Clinical trials
Microvascular Dysfunction clinical trials
Below are recruiting microvascular dysfunction clinical trials, each written for real people, not researchers. We’re tracking 54 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06669962Recruiting
Studying heart function in Takotsubo syndrome
This trial aims to understand the chemical and physical changes in the heart's blood vessels during Takotsubo syndrome, a temporary heart condition often triggered by stress. It may help doctors better diagnose and treat this condition.
Turin, TurinAges 18–90 - NCT07604467Recruiting
Understanding Stem Cells in Takotsubo Heart Syndrome
This study examines how certain stem cells (CD34+ cells) may contribute to takotsubo syndrome, a temporary heart condition often triggered by stress. By understanding this connection, researchers hope to improve treatment and recovery for patients with this condition.
Ljubljana, LjubljanaAges 18 years+ - NCT06735521Recruiting
Heart MRI stress test for Fontan circulation
This study uses a special heart MRI with a medicine that stresses the heart (like exercise) to look at blood flow in people who have had the Fontan surgery. The goal is to better understand how the heart works after this surgery.
StockholmAges 18 years+ - NCT07380919RecruitingPhase 2/Phase 3
Study of ranolazine to prevent heart muscle damage after a heart attack
This trial tests whether a medication called ranolazine can help prevent damage to tiny blood vessels in the heart after a certain type of heart attack (STEMI). You may be eligible if you recently had this kind of heart attack and had a successful procedure to open a blocked artery, but still have other blockages that can be treated with stents.
Catanzaro, ItalyAges 18–80 - NCT05426408Recruiting
Test study for heart attacks without blocked arteries
This study looks at people who may have MINOCA (heart attack symptoms with no major artery blockage) or takotsubo syndrome (a temporary stress-related heart condition). The goal is to better understand these causes and how they should be diagnosed and treated.
StockholmAges 35–79 - NCT06588244Recruiting
Registry for chest pain with open arteries
This study is looking at people who have chest pain or shortness of breath but whose heart arteries look fairly open on an angiogram. It aims to understand why they have symptoms and how to improve care. You may qualify if you're having a coronary angiogram and it shows no major blockages.
Naples, ItalyAges Any age - NCT07293338Recruiting
Heart muscle blood flow study for dilated cardiomyopathy
This study looks at how small blood vessels in the heart affect outcomes in people with dilated cardiomyopathy (an enlarged, weak heart). You may qualify if you have heart failure with a weak pump and no significant blockages in your main heart arteries.
Hangzhou, ZhejiangAges 18 years+ - NCT05917587RecruitingEarly Phase 1
Metformin for blood-vessel function after pregnancy diabetes
This early study tests whether metformin can improve how small blood vessels work after gestational diabetes (pregnancy diabetes). It may help some people who feel long-term effects after delivery by improving blood-vessel-related function.
Iowa City, IowaAges 18–45 - NCT07093528Recruiting
CS Reducer study for heart failure with preserved pumping function
This trial is testing a device called CS Reducer to see if it can help people with a certain type of heart failure (HFpEF) and a problem with small blood vessels in the heart (CMD). The device may improve blood flow and reduce symptoms.
Rochester, MinnesotaAges 18 years+ - NCT06606821RecruitingPhase 4
Tirzepatide for heart health in people with overweight or obesity
This trial tests the weight‑loss medication tirzepatide (Mounjaro) in people who are overweight or have obesity and have stable coronary artery disease. The goal is to see if tirzepatide can reduce dangerous fatty plaque in heart arteries.
CopenhagenAges 18 years+ - NCT07055152Recruiting
Eye scan to understand heart attack risk in MINOCA patients
This study uses a special eye scan (OCTA) to look at tiny blood vessels in the eye and see if they can help predict outcomes for people who had a heart attack without blocked arteries (MINOCA). It compares these patients to others with typical heart attacks and healthy people.
Pisa, PisaAges Any age - NCT06969547Recruiting
Heart muscle coordination and microvessel function SPECT study
This study uses a special heart scan (SPECT) to look at how well the heart muscle is squeezing and how well the tiny blood vessels in the heart are working. It may help doctors understand why some people have chest pain even when their main arteries are not blocked.
TomskAges 18–75 - NCT06843902RecruitingPhase 2
Improving heart blood flow in women with HIV and diabetes or kidney problems
This trial tests a new approach to improve blood flow in the hearts of women with HIV who also have diabetes or kidney problems. It might help prevent heart disease in this population.
Boston, MassachusettsAges 45–75 - NCT05984537RecruitingPhase 4
Bivalirudin during angioplasty for high-risk heart plaques
This study tests whether a blood thinner called bivalirudin, given during a procedure to open blocked heart arteries (PCI), helps blood flow better in the tiny vessels of the heart afterward. It is for people with a recent unstable heart condition and a high-risk plaque seen on a CT scan.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04822649Recruiting
Assessing exercise capacity in people with heart microvascular problems
This study looks at how well you can exercise and how your body composition relates to tiny blood-vessel problems in the heart. It may help doctors better understand symptoms and function in people who don’t have major blockages in the large heart arteries.
SeoulAges 20–80 - NCT06239974Recruiting
Vericiguat for chest pain from small vessel heart disease
This study tests whether a medication called vericiguat can improve chest pain caused by problems in the tiny blood vessels of the heart (not by large blockages). You may be a candidate if you have stable chest pain, are 40–75, and have had tests showing your heart's small vessels aren't working well.
Hong KongAges 40–75 - NCT06083155Enrolling by invitation
Dutch registry of coronary function tests
This study collects information from people who are already scheduled for a coronary function test, to learn more about heart vessel health. By joining, you help researchers understand patterns and improve care for others.
Nijmegen, GelderlandAges Any age - NCT05593549RecruitingEarly Phase 1
Studying blood vessel damage in type 2 diabetes
This early study looks at how “autophagy” (your body’s cell recycling process) relates to small blood-vessel problems in people with type 2 diabetes. It may help researchers understand mechanisms and possible future treatments, mainly for people who meet specific health and medication criteria.
Milwaukee, WisconsinAges 18–80 - NCT05946785RecruitingEarly Phase 1
Study of blood-vessel changes after gestational diabetes
This early-stage study looks at how “oxidative stress” (cell damage from stress molecules) may affect small blood vessels after pregnancy, especially in people who had gestational diabetes. The goal is to better understand what’s going on and whether these changes could be linked to future health risks.
Iowa City, IowaAges 18–50 - NCT05915260Enrolling by invitation
Heart MRI study in adults with type 2 diabetes
This study uses a heart scan (MRI) to learn more about how the heart is affected in people with type 2 diabetes. It may help researchers better understand changes in the heart over time and who might benefit from future care.
SlagelseAges 18–80 - NCT05616910Enrolling by invitationPhase 2
Inhaled nitric oxide for microvascular problems after brain injury
This Phase 2 study tests whether inhaled nitric oxide can improve tiny blood-flow problems in the brain after traumatic brain injury. If you qualify, you may receive inhaled nitric oxide and be monitored for safety and recovery.
Philadelphia, PennsylvaniaAges 18–75 - NCT05634031Recruiting
Study of heart vessel dysfunction seen on heart imaging
This study looks at coronary microvascular dysfunction (small blood vessel problems in the heart) using heart imaging. It may help researchers understand causes of chest tightness with activity and shortness of breath when the main heart arteries are not blocked.
New York, New YorkAges 18 years+ - NCT05198791RecruitingPhase 2
Eplerenone for heart injury without blocked heart arteries
This Phase 2 study tests whether eplerenone can improve outcomes after a heart attack (or similar heart injury) when coronary angiography shows no blocked heart arteries. It focuses on people with added cardiovascular risk factors and evaluates how well the treatment works for heart recovery and strain on the heart.
East Kilbride, LanarkshireAges 18 years+ - NCT05069740RecruitingEarly Phase 1
Study inflammation and blood vessel changes in endometriosis
This early study looks at how inflammation may affect small blood vessels in people with endometriosis. It may help researchers understand what’s driving symptoms like pain and what could be targeted in the future.
University Park, PennsylvaniaAges 18–45
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Common questions
- Are there clinical trials for microvascular dysfunction?
- Yes. Clin2 currently lists 54 recruiting microvascular dysfunction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a microvascular dysfunction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a microvascular dysfunction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.