Clinical trials
Mitral Valve Disease clinical trials
Below are recruiting mitral valve disease clinical trials, each written for real people, not researchers. We’re tracking 109 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02245763Recruiting
Mitral valve procedure registry for patients who can take blood thinners
This is a study that collects medical information about people having a mitral valve procedure, to better understand outcomes. It may help because it improves how doctors choose and manage care for mitral valve problems.
Washington D.C., District of ColumbiaAges 1 year+ - NCT02996552Recruiting
Ring repair for mild-to-moderate leaky right valve
This trial looks at whether adding a specific repair to the right valve (called tricuspid annuloplasty) during mitral valve surgery helps people whose right valve leakage is not severe. It compares doing the extra right-valve repair versus doing only the mitral valve repair.
Rozzano, MilanoAges 18 years+ - NCT06952374Recruiting
Shockwave balloon for severe mitral valve calcium
This trial tests a special balloon (Shockwave) to treat severe calcium buildup in the mitral valve. It may help people with tight valve opening who cannot have standard surgery.
Shatin, New TerritoriesAges 18 years+ - NCT04097145Recruiting
Heart valve repair for severe leaking tricuspid valve
This trial tests a catheter-based procedure (done through the blood vessels) to repair a severely leaky tricuspid valve. It may help people with symptoms or past hospitalizations from tricuspid valve leakage who are higher-risk for standard surgery.
Phoenix, ArizonaAges 18 years+ - NCT04258488RecruitingPhase 4
Blood thinner pill vs warfarin after mechanical aortic valve
This study compares a blood thinner pill (a factor Xa inhibitor) with warfarin (vitamin K antagonist) in people who have had a mechanical aortic valve replacement. It looks at which option works better and is safer over the long term.
Bucheon-siAges 19 years+ - NCT04898335Recruiting
Tendyne heart valve registry for real-world patient experiences
This registry collects information from people who received the Tendyne mitral valve in routine care. It helps doctors understand how the valve performs in everyday practice and may guide future care.
LinzAges 18 years+ - NCT05061004Recruiting
Testing a new mitral valve treatment delivered through a catheter
This trial tests a new mitral valve device that may improve blood flow in people with significant mitral valve leakage or narrowing, using a catheter instead of open-heart surgery. It’s meant for patients who doctors think this catheter approach is a better fit than surgery.
Phoenix, ArizonaAges 18 years+ - NCT06027788Recruiting
Embolic protection during heart valve surgery
This trial tests a device that may help protect your brain from small particles during heart valve surgery. It is for people 60 and older having certain types of valve replacement or repair.
North Little Rock, ArkansasAges 60 years+ - NCT04733404Recruiting
Dragonfly device study for functional mitral valve leakage
This trial tests a catheter-based procedure (putting a small device through blood vessels) to repair a leaking mitral valve caused by heart muscle problems. It aims to reduce symptoms and improve heart function and safety in people who are still having heart failure symptoms despite standard treatment.
Hangzhou, ZhejiangAges 18 years+ - NCT07516145Recruiting
Robotic catheter repair for leaky tricuspid heart valve
This trial tests a new robotic catheter procedure to repair a leaky tricuspid valve (the valve on the right side of your heart). Instead of open-heart surgery, doctors thread a tiny device through a vein in your neck to fix the valve. It may be an option if you have severe leaking and your heart team thinks surgery is too risky for you.
ShatinAges 18–90 - NCT06607471Recruiting
Study on non-ischemic heart muscle diseases
This study looks at different types of heart muscle diseases that are not caused by blocked arteries (non-ischemic cardiomyopathies). It aims to better understand how to diagnose, predict outcomes, and treat these conditions by gathering information from many patients over time.
Milan, MilanoAges 18 years+ - NCT06797687Recruiting
Studying the mitral valve with different scans before surgery
This study looks at how well CT scans and 3D echo (ultrasound) measure the mitral valve ring before surgery for severe mitral valve leakage. It may help doctors better plan valve repair.
RomaAges 18 years+ - NCT03958773Enrolling by invitation
Transcatheter treatment for severe leaking mitral valve
This study tests a new catheter-based system to treat severe mitral valve leaking when open-heart surgery is considered high risk. It may help improve blood flow and symptoms by repairing the valve without open surgery, using ultrasound guidance and follow-up visits to track safety and results.
KaunasAges 18 years+ - NCT07055919Recruiting
Assist system for mitral valve clip procedure
This study is testing a new assist system to help doctors perform a minimally invasive procedure (MitraClip) that clips the leaky mitral valve without open-heart surgery. It is for people with severe mitral regurgitation who cannot safely have surgery or choose not to.
Xiamen, FujianAges 18 years+ - NCT06600191Recruiting
New mitral valve study for leak repair
This trial tests a new device called the Capstan system to fix a leaky mitral valve (mitral regurgitation) without open-heart surgery. It may help people whose valve leak is moderate to severe and still have symptoms despite medicines.
MelbourneAges 18 years+ - NCT06823700Recruiting
Study of SQ-Kyrin device for leaky mitral valve from heart failure
This trial tests a new device (SQ-Kyrin) to fix a leaky mitral valve without open-heart surgery. It is for people with heart failure whose valve leak causes symptoms, and who are not good candidates for traditional surgery.
Valladolid, ValladolidAges 18 years+ - NCT05496998Recruiting
Heart valve replacement using a catheter for leaking mitral valve
This trial studies a catheter-based procedure to replace the mitral valve in people with severe (or specific moderate) mitral valve leakage that causes symptoms. It may help by reducing leaking and related symptoms when standard surgery or less invasive fixes aren’t suitable for you.
AarhusAges 18 years+ - NCT07741383Recruiting
Combined procedure for severe mitral regurgitation and atrial fibrillation
This study tests whether combining a valve repair procedure with a heart rhythm reset procedure is safe and effective for people with severe mitral regurgitation and atrial fibrillation. It may help improve heart function and reduce symptoms.
Hangzhou, ZhejiangAges 18 years+ - NCT03389542Recruiting
Early mitral valve repair versus watchful waiting
This trial compares doing mitral valve repair early versus closely monitoring without surgery in people who have severe leakage but no symptoms. It aims to see whether early repair helps prevent future heart problems.
AmiensAges 18–75 - NCT07042529Recruiting
Optimizing valve placement during TAVI
This trial is testing a better way to position a new heart valve during a TAVI procedure. The goal is to help the valve work as well as possible for people with severe aortic stenosis.
AalstAges 18 years+ - NCT05298124Recruiting
Repairing a leaking mitral valve in severe heart shock
This trial tests a catheter-based procedure to repair a leaking mitral valve in people who are in severe heart shock and need medication support. The goal is to reduce the valve leak and see if it helps patients stabilize and recover.
Rochester, MinnesotaAges 18 years+ - NCT07213531Recruiting
AI guidance for heart valve treatments
This trial uses artificial intelligence to improve outcomes for patients getting minimally invasive heart valve procedures. It looks at CT scans and ultrasound images to help doctors plan and perform treatments for the aortic, mitral, and tricuspid valves.
New York, New YorkAges 18 years+ - NCT05002543Recruiting
Real-world study of heart valve repair devices for multiple valves
This study checks how well and how safely CORCYM valve devices work in real-world patients with heart valve problems in the aortic, mitral, and/or tricuspid positions. It may help doctors understand expected outcomes outside of tightly controlled research settings.
Indianapolis, IndianaAges Any age - NCT07360899Recruiting
Closing the left atrial appendage during heart surgery to prevent stroke
This trial tests if closing the left atrial appendage with a special stitch during planned heart surgery can help prevent strokes in people with atrial fibrillation. If you already need heart surgery, this extra step may reduce your future stroke risk.
Kamenitz, VojvodinaAges 18 years+
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Common questions
- Are there clinical trials for mitral valve disease?
- Yes. Clin2 currently lists 109 recruiting mitral valve disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mitral valve disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mitral valve disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.