Clinical trials
Major Depression Disorder clinical trials
Below are recruiting major depression disorder clinical trials, each written for real people, not researchers. We’re tracking 508 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06213324RecruitingPhase 4
Ketamine's effects on brain circuits in depression
This trial studies how ketamine affects brain circuits in people with depression compared to healthy volunteers. It involves a single infusion of ketamine and brain scans before and after.
New York, New YorkAges 18–65 - NCT06223880RecruitingPhase 4
AXS-05 vs Bupropion to prevent depression relapse
This study tests whether a new drug called AXS-05 can prevent depression from coming back, compared to an older drug called bupropion. If you have major depression and are at risk of relapse, this trial may help you stay well.
Bellflower, CaliforniaAges 18–65 - NCT06234176Recruiting
Psychomotor therapy for quality of life in depression
This study tests whether a special type of therapy called psychomotor therapy (which focuses on the connection between your mind and body) can improve quality of life for people with severe depression. You’ll continue your usual care while also receiving this therapy, and the researchers will track how your mood and daily life change over time.
LimogesAges 20–60 - NCT06274112Recruiting
Using brain stimulation to understand social motivation in depression or social anxiety
This study uses transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, to explore how the brain processes social motivation in people with major depressive disorder or social anxiety disorder. Understanding these brain processes could help develop new treatments for social avoidance.
Auburn, AlabamaAges 25–50 - NCT06309472RecruitingPhase 2
Mirtazapine for depression in inflammatory bowel disease
This trial tests whether the antidepressant mirtazapine can help people with Crohn's disease or ulcerative colitis who also have moderate or severe depression. If you are at least 18 and your IBD treatment is stable, this study could see if this medication improves your mood without interfering with your gut condition.
LondonAges 18–125 - NCT06311136Recruiting
Mood support through a smartphone app
This trial tests a smartphone-based program designed to help people manage their emotions in the moment. It may be especially helpful if you currently have mild to moderate depression.
HeidelbergAges 18–65 - NCT06323785Recruiting
Whole-body hyperthermia for depression
This trial tests whether safely raising your body temperature (whole-body hyperthermia) can help relieve depression. It's for people with moderate to severe major depression who are not currently taking antidepressants.
ZurichAges 18–65 - NCT07696871RecruitingPhase 1/Phase 2
Cannabidiol oil for treatment-resistant depression
This trial tests if cannabidiol (CBD) oil can help people with major depression that has not improved with standard antidepressants. You will take CBD oil or a placebo while continuing your current antidepressant treatment to see if it improves your symptoms.
Tubarão, Santa CatarinaAges 18–69 - NCT06746155Recruiting
Predictors of relapse in major depression
This study looks at adults with major depressive disorder who have responded to treatment, to find out what might predict a relapse. You will wear a wrist activity monitor and complete questionnaires.
Calgary, AlbertaAges 18–70 - NCT06345859RecruitingPhase 2
Brain and emotion study for young adults with or without depression history
This study looks at how the brain regulates mood and body signals in young adults ages 18-27. It includes people who have had depression in the past but are now well, as well as healthy volunteers with no psychiatric history.
Los Angeles, CaliforniaAges 18–27 - NCT06376734RecruitingPhase 2
TMS for depression, anxiety, OCD, or schizophrenia
This study tests whether a brain stimulation technique called TMS can help people with depression, anxiety, OCD, or schizophrenia. It aims to find better ways to target the treatment for each person's specific needs.
Sunnyvale, CaliforniaAges 18–65 - NCT06384209Recruiting
Friendship Bench Plus for Depression
This study tests whether a structured talk therapy program called the Friendship Bench can help adults with moderate to severe depression. You will have conversations with trained lay counselors who guide you through problem-solving techniques.
HarareAges 18 years+ - NCT06396312Recruiting
Predicting lithium response in difficult depression
This study looks at how to predict which people with hard-to-treat depression will benefit from adding lithium to their antidepressant. If you have treatment-resistant depression and are considering lithium, this trial may help find the best treatment for you.
Munich, BavariaAges 18 years+ - NCT06398496Recruiting
Exercise, gut health, mood in depression
This trial studies whether a 12-week exercise program can improve gut bacteria, mood, and thinking in people with depression. It may help if you are looking for a non-medication way to support your mental health.
Cork, Cork CountyAges 18–59 - NCT06398561Recruiting
Peer support for major depression
This study tests whether talking with a trained peer supporter can help people with major depression. You would meet with someone who has been through similar challenges and learn ways to feel better.
Palma de Mallorca, Balearic IslandsAges 18–85 - NCT06404320Recruiting
Exercise program for treatment-resistant depression
This study tests whether a physical activity program can help adults whose depression hasn’t improved after trying at least two antidepressants. If you’re sedentary, between 18 and 65, and have treatment-resistant depression, this program might offer a new way to feel better through exercise.
Toronto, OntarioAges 18–65 - NCT06409325Recruiting
Magnetic Seizure vs. Electric Shock for Depression
This study compares two brain stimulation treatments—Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT)—to see which works better for severe depression. If you are on a stable antidepressant and haven't had recent brain stimulation, this trial may be an option for you.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06410599RecruitingPhase 2
Medication boost for tough-to-treat chronic depression
This trial tests a new medication added to your current treatment for chronic depression that hasn't gotten better with at least two antidepressants and 12 therapy sessions. It might help when standard treatments aren't enough.
Tübingen, Baden-WürtembergAges 18–64 - NCT06412315Recruiting
Brain scan and citalopram study for healthy volunteers
This study uses a powerful 7T MRI scanner to look at a part of the brain called the amygdala, and tests how the drug citalopram affects brain activity during emotional tasks. It may help researchers understand more about mood disorders.
Oxford, OxfordshireAges 18–40 - NCT06417437RecruitingPhase 4
Brain-computer interface test for depression
This trial tests a non-invasive brain-computer interface (BCI) to help people with depression. It may be a good fit for teenagers and adults who are right-handed, Han Chinese, and have moderate to severe depression without other major health problems.
Shanghai, Shanghai MunicipalityAges 12 years+ - NCT06439043Recruiting
Testing adapted EMDR for depression online vs in person
This study looks at a talking therapy called EMDR adapted for depression. It compares doing the sessions online versus face-to-face to see which works better.
KohatAges 20–50 - NCT06442423RecruitingPhase 1
Psilocybin study for people with psychiatric symptoms
This trial tests if psilocybin, a substance found in certain mushrooms, can help people with various mental health symptoms that affect daily life. You would take a single dose in a supervised setting and be monitored for changes in your mood and well-being.
New Haven, ConnecticutAges 18 years+ - NCT06443216Recruiting
Sleep modulation to treat depression
This study tests whether adjusting sleep patterns can help treat depression. It uses gentle brain stimulation (tDCS or TMS) and sound to study sleep's effect on mood.
GenevaAges 30–60 - NCT06450704Recruiting
Exercise for depression: brain and body health
This trial tests if a 12-week exercise program can reduce inflammation and improve brain function in people with depression. It's for adults currently taking antidepressant medication and looking for extra help through physical activity.
Alcalá de Henares, MadridAges 18–65
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Common questions
- Are there clinical trials for major depression disorder?
- Yes. Clin2 currently lists 508 recruiting major depression disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.