Clinical trials
Major Surgery clinical trials
Below are recruiting major surgery clinical trials, each written for real people, not researchers. We’re tracking 84 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07665463Recruiting
Recovery after surgery with or without opioids
This study compares recovery quality after major urological surgery using either opioid-free or opioid-based general anesthesia. It aims to see if avoiding opioids can improve how patients feel after surgery.
Krakow, Lesser Poland VoivodeshipAges 18–75 - NCT07651722Recruiting
Pain control and gut recovery after abdominal surgery
This trial tests a combination of two pain-management approaches—a long-acting numbing medicine injected near nerves and a self-administered opioid—to see if they help your gut function better and control pain after bowel or colon surgery.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT06704451Recruiting
IL-33 and memory after major abdominal surgery
This study looks at whether a protein called IL-33 is linked to memory and thinking problems that can happen after major abdominal surgery. It may help doctors find patients at risk earlier.
Kunming, YunnanAges Any age - NCT07589348Recruiting
Brain Function After Gynecologic Surgery
This study measures whether women experience changes in thinking and memory after having gynecologic surgery (removal of uterus and/or ovaries). Researchers want to understand how anesthesia and surgery affect the brain and identify who might be at risk.
İzmit, KocaeliAges 18 years+ - NCT06753409Recruiting
Brain monitoring during anesthesia for major abdominal surgery
This study tests whether using a special brain wave monitor during anesthesia can improve recovery for people having major abdominal surgery lasting more than two hours.
AsyutAges 18–70 - NCT06799832Recruiting
Guiding fluid management during major abdominal surgery using a new index
This study tests whether a new tool, the urethral perfusion index, can help doctors better manage fluids during and after major abdominal surgery. It uses standard catheters already in place, so there's no extra device needed.
HamburgAges 45 years+ - NCT07349784Recruiting
Automated lung opening steps during laparoscopic surgery
This trial tests a computer-controlled method to open collapsed lung parts during laparoscopic colorectal cancer surgery. It aims to improve breathing and reduce complications after surgery.
Istanbul, BakırkoyAges 18–80 - NCT07329530Recruiting
Muscle and metabolism study in ICU survivors
This study looks at muscle and metabolism changes in people who have been in the ICU for at least 7 days after major abdominal surgery. It aims to understand how recovery affects the body.
LiègeAges 18 years+ - NCT03113435Recruiting
Oxygen plan during major belly surgery for adults
This study tests a more guided oxygen plan during long major abdominal operations to help manage how much oxygen your body uses. It compares the new oxygen approach to the current standard method during surgery.
RomaAges 18 years+ - NCT07239557Enrolling by invitation
Best timing for lung expansion moves during surgery
This trial tests different time intervals for a lung-opening technique (alveolar recruitment) during planned abdominal surgery, aiming to restore 90% of lung volume. It may help lower the risk of lung complications after surgery.
Guangzhou, GuangdongAges 65–80 - NCT05990790RecruitingPhase 4
Comparing anesthetics and their effect on confusion after surgery
This study compares three different anesthesia medicines to see which one might lower the chance of confusion or delirium after major surgery. If you are 65 or older and having a long, planned non-heart surgery, this trial could help determine the safest option for you.
InnsbruckAges 65 years+ - NCT07085806Recruiting
Pentoxifylline for liver growth after donor surgery
This study tests if a medicine called pentoxifylline can help your liver grow faster after donating a large part of it. You would take the medicine before and after your donor surgery.
New DelhiAges 18–55 - NCT07050771RecruitingPhase 2
Prehabilitation before cancer surgery study
This trial tests a comprehensive program of exercise, nutrition, and wellness support before and after major cancer surgery. It aims to help patients recover faster and better, whether or not they also receive chemotherapy or radiation before surgery.
Houston, TexasAges 18 years+ - NCT06871150Recruiting
Fluid management during major abdominal cancer surgery
This trial compares three different approaches to guiding fluid management during major abdominal cancer surgery. The goal is to find the best way to maintain stable blood pressure and organ function during the procedure.
Bergamo, ItalyAges 65 years+ - NCT06678672Recruiting
Help for veterans who smoke before major surgery
This study tests a program to help veterans who smoke quit before a planned major surgery. The program uses rewards to encourage quitting, and it may improve surgery outcomes.
San Francisco, CaliforniaAges 18 years+ - NCT06657924RecruitingPhase 2
TXA to Prevent Bleeding in Colorectal Surgery
This trial tests a medicine called tranexamic acid (TXA) given right before major colorectal surgery to see if it helps reduce bleeding. If it works, it could make surgery safer for people like you.
Cleveland, OhioAges 18–100 - NCT06294119Recruiting
Brain-heart-vessel interaction study in heart surgery patients
This study looks at how your brain, heart, and blood vessels work together during heart surgery. It uses simple tests to measure these connections, which may help doctors better understand your health.
San Donato Milanese, MilanAges 18 years+ - NCT06119542Recruiting
GlycOrtho: Endothelial damage in major spine surgery
This study looks at how major spine surgery affects the inner lining of blood vessels. It measures a substance called syndecan-1 in the blood to understand this damage.
Bologna, BOAges 12–75 - NCT05168943Recruiting
Comparing nylon and polyurethane epidural tubes for major surgery
This trial compares two types of epidural catheters (nylon vs polyurethane) in people having major orthopedic surgery. It may help find which catheter type is safer and works better for pain control during and after surgery.
Damanhūr, El-BeheiraAges 21–60 - NCT07634666Recruiting
Heart Safety Monitoring During Urologic Cancer Surgery
This study tracks heart health before and after major surgery for prostate or kidney cancer in older adults. Researchers want to predict which patients might experience heart problems after surgery so they can provide better care.
SeoulAges 60 years+ - NCT05828862Recruiting
Checks blood-pressure drops during major upper stomach surgery
This trial studies what happens when blood pressure drops during planned (elective) major upper gastrointestinal surgery and looks at related blood chemistry. Your care team may collect samples during the operation to understand why this happens and how to improve outcomes.
TaipeiAges 20–80 - NCT07558681Recruiting
Antibiotic dosing during liver and pancreas surgery
This study checks if the standard dose of an antibiotic (piperacillin/tazobactam) reaches effective levels in the blood during major liver or pancreas surgery. The goal is to improve infection prevention after surgery.
Vandœuvre-lès-Nancy, LorraineAges 18 years+ - NCT05812248Recruiting
Tracking heart and blood vessel events after major non-heart surgery
This study follows people after major surgery to see what predicts heart and blood vessel problems later. It does not test a new drug; it mainly collects health information to help clinicians reduce risk.
Guangzhou, GuangdongAges 45 years+ - NCT06279000RecruitingPhase 3
Colchicine for heart risk during major non-heart surgery
This study tests whether a low-cost, anti-inflammatory drug called colchicine can reduce heart complications after major non-heart surgery. If you have heart or blood vessel risk factors and are scheduled for a major operation, this trial may help protect your heart.
Sankt Gallen, Canton of St. GallenAges 45 years+
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Common questions
- Are there clinical trials for major surgery?
- Yes. Clin2 currently lists 84 recruiting major surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.