Clinical trials
Major Surgery clinical trials
Below are recruiting major surgery clinical trials, each written for real people, not researchers. We’re tracking 95 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07222072RecruitingPhase 4
Methadone to reduce opioid use after spine surgery
This study tests whether giving methadone during and after major spine surgery can help reduce the need for other opioid pain medicines later. It is for adults having multilevel fusion in the lower or mid-back.
Cleveland, OhioAges 18–72 - NCT06678672Recruiting
Help for veterans who smoke before major surgery
This study tests a program to help veterans who smoke quit before a planned major surgery. The program uses rewards to encourage quitting, and it may improve surgery outcomes.
San Francisco, CaliforniaAges 18 years+ - NCT05355909Recruiting
High-intensity pre-surgery training before major belly surgery
This trial tests whether a structured, high-activity fitness program before elective abdominal surgery can help you prepare and recover better. It’s meant for people considered at moderate to high surgical risk who can safely do pre-op exercise.
Innsbruck, TyrolAges 18–99 - NCT05168943Recruiting
Comparing nylon and polyurethane epidural tubes for major surgery
This trial compares two types of epidural catheters (nylon vs polyurethane) in people having major orthopedic surgery. It may help find which catheter type is safer and works better for pain control during and after surgery.
Damanhūr, El-BeheiraAges 21–60 - NCT03113435Recruiting
Oxygen plan during major belly surgery for adults
This study tests a more guided oxygen plan during long major abdominal operations to help manage how much oxygen your body uses. It compares the new oxygen approach to the current standard method during surgery.
RomaAges 18 years+ - NCT07085806Recruiting
Pentoxifylline for liver growth after donor surgery
This study tests if a medicine called pentoxifylline can help your liver grow faster after donating a large part of it. You would take the medicine before and after your donor surgery.
New DelhiAges 18–55 - NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT07329530Recruiting
Muscle and metabolism study in ICU survivors
This study looks at muscle and metabolism changes in people who have been in the ICU for at least 7 days after major abdominal surgery. It aims to understand how recovery affects the body.
LiègeAges 18 years+ - NCT06871150Recruiting
Fluid management during major abdominal cancer surgery
This trial compares three different approaches to guiding fluid management during major abdominal cancer surgery. The goal is to find the best way to maintain stable blood pressure and organ function during the procedure.
Bergamo, ItalyAges 65 years+ - NCT06799832Recruiting
Guiding fluid management during major abdominal surgery using a new index
This study tests whether a new tool, the urethral perfusion index, can help doctors better manage fluids during and after major abdominal surgery. It uses standard catheters already in place, so there's no extra device needed.
HamburgAges 45 years+ - NCT06119542Recruiting
GlycOrtho: Endothelial damage in major spine surgery
This study looks at how major spine surgery affects the inner lining of blood vessels. It measures a substance called syndecan-1 in the blood to understand this damage.
Bologna, BOAges 12–75 - NCT04103372Recruiting
MRI check for early rectal cancer or large polyps
This trial uses a special MRI before treatment to better understand early rectal cancer or suspicious large polyps. It may help doctors choose care that avoids bigger surgery when possible.
Reading, BerkshireAges 16–100 - NCT05990790RecruitingPhase 4
Comparing anesthetics and their effect on confusion after surgery
This study compares three different anesthesia medicines to see which one might lower the chance of confusion or delirium after major surgery. If you are 65 or older and having a long, planned non-heart surgery, this trial could help determine the safest option for you.
InnsbruckAges 65 years+ - NCT06267378Recruiting
Frailty and its effects on older patients having major gut surgery
This study looks at how frailty affects recovery and outcomes for patients aged 70 and older who are having planned surgery to remove colorectal cancer. The goal is to better understand frailty's impact so care can be improved.
Doncaster, South YorkshireAges 18 years+ - NCT06294119Recruiting
Brain-heart-vessel interaction study in heart surgery patients
This study looks at how your brain, heart, and blood vessels work together during heart surgery. It uses simple tests to measure these connections, which may help doctors better understand your health.
San Donato Milanese, MilanAges 18 years+ - NCT06387303RecruitingEarly Phase 1
Comparing IV Methadone vs Spinal Morphine for Pain After Abdominal Surgery
This study compares two strong painkillers—methadone given through an IV versus morphine injected into the spine—to see which provides better pain relief and recovery after major abdominal surgery. It may help you if you're having open surgery and want less pain afterward.
Charlottesville, VirginiaAges 18–75 - NCT06513598Recruiting
Finding infection signs after abdominal cancer surgery
This study looks for ways to better predict and catch infections after major abdominal cancer surgery. If you are having surgery for certain cancers (esophagus, stomach, pancreas, liver, bile ducts, colon, or rectum), the researchers will check your blood and other samples for early signs of infection so they can start treatment sooner.
VilniusAges 18 years+ - NCT06657924RecruitingPhase 2
TXA to Prevent Bleeding in Colorectal Surgery
This trial tests a medicine called tranexamic acid (TXA) given right before major colorectal surgery to see if it helps reduce bleeding. If it works, it could make surgery safer for people like you.
Cleveland, OhioAges 18–100 - NCT06704451Recruiting
IL-33 and memory after major abdominal surgery
This study looks at whether a protein called IL-33 is linked to memory and thinking problems that can happen after major abdominal surgery. It may help doctors find patients at risk earlier.
Kunming, YunnanAges Any age - NCT06753409Recruiting
Brain monitoring during anesthesia for major abdominal surgery
This study tests whether using a special brain wave monitor during anesthesia can improve recovery for people having major abdominal surgery lasting more than two hours.
AsyutAges 18–70 - NCT07050771RecruitingPhase 2
Prehabilitation before cancer surgery study
This trial tests a comprehensive program of exercise, nutrition, and wellness support before and after major cancer surgery. It aims to help patients recover faster and better, whether or not they also receive chemotherapy or radiation before surgery.
Houston, TexasAges 18 years+ - NCT07349784Recruiting
Automated lung opening steps during laparoscopic surgery
This trial tests a computer-controlled method to open collapsed lung parts during laparoscopic colorectal cancer surgery. It aims to improve breathing and reduce complications after surgery.
Istanbul, BakırkoyAges 18–80 - NCT07512752Recruiting
Preoperative Stress and Confusion After Orthopedic Surgery
This study examines how anxiety before major joint surgery (hip or knee) affects confusion and delirium after surgery in adults 65 and older. Understanding this connection may help doctors better manage patients' emotional and mental health around surgery.
ElâzığAges 65 years+ - NCT07589348Recruiting
Brain Function After Gynecologic Surgery
This study measures whether women experience changes in thinking and memory after having gynecologic surgery (removal of uterus and/or ovaries). Researchers want to understand how anesthesia and surgery affect the brain and identify who might be at risk.
İzmit, KocaeliAges 18 years+
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Common questions
- Are there clinical trials for major surgery?
- Yes. Clin2 currently lists 95 recruiting major surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.