Clinical trials
Major Surgery clinical trials
Below are recruiting major surgery clinical trials, each written for real people, not researchers. We’re tracking 95 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07651722Recruiting
Pain control and gut recovery after abdominal surgery
This trial tests a combination of two pain-management approaches—a long-acting numbing medicine injected near nerves and a self-administered opioid—to see if they help your gut function better and control pain after bowel or colon surgery.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT07239557Enrolling by invitation
Best timing for lung expansion moves during surgery
This trial tests different time intervals for a lung-opening technique (alveolar recruitment) during planned abdominal surgery, aiming to restore 90% of lung volume. It may help lower the risk of lung complications after surgery.
Guangzhou, GuangdongAges 65–80 - NCT07634666Recruiting
Heart Safety Monitoring During Urologic Cancer Surgery
This study tracks heart health before and after major surgery for prostate or kidney cancer in older adults. Researchers want to predict which patients might experience heart problems after surgery so they can provide better care.
SeoulAges 60 years+ - NCT06619626Recruiting
Lung opening technique in obese women having gynecologic cancer surgery
This trial tests a lung opening technique (alveolar recruitment) during surgery to improve breathing in obese patients. It may help women with a moderate risk of breathing problems after gynecologic cancer surgery.
IstanbulAges 18 years+ - NCT05828862Recruiting
Checks blood-pressure drops during major upper stomach surgery
This trial studies what happens when blood pressure drops during planned (elective) major upper gastrointestinal surgery and looks at related blood chemistry. Your care team may collect samples during the operation to understand why this happens and how to improve outcomes.
TaipeiAges 20–80 - NCT05812248Recruiting
Tracking heart and blood vessel events after major non-heart surgery
This study follows people after major surgery to see what predicts heart and blood vessel problems later. It does not test a new drug; it mainly collects health information to help clinicians reduce risk.
Guangzhou, GuangdongAges 45 years+ - NCT05732714Recruiting
Reduce heart event risk after major non-heart surgery
This study looks at ways to lower the chance of heart-related problems after major surgery that is not directly related to the heart. It focuses on people at higher heart risk who are expected to stay in the hospital for at least two days after surgery.
Toronto, OntarioAges 45–75 - NCT06279000RecruitingPhase 3
Colchicine for heart risk during major non-heart surgery
This study tests whether a low-cost, anti-inflammatory drug called colchicine can reduce heart complications after major non-heart surgery. If you have heart or blood vessel risk factors and are scheduled for a major operation, this trial may help protect your heart.
Sankt Gallen, Canton of St. GallenAges 45 years+ - NCT06926374Recruiting
Robotic surgery for gastrointestinal and urologic conditions
This trial tests a new robotic surgery system for common operations on the colon, rectum, prostate, kidney, bladder, stomach, esophagus, gallbladder, and hiatal hernia. It may offer a less invasive option for patients who need surgery for these conditions.
Hong KongAges 18–80 - NCT05824260Recruiting
Study of risk factors for complications after major surgery
This study looks at patients who've had major abdominal, bone, or blood-vessel surgery to understand what factors make some people more likely to have complications afterward. It analyzes information already collected from hospitals to help doctors better predict and prevent problems.
AmiensAges 18 years+ - NCT06510140Recruiting
Brain monitoring and frailty to predict confusion after surgery in older adults
This study tests if monitoring your brain waves during surgery and checking your frailty level can help predict whether you might become confused after surgery. It aims to improve care for older adults having major non-cardiac operations.
Saint-EtienneAges 75 years+ - NCT06225453Recruiting
Personalized blood pressure care during surgery
This study compares a personalized approach to managing blood pressure during surgery with the usual one-size-fits-all method. It looks at older adults or those with certain heart or blood vessel conditions having non-emergency surgery to see if individual targets can improve recovery.
SeongnamAges 45 years+ - NCT06952387Recruiting
Personalized blood pressure for high-risk surgery patients
This study tests whether personalized blood pressure management during and after major surgery can reduce complications and death in older adults with heart or blood vessel risks. It aims to find the safest blood pressure targets for each patient.
Guangzhou, GuangdongAges 65–90 - NCT07263061Recruiting
Recovery of albumin after major liver and pancreas surgery
This trial tracks how quickly your albumin (a protein in your blood) returns to normal after major surgery on your liver, pancreas, or bile ducts, to see if that predicts your recovery. It may help doctors understand how you are healing.
New Delhi, National Capital Territory of DelhiAges 13–80 - NCT07351149Recruiting
Study on kidney injury after major surgery in children
This trial looks at how often children develop kidney problems after major surgery that isn't on the heart or kidneys. The goal is to learn more about these injuries and how to prevent them.
Perth, Western AustraliaAges birth–16 years - NCT07410988RecruitingPhase 4
Starch vs. crystalloid fluid for heart surgery patients
This trial compares two types of IV fluids (a starch solution vs. a balanced salt solution) to see which one better protects kidneys after heart surgery. It is for adults having planned heart surgery who do not have severe kidney problems.
DaejeonAges 19 years+ - NCT05454280RecruitingPhase 3
Manage surgical risk after high-risk cancer operations
This study looks at a “risk-based plan” to help guide care after major cancer surgery, aiming to improve recovery and outcomes. You may be in the study when you’re about to have elective (planned) high-risk cancer surgery and then again just before hospital discharge.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07362342Recruiting
Right heart function after lung lobe removal surgery
This study looks at how the right side of the heart handles the stress of having a lung lobe removed. It compares different surgery types (VATS, robotic, or open) and focuses on people with moderate to high heart and lung risk factors.
Rozzano, MIAges 18 years+ - NCT06631872Recruiting
Surgery school prehabilitation via telehealth for lung or abdominal cancer
This trial tests a telehealth program to help you get ready (prehab) before lung or major abdominal cancer surgery. It aims to improve your recovery and might be easier than attending in person.
New Lambton Heights, New South WalesAges 18 years+ - NCT07164833RecruitingPhase 2
Testing a drug to prevent kidney injury after heart surgery
This study tests a new medicine, BX-001N, to see if it can prevent kidney damage during and after heart surgery for aortic disease. It is for people with moderate kidney problems who are having planned surgery that stops the heart briefly.
DaeguAges 19–90 - NCT06720883Recruiting
Robot-assisted surgery for bile duct cancer
This study tests whether robot-assisted surgery is safe and effective for people with perihilar cholangiocarcinoma (a type of bile duct cancer). It may be a good fit for patients whose cancer has not spread and who are healthy enough for major surgery.
PadovaAges 18 years+ - NCT07350265Recruiting
Testing a lung surgery technique to reduce air leaks
This study tests a special ventilation method during lung surgery to see if it can predict air leaks after the procedure. If successful, it could help patients recover more smoothly after a lobectomy or segmentectomy.
AntonyAges 18 years+ - NCT06670248Recruiting
Study of blood vessel health during burn surgery
This trial looks at how a protective layer inside your blood vessels (called the glycocalyx) responds during surgery to remove burned skin. The goal is to improve care for people with major burns.
Barcelona, SpainAges 18 years+
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Common questions
- Are there clinical trials for major surgery?
- Yes. Clin2 currently lists 95 recruiting major surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.