Clinical trials
Lung Cancer, Non-Small Cell clinical trials
Below are recruiting lung cancer, non-small cell clinical trials, each written for real people, not researchers. We’re tracking 1,118 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07390838RecruitingPhase 1
Study of SH009 for advanced solid tumors
This trial tests an investigational drug called SH009 for people with advanced solid tumors that have stopped responding to standard treatments. It aims to see if the drug is safe and effective.
ShanghaiAges 18 years+ - NCT07392658RecruitingPhase 2
Amivantamab plus chemo for EGFR-mutated lung cancer
This trial tests whether the drug amivantamab combined with a single chemotherapy drug can help people with advanced non-small cell lung cancer that has a specific EGFR gene mutation (exon20 insertion). It is for people who cannot safely receive standard platinum-based chemotherapy.
Roma, Roma (RM)Ages 18–99 - NCT07394062Recruiting
Comparing chemo-immunotherapy combinations for advanced lung cancer
This study compares two standard treatments for metastatic non-small cell lung cancer when the tumor has low levels of a protein called PD-L1. It looks at how well chemotherapy plus pembrolizumab works versus chemotherapy plus nivolumab and ipilimumab.
AnkaraAges 18 years+ - NCT01994057Recruiting
Looking back at EGFR-targeted pills for lung cancer
This study looks back at how people with non-small cell lung cancer (NSCLC) were treated with EGFR-targeted medicines (gefitinib, erlotinib, and osimertinib). It may help doctors understand which patients benefit most and what side effects to expect.
Guangzhou, GuangdongAges 18–85 - NCT00900419Recruiting
Check biomarkers during bronchoscopy in breathing and throat pre-cancer
This study looks at “biomarkers” (measurable signals in samples) taken during bronchoscopy or related procedures in people with severe airway pre-cancer or certain lung/throat cancers, and in healthy volunteers. The goal is to better understand what these biomarkers mean and how they might help with diagnosis, staging, or monitoring.
Aurora, ColoradoAges 21–90 - NCT00682032Recruiting
Beta-glucan for non-small cell lung cancer
This study tests whether beta-glucan, a supplement taken by mouth, can help people with non-small cell lung cancer. You may be able to join if you’re newly diagnosed (no recent treatment) and can safely take pills.
Louisville, KentuckyAges 18 years+ - NCT00897117Recruiting
Providing tumor tissue samples during lung cancer surgery
This study collects and analyzes tumor tissue from people with early-stage non-small cell lung cancer who are planning surgery. It may help researchers learn more about the cancer by studying samples taken at the time of your operation.
Nashville, TennesseeAges 18–120 - NCT01803542RecruitingPhase 2
Stereotactic radiation for lung metastases or early lung tumors
This trial studies a precise, high-dose radiation technique (SBRT) to treat tumors in the lungs. It may help control cancer in people who either have early-stage lung cancer that is not fully operable or have limited lung metastases from other cancers.
Toronto, OntarioAges 18 years+ - NCT01786590Recruiting
Ultrasound biopsy to stage lung cancer before SBRT
This trial looks at using a scope with an ultrasound tip (EBUS-TBNA) to take small tissue samples from lymph nodes to figure out the cancer stage before stereotactic body radiotherapy (SBRT). The goal is to help confirm how far the cancer has spread so SBRT can be planned appropriately.
Toronto, OntarioAges 18 years+ - NCT01720836RecruitingPhase 1/Phase 2
MUC1 peptide vaccine study for non-small cell lung cancer
This trial tests a vaccine made from a lung-cancer target (MUC1) to help your immune system recognize and fight the cancer. It is designed to measure immune response and safety, and it may help some people develop a stronger anti-cancer immune reaction.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT02133196RecruitingPhase 2
T-cell treatment for lung cancer that has spread
This Phase 2 study tests a T-cell–based immunotherapy for people with metastatic non-small cell lung cancer that has grown despite prior treatment. It may help your immune system recognize and fight your cancer using cells made from your tumor.
Bethesda, MarylandAges 18–72 - NCT02889666RecruitingPhase 1
Chemo plus surgery for recurrent lung cancer
This Phase 1 trial tests whether giving chemotherapy along with surgery is safe and tolerable for people with recurrent non-small cell lung cancer. It may help guide future treatment for cancer that has returned, especially if it has not spread to distant sites.
Changchun, JilinAges 18–75 - NCT02682667Recruiting
Providing blood samples for cancer immunotherapy research
This study collects and stores blood/tissue samples (called biospecimens) to support immunotherapy research at the cancer center. If you may qualify, your samples help researchers test new immune-based cancer treatments.
Bethesda, MarylandAges 18–120 - NCT02146170Recruiting
Blood and tissue collection study for several lung and chest cancers
This study collects tissue (and follows patients over time) to better understand the natural course of several types of chest cancers. It may help researchers learn which tests and treatments work best in different cancer types.
Bethesda, MarylandAges 18 years+ - NCT02511288Recruiting
Blood tests to monitor advanced lung cancer during care
This study checks whether “liquid biopsies” (blood tests) can help monitor advanced non-small-cell lung cancer. It looks at different patient groups based on timing and tumor features, aiming to make cancer tracking easier and less invasive.
AnnecyAges 18 years+ - NCT02570815RecruitingPhase 1
Fluorescent-guided robotic lung surgery for early lung cancer
This early-stage trial tests a robotic lung surgery that uses a special dye with near-infrared light to help the surgeon remove only the tumor area. If you have a small, early lung cancer, this approach may help improve accuracy while limiting how much lung is removed.
Hamilton, OntarioAges 18 years+ - NCT02838836Recruiting
Checking for cancer DNA and tumor cells in bodily samples
This study looks for cancer-related material in blood, urine, and sometimes bone marrow. It may help researchers understand how to detect cancer activity and track it over time using less invasive tests.
Columbia, MissouriAges 18 years+ - NCT02468024RecruitingPhase 3
Surgery or focused radiation for early lung cancer
This study compares two treatments—removing only part of the lung (sublobar resection) versus a focused radiation approach (stereotactic ablative radiotherapy)—for early-stage non-small cell lung cancer. It aims to see which option works better with fewer problems for the right patients.
La Jolla, CaliforniaAges 18 years+ - NCT02622581Recruiting
Lung cancer testing and treatment outcomes research study platform
This study collects information from adults with different types and stages of lung cancer to connect molecular test results with treatment choices and outcomes. It may help improve how lung cancer is diagnosed and managed by building a better understanding of what works for different patients.
OldenburgAges 18 years+ - NCT03193567RecruitingPhase 1
Cell therapy study for advanced lung cancer after treatment failure
This Phase 1 trial tests a powerful “killing cell” therapy for people with advanced non-small cell lung cancer whose cancer did not respond to standard chemotherapy and targeted drugs. The goal is to see if this new treatment is safe and may work after other treatments have failed.
ShanghaiAges 18–70 - NCT03042221Recruiting
Early re-biopsy to find why tumors survive targeted drugs
This study takes a small tumor sample early after starting targeted treatment (or uses blood if a biopsy isn’t possible) to look for clues—called biomarkers—about why some tumor cells survive. The results may help improve how future patients’ treatments are chosen for certain lung cancer gene mutations.
Aurora, ColoradoAges 18–85 - NCT03093688RecruitingPhase 1/Phase 2
Testing an immune-cell infusion for advanced solid tumors
This trial tests whether adding special immune cells (iNKT cells and CD8+ T cells) given by IV infusion can help treat advanced cancers. It mainly looks at safety first, and also checks whether the treatment can shrink or control cancer.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT03290534RecruitingPhase 2
Implantable radiation sheet for early-stage lung cancer
This Phase 2 study tests whether a permanently implanted, low-dose radiation “sheet” can be used to treat certain early-stage lung cancers. It may help shrink or control tumors while delivering radiation directly at the cancer site.
New York, New YorkAges 18 years+ - NCT05136846RecruitingPhase 1
Papaverine with chemoradiation for stage II–III lung cancer
This early-phase trial tests whether adding papaverine to standard chemoradiation can improve treatment for stage II–III non-small cell lung cancer (and some limited stage IV cases). It aims to see if the combination is safe and tolerable while targeting the cancer with radiation and chemotherapy.
Duarte, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for lung cancer, non-small cell?
- Yes. Clin2 currently lists 1,118 recruiting lung cancer, non-small cell studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lung cancer, non-small cell trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lung cancer, non-small cell trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Non Small Cell Lung Cancer
- Non-squamous Non-small Cell Lung Cancer
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Metastatic Non-squamous Non Small Cell Lung Cancer
- Squamous Cell Non-small Cell Lung Cancer
- Advanced Non-squamous Non-small-cell Lung Cancer
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.