Clinical trials
Major Trauma clinical trials
Below are recruiting major trauma clinical trials, each written for real people, not researchers. We’re tracking 18 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06606119Recruiting
Brain, bone marrow, and gut study after major injury
This study is looking at how the brain, bone marrow, and gut interact after a severe injury. It may help doctors understand how to better treat trauma patients.
Gainesville, FloridaAges 18–100 - NCT04588311RecruitingPhase 3
Epoetin to improve outcomes in severe trauma ICU patients
This trial tests epoetin alfa (a blood-building medicine) to help reduce death and severe disability in critically ill trauma patients in the ICU. You may be considered if your ICU team expects a longer stay and the timing after injury is early.
Camperdown, New South WalesAges 18–75 - NCT06551350Recruiting
Studying trauma patient referral in one region
This trial looks at how seriously injured patients were referred to a trauma center in 2023. It aims to understand if the right patients were sent to the right place quickly using an emergency medical team (MICU).
PontoiseAges 18 years+ - NCT05613972Recruiting
Combined therapy for adults with suicidal thoughts and childhood trauma
This study tests a new combination of talk therapies for adults who have both suicidal thoughts and a history of childhood trauma. The goal is to see if this combined approach reduces suicide risk better than usual care.
Toronto, OntarioAges 18 years+ - NCT06930820Recruiting
Registry of severe trauma patients
This trial is a registry that collects information about all patients who come to the Emergency Department with a serious injury. It helps doctors learn more about how to treat and improve care for people with severe trauma.
Pavia, PaviaAges 18 years+ - NCT05449522Recruiting
Vitamin D after major trauma in ICU patients
This trial tests whether giving vitamin D to adults in the ICU after major trauma can improve outcomes. It’s meant for people who don’t have certain conditions that raise calcium levels or make feeding with the study plan unsafe.
TaipeiAges 20 years+ - NCT04839497RecruitingPhase 2
Safety and benefit of injecting fibroblast cells in leg amputees’ skin
This Phase 2 study tests whether injecting a patient’s own (autologous) fibroblast cells into the end of a transtibial (below-knee) amputation is safe and may improve outcomes. You may qualify if you have a certain type of prosthesis timing and healthy skin on the stump, and you can follow frequent visit and wound-care instructions.
Baltimore, MarylandAges 18–75 - NCT04678154RecruitingPhase 3
Antibiotic trial for severe open fractures of the leg or foot
This trial tests a new way of giving antibiotics to people with severe open fractures in the leg, ankle, or foot. The goal is to see if it helps prevent infections after surgery.
Redwood City, CaliforniaAges 18–64 - NCT04789044RecruitingPhase 2
PEG treatment to improve nerve repair after upper-arm injury
This Phase 2 study tests a PEG-based approach meant to help damaged peripheral nerves heal and regain movement and feeling after an upper-arm/hand nerve injury. You may be screened quickly after injury to see if the nerve pattern and your health situation fit the study plan.
Baltimore, MarylandAges 18–80 - NCT05699174RecruitingPhase 3
Compare two antibiotic routes for infected broken bones after surgery
This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.
Indianapolis, IndianaAges 18 years+ - NCT05889559Recruiting
Testing a fluid drainage method to detect leg pressure problems
This study looks at a special drainage measurement (“tissue ultrafiltration”) to better detect and treat acute compartment syndrome, a dangerous increase in pressure in the leg after major injury. It may help doctors identify who needs urgent treatment and improve outcomes after severe leg fractures or crush injuries.
Baltimore, MarylandAges 18–60 - NCT06337292RecruitingPhase 3
Wound vacuum therapy for high-risk leg fractures
This trial tests if a special wound vacuum (negative pressure therapy) applied after surgery can lower the risk of infections and other complications in people with severe leg fractures. If you have a high-risk tibia or ankle fracture, this treatment may help you heal better.
Baltimore, MarylandAges 18 years+ - NCT07006675RecruitingPhase 3
NSAIDs for Tibia Fracture Pain and Healing Study
This study tests whether NSAID pain relievers (like ibuprofen) affect bone healing after a broken tibia and if they can help reduce the need for stronger painkillers. If you qualify, you could help doctors learn the safest way to manage pain after this common injury.
Indianapolis, IndianaAges 18–80 - NCT06627218Recruiting
Comparing two ways to use PCC for traumatic bleeding
This study compares two approaches to using a blood-clotting medicine (called PCC) for people with severe bleeding after a traumatic injury. It aims to find out whether giving PCC more freely or strictly following guidelines leads to better outcomes.
Hangzhou, ZhejiangAges 18–80 - NCT07235696Recruiting
Game intervention to build resilience after stress
This trial tests if a computer game can help people bounce back from major life stress. If you have had a big stressful event in the last 5 years and are fluent in Cantonese or Mandarin, you may be able to join.
Hong KongAges 23–35 - NCT07250893Recruiting
Resolving early life stress in depression: a psychotherapy study
This trial tests if a specific type of psychotherapy can help people with moderate-to-severe depression who experienced stress or adversity in childhood (before age 18). Researchers want to see how the treatment works in the brain and whether it improves depression symptoms.
Hamilton, OntarioAges 18–65 - NCT05527509Recruiting
Study of risk and resilience in new RCMP cadets
This study follows people as they start RCMP Cadet Training to learn what factors affect “risk” and “resilience” (how well someone adapts under stress). It may help improve support for cadets during training.
Regina, SaskatchewanAges 19–57 - NCT06670248Recruiting
Study of blood vessel health during burn surgery
This trial looks at how a protective layer inside your blood vessels (called the glycocalyx) responds during surgery to remove burned skin. The goal is to improve care for people with major burns.
Barcelona, SpainAges 18 years+
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Common questions
- Are there clinical trials for major trauma?
- Yes. Clin2 currently lists 18 recruiting major trauma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major trauma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major trauma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.