Clinical trials
Major Surgery clinical trials
Below are recruiting major surgery clinical trials, each written for real people, not researchers. We’re tracking 94 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07450950Recruiting
Learning from patients before and after major cancer surgery
This trial looks at how people understand health information and what they expect before and after major cancer surgery. The goal is to help doctors better support patients by learning about their hopes and possible regrets.
Copenhagen, CopenhagenAges 18 years+ - NCT07200726Recruiting
Brain inflammation and thinking after heart surgery
This study looks at whether brain inflammation during heart surgery may affect memory and thinking. It includes people aged 60 and older who are having planned heart surgery.
Genk, LimburgAges 60 years+ - NCT06859892RecruitingPhase 4
Drug combo study for better sleep after major surgery
This study tests whether a combination of two medicines, dexmedetomidine and esketamine, can help improve sleep problems after major non-heart surgery. You may be eligible if you are having planned surgery lasting at least one hour and will use a pain pump after surgery.
BeijingAges 18 years+ - NCT07452263Recruiting
Frailty screening tool for older adults before major surgery
This study tests a simple frailty screening tool in older adults before major surgery. It aims to see if the tool helps identify patients who might need extra support before and after their operation.
Reykjavik, HofudborgarsvaedidAges 70 years+ - NCT06182215Recruiting
Brain function after major abdominal surgery in older adults
This trial studies whether older adults experience thinking or memory changes after major abdominal surgery. It aims to understand these changes so doctors can better support recovery.
Guangzhou, GuangdongAges 65–90 - NCT01528189Recruiting
High-dose insulin to reduce infections after major surgery
This trial tests whether giving high-dose insulin around the time of major abdominal surgery can lower the risk of post-surgery infections. If you’re having elective liver, pancreas, or colorectal surgery, the study looks at whether tighter sugar control helps your recovery.
Montreal, QuebecAges 18 years+ - NCT06774274RecruitingPhase 4
Ketamine for pain after major orthopedic surgery: drip vs. pump
This study tests two ways of giving a medicine called ketamine to control pain after major bone or joint surgery. One method is a steady infusion (drip) through a vein, and the other is a patient-controlled pump (PCA) that lets you press a button for more medicine when you need it.
Medellín, AntioquiaAges 18 years+ - NCT07199881Recruiting
Breathing effort study after major abdominal surgery
This study checks how your breathing effort changes with different levels of breathing support from the ventilator after major abdominal surgery. It helps doctors find the best settings to help you breathe comfortably while you recover.
Bangkok, BangkoknoiAges 18 years+ - NCT07611721Recruiting
Testing a glucose monitor in critically ill surgery patients
This study tests whether a wearable glucose monitor (Dexcom G7) works well in patients in intensive care after major abdominal surgery or organ transplant who need insulin therapy. The monitor measures blood sugar continuously to help doctors manage insulin doses more safely.
PragueAges 18 years+ - NCT07335042Recruiting
Heart injury risk after major liver or bile duct surgery
This study looks at whether certain patients have heart muscle injury (called MINS) after major liver or bile duct surgery. If you are having this type of surgery, your doctors will check your heart with a special blood test before and after. The goal is to find out who is at risk and help prevent problems.
BeijingAges 18–85 - NCT07303855Recruiting
Better fluid management after major abdominal surgery
This study compares two ways of giving fluids to people after major abdominal surgery in the ICU. It will see if using a measure of how much blood the heart pumps (cardiac index) is better than the usual method based on vein pressure.
Jakarta Pusat, DKI JakartaAges 18–65 - NCT07168421RecruitingPhase 4
Landiolol to prevent fast heart rate during major surgery
This trial tests a short-acting medicine called landiolol to see if it can prevent dangerously fast heart rates during and after major surgery. It is for people who have heart risks and are having a planned non-cardiac surgery.
BernAges 45 years+ - NCT07186634RecruitingPhase 4
Surgery recovery medicine platform trial
This trial tests different medicines to improve recovery after surgery. It includes adults having surgery that lasts at least 2 hours and requires an overnight hospital stay.
Melbourne, VictoriaAges 18 years+ - NCT06184724Recruiting
Pre-surgery check for older adults
This trial tests whether a comprehensive geriatric assessment before major surgery helps older adults. It looks at how well clinics can offer this check to patients 80 or older.
Madison, WisconsinAges 18 years+ - NCT06584825Recruiting
Better vital sign monitoring after major surgery
This trial tests if using a home monitoring device after major surgery can help catch problems early. You or your caregiver would take your vital signs (like heart rate and blood pressure) daily and share them with your care team.
Vancouver, British ColumbiaAges 19 years+ - NCT06666985RecruitingPhase 4
Spinal morphine for pain relief after major abdominal surgery
This trial tests whether a single injection of morphine into the fluid around the spine can provide better pain relief after planned laparoscopic or robotic abdominal surgery. If you are having one of several types of major abdominal surgery that lasts at least 2 hours and requires a hospital stay of at least 1 day, this study may be an option.
Guangzhou, GuangdongAges 18 years+ - NCT05630443Recruiting
Prone position after major abdominal cancer surgery
This study looks at whether placing you in a face-down (prone) position after major abdominal cancer surgery can improve recovery. You may be offered this positioning approach after your operation if it’s safe for you.
GothenburgAges Any age - NCT07273136Recruiting
Belly nerve block vs. epidural for pain after cancer surgery
This study compares two ways to manage pain after major abdominal cancer surgery: a numbing injection around the belly muscles (subcostal and lateral TAP block) versus an epidural (a thin tube placed in your back). The goal is to see which provides better pain relief.
AsyutAges 18 years+ - NCT06530641RecruitingPhase 4
Comparing heart protection solutions during major heart surgery
This trial compares two types of cardioplegia (a solution that stops your heart during surgery) to see which one leads to better outcomes. It is for adults undergoing major heart surgery with a heart-lung machine.
Madrid, MadridAges 18 years+ - NCT07275307Recruiting
Test of a wound gel to prevent infections after heart surgery
This study tests whether a special gel applied to the chest incision during heart surgery can lower the chance of wound infections. The gel may help keep the incision site clean and help it heal better.
San Donato Milanese, MichiganAges 18 years+ - NCT06247384Recruiting
Predicting low blood pressure during major abdominal surgery
This trial tests a tool that predicts drops in blood pressure during major abdominal surgery. It may help doctors manage blood pressure better during and after surgery.
Poznan, PoznańAges 18–80 - NCT05728775RecruitingPhase 4
Comparing two anesthetics after major non-heart surgery
This trial compares the anesthesia medicines remimazolam and propofol during major surgery to see how patients do afterward. It may help guide which anesthetic is safer or leads to better recovery in higher-risk patients.
Hefei, AnhuiAges 45 years+ - NCT06635551Recruiting
Comparing blood clot risks after cancer vs. non-cancer surgery
This trial studies how often blood clots form in catheters after major surgery, comparing patients with and without cancer. It may help doctors prevent clotting in the future.
Mersin, YenişehirAges 18–80 - NCT05440331Recruiting
Study of safer handoffs during major surgery in operating rooms
This trial looks at how well information is passed (a “handoff”) between anesthesia team members during major surgery. The goal is to improve safety by reducing preventable mistakes around the time patients move from one caregiver to another.
Boulogne-BillancourtAges 18 years+
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Common questions
- Are there clinical trials for major surgery?
- Yes. Clin2 currently lists 94 recruiting major surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.