Clinical trials
Major Neurocognitive Disorder clinical trials
Below are recruiting major neurocognitive disorder clinical trials, each written for real people, not researchers. We’re tracking 50 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04889794Recruiting
Helps pharmacists support seniors with memory problems after work changes
This study looks at whether reorganizing work in family medicine clinics changes how pharmacists review and support seniors who have major memory (cognitive) problems. It may help improve medication support and seniors’ autonomy with guidance that fits their needs.
Montreal, QuebecAges 65 years+ - NCT07200726Recruiting
Brain inflammation and thinking after heart surgery
This study looks at whether brain inflammation during heart surgery may affect memory and thinking. It includes people aged 60 and older who are having planned heart surgery.
Genk, LimburgAges 60 years+ - NCT04825847Recruiting
Testing brain changes after major surgery in older adults
This study looks at how memory and thinking change after major surgery in people age 70 and older. It may help doctors understand who is at risk and how to reduce problems with thinking after surgery.
Montreal, QuebecAges 70 years+ - NCT07065240RecruitingPhase 2
Study of SPT-300 for major depression with or without anxiety
This trial tests an experimental oral medication, SPT-300, for people with major depressive disorder, even if they also have mild anxiety. The goal is to see if it helps improve mood safely.
Chino, CaliforniaAges 18–65 - NCT06608589Recruiting
Improving care transitions for older adults with memory problems
This study tests a program called CoMPAS+ MNCD to help older adults with memory or thinking problems move smoothly between care settings. It also looks at how to train healthcare workers and improve services in the region.
Québec, QuebecAges 65 years+ - NCT06615167Recruiting
Testing ALZGUARD app for diagnosing dementia
This trial tests an app called ALZGUARD that helps doctors diagnose major neurocognitive disorders (like dementia). If you are between 55 and 85 years old, you may be able to help see if the app works well and is safe.
Chuncheon, Gangwon-doAges 55–85 - NCT07205003Recruiting
Artery stiffness test for memory disorders
This study looks at how the stiffness of your carotid artery (the main artery in your neck) relates to memory problems. It involves a brain MRI that you may already have planned, and results could help doctors better understand certain types of dementia.
RouenAges 70 years+ - NCT07237009Recruiting
Personalized reminiscence therapy for memory loss
This trial tests a digital app that uses personal photos and memories to help people with early memory problems feel less depressed or apathetic. It's designed for seniors who have mild cognitive impairment or early dementia.
AngersAges 60 years+ - NCT07279714RecruitingPhase 2
Fisetin for mild Alzheimer's disease
This trial tests whether a supplement called fisetin can help people with mild Alzheimer's disease or mild cognitive impairment. Fisetin is a natural compound found in fruits and vegetables that may reduce aging-related changes in the body.
Toronto, OntarioAges 60 years+ - NCT07526740Recruiting
Brain Stimulation and Training for Mild Memory Loss
This study tests whether combining brain stimulation (TMS) with cognitive training games can help people with mild cognitive impairment—early memory and thinking problems. The goal is to see if this combination improves thinking abilities and slows cognitive decline.
Charleston, South CarolinaAges 60–85 - NCT06692361Recruiting
Gut bacteria transplant for depression not helped by escitalopram
This trial tests whether transplanting healthy gut bacteria (fecal microbiota) can help people with depression that does not respond well to the antidepressant escitalopram. You will first take escitalopram for 2 weeks, and if it doesn't help enough, you may receive either the real transplant or a placebo capsule.
Wuhu, AnhuiAges 18–65 - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Bellflower, CaliforniaAges 18–74 - NCT04751331RecruitingPhase 1/Phase 2
Study brain response to inflammation in depression
This early-stage study tests how your brain responds to an “inflammatory challenge” in people with major depressive disorder and in healthy volunteers. It may help researchers understand the immune-to-brain link in depression and guide future treatments.
Tulsa, OklahomaAges 18–65 - NCT06902298RecruitingPhase 1/Phase 2
Ultrasound brain stimulation for depression
This trial tests a new, non-invasive ultrasound treatment for people with depression who haven't gotten enough relief from at least two prior treatments. It uses sound waves to gently stimulate areas of the brain linked to mood.
Salt Lake City, UtahAges 18–65 - NCT06606353Recruiting
Talk-to-Jo: A digital companion for memory issues
This trial tests a French-speaking digital assistant called Talk-to-Jo for people recently diagnosed with mild to moderate memory or thinking problems and their caregivers. The goal is to see if this tool helps both the person with memory issues and the person caring for them.
Montreal, QuebecAges 65 years+ - NCT07730957Recruiting
Music program to reduce care refusal in nursing home residents
This trial tests whether a structured music program can help reduce care refusal (like agitation or aggression during bathing) in nursing home residents with memory or thinking problems. Residents who show these behaviors may be eligible.
AmiensAges 18 years+ - NCT04436081RecruitingPhase 2
CBD oil without THC for agitation in Alzheimer’s dementia
This trial studies whether a THC-free CBD oil softgel can reduce agitation in people with Alzheimer’s-related dementia. It compares CBD to a control to see if it improves difficult behaviors and is safe over the study period.
Norfolk, VirginiaAges 50–90 - NCT06631742Recruiting
Exergaming for dementia: a fun exercise trial
This trial tests whether playing interactive video games that combine exercise and thinking challenges (called 'exergaming') can help people with dementia. It aims to see if this fun way to move and think can improve memory, daily function, and quality of life.
Wetzikon, Canton of ZurichAges Any age - NCT06701630Recruiting
Italian study of daily thinking and memory scales
This study is testing new questionnaires to better understand everyday thinking and memory problems in older adults. It aims to improve how doctors identify and track conditions like mild cognitive impairment and early dementia.
Milan, MichiganAges 60 years+ - NCT06488807Recruiting
Smell therapy to prevent confusion after surgery
This study tests whether a simple smell-based activity before and after surgery can help prevent confusion and memory problems in older adults. It is for people 65 and older who are having a long surgery under general anesthesia.
ShanghaiAges 65 years+ - NCT04289142RecruitingPhase 4
Testing memory effects of dexmedetomidine during heart surgery
This study looks at how a sleep medicine called dexmedetomidine affects thinking and memory after heart surgery. It compares cognitive outcomes over time to see if this sedation choice changes long-term brain function.
Vancouver, British ColumbiaAges 60 years+ - NCT05888961Recruiting
Study of taste changes in people with memory problems
This study tracks how taste perception works in people with different stages of memory and thinking problems, including mild to moderate Alzheimer-type conditions. It uses non-painful taste testing and brain-wave measurements to understand changes over time and may help improve how these conditions are assessed.
DijonAges 18 years+ - NCT05886114Recruiting
Lifestyle program to help older adults at risk of memory decline
This trial tests a multi-part lifestyle program to help older adults who may be starting to decline in thinking and memory. It may help slow cognitive decline by combining lifestyle changes over 24 months.
Hangzhou, ZhejiangAges 60–80 - NCT06853405Recruiting
Nutrition program to prevent memory decline
This study tests whether nutrition-based changes can help prevent memory loss and thinking problems in people who are at higher risk for dementia. To join, you need to be between 55 and 85, have at least 4 years of schooling, and have an elevated dementia risk score.
Porto, PortugalAges 55–85
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Common questions
- Are there clinical trials for major neurocognitive disorder?
- Yes. Clin2 currently lists 50 recruiting major neurocognitive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major neurocognitive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major neurocognitive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.