Clinical trials
Major Depressive Episode clinical trials
Below are recruiting major depressive episode clinical trials, each written for real people, not researchers. We’re tracking 195 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07810023Enrolling by invitation
Ketamine shot for suicidal distress in the emergency room
This study tests whether a single ketamine injection can quickly reduce suicidal thoughts in people waiting to be admitted to the psychiatric unit. Ketamine is a fast-acting medication that may help calm the mind during a crisis.
Evanston, IllinoisAges 18 years+ - NCT07694076Recruiting
Real-time brain feedback for depression
This trial uses a powerful MRI scanner to give you real-time feedback on brain activity linked to depression. You will learn to regulate that activity, which may reduce symptoms.
OxfordAges 18–65 - NCT05813093Recruiting
Brain stimulation and brain scans for hard-to-treat depression
This trial tests an alternating combination of brain stimulation and brain imaging to see if it helps people with depression that hasn’t improved with usual treatments. The goal is to find a safer, more effective approach for people whose depression has been very difficult to treat.
Toronto, OntarioAges 20–65 - NCT07645157RecruitingPhase 2
Sertraline and Probiotics for Teen Depression
This study tests whether combining an antidepressant medication (sertraline) with special bacteria supplements (probiotics) can help treat depression in teenagers ages 12–18. Researchers believe the probiotics may help the medication work better by improving gut health.
Chongqing, YuzhongAges 12–18 - NCT07619092Recruiting
Flumazenil to reverse sedation during depression treatment
This trial tests whether flumazenil (a medication that reverses sedation from anti-anxiety drugs) can safely help patients wake up faster after electroconvulsive therapy (ECT), a treatment for severe depression. The goal is to see if it improves recovery time without causing problems.
Frederiksberg, Capital RegionAges 18 years+ - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
Phoenix, ArizonaAges 18–75 - NCT06729541Recruiting
Precision treatments for common mental disorders
This study is developing more personalized treatments for schizophrenia, depression, or bipolar disorder. It may help find the best treatment approach for your specific situation.
Beijing, Beijing MunicipalityAges 18–65 - NCT07539805RecruitingPhase 2
Sertraline Plus Probiotic for Teen Depression
This study tests whether combining sertraline (an antidepressant) with a specific probiotic called Lactobacillus crispatus can safely and effectively treat depression in teenagers. The probiotic may help by improving gut health, which researchers believe could support mental health.
Longgang, Chongqing MunicipalityAges 12–18 - NCT07490353RecruitingPhase 1
Can psilocybin help treat loss of pleasure?
This trial tests if psilocybin, a psychedelic substance, can improve the ability to feel pleasure (anhedonia) in people with depression who are not taking antidepressants. It also includes healthy volunteers as a comparison group.
Vienna, State of ViennaAges 18–55 - NCT06234176Recruiting
Psychomotor therapy for quality of life in depression
This study tests whether a special type of therapy called psychomotor therapy (which focuses on the connection between your mind and body) can improve quality of life for people with severe depression. You’ll continue your usual care while also receiving this therapy, and the researchers will track how your mood and daily life change over time.
LimogesAges 20–60 - NCT07377682Recruiting
Trazodone for depression with mild memory problems
This study tests how well the antidepressant trazodone works in older adults with major depression and mild cognitive impairment (early memory or thinking problems). It looks at real-world results in people starting this treatment.
Lodz, PolandAges 55 years+ - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
Bentonville, ArkansasAges 18–75 - NCT07281352RecruitingPhase 1/Phase 2
Psilocybin therapy for depression
This study tests if psilocybin (a psychedelic) combined with cognitive behavioral therapy (CBT) can help people with major depression. You would receive the psilocybin in a supervised setting and have talk therapy before and after.
Los Angeles, CaliforniaAges 21–60 - NCT06410599RecruitingPhase 2
Medication boost for tough-to-treat chronic depression
This trial tests a new medication added to your current treatment for chronic depression that hasn't gotten better with at least two antidepressants and 12 therapy sessions. It might help when standard treatments aren't enough.
Tübingen, Baden-WürtembergAges 18–64 - NCT07242105Recruiting
Improving brain activity in depression
This study tests if a type of brain stimulation (TMS) can improve brain function in people with depression. It also includes a small group of epilepsy patients who are already having brain monitoring. The goal is to find new ways to treat depression by targeting specific brain areas.
Iowa City, CaliforniaAges 18–65 - NCT07230990Recruiting
Brain Stimulation Study for Depression
This study uses a special type of brain stimulation (rTMS, which uses magnetic pulses) to treat depression. It focuses on part of the brain called the orbitofrontal cortex and aims to understand how stimulating it helps improve mood.
Boston, MassachusettsAges 18–65 - NCT07226232RecruitingPhase 3
Psilocybin for veterans with treatment-resistant depression
This study tests whether psilocybin (a psychedelic substance) can help veterans with depression that hasn't improved with standard treatments.
Birmingham, AlabamaAges 18–75 - NCT07212465Recruiting
Brain stimulation for depression in older adults
This study tests a new, faster brain stimulation method for depression in adults aged 60-85 who haven't improved with medication. The treatment targets a part of the brain linked to mood and may offer relief for those who have not found other treatments effective.
Toronto, OntarioAges 60–85 - NCT05295888Recruiting
Temporal Interference treatment for moderate-to-severe depression
This study tests temporal interference (TI), a brain stimulation method, to treat depression. You may be a candidate if you have moderate-to-severe major depression and can follow the study schedule and safety screening.
Toronto, OntarioAges 18–65 - NCT06781593Recruiting
Light therapy and CPAP for depression with sleep apnea
This study tests if adding bright light therapy to standard CPAP treatment helps improve mood in people who have both depression and sleep apnea. You may benefit if your depression and sleep apnea are both being treated.
Bron, FranceAges 18 years+ - NCT06404320Recruiting
Exercise program for treatment-resistant depression
This study tests whether a physical activity program can help adults whose depression hasn’t improved after trying at least two antidepressants. If you’re sedentary, between 18 and 65, and have treatment-resistant depression, this program might offer a new way to feel better through exercise.
Toronto, OntarioAges 18–65 - NCT07140575Recruiting
Brain stimulation for teens with depression in the hospital
This trial tests if a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help teens with depression who haven't gotten enough relief from therapy or medication. It's designed for youth who are currently in the hospital or planning to be admitted.
Toronto, OntarioAges 14–19 - NCT07033780RecruitingPhase 1
Brain stimulation study for depression treatment
This trial tests a new type of brain stimulation called theta-burst stimulation to see if it helps treat depression. It is for people aged 18-50 who are currently experiencing a major depressive episode and are on a stable antidepressant regimen.
Toronto, OntarioAges 18–50 - NCT07003997RecruitingPhase 2
Targeting inflammation for depression treatment
This trial tests whether a medication that targets inflammation in the body can help relieve depression symptoms. You will have blood tests and an MRI to see how your brain and immune system respond.
Atlanta, GeorgiaAges 25–55
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Common questions
- Are there clinical trials for major depressive episode?
- Yes. Clin2 currently lists 195 recruiting major depressive episode studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depressive episode trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depressive episode trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.