Clinical trials
Migraine Headache, With or Without Aura clinical trials
Below are recruiting migraine headache, with or without aura clinical trials, each written for real people, not researchers. We’re tracking 193 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06795867Recruiting
ACT therapy for chronic migraine disability
This study tests whether Acceptance and Commitment Therapy (ACT), a type of talk therapy that helps you accept difficult thoughts and feelings, can reduce disability caused by chronic migraine. You will be placed in one of two groups to compare ACT with your usual care.
Boston, MassachusettsAges 18–65 - NCT06796725Recruiting
Study of TMS for migraine guided by brain imaging
This study tests whether repetitive transcranial magnetic stimulation (rTMS), guided by magnetoencephalography (MEG), can help people with frequent migraines or tension-type headaches. If you have headaches 15 or more days per month, this treatment might reduce your pain.
ShanghaiAges 15–50 - NCT06802471Recruiting
Can electroacupuncture help medication overuse headache?
This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can help people who have headaches very often because they use pain relievers too much. If you join, you will receive either real or sham (placebo) electroacupuncture, and your headaches and quality of life will be tracked for several months.
Beijing, Beijing MunicipalityAges 18–80 - NCT06808230Recruiting
Cocoa extract for migraine prevention study
This trial tests whether taking cocoa extract daily can help prevent migraine attacks in people with 4-14 migraines per month. You'll use a phone app to track your headaches and take either cocoa extract or a placebo.
Boston, MassachusettsAges 18 years+ - NCT06810505RecruitingPhase 3
Oral atogepant for preventing migraines in teens
This trial tests an oral medication called atogepant to see if it can prevent migraines in teens aged 12–17. It aims to reduce how often migraines happen and track any side effects.
Huntsville, AlabamaAges 12–17 - NCT06824025RecruitingEarly Phase 1
Comparing two drugs for headache after spinal anesthesia in C-section
This trial tests if a combination of neostigmine and atropine works better than lidocaine for treating severe headaches that can happen after spinal anesthesia during a planned C-section. It aims to find a more effective way to relieve this type of headache.
MinyaAges 18–35 - NCT06875869Recruiting
Pressure techniques for cervicogenic headache
This trial compares two different pressure techniques (ischemic compression and the Jones technique) to see which better relieves head pain that starts from the neck (cervicogenic headache). It may help if you are an adult aged 25 to 35 with neck-related headaches and specific tender points in your muscles.
Bahawalpur, Punjab ProvinceAges 25–35 - NCT06904287RecruitingPhase 3
Magnesium for migraine treatment in adults
This trial tests if adding magnesium to a standard migraine medication (prochlorperazine) helps treat migraines more effectively. It could be a good option for adults with migraines who haven't taken these drugs recently.
Oak Lawn, IllinoisAges 18 years+ - NCT06943625Recruiting
Green light and brain stimulation for migraine
This trial tests whether combining green light therapy with a gentle brain stimulation technique (transcranial direct current stimulation, or tDCS) can help reduce migraine pain. It may be an option for people with frequent migraines who have not found relief from other treatments.
Rawalpindi, Punjab ProvinceAges 18 years+ - NCT06953622Recruiting
Migraine and PFO: A Follow-up Study
This study is for people who have migraines and a small hole in their heart called a patent foramen ovale (PFO). It will track your health over time to learn more about how these conditions are related.
BeijingAges Any age - NCT06995729RecruitingPhase 1
Testing zavegepant nasal spray in children with migraines
This trial tests whether the medicine zavegepant (given as a nasal spray) is safe and works well for children aged 6 to 11 who have a history of migraines. If your child gets migraines, this study may help find a new treatment option.
Little Rock, ArkansasAges 6–11 - NCT07006454Recruiting
Neck glide techniques for headache from neck problem
This trial tests two different gentle hand-on-neck techniques to see which works better for headaches caused by a neck problem. It may help if your headache is linked to neck stiffness or injury.
IslamabadAges 18–44 - NCT07029126Recruiting
Fremanezumab for migraine with depression: caregiver impact study
This trial tests if fremanezumab, a migraine prevention drug, can also reduce the stress and improve the relationship between migraine patients with mild depression and their caregivers. If you or someone you care for has migraines and low mood, this study may help understand how the caregiver is affected.
Rome, ItalyAges 18 years+ - NCT07061847RecruitingPhase 2
Lidocaine infusion for severe chronic migraines
This trial tests if a lidocaine infusion into an artery in the head can reduce severe chronic daily headaches. It is for people who have tried multiple treatments without enough relief.
Great Neck, New YorkAges 18–75 - NCT07072910RecruitingPhase 2
Cabergoline for migraine prevention
This trial tests if a once-weekly medication called cabergoline can reduce how often you get migraine headaches. It is for adults who have between 4 and 14 migraine days per month.
Aarhus NAges 18 years+ - NCT07093138RecruitingPhase 4
CBD cream for migraine attacks
This trial tests whether a cream made with cannabidiol (CBD) can help stop migraine attacks. It is for people aged 18 to 55 who have had migraines for at least a year and get 2 to 8 attacks per month.
TehranAges 18–55 - NCT07163208Recruiting
Laser therapy for headache from neck problems
This trial tests if different types of low-level laser light can help reduce headaches caused by neck issues. It is a non-invasive treatment option for people whose headaches have lasted at least three months.
Lahore, Punjab ProvinceAges 18–65 - NCT07163416Recruiting
Italian migraine registry study for adults
This study tracks people with migraine to learn more about their condition and improve care. You may join if you have episodic or chronic migraine, with or without aura or medication overuse headaches.
Roma, RomaAges 18 years+ - NCT07170176Recruiting
PFO closure and migraine: can it help?
This trial tests if closing a common heart defect (PFO) can improve migraine symptoms and brain function. It compares people with migraine who get the closure procedure to those without migraine.
Luoyang, HenanAges 18–60 - NCT07054801RecruitingPhase 2
Testing lidocaine and steroids for headache after bleeding stroke
This study tests whether giving two medicines (lidocaine and methylprednisolone) directly into the artery during a routine brain vessel procedure can help relieve headaches caused by a bleeding stroke. It may help find a new treatment for this type of headache.
San Francisco, CaliforniaAges 18 years+ - NCT07279623Recruiting
Nasal stimulation device for migraine prevention
This trial tests if a gentle nasal stimulation device can help prevent migraines. It is for adults with frequent migraines (at least 8 days per month).
StockholmAges 18–65 - NCT07304518RecruitingPhase 2
PRT-064040 nasal spray for migraine in adults
This trial tests a new nasal spray, PRT-064040, to see if it can help treat migraine attacks. It is for adults who have had migraines for at least a year and get 2 to 8 moderate to severe migraines per month.
Beijing, Beijing MunicipalityAges 18–75 - NCT07307508Recruiting
Scalp block for headache after aneurysm bleeding
This trial tests if a scalp nerve block can better manage severe headaches after a brain aneurysm rupture. It is for patients who had an aneurysm treated with coiling in the intensive care unit.
DohaAges 18 years+ - NCT07310290Recruiting
Study of Ubrogepant for Migraine During the Prodrome Phase
This study looks at how well the migraine medication ubrogepant works when taken during the early signs of a migraine (prodrome). It may help people who already use ubrogepant for their migraines.
Aliso Viejo, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for migraine headache, with or without aura?
- Yes. Clin2 currently lists 193 recruiting migraine headache, with or without aura studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine headache, with or without aura trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine headache, with or without aura trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.