Clinical trials
Major Depression clinical trials
Below are recruiting major depression clinical trials, each written for real people, not researchers. We’re tracking 453 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06390462Recruiting
Counseling for teens in school-based primary care
This study tests a brief counseling approach called Interpersonal Counseling for Adolescents (IPC-A) in school settings. It aims to help teens with emotional or social challenges before they become more serious, and it's designed for those who aren't already in mental health treatment.
HämeenlinnaAges 13–16 - NCT06392867Recruiting
Brain stimulation for stubborn depression: intensity study
This study tests a type of brain stimulation called TMS (transcranial magnetic stimulation) for people with depression that hasn't improved with at least two antidepressants. Researchers want to see if a faster version of TMS (theta-burst stimulation) helps reduce depression symptoms.
Hong KongAges 18–70 - NCT06983405Recruiting
Physical therapy for depression and quality of life pilot
This study is testing whether adding physical therapy to your usual depression care can improve your quality of life while you are in the hospital. If you are an adult admitted to the psychiatry unit with major depression, you may be able to join.
Zaragoza, AragonAges 18 years+ - NCT07193901RecruitingPhase 2
Nasal spray for depression with suicidal thoughts
This trial tests an experimental nasal spray for people with major depression who are currently having suicidal thoughts. It aims to see if the spray can quickly reduce depression and suicidal feelings.
BeijingAges 18–64 - NCT07462013Recruiting
Lifestyle changes to prevent memory loss with depression
This study tests if healthy lifestyle changes can protect memory and thinking skills in people with depression who have no or mild memory problems.
Taichung, TaichungAges 50–80 - NCT04581902Recruiting
Study blood and brain markers in moderate to severe depression
This study looks at changes in depression “markers” to understand what treatments help and why. You’ll have non-invasive brain stimulation and scans before and after treatment, over about 8 weeks.
San Francisco, CaliforniaAges 18–70 - NCT06402955RecruitingPhase 2
Imaging depression in Parkinson's disease
This study uses brain imaging (PET scans) to understand depression in people with Parkinson's disease. It may also test a depression treatment called ketamine, but the main goal is to see how the brain changes with depression.
New Haven, ConnecticutAges 40–80 - NCT06537921Recruiting
Testing minocycline for depression with obesity
This trial tests whether adding the antibiotic minocycline to your current antidepressant helps people with both depression and obesity. It aims to see if reducing inflammation can improve mood.
LondonAges 18–65 - NCT07554755Recruiting
Transcranial Stimulation for Teen Depression with Self-Injury
This trial tests a non-invasive brain stimulation treatment (TIS) for teenagers aged 12–22 with depression who injure themselves without wanting to die. The goal is to reduce depression symptoms and self-injury urges.
Hefei, AnhuiAges 12–22 - NCT06512324Enrolling by invitation
TMS with remote viewing for depression and anxiety
This trial tests whether adding 'remote viewing' (a technique where a person tries to perceive a distant target) to standard TMS brain stimulation can improve depression and anxiety symptoms. It is for people already getting TMS and who can attend weekly visits.
Encinitas, CaliforniaAges 12 years+ - NCT06136546RecruitingPhase 2
Infliximab for depression with cognitive problems
This trial tests if a medicine called infliximab, given through an IV, can help improve thinking and memory problems in people with moderate to severe depression who also have high inflammation levels. It aims to see if lowering inflammation can ease both mood and cognitive symptoms.
Boston, MassachusettsAges 25–50 - NCT04972136Recruiting
Brain stimulation treatment for depression in young adults with autism
This trial studies a noninvasive brain stimulation (rTMS) to help reduce depression symptoms in young adults who have autism. It aims to find out if this treatment can improve mood and daily functioning without requiring recent changes to medications.
Toronto, OntarioAges 16–35 - NCT05866575Recruiting
Brain-modeling trial to predict depression treatment response
This trial uses computer modeling based on brain measurements to try to predict which depression treatment will work for you. It may help match you with the most effective option faster by understanding your motivation-related brain patterns.
La Tronche, IsèreAges 18 years+ - NCT07127913Recruiting
Closed-loop brain stimulation for hard-to-treat bipolar depression
This trial tests a closed-loop deep brain stimulation system for people with bipolar II disorder whose depression has not responded to standard treatments. The device sends targeted electrical pulses to the brain based on real-time activity, aiming to reduce depression symptoms.
San Francisco, CaliforniaAges 22–70 - NCT06821646Enrolling by invitation
Brain responses in depression and autism with TMS and EEG
This study uses brain stimulation (TMS) and brain wave recording (EEG) to understand how the brain works in people with autism, depression, or both. It may help find better ways to treat these conditions.
TaipeiAges 20–50 - NCT06656416RecruitingPhase 2
ALTO-100 for bipolar depression
This trial tests an investigational drug called ALTO-100 in people with bipolar I or II who are currently experiencing depression. It looks at whether this new medicine can help improve depression symptoms when taken alongside your usual mood stabilizer or antipsychotic medication.
Chandler, ArizonaAges 18–70 - NCT07294924Recruiting
Predicting depression treatment response with brain imaging
This study uses a special brain-imaging headband to see if it can predict how well people with depression respond to a treatment called accelerated rTMS (a type of brain stimulation). It compares results with people who do not have depression.
Los Angeles, CaliforniaAges 18–75 - NCT04191811Recruiting
Using brain signals to predict CBT success for mood or sleep issues
This study tests whether brain measurements can help predict who will benefit from a type of talk therapy called CBT (cognitive behavioral therapy). If you have depression, social anxiety, or insomnia, your brain “response variability” may be used to personalize or improve treatment planning.
Huddinge, Stockholm CountyAges 18 years+ - NCT06050070Recruiting
Using Real-Time Brain Imaging to Help Depression
This study tests whether real-time brain imaging (fMRI) can help people with depression learn to change their brain activity. You will receive feedback on your brain signals while thinking positive or neutral thoughts.
Ann Arbor, MichiganAges 18–55 - NCT06748209RecruitingPhase 4
Mobile TMS for treatment-resistant depression
This trial tests if delivering transcranial magnetic stimulation (TMS) through a mobile unit can help people with depression that hasn't improved with other treatments.
Charleston, South CarolinaAges 22–80 - NCT05671419Recruiting
Mindful self-compassion training for anxiety and depression
This study tests whether a structured “mindful self-compassion” program can reduce symptoms of anxiety disorders or depression. It’s meant to help by improving how you relate to yourself during difficult thoughts and feelings.
Washington D.C., District of ColumbiaAges 18–75 - NCT06376734RecruitingPhase 2
TMS for depression, anxiety, OCD, or schizophrenia
This study tests whether a brain stimulation technique called TMS can help people with depression, anxiety, OCD, or schizophrenia. It aims to find better ways to target the treatment for each person's specific needs.
Sunnyvale, CaliforniaAges 18–65 - NCT07216404RecruitingPhase 2
Psilocybin therapy for depression in lung cancer patients
This trial tests whether a psychedelic-assisted therapy can help treat major depression in people with non-small cell lung cancer. If you have moderate to severe depression and are receiving cancer treatment, you may be able to join.
Columbus, OhioAges 18 years+ - NCT07454070Recruiting
Testing ear nerve stimulation for depression after a heart attack
This trial tests if a gentle, non-invasive ear stimulation device can help relieve depression in people who have had a heart attack and a stent placed. It aims to offer a drug-free option for those who choose not to take antidepressants or see a therapist.
Xi'an, ShaanxiAges 18 years+
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Common questions
- Are there clinical trials for major depression?
- Yes. Clin2 currently lists 453 recruiting major depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.