Clinical trials
Major Depression Disorder clinical trials
Below are recruiting major depression disorder clinical trials, each written for real people, not researchers. We’re tracking 505 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06004115RecruitingPhase 4
Brain scanning study for depression and anxiety
This study uses brain scans (fMRI) to understand how people with both depression and anxiety respond to threat. If you have either or both conditions, participating could help researchers find better treatments.
Tulsa, OklahomaAges 18–65 - NCT07167849Recruiting
Digital help while waiting for therapy
This trial tests a brief digital program for people waiting for outpatient therapy. It aims to provide support during the wait and see if it helps improve mental health symptoms.
BernAges 18 years+ - NCT07221409Recruiting
Virtual reality to help cancer patients feel better during treatment
This trial tests whether using virtual reality can help reduce stress, anxiety, and other emotional symptoms in people being treated for cancer. Patients undergoing chemotherapy, bone marrow transplant, or CAR-T therapy may be eligible.
Jacksonville, FloridaAges 18–90 - NCT07745374Recruiting
Deep brain stimulation for bipolar depression
This study tests whether deep brain stimulation (DBS), a surgical treatment that uses electrical pulses to target specific brain areas, is safe and feasible for people with bipolar depression that hasn't improved with other treatments. It may offer a new option for those who have exhausted standard therapies.
New York, New YorkAges 22–70 - NCT06968013Recruiting
Sleep Therapy for Insomnia with Depression
This trial tests a sleep-focused treatment (WBT) for people who have both insomnia and depression. It aims to see if improving sleep can also help lift mood.
BeijingAges 8 years+ - NCT02122562RecruitingPhase 2
Ketamine treatment for depression that hasn’t responded to care
This Phase 2 study tests ketamine for people with major depression that hasn’t improved after at least one antidepressant. It aims to see whether ketamine can reduce depression symptoms during a current depressive episode.
Iowa City, IowaAges 18–55 - NCT07681492Recruiting
Depression, aging, and antidepressants: a belief study
This trial studies how depression and antidepressants affect belief updating in older adults. You may join if you are over 65, have major depression, and are starting a new antidepressant. The goal is to learn more about how your brain adjusts beliefs over time.
RennesAges 65 years+ - NCT06371352Recruiting
Brain stimulation for sleep and fatigue in depression
This study tests a noninvasive brain stimulation treatment (theta burst stimulation) to see if it can improve sleep, reduce daytime sleepiness, and ease fatigue in people with depression.
WarsawAges 18–65 - NCT07205003Recruiting
Artery stiffness test for memory disorders
This study looks at how the stiffness of your carotid artery (the main artery in your neck) relates to memory problems. It involves a brain MRI that you may already have planned, and results could help doctors better understand certain types of dementia.
RouenAges 70 years+ - NCT07362511Recruiting
Imagery rescripting for depression in primary care
This study tests a type of talk therapy called 'imagery rescripting' for people with depression in primary care. In this approach, you learn to change painful mental images into more helpful ones, which may reduce depressive feelings.
Amsterdam, North HollandAges 18–70 - NCT06719427RecruitingPhase 1
Brain waves study for depression treatment with rTMS
This study looks at brain wave patterns in people with depression who are receiving a type of brain stimulation called rTMS. It aims to understand how the brain changes during recovery, which may help improve future treatments.
North York, OntarioAges 18–80 - NCT07246044Recruiting
Brain stimulation for teens with bipolar depression targeting S1
This trial tests a non-invasive brain stimulation technique (HD-tDCS) to see if it can help teens with bipolar disorder who are currently in a depressive episode. It aims to find a new treatment option for adolescent bipolar depression.
Nanjing, JiangsuAges 12–18 - NCT07272213Recruiting
Thyroid hormone levels, mood, and sexual health in pregnancy
This study looks at how thyroid-stimulating hormone (TSH) levels during pregnancy are linked to depression, anxiety, and sexual function in pregnant women.
Istanbul, GaziosmanpaşaAges 18–45 - NCT06722781Recruiting
Online group therapy for common mental health conditions
This trial tests an online group therapy for people waiting for high intensity CBT. It aims to provide quicker support for conditions like depression, anxiety, and PTSD.
Doncaster, South YorkshireAges 17 years+ - NCT05570110RecruitingPhase 1/Phase 2
Enoxolone for depression, using body signals to track response
This study tests enoxolone, a medication related to licorice, in people with unipolar (non-bipolar) major depression. It also looks at your body “signals” (biomarkers) to see which ones match with whether treatment helps.
Marburg, HesseAges 18 years+ - NCT06392867Recruiting
Brain stimulation for stubborn depression: intensity study
This study tests a type of brain stimulation called TMS (transcranial magnetic stimulation) for people with depression that hasn't improved with at least two antidepressants. Researchers want to see if a faster version of TMS (theta-burst stimulation) helps reduce depression symptoms.
Hong KongAges 18–70 - NCT07639359RecruitingPhase 2
Ketamine for depression in intensive care patients
This study tests whether low-dose ketamine infusions can reduce depressive symptoms in patients staying in the intensive care unit for at least 6 days. Ketamine is a medication that may work differently than standard antidepressants and could provide faster relief.
Jacksonville, FloridaAges 18–99 - NCT07197138Recruiting
TMS for depression with long COVID
This trial tests whether accelerated TMS (a brain stimulation treatment) can help people with depression who also have long COVID. It may be an option if your depression hasn't improved enough with medication alone.
Munich, BavariaAges 18–65 - NCT06765057RecruitingPhase 2/Phase 3
Probiotics for Depression and Metabolic Health
This trial tests whether taking a probiotic supplement can improve both depression symptoms and metabolic health (like waist size, blood sugar, and cholesterol) in people with major depression. It may be a good fit if you are already on an antidepressant and have signs of metabolic syndrome.
Riyadh, Riyadh RegionAges 18–65 - NCT06319378RecruitingPhase 2
Psilocybin for cancer-related depression
This trial tests whether a single dose of psilocybin, a psychedelic medication, can safely and effectively treat major depression in people with cancer. If you have cancer and have been feeling depressed for at least a month, you may qualify.
Gothenburg, GöteborgAges 20–80 - NCT06907654Recruiting
Couples' affect and relationships study
This study looks at how couples' moods and relationships interact over time. You and your partner will use a smartphone app and respond to daily text surveys for 3 weeks.
Madison, WisconsinAges 18 years+ - NCT05388461Recruiting
Follow-up after ECT for major depression
This study checks how well electroconvulsive therapy (ECT) works for people with major depression right after treatment and again 6 months later. You may be able to take part if you had ECT for major depression at the specified hospitals and agree to be included in a neurostimulation follow-up registry.
BergenAges 18 years+ - NCT05575960Recruiting
Therapy for depression in teens and young adults
This study tests interpersonal psychotherapy, a structured talking therapy, to help teens and young adults with major depression. You might benefit from regular sessions focused on relationships and day-to-day stress.
NorrköpingAges 15–18 - NCT05964192Recruiting
Neuro test help after rTMS for treatment-resistant depression
This study checks whether a set of brain and hormone-related blood/marker tests can help predict or improve how well rTMS works for depression. It’s for adults whose depression has not responded to two antidepressants.
Rouffach, AlsaceAges 18–65
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Common questions
- Are there clinical trials for major depression disorder?
- Yes. Clin2 currently lists 505 recruiting major depression disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.