Clinical trials
Moderate to Severe Traumatic Brain Injury clinical trials
Below are recruiting moderate to severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 96 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06792877Recruiting
Mindfulness for thinking in early Alzheimer's
This study tests if mindfulness training can help protect thinking and memory in early-stage Alzheimer's disease. It compares mindfulness to other activities to see if it slows down memory loss.
Boston, MassachusettsAges 50–100 - NCT06830291Recruiting
Validating a digital cognitive test for head trauma patients
This study aims to validate a digital cognitive assessment tool (Neuralix) for people who have experienced moderate to severe head trauma within the past 5 years. Participation helps ensure the tool is accurate and useful for monitoring recovery.
ClamartAges 18–65 - NCT06855186Recruiting
Rehabilitation for concussion based on your symptoms
This study tests a symptom-focused rehabilitation program for people who had a mild traumatic brain injury (concussion) at least 3 months ago. It aims to help with ongoing cognitive complaints like memory or concentration problems.
Wahiawa, HawaiiAges 18–64 - NCT07044596Recruiting
Non-invasive brain stimulation to slow cognitive decline
This study tests whether a gentle, non-invasive electrical stimulation can help slow memory loss or thinking problems. It is looking for healthy volunteers and people who have had a mild traumatic brain injury within the past year.
Madison, WisconsinAges 20–85 - NCT07055633Recruiting
Improving cognitive rehab for veterans with concussion and PTSD
This trial tests a program to help veterans with memory, attention, or thinking problems after a mild concussion (mTBI) and with PTSD. It also looks at depression and sleep issues. The goal is to improve thinking and daily life.
San Diego, CaliforniaAges 18 years+ - NCT07282691Recruiting
Validating eye tests for mild brain injury
This study looks at eye tests for people who had a mild brain injury (mTBI) in the last 1 to 6 months. It aims to better understand and measure eye movement problems that can happen after such an injury.
Philadelphia, PennsylvaniaAges 18–35 - NCT07332299Recruiting
Brain stimulation and training for seniors with TBI
This study tests if a wearable brain stimulation device (tDCS) combined with computer-based training can improve attention and concentration in older veterans with a history of mild brain injury. It involves several sessions from home using a headset and computer.
Minneapolis, MinnesotaAges 65 years+ - NCT06819904Recruiting
Combined talk therapy and balance rehab for mild TBI
This trial tests a new type of therapy that combines acceptance and commitment therapy (a counseling approach) with vestibular rehabilitation (exercises for balance and dizziness). It's designed for people with mild traumatic brain injury who still have symptoms like dizziness, anxiety, or memory problems.
Pittsburgh, PennsylvaniaAges 18–49 - NCT07624825Recruiting
Emotional Awareness Therapy After Brain Injury
This study tests whether a therapy focused on recognizing and understanding emotions can help people recover better after a moderate or severe traumatic brain injury (TBI). You'll participate if you're at least 6 months past your injury and struggle to identify or describe your feelings.
Edison, New JerseyAges 18 years+ - NCT06973018Enrolling by invitation
Online cognitive rehab for mild memory problems
This trial tests an online program to help people with mild to moderate cognitive problems after a brain injury or nervous system disease improve their thinking skills. It is for Swedish speakers with internet access.
Stockholm, Stockholm CountyAges 18 years+ - NCT04043442Enrolling by invitationPhase 2
Brain stimulation study for alcohol use with mild brain injury
This trial tests a type of brain stimulation to help with day-to-day functioning in people who have alcohol use disorder and a history of mild traumatic brain injury. It also uses brain and symptom testing to see who may benefit most and why.
Hines, IllinoisAges 22–65 - NCT07109804Recruiting
Deep brain stimulation to improve walking after spinal cord injury
This study tests whether stimulating a small area deep in the brain (the cuneiform nucleus) with a device called deep brain stimulation (DBS) can help people walk better after a spinal cord injury. The goal is to see if it improves walking speed and stability.
Miami, FloridaAges 22–70 - NCT07548580Recruiting
Early Movement Therapy for Brain Injury in Hospital ICU
This study looks at how gentle, early physical movement during ICU care affects recovery in patients with serious brain injuries like stroke or head trauma. Researchers will track how patients respond to a structured movement program while they're on a breathing machine.
CopenhagenAges 18 years+ - NCT07065916Enrolling by invitation
Arm More + Camp: Helping kids with arm weakness
This trial tests a program called 'Arm More + Camp' to help kids and teens with arm weakness due to cerebral palsy or a brain injury improve their movement. It’s a group camp-style study that fits into the school year.
Calgary, AlbertaAges 5–17 - NCT07008703RecruitingPhase 1/Phase 2
Study of sss40 for cancer bone pain
This trial tests a new injection called sss40 to treat moderate-to-severe pain caused by cancer that has spread to the bones. The goal is to see if it is safe and effective for people whose pain is not being controlled by current treatments.
Zhengzhou, HenanAges 18 years+ - NCT07472985Recruiting
Early cycling exercise after spinal cord injury
This trial tests if starting leg cycling exercise within the first week after spinal cord injury is safe and helpful. It is for adults who had surgery within 48 hours of their injury and have a specific level of paralysis.
Montreal, QuebecAges 18 years+ - NCT06127316Recruiting
Heel lift height and foot pressure with custom braces
This study tests if changing the height of a heel lift in a custom foot brace can improve how weight is distributed on your foot after a serious ankle or hindfoot injury. If you have pain when walking, this could help find better ways to reduce that pain.
Iowa City, IowaAges 18–65 - NCT07748091Recruiting
Brain wave and inflammation markers in shock therapy for depression
This study looks at brain wave patterns and markers of inflammation in people with depression that hasn't improved with other treatments and who are receiving electroconvulsive therapy (ECT, also known as shock therapy). The goal is to understand how these markers might relate to how well ECT works.
Istanbul, BakırköyAges 18–60 - NCT07740694Recruiting
ECT study for older adults with depression
This study looks at how ECT affects brain activity and inflammation in older adults with depression. It may help researchers understand why ECT works and improve treatment.
Istanbul, BakırköyAges 55 years+ - NCT05974202Recruiting
Brain stimulation and therapy for cocaine use
This study tests a combination of brain stimulation (rTMS) and talk therapy (CBT) to help people reduce cocaine use. It's for adults who want treatment and use cocaine at least once a week.
New York, New YorkAges 22–65 - NCT06396312Recruiting
Predicting lithium response in difficult depression
This study looks at how to predict which people with hard-to-treat depression will benefit from adding lithium to their antidepressant. If you have treatment-resistant depression and are considering lithium, this trial may help find the best treatment for you.
Munich, BavariaAges 18 years+ - NCT06867809Recruiting
Spinal and brain stimulation for arm movement after neck injury
This study tests whether using a combination of spinal and brain stimulation can help improve arm and hand movement in people who have had a cervical spinal cord injury (neck area) at least one year ago. It is for those with some remaining movement but not full strength.
New York, New YorkAges 18 years+ - NCT06015451Recruiting
Exercise for concussion symptoms and headache
This trial tests whether a carefully supervised exercise program can help people who still have headaches or other symptoms weeks after a mild head injury. If you get symptoms when you try to be active, this study may offer a structured way to help you recover.
TrondheimAges 18–65 - NCT05865327Recruiting
Nerve freezing for rib-fracture pain using ultrasound guidance
This trial tests whether freezing a specific nerve (a “cryoneurolysis” treatment) through a catheter can better control pain from traumatic rib fractures. It’s offered to adults who have rib fractures soon after hospital admission and can use a pain control method called patient-controlled regional analgesia.
Toronto, OntarioAges 18–100
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Common questions
- Are there clinical trials for moderate to severe traumatic brain injury?
- Yes. Clin2 currently lists 96 recruiting moderate to severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a moderate to severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a moderate to severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.