Clinical trials
Moderate to Severe Traumatic Brain Injury clinical trials
Below are recruiting moderate to severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 96 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07269457RecruitingPhase 2
Vitamin D3 for recovery after mild to moderate brain injury
This trial tests if taking vitamin D3 can help reduce swelling and speed up recovery after a mild to moderate traumatic brain injury. It is for people who have low vitamin D levels.
LagosAges 18–65 - NCT07356167Recruiting
Neurosensory training for mild brain injury symptoms
This study tests a special training program that uses sound and head movements to help people with long-lasting symptoms after a mild brain injury or sudden sensory event. The goal is to see if this 'neurosensory' training can reduce problems like dizziness, headache, and brain fog.
Miami, FloridaAges 18 years+ - NCT07357090Recruiting
Carbon dioxide and brain waste clearance trial
This trial tests if breathing in carbon dioxide helps the brain clear waste. It may show how the brain heals after a traumatic brain injury (TBI).
Albuquerque, New MexicoAges 18–82 - NCT07404761Recruiting
Moving your arm after stroke or TBI
This study tests a device that uses mild electrical pulses and augmented reality (a computer overlay on real life) to help people who have arm or hand weakness after a recent stroke or brain injury regain movement.
HaifaAges 18 years+ - NCT07606300Recruiting
Light Training to Help Light Sensitivity After Head Injury
This trial tests whether a training program using colored light targets can help reduce light sensitivity (photophobia) that some people experience after a traumatic brain injury. The training involves focusing your eyes on lights during several visits.
Columbus, OhioAges 18–80 - NCT07655310Recruiting
Parent factors and CT use in kids with minor head injury
This study looks at how a parent's background and understanding of health information might affect whether a child with a minor head injury gets a CT scan. It aims to better understand these factors to improve care.
BursaAges Up to 17 years - NCT06901310Enrolling by invitation
Hyperbaric oxygen for mild head injuries in combat athletes
This study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a special chamber) helps men recover from mild head injuries better than the current standard care (rest). It is for male unarmed combat athletes who have been suspended for a head injury.
Marshfield, WisconsinAges 18 years+ - NCT05929833Enrolling by invitation
Brain injury education program for recovery at home
This study tests a recovery-focused brain injury education and support program for people with traumatic brain injury (TBI) who plan to go home after hospital stay. If you qualify, you and a caregiver/friend may get training and therapy support aimed at improving recovery.
Durham, North CarolinaAges 18 years+ - NCT07215195Recruiting
Brain injury, sleep, and mental health study
This study looks at how brain injuries affect sleep and mental health in the months after injury. It is for people who have had a stroke, brain bleed, or traumatic brain injury within the past year and are willing to let the research team contact their doctor if needed.
OxfordAges 18 years+ - NCT02920788Recruiting
Rehab program study for mild traumatic brain injury symptoms
This trial studies whether a specific rehabilitation program (“GOALS”) helps veterans with mild traumatic brain injury (TBI) who still have thinking or memory problems. It compares the program to usual care, using regular assessments and training over time.
San Francisco, CaliforniaAges 18 years+ - NCT07169370Recruiting
Exercise program for chronic brain injury survivors
This trial tests a 12-week exercise platform designed for people with chronic brain injury. It aims to help you become more active safely at home.
Columbus, OhioAges 18 years+ - NCT06859996Recruiting
Cognitive rehab study for memory and focus after mild brain injury
This study tests two different types of cognitive rehabilitation (education and problem-solving strategies) delivered via video appointments. It may help people with ongoing thinking and memory problems after a mild brain injury.
Seattle, WashingtonAges 18 years+ - NCT06465290Recruiting
Brain recovery treatment for recent stroke with ankle stiffness
This trial tests a treatment to help your brain recover after a stroke. It focuses on improving ankle movement and leg strength using exercises that promote brain rewiring.
Baltimore, MarylandAges 30–85 - NCT05049057RecruitingPhase 2
Testing a nerve-blocking shot for recent mild TBI
This Phase 2 study tests a medication that blocks a pain signal (a CGRP receptor antibody) in people who recently had a mild traumatic brain injury (mTBI) and are also dealing with post-traumatic headache (PTH). The goal is to see if it can reduce symptoms and improve recovery after the injury.
Fort Bragg, North CarolinaAges 18–50 - NCT05426967Recruiting
Brain stimulation for depression after mild traumatic brain injury
This trial studies a noninvasive brain treatment (rTMS) to reduce depression symptoms in people with past mild traumatic brain injury from military service. It may help by changing brain activity, while also requiring stable mental health care and regular follow-up.
Palo Alto, CaliforniaAges 18–55 - NCT05589064Recruiting
Diet and nutrition program for lingering concussion symptoms
This study tests whether a dietary and nutrition intervention can improve symptoms that linger after a concussion. It may help people whose post-concussion symptoms have lasted a short to medium time (at least 2 weeks).
Moncton, New BrunswickAges 16 years+ - NCT05683145Recruiting
Better sleep for people with moderate or severe TBI
This trial studies an approach to improve insomnia (trouble falling or staying asleep) in people who had a moderate-to-severe traumatic brain injury at least one year ago. If you qualify, it may help you restore more regular, efficient sleep after TBI.
Aurora, ColoradoAges 18–60 - NCT05943756Recruiting
Well-being program for adults living with moderate to severe brain injury
This trial tests whether a well-being program can improve quality of life in adults with moderate to severe traumatic brain injury (TBI) more than a year after the injury. If you meet the language and medical-history requirements, you may be invited to join and complete program sessions and screening.
East Hanover, New JerseyAges 18 years+ - NCT06034509Recruiting
Thinking and blood vessel health after head injury
This study looks at how a past traumatic brain injury (TBI) might affect your thinking skills and blood vessel health over time. You may be eligible if you had a TBI at least 3 years ago and have already completed an earlier evaluation at the National Intrepid Center of Excellence (NICoE).
Bethesda, MarylandAges 18–74 - NCT06148324Recruiting
Wellness program for traumatic brain injury recovery
This study tests a wellness program for people who had a moderate or severe traumatic brain injury (TBI) at least a year ago. The program is done online, so you can join from home, and it aims to help you with your recovery and well-being.
New York, New YorkAges 18–70 - NCT06222450Recruiting
Vestibular rehab app for dizziness after mild brain injury
This study tests a smartphone app with exercises to help improve balance and dizziness in people who have had a mild traumatic brain injury. You may be eligible if you are still experiencing dizziness or balance problems.
Tampa, FloridaAges 18 years+ - NCT06381674Recruiting
Wearable tech for balance rehab after concussion
This study tests whether a wearable device can help people with balance and vision problems after a mild concussion. You will use the device to guide your own exercises and help improve your recovery.
Portland, OregonAges 18–60 - NCT06562127Recruiting
Water exercise and cognitive training for veterans with TBI
This trial tests if combining water-based exercise with cognitive training over eight months can help improve thinking and memory in veterans with a past mild or moderate brain injury. It may benefit veterans aged 50-89 who have ongoing cognitive complaints.
Palo Alto, CaliforniaAges 50–89 - NCT06723743Recruiting
Nerve stimulation for attention and memory
This study tests if a gentle, non-invasive nerve stimulation device can help improve attention and memory in veterans with PTSD, depression, or mild brain injury. It uses a small device on the ear to stimulate a nerve that may influence brain function.
Houston, TexasAges 25–64
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Common questions
- Are there clinical trials for moderate to severe traumatic brain injury?
- Yes. Clin2 currently lists 96 recruiting moderate to severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a moderate to severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a moderate to severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.