Clinical trials
Major Neurocognitive Disorder clinical trials
Below are recruiting major neurocognitive disorder clinical trials, each written for real people, not researchers. We’re tracking 45 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06597591Recruiting
Virtual reality training to improve self-control in memory loss patients
This study tests whether a virtual reality training game can help improve your ability to stop yourself or control impulses, which can be affected in early memory problems. You will use a VR headset to practice these skills in a safe, fun environment.
NiceAges 60 years+ - NCT06088121Recruiting
TMS with cognitive training for mild Alzheimer's dementia
This study tests a combination of brain stimulation (TMS) and cognitive training to improve memory and thinking in people with mild Alzheimer's. It may help if you are already on a stable dose of a donepezil-type medication and have a confirmed Alzheimer's diagnosis.
Incheon, Bupyeong 6(yuk)-dong, Bupyeong-guAges 60–85 - NCT07377682Recruiting
Trazodone for depression with mild memory problems
This study tests how well the antidepressant trazodone works in older adults with major depression and mild cognitive impairment (early memory or thinking problems). It looks at real-world results in people starting this treatment.
Lodz, PolandAges 55 years+ - NCT07589348Recruiting
Brain Function After Gynecologic Surgery
This study measures whether women experience changes in thinking and memory after having gynecologic surgery (removal of uterus and/or ovaries). Researchers want to understand how anesthesia and surgery affect the brain and identify who might be at risk.
İzmit, KocaeliAges 18 years+ - NCT06375213Recruiting
Memory and thinking study for all ages
This study looks at how well people think and remember as they age. It includes healthy volunteers, people with mild memory issues, and those with dementia—both early- and late-onset.
Pathum Wan, BangkokAges 35 years+ - NCT05457725Recruiting
Study how aging affects learning to trust and distrust
This study looks at how thinking and learning processes change with age, especially around deciding what to trust. You may be asked to complete computer tasks and brief memory/thinking tests to understand these changes.
Gainesville, FloridaAges 18–100 - NCT06036095RecruitingPhase 4
Comparing two types of anesthesia in older adults having surgery
This study compares two types of general anesthesia for older adults (70+) having planned non-heart, non-brain surgery that lasts at least 2 hours. The goal is to see which type might be better for preserving thinking and memory after surgery.
Portland, OregonAges 70–110 - NCT06718140Enrolling by invitationPhase 1
Ultrasound for memory in mild cognitive decline
This study tests if a non-invasive ultrasound treatment can help memory in people with mild cognitive impairment (mNCD) and healthy older adults. It involves MRI scans and focused ultrasound sessions.
Charleston, South CarolinaAges 50–85 - NCT06700291Recruiting
Frailty and thinking problems after surgery in older adults
This study looks at how frailty (a state of being physically weak and less resilient) before hip or knee replacement surgery affects thinking and memory problems after surgery in older adults. It aims to help identify patients who may need extra support.
TbilisiAges 65 years+ - NCT06523296Recruiting
Antibodies and thinking problems in myasthenia or Alzheimer's
This study looks at whether certain antibodies are linked to memory and thinking problems in people with myasthenia gravis or Alzheimer's disease. It involves a one-time use of leftover spinal fluid from a previous diagnostic test.
Nice, Alpes MaritimesAges 18 years+ - NCT06237218Recruiting
Occupational therapy to prevent falls in older adults with dementia
This program tests whether a special type of home-based occupational therapy (called COTID) can help older adults with dementia avoid falling again after a fall that sent them to the hospital. It compares this new approach to usual occupational therapy care.
LimogesAges 75 years+ - NCT05561205Recruiting
Brain stimulation to treat persistent apathy
This trial tests a noninvasive brain stimulation treatment (called rTMS) to help people who have had ongoing apathy (lack of motivation/interest) for at least a month. You might benefit if your apathy is persistent, your other symptoms are stable, and you meet the safety and medication rules.
Toronto, OntarioAges Any age - NCT06626152RecruitingPhase 2
L-DOPA challenge test for depression in older adults
This study tests whether a medication called L-DOPA (used for Parkinson's disease) can help predict how well older adults with depression will respond to treatment. You will take a single dose of L-DOPA and then do simple tasks to measure your mood and thinking.
Vancouver, British ColumbiaAges 60 years+ - NCT07694076Recruiting
Real-time brain feedback for depression
This trial uses a powerful MRI scanner to give you real-time feedback on brain activity linked to depression. You will learn to regulate that activity, which may reduce symptoms.
OxfordAges 18–65 - NCT07493317RecruitingPhase 2
Tocilizumab for depression with inflammation
This trial tests a medication called tocilizumab, which targets inflammation, to see if it can improve symptoms of major depression in people with signs of inflammation. You may be eligible if you have depression with a high monocyte count and significant loss of interest or pleasure.
New York, New YorkAges 18–70 - NCT07383467Recruiting
Single session help for teens with anxiety or depression
This trial offers a one-time digital self-help program for Hong Kong teens aged 12 to 17 who feel anxious or down. It aims to see if a single session can make a difference.
Hong KongAges 12–17 - NCT06860165Recruiting
Mood tracking app study for adults with depression
This study tests a smartphone app (EmoDTx) that monitors mood in people with unipolar depression. It aims to see if the app can provide helpful digital measurements of your mood.
Changé, FranceAges 18 years+ - NCT06213324RecruitingPhase 4
Ketamine's effects on brain circuits in depression
This trial studies how ketamine affects brain circuits in people with depression compared to healthy volunteers. It involves a single infusion of ketamine and brain scans before and after.
New York, New YorkAges 18–65 - NCT03665831Recruiting
Deep TMS for depression and memory problems in older adults
This study tests a type of brain stimulation called Deep TMS to help reduce depression and improve or stabilize memory-related symptoms in older adults with Alzheimer’s disease. It’s mainly for people whose depression did not improve or could not be tolerated with antidepressant medicine.
Toronto, OntarioAges 60 years+ - NCT04061148Recruiting
Near-infrared testing to assess depression
This study uses a near-infrared light test to measure things related to depression. It includes people without depression and people diagnosed with major depressive disorder receiving care at UCSF/SFVAMC, to see how well the test fits with depression status.
San Francisco, CaliforniaAges 18 years+ - NCT06678672Recruiting
Help for veterans who smoke before major surgery
This study tests a program to help veterans who smoke quit before a planned major surgery. The program uses rewards to encourage quitting, and it may improve surgery outcomes.
San Francisco, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for major neurocognitive disorder?
- Yes. Clin2 currently lists 45 recruiting major neurocognitive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major neurocognitive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major neurocognitive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.