAges 18 years+ - NCT06082180RecruitingPhase 3
Preventive neck lymph node removal in low-risk thyroid cancer
This trial is for people with low-risk papillary thyroid cancer. It compares two surgical approaches: one that removes just the thyroid gland, and another that also removes some lymph nodes in the center of the neck as a preventive measure. The goal is to see if removing these lymph nodes helps prevent the cancer from coming back.
Beijing, Beijing MunicipalityAges 18–70 - NCT06085729RecruitingPhase 1/Phase 2
Study of ADI-PEG20 with chemo for aggressive prostate cancer
This study tests a combination of three drugs—ADI-PEG20, carboplatin, and cabazitaxel—in men with aggressive variant prostate cancer that has stopped responding to hormone therapy. The goal is to see if this combination can shrink or slow the cancer.
Houston, TexasAges 18 years+ - NCT06100718Recruiting
Detecting new cancer after a stroke in at-risk patients
This study looks for hidden cancers in people who have had a stroke and have high levels of a blood marker called D-dimer. It aims to see if a full cancer screening one year later can find new cancers that might have been missed.
Lausanne, Canton of VaudAges 18 years+ - NCT06112704RecruitingPhase 2
HS-20093 for advanced esophageal and other solid tumors
This trial tests an investigational drug called HS-20093 for people with advanced esophageal cancer or other solid tumors that have not responded to prior treatment. The drug targets a protein on cancer cells called B7-H3, and the study aims to see if it can shrink tumors or slow their growth.
Hefei, AnhuiAges 18 years+ - NCT06123338RecruitingPhase 2
Pembrolizumab plus chemo and trastuzumab for HER2+ stomach cancer
This trial tests adding pembrolizumab to standard trastuzumab and chemotherapy for people with HER2-positive stomach or esophageal cancer that can be fully removed with surgery. The goal is to see if this combination improves outcomes before and after surgery.
Boston, MassachusettsAges 18 years+ - NCT06127797Recruiting
MRI surveillance study for breast cancer survivors with dense breasts
This study is testing whether adding an MRI to your regular mammogram can help find any new breast cancers earlier. It is for women who have had breast cancer before and still have dense breast tissue, making mammograms harder to read.
Houston, TexasAges 18 years+ - NCT06140589Recruiting
Cadonilimab for advanced cervical cancer
This trial tests a new immunotherapy drug called cadonilimab for women with cervical cancer that has returned, spread, or is advanced. The goal is to see if it works well, how safe it is, and if it costs less than standard treatments.
Fuzhou, FujianAges 18–80 - NCT06150898RecruitingPhase 2
Ketorolac and pregabalin for estrogen receptor positive breast cancer before surgery
This trial tests whether two medications, ketorolac (a pain reliever) and pregabalin (a nerve pain drug), can help treat estrogen receptor (ER) positive breast cancer when taken before surgery. It may offer better pain control and possibly improve cancer outcomes.
Brussels, Brussels CapitalAges 18–70 - NCT06177925RecruitingPhase 2
Immunotherapy plus chemoradiation for limited spread SCLC
This trial tests a combination of an immunotherapy drug (adebrelimab) plus standard chemotherapy and radiation for people with extensive-stage small cell lung cancer that has only spread to a few places. The goal is to see if this approach can help control the cancer better.
GuangzhouAges 18–75 - NCT06184880Recruiting
Physical activity program for sedentary cancer patients
This trial tests whether a remote physical activity program can help reduce time spent sitting for people with new upper aerodigestive tract cancer. If you qualify, you may be able to take part in exercise sessions from home.
ValenceAges 18 years+ - NCT06193369Recruiting
Digital peer support for young adults with cancer
This trial connects you with a trained peer (someone who has been through cancer) who provides support and guidance online. It's for young adults who finished treatment for certain cancers in the past year.
Toronto, OntarioAges 18–40 - NCT06200831Recruiting
Same surgery or two surgeries for colorectal cancer with liver spread
This trial compares having one surgery to remove both the colon tumor and liver tumors at the same time versus having two separate surgeries. It aims to find which approach is safer and works better for patients whose cancer has spread only to the liver.
OsloAges 18–80 - NCT06225284RecruitingPhase 2
Chemotherapy with or without hormone drug for premenopausal TNBC
This trial tests whether adding a hormone-blocking drug (GnRH agonist) to standard chemotherapy before surgery helps premenopausal women with triple-negative breast cancer. It aims to improve treatment outcomes by targeting hormones that may fuel tumor growth.
TaipeiAges 18 years+ - NCT06228599Recruiting
Targeted therapy for pancreatic cancer with high risk of return
This trial tests if personalized medicines, chosen based on the genetic profile of your tumor, can help prevent pancreatic cancer from coming back after surgery. It is for people who have had their pancreatic tumor removed but have features that suggest a higher chance of recurrence.
Milwaukee, WisconsinAges 18 years+ - NCT06235216RecruitingPhase 2
Sacituzumab govitecan for advanced thyroid cancer
This trial tests a new drug called sacituzumab govitecan for people with advanced thyroid cancer that has stopped responding to standard treatments. It may be an option for those with differentiated thyroid cancer (after certain prior therapies) or anaplastic thyroid cancer (first-line or after one prior treatment).
BarcelonaAges 18 years+ - NCT06263153RecruitingPhase 2
Futibatinib and durvalumab before bladder cancer surgery
This trial tests two drugs (futibatinib and durvalumab) given before bladder removal surgery for people with muscle-invasive bladder cancer who cannot take standard cisplatin chemotherapy. The goal is to see if the combination shrinks the tumor and improves outcomes.
Ann Arbor, MichiganAges 18 years+
Hear when a new Lung Cancer (Locally Advanced or Metastatic) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for lung cancer (locally advanced or metastatic)?
- Yes. Clin2 currently lists 5,859 recruiting lung cancer (locally advanced or metastatic) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lung cancer (locally advanced or metastatic) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lung cancer (locally advanced or metastatic) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Locally Advanced or Metastatic Breast Cancer
- Locally Advanced Non-Small Cell Lung Cancer
- Advanced or Metastatic Non-small Cell Lung Cancer
- Colorectal Cancer (Locally Advanced or Metastatic)
- Liver Cancer (Locally Advanced or Metastatic)
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.