Clinical trials
Major Depression Disorder clinical trials
Below are recruiting major depression disorder clinical trials, each written for real people, not researchers. We’re tracking 505 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05466851Recruiting
Study testing anxiety and depression biology and therapy markers
This study looks at “biopsychosocial markers” (biological, psychological, and social signs) in people with major depression and/or anxiety. It aims to understand what changes with treatment and how those changes connect to symptoms like anxiety and depression.
New York, New YorkAges 18–65 - NCT07259109Enrolling by invitation
Understanding mental health in teens
This study looks at how mental health conditions affect teenagers aged 12 to 20. It may help doctors better understand and support teens with these challenges.
Messina, ItalyAges 12–20 - NCT07653113Enrolling by invitation
Music therapy for depression and anxiety in men
This trial tests whether a special type of music therapy, based on Chinese five-element theory, can help men with depression and anxiety. It is designed for male inpatients who have not taken antidepressants recently.
Shanxi, ShanxiAges 18–44 - NCT05097586Recruiting
At-home brain stimulation trial for depression during pregnancy
This trial tests whether doing at-home, noninvasive brain stimulation (tDCS) can reduce depression symptoms during pregnancy. It may help people who are in a depressive episode but prefer not to take antidepressant medication right now.
Toronto, OntarioAges 18 years+ - NCT07380451Recruiting
Personalized therapy for depression with childhood trauma
This trial tests a flexible, personalized therapy program for adults with depression who also have a history of childhood trauma and personality challenges. It aims to see if this approach helps more than standard care, and you'll receive weekly therapy from a community clinic in Chile.
SantiagoAges 18–65 - NCT06370988Recruiting
Theta-burst stimulation for bipolar depression
This study tests a type of brain stimulation (theta-burst TMS) to see if it helps improve depression in people with bipolar disorder. It might be a good option if you have tried medication but still feel depressed.
Toronto, OntarioAges 18–65 - NCT06668571RecruitingPhase 2
Ketamine for treatment-resistant depression
This study tests if intravenous ketamine can help people with treatment-resistant depression who haven't found relief from at least two other treatments. If you qualify, you'll receive ketamine infusions to see if it improves your mood.
Rochester, MinnesotaAges 18–65 - NCT07412132RecruitingPhase 3
Testing lacosamide for hard-to-treat bipolar depression
This study tests if a medication called lacosamide can help people with bipolar depression that has not improved with at least two other treatments. It's for those with moderate to severe depression in bipolar I or II.
São Paulo, São PauloAges 18–65 - NCT05698589Recruiting
Therapy program to reduce self-stigma in mental health
This study looks at how a program may help people with long-term mental health conditions feel less shame about their diagnosis (self-stigma). It is meant for adults who are stable enough to participate and who speak French.
BordeauxAges 18 years+ - NCT05934474Recruiting
Study collects blood to learn about inflammation in mental illness
This study collects biological samples to better understand how “inflammation” in the body may relate to certain mental health conditions. Your results may help doctors learn more about causes and future treatments, even if the study does not give a new drug.
NantesAges 18 years+ - NCT07120711Recruiting
Sleep apnea, thinking, and mood study for kids and adults
This study looks at how sleep apnea affects thinking and mood by checking certain proteins in the body. They want to see if these proteins can help predict or explain changes in memory, focus, or emotions.
ShanghaiAges 5 years+ - NCT05569018Recruiting
Spanish blended group therapy for anxiety and depression symptoms
This study tests whether a group therapy program delivered in both online and in-person formats can reduce emotional symptoms like anxiety and depression. If you qualify, you may be assigned to receive this structured group treatment during the study period.
Castellon, CastellónAges 18 years+ - NCT07211217Recruiting
Time-restricted eating for bipolar depression
This study tests if eating only during a specific daily window can help with weight loss and mood in people with bipolar disorder who are currently depressed and overweight.
Boston, MassachusettsAges 18–65 - NCT07007247Enrolling by invitation
Digital aftercare for teens with depression after hospital discharge
This pilot study tests a digital program to support adolescents aged 12–17 with depression after they leave the hospital. It aims to help prevent relapse and improve well-being using a smartphone, tablet, or computer.
HamburgAges 12–17 - NCT07269964Recruiting
At-home brain stimulation for depression maintenance
This trial tests if a gentle, at-home brain stimulation treatment (tDCS) can help prevent depression from returning after successful initial treatment with esketamine, rTMS, or ECT. It is for people who are stable but want to stay well.
München, BavariaAges 18 years+ - NCT07281352RecruitingPhase 1/Phase 2
Psilocybin therapy for depression
This study tests if psilocybin (a psychedelic) combined with cognitive behavioral therapy (CBT) can help people with major depression. You would receive the psilocybin in a supervised setting and have talk therapy before and after.
Los Angeles, CaliforniaAges 21–60 - NCT06580145RecruitingPhase 2
Leucine for midlife depression
This study tests whether leucine, a common amino acid supplement, can help treat moderate to severe depression in people aged 40–65. You'll have blood tests, an MRI, and a lumbar puncture to measure changes in your brain.
Atlanta, GeorgiaAges 35–65 - NCT06824415Recruiting
Sleep TMS for depression
This trial tests whether a type of brain stimulation called TMS (transcranial magnetic stimulation), given during sleep, can improve depression. It's for adults who have not gotten enough relief from antidepressant medication.
Stanford, CaliforniaAges 18–65 - NCT07140575Recruiting
Brain stimulation for teens with depression in the hospital
This trial tests if a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help teens with depression who haven't gotten enough relief from therapy or medication. It's designed for youth who are currently in the hospital or planning to be admitted.
Toronto, OntarioAges 14–19 - NCT07560878RecruitingEarly Phase 1
Brain Stimulation and Medication Study for Depression
This early-stage study tests a type of magnetic brain stimulation called theta burst stimulation combined with study medications to help treat moderate to severe depression. Researchers want to understand how this combination affects brain communication and may help reduce depressive symptoms.
Belmont, MassachusettsAges 18 years+ - NCT06508710RecruitingPhase 3
Ketamine plus venlafaxine for severe depression
This trial tests whether adding ketamine to the antidepressant venlafaxine helps relieve severe depression faster than venlafaxine alone. If you are hospitalized for a serious depression and you meet safety criteria, you may be eligible.
Le Kremlin-Bicêtre, FranceAges 18–65 - NCT07716098RecruitingPhase 3
Esketamine nasal spray for treatment-resistant depression
This study tests esketamine nasal spray versus a placebo in adults with depression that has not improved after trying at least two other antidepressants. It aims to see if the spray can help when standard pills have not worked.
Skokie, IllinoisAges 18 years+ - NCT06187454Recruiting
Brain stimulation for depression
This trial tests if a gentle brain stimulation called tDCS can help people with depression who haven't gotten better from antidepressants. It uses a small current on the scalp to try to improve mood.
TaipeiAges 60 years+ - NCT06898606RecruitingPhase 1/Phase 2
Psilocybin mushrooms with or without Prozac for stubborn depression
This study tests whether a dose of psilocybin (the active ingredient in magic mushrooms) can help treat depression that hasn't improved with standard antidepressants. Some participants will also take the antidepressant fluoxetine (Prozac) to see if it changes the effects.
Foz do Iguaçu, ParanáAges 25–65
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Common questions
- Are there clinical trials for major depression disorder?
- Yes. Clin2 currently lists 505 recruiting major depression disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.