Clinical trials
Major Depressive Episode clinical trials
Below are recruiting major depressive episode clinical trials, each written for real people, not researchers. We’re tracking 201 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07140575Recruiting
Brain stimulation for teens with depression in the hospital
This trial tests if a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help teens with depression who haven't gotten enough relief from therapy or medication. It's designed for youth who are currently in the hospital or planning to be admitted.
Toronto, OntarioAges 14–19 - NCT07212465Recruiting
Brain stimulation for depression in older adults
This study tests a new, faster brain stimulation method for depression in adults aged 60-85 who haven't improved with medication. The treatment targets a part of the brain linked to mood and may offer relief for those who have not found other treatments effective.
Toronto, OntarioAges 60–85 - NCT07230990Recruiting
Brain Stimulation Study for Depression
This study uses a special type of brain stimulation (rTMS, which uses magnetic pulses) to treat depression. It focuses on part of the brain called the orbitofrontal cortex and aims to understand how stimulating it helps improve mood.
Boston, MassachusettsAges 18–65 - NCT07242105Recruiting
Improving brain activity in depression
This study tests if a type of brain stimulation (TMS) can improve brain function in people with depression. It also includes a small group of epilepsy patients who are already having brain monitoring. The goal is to find new ways to treat depression by targeting specific brain areas.
Iowa City, CaliforniaAges 18–65 - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
Bentonville, ArkansasAges 18–75 - NCT07377682Recruiting
Trazodone for depression with mild memory problems
This study tests how well the antidepressant trazodone works in older adults with major depression and mild cognitive impairment (early memory or thinking problems). It looks at real-world results in people starting this treatment.
Lodz, PolandAges 55 years+ - NCT07490353RecruitingPhase 1
Can psilocybin help treat loss of pleasure?
This trial tests if psilocybin, a psychedelic substance, can improve the ability to feel pleasure (anhedonia) in people with depression who are not taking antidepressants. It also includes healthy volunteers as a comparison group.
Vienna, State of ViennaAges 18–55 - NCT07539805RecruitingPhase 2
Sertraline Plus Probiotic for Teen Depression
This study tests whether combining sertraline (an antidepressant) with a specific probiotic called Lactobacillus crispatus can safely and effectively treat depression in teenagers. The probiotic may help by improving gut health, which researchers believe could support mental health.
Longgang, Chongqing MunicipalityAges 12–18 - NCT07619092Recruiting
Flumazenil to reverse sedation during depression treatment
This trial tests whether flumazenil (a medication that reverses sedation from anti-anxiety drugs) can safely help patients wake up faster after electroconvulsive therapy (ECT), a treatment for severe depression. The goal is to see if it improves recovery time without causing problems.
Frederiksberg, Capital RegionAges 18 years+ - NCT07645157RecruitingPhase 2
Sertraline and Probiotics for Teen Depression
This study tests whether combining an antidepressant medication (sertraline) with special bacteria supplements (probiotics) can help treat depression in teenagers ages 12–18. Researchers believe the probiotics may help the medication work better by improving gut health.
Chongqing, YuzhongAges 12–18 - NCT02994433RecruitingPhase 1
Testing nitrous oxide for depression brain circuit activity
This early study tests whether nitrous oxide, aimed at specific brain circuits, can change depression-related brain activity. It is mainly for adults with major depression or treatment-resistant depression, and includes brain imaging during the study.
St Louis, MissouriAges 18–65 - NCT04057378RecruitingPhase 4
Testing the best electrical settings for ECT for depression
This trial studies which electrical “pulse settings” work best during electroconvulsive therapy (ECT) for people with depression. It may help doctors personalize ECT so the treatment is safer and works as well as possible for you.
ÖrebroAges 18 years+ - NCT05573074Recruiting
Light treatment trial for brain blood flow in depression
This study tests whether shining near-infrared light through the head can change brain blood flow and reduce depression symptoms. If you have major depression, you may be offered a non-drug, device-based approach to see how well it helps.
Boston, MassachusettsAges 18–65 - NCT05786066RecruitingPhase 2
Test whether blocking AMPA changes ketamine’s suicide relief
This study looks at whether an “AMPA receptor blocker” changes how ketamine affects suicidal thoughts in people with depression that hasn’t improved with usual treatments. If you qualify, you may receive ketamine and the study medicine, while continuing your regular mental health care.
West Haven, ConnecticutAges 21–65 - NCT06054321Recruiting
Depression medication study for adults 19 to 65
This study tests a new way of choosing antidepressants for people with major depression. It's designed for adults aged 19–65 who have moderate to severe depression and are either starting a new antidepressant or have been off psychiatric meds for at least a month.
GwangjuAges 19–65 - NCT06223880RecruitingPhase 4
AXS-05 vs Bupropion to prevent depression relapse
This study tests whether a new drug called AXS-05 can prevent depression from coming back, compared to an older drug called bupropion. If you have major depression and are at risk of relapse, this trial may help you stay well.
Bellflower, CaliforniaAges 18–65 - NCT06311136Recruiting
Mood support through a smartphone app
This trial tests a smartphone-based program designed to help people manage their emotions in the moment. It may be especially helpful if you currently have mild to moderate depression.
HeidelbergAges 18–65 - NCT05598034Recruiting
Brain stimulation with tDCS for moderate depression
This study tests whether a noninvasive brain stimulation called tDCS can improve depression symptoms. It also uses MRI scans, aiming to understand how brain changes may relate to symptom improvement.
Los Angeles, CaliforniaAges 20–55 - NCT05745194Recruiting
Mediterranean diet study for depression with inflammation
This study tests whether a Mediterranean-style diet can improve depression symptoms in people who have depression and higher inflammation in their blood. It may help by targeting nutrition-related inflammation that can worsen mood for some people.
Loures, Lisbon DistrictAges 18–70 - NCT06309472RecruitingPhase 2
Mirtazapine for depression in inflammatory bowel disease
This trial tests whether the antidepressant mirtazapine can help people with Crohn's disease or ulcerative colitis who also have moderate or severe depression. If you are at least 18 and your IBD treatment is stable, this study could see if this medication improves your mood without interfering with your gut condition.
LondonAges 18–125 - NCT06452849Recruiting
Brain magnetic stimulation treatment for teen depression
This trial is testing a non-invasive treatment that uses safe magnetic pulses to stimulate specific parts of the brain in teens with moderate to severe depression. The goal is to see if this can help improve mood without medication changes.
Shanghai, Shanghai MunicipalityAges 14–18 - NCT06972368Recruiting
Home brain stimulation for depression in borderline personality disorder
This trial tests whether a gentle brain stimulation device (tDCS) used at home can help with depression in people with borderline personality disorder. If you have BPD and current depression, you may be able to participate from home using your smartphone.
Montreal, QuebecAges 18–65 - NCT06389175Enrolling by invitation
Non-invasive ear stimulation for depression
This study uses a gentle, non-invasive device that stimulates the vagus nerve in your ear to see if it can improve how your stomach and brain communicate, which may help with depression symptoms.
BonnAges 18–55 - NCT06572683Enrolling by invitation
Novel TMS for hard-to-treat depression
This trial tests a new type of transcranial magnetic stimulation (TMS) for people with severe depression that hasn't improved with multiple medications or therapy. It uses a different frequency pattern to target brain circuits.
Los Angeles, CaliforniaAges 21–75
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Common questions
- Are there clinical trials for major depressive episode?
- Yes. Clin2 currently lists 201 recruiting major depressive episode studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depressive episode trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depressive episode trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.