Clinical trials
Malignancy clinical trials
Below are recruiting malignancy clinical trials, each written for real people, not researchers. We’re tracking 1,542 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06181032RecruitingPhase 1
Immunotherapy and chemo combo before surgery for bile duct cancer
This trial tests a combination of an immunotherapy (adebrelimab), a targeted therapy (apatinib), and two chemotherapy drugs (gemcitabine and cisplatin) given before surgery for biliary tract cancers that are removable but at high risk of coming back. The goal is to see if this approach helps shrink the tumor and improve outcomes after surgery.
Fuzhou, FujianAges 18–75 - NCT05579275RecruitingEarly Phase 1
Study JCXH-212 to treat advanced solid tumors safely
This early trial tests whether JCXH-212 alone, or with toripalimab (an immunotherapy drug), is safe and tolerable in people with advanced solid cancers. It also looks at whether treatment can help by targeting tumor “neoantigens” found in your tumor tissue.
Beijing, Beijing MunicipalityAges 18–75 - NCT06433869RecruitingPhase 2
Three-drug combination for malignant ascites from digestive cancers
This trial tests three drugs (bevacizumab, serplulimab, and rmhTNF-NC) given together to treat fluid buildup in the belly caused by digestive system cancers. It’s for people whose ascites has not improved after standard treatments.
Guangzhou, GuangdongAges 18 years+ - NCT07824934RecruitingPhase 1
Study of a new drug for advanced solid tumors
This trial tests a new drug, HEC-921, given alone or with other cancer treatments for people with advanced solid tumors. It may be an option for those who have tried standard treatments or who have a specific marker on their tumor.
ShanghaiAges 18 years+ - NCT06487663Recruiting
TACE plus immunotherapy for untreated liver cancer
This study tests combining TACE (a procedure to block the tumor's blood supply) with immunotherapy drugs for liver cancer that has not spread outside the liver. It is for people who have not had any prior treatment for their liver cancer and are healthy enough for TACE.
TianjinAges 18–75 - NCT07810933RecruitingPhase 1/Phase 2
Study of a new ALK inhibitor for advanced cancer
This trial tests a new pill, SY-12321, for people with advanced cancer that has a specific change called ALK. The study aims to see if the drug can shrink tumors or slow their growth, and it may be an option if you've already tried other ALK-targeting treatments.
Guangzhou, GuangdongAges 18 years+ - NCT06468098RecruitingPhase 1
Study of IBI363 for advanced cancer
This trial tests a new drug called IBI363 for people with advanced cancer that has not responded to other treatments. It aims to see if the drug can help shrink tumors or slow cancer growth.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04807257RecruitingPhase 1/Phase 2
Targeted radiation for advanced skin tumors with a nano-therapy
This Phase 1/2 study tests an “Auger molecular therapy” treatment that uses targeted radiation on certain advanced cancers that have spread to the skin. It may help shrink or control skin tumors where the lesion size and location fit the treatment device.
TaipeiAges 18 years+ - NCT07790445RecruitingPhase 4
Adjuvant chemotherapy for bile duct cancer after surgery
This study tests whether giving chemotherapy directly into the liver (HAIC) plus an oral chemo pill (capecitabine) after surgery helps prevent bile duct cancer from coming back, compared to just the pill. It's for people who recently had their cancer completely removed.
Zhengzhou, HenanAges 18 years+ - NCT07790679Recruiting
Microbial testing for severe outer ear infections
This study is looking at people with a severe outer ear infection called malignant otitis externa, which often affects those with diabetes or weakened immune systems. The goal is to test for bacteria or fungi in the infection to guide better treatment.
Sohag, Sohag GovernorateAges Any age - NCT06550102Recruiting
Drug response profiling for blood cancers
This study collects tumor samples from children and young adults with blood cancers to test how their cancer responds to different drugs. The goal is to find more effective treatments for each person.
Zurich, Canton of ZurichAges Up to 40 years - NCT07752953Recruiting
Personalized immune cell therapy for solid tumors
This trial tests a personalized cancer vaccine made from your own immune cells to help your body fight the tumor. It is for people with solid tumors that have not responded to other treatments.
Qinhuangdao, HebeiAges 18–75 - NCT06592417RecruitingPhase 1
Study of JSKN016 for advanced solid tumors
This trial tests a new drug called JSKN016 for people with advanced cancer that has not responded to other treatments. It focuses on certain lung and breast cancers with specific genetic markers.
Fuzhou, FujianAges 18 years+ - NCT06584006RecruitingPhase 2
Boosting low white blood cells in blood cancer patients
This trial tests a combination of two medicines—thymalfasin and IL-2—to see if they can help raise low white blood cell counts (lymphocytes) in people with blood cancers. If you have low lymphocytes from your cancer or its treatment, this study may offer a way to boost your immune system.
Xiamen, FujianAges 18 years+ - NCT06613945Recruiting
Comparing two ways to open blocked bile ducts in liver cancer
This study compares two procedures to drain bile from the liver in people with blocked bile ducts caused by cancer that cannot be removed. It looks at whether using an ultrasound-guided approach along with standard ERCP works better than ERCP alone.
Al Mansurah, Dakahlia GovernorateAges 18 years+ - NCT07734116RecruitingPhase 1/Phase 2
Nivolumab for solid tumors and epithelioid sarcoma
This trial tests a new immunotherapy drug (nivolumab) in children and adults with certain hard-to-treat solid tumors. It may help if standard treatments haven't worked or aren't an option.
Chiba, ChibaAges 12 years+ - NCT06637345Recruiting
Mesothelioma radiotherapy side effect study (MESORTIBO)
This study looks for markers in the blood that can predict side effects in patients with pleural mesothelioma who receive high-dose radiation. If you've had chemotherapy and are getting or have gotten high-dose radiation to the whole chest, researchers want to see if they can identify who is at higher risk of side effects.
Aviano, PordenoneAges 18 years+ - NCT04584333Recruiting
Dentist care for alcohol-related mouth changes
This trial looks at whether a dentist-led approach can help control ongoing mouth conditions linked with heavy alcohol use. It focuses on adults with long-lasting mouth patches diagnosed by biopsy as oral lichen planus or oral leukoplakia.
Santiago de Compostela, A CoruñaAges 40 years+ - NCT07704658RecruitingPhase 4
Pralsetinib drug interaction study for advanced solid tumors
This trial tests how pralsetinib interacts with other drugs in people with advanced solid tumors that have a specific RET gene change. It aims to find the right dose and safety profile.
Logroño, La RiojaAges 18 years+ - NCT06390774RecruitingPhase 1
Study of SSGJ-705 for advanced cancers
This phase 1 trial tests a new targeted drug (SSGJ-705) for people with advanced solid tumors or lymphomas. Doctors will check safety and find the best dose, and there may be a chance the drug helps shrink or control the cancer.
Jinan, ShandongAges 18–75 - NCT04684459RecruitingEarly Phase 1
CAR-T therapy for tumors with HER2 and PD-L1 markers
This early-phase trial tests CAR-T cells designed to attack tumors that have high HER2 and PD-L1. It may help people with certain solid cancers that have not responded well to standard treatment.
Chengdu, SichuanAges 18–75 - NCT07670949Recruiting
68Ga-EV203 imaging for blood cancers
This trial uses a special imaging agent called 68Ga-EV203 to see where certain blood cancers (multiple myeloma, non-Hodgkin lymphoma, or acute myeloid leukemia) are located in the body. It helps doctors understand how the agent spreads and how safe it is.
Hangzhou, ZhejiangAges 18–75 - NCT05141474RecruitingEarly Phase 1
Personalized immune cell treatment for advanced cancers after failed therapy
This trial tests a personalized therapy made from your own immune cells (TIL) picked to match your tumor’s “neoantigens,” plus standard immune-boosting medicine (including IL-2). It’s for people with advanced epithelial or immune “resistant” solid tumors whose cancer has continued growing despite available treatments.
BarcelonaAges 18 years+ - NCT06682936Recruiting
Outpatient talc procedure for cancer-related fluid buildup
This trial tests whether a talc procedure to seal the lung (pleurodesis) can be done safely in an outpatient setting for people with fluid buildup from cancer. It aims to make the treatment more convenient.
Stockton-on-Tees, County DurhamAges 18 years+
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Common questions
- Are there clinical trials for malignancy?
- Yes. Clin2 currently lists 1,542 recruiting malignancy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a malignancy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a malignancy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.