Clinical trials
Mitral Valve Disease clinical trials
Below are recruiting mitral valve disease clinical trials, each written for real people, not researchers. We’re tracking 109 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07830888Recruiting
Mitral valve prolapse rhythm risk study
This study looks at people with mitral valve prolapse who also have rhythm problems like extra beats or fast heart rhythms. The goal is to better understand risk and improve care.
OsloAges Any age - NCT07197736Recruiting
Improving heart ultrasound use at Columbia
This study involves cardiologists who read heart ultrasounds in Columbia's echo lab. It aims to improve how these tests are used to help patients.
New York, New YorkAges 18 years+ - NCT07059793Recruiting
Study of a new mitral valve replacement for heart patients
This trial is testing a replacement valve (called MITRIS) for people whose own mitral valve or a previous artificial valve is not working well. The goal is to see how well the valve works over time after it is implanted.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05927441Recruiting
Heart valve repair/stenting test for leaky mitral valve
This study tests a catheter-based procedure to treat a leaky mitral valve (either FMR or DMR, depending on the group you’re in). It may help reduce symptoms and improve heart function in people who are sick from valve leakage but are able to undergo this specific approach.
BonnAges 18 years+ - NCT06634121Recruiting
Comparing MitraClip and PASCAL for mitral valve repair
This trial compares two devices (MitraClip and PASCAL) for repairing a leaky mitral valve (mitral regurgitation). The goal is to see which device works better in a wide range of patients who need this type of repair.
Munich, BavariaAges 18 years+ - NCT06557616Recruiting
CoolCryo system for treating atrial fibrillation during mitral valve surgery
This trial tests a new tool called CoolCryo that freezes heart tissue to treat atrial fibrillation while you have mitral valve surgery. If you are already having this surgery and also have AF, this device could correct both problems at once.
BydgoszczAges 18 years+ - NCT07058935Recruiting
Heart valve re-replacement study for Asia-Pacific patients
This study looks at how well a new valve works when placed inside a previous mitral or tricuspid valve repair or replacement. It may help people who need another procedure on these heart valves.
New Lambton HeightsAges 21 years+ - NCT04343313Recruiting
Transcatheter repair for leaky mitral valve in high-risk adults
This pilot study tests a newer catheter-based way to reduce leakage of the mitral valve in people who feel sick from mitral regurgitation but are considered too high-risk for standard surgery. If you fit the valve and heart anatomy needs, the study may help improve symptoms and valve function without open-heart surgery.
New York, New YorkAges 21–95 - NCT07601269RecruitingEarly Phase 1
New Mitral Valve Implant for Heart Valve Disease
This early-stage trial tests a new device called the ReValve System that replaces a damaged mitral valve (the valve that controls blood flow in your heart). The study is for people with a weakened heart who have leaking mitral valves and are experiencing heart failure symptoms.
São Paulo, São PauloAges 18 years+ - NCT06757049Recruiting
Using the Edwards MITRIS RESILIA valve in Asian patients
This study looks at how well a new mitral valve (the Edwards MITRIS RESILIA) works in people of Asian descent. It aims to see if this valve is safe and effective for patients who need mitral valve replacement.
Seoul, SONGPA-GUAges 19 years+ - NCT05310461Recruiting
Early or delayed valve surgery for mixed heart valve disease
This study compares doing aortic valve replacement sooner versus waiting, in people with moderate aortic valve narrowing plus at least moderate leakage in the mitral valve. It aims to see which timing improves heart symptoms and outcomes while keeping treatment safe.
BernAges 18 years+ - NCT06414265Recruiting
Testing a new valve for severe mitral regurgitation
This trial tests a new device called the SATURN system, which places a new mitral valve without open-heart surgery. It is for people aged 65 and older with severe mitral regurgitation who are at high risk for surgery.
TbilisiAges 65 years+ - NCT05455489Recruiting
MitraClip registry for severe mitral valve leakage patients
This registry study collects information on people with severe mitral valve leakage (regurgitation) who are treated with the MitraClip G4 device. It aims to better understand which patients benefit most and how well the procedure works in real-world care.
San Donato Milanese, MilanoAges 18 years+ - NCT06075823Recruiting
Mitral valve repair for heart failure with ATTR amyloidosis
This trial tests a clip procedure to fix a leaky heart valve in people who also have a heart condition called ATTR-CM, which can cause heart failure. The clip is placed without open-heart surgery to help improve symptoms and quality of life.
GrazAges 18 years+ - NCT07450911RecruitingPhase 1
Mitral valve replacement with the ReValve system
This study is for people with severe mitral valve leakage (mitral regurgitation) who may need a valve replacement. It tests whether the ReValve system is safe and can help improve symptoms and heart function.
TbilisiAges 18 years+ - NCT06455787Recruiting
J-Valve study for leaky aortic valve patients
This study tests a new, less invasive device called J-Valve for people with severe aortic regurgitation (a leaky aortic valve). It is placed through a tube in the leg artery, avoiding open-heart surgery, and may help those who are at high risk for surgery.
Scottsdale, ArizonaAges 18 years+ - NCT06830499Recruiting
Sapien 3 valve for younger Chinese patients with severe aortic stenosis
This trial tests a newer artificial heart valve (Sapien 3) placed through a small tube in the leg, for younger people (50–70) with severe aortic stenosis. It aims to see if this less invasive option works well in this age group.
Xi'an, ShaanxiAges 50–70 - NCT07848152Recruiting
Monitoring new heart devices
This study follows patients who receive a special new device for a heart condition, either to close a small hole in the heart or to repair a leaky heart valve. The goal is to see how safe and effective these devices are over time.
Lanzhou, GansuAges 18 years+ - NCT05610566Recruiting
HighLife valve replacement for severe leaking mitral valve
This trial studies a new catheter-based valve replacement system for people with moderate to severe, or severe, mitral valve regurgitation (a leaky mitral valve). It aims to check whether the procedure is safe and can improve heart function compared with expected care.
Suzhou, JiangsuAges 18 years+ - NCT04442100Recruiting
Testing a new easy-change heart valve replacement system
This study tests a biological (tissue) heart valve replacement system designed to be easier to change later. It may help people who need valve surgery because their valve is narrowed or damaged.
Tomsk, Tomsk OblastAges 60 years+ - NCT07709208Recruiting
Mitral valve repair for leak that worsens with exercise
This trial tests a procedure to fix a leaky mitral valve that only becomes severe during exercise. It may help people with symptoms like shortness of breath or fatigue who haven't responded to standard heart medications.
DüsseldorfAges 18 years+ - NCT07691307Recruiting
TruGamma tricuspid valve replacement study
This trial tests a new device called TruGamma to replace the tricuspid valve without open-heart surgery. It is for older adults with severe tricuspid regurgitation who cannot have surgery and still have symptoms despite medication.
Beijing, Beijing MunicipalityAges 65 years+ - NCT06467110Enrolling by invitation
Study of SQ-Kyrin TMVr System for leaky mitral valve
This trial tests a new device called the SQ-Kyrin TMVr System to treat severe mitral regurgitation (a leaky heart valve) in people who are not good candidates for traditional open-heart surgery. The goal is to repair the valve without major surgery, using a catheter-based approach.
Shenyang, LiaoningAges 18 years+ - NCT06917664RecruitingPhase 4
Treating moderate mitral regurgitation in heart surgery patients
This trial looks at how to treat moderate mitral regurgitation (a leaky heart valve) in people who are already having coronary artery bypass surgery (CABG). It aims to find the best way to manage this condition to improve heart function.
Beijing, Beijing MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for mitral valve disease?
- Yes. Clin2 currently lists 109 recruiting mitral valve disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mitral valve disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mitral valve disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.